BG105236A - New carboxylic acid derivatives carrying keto side-chains, their production and use as endothelin-receptor antagonists - Google Patents

New carboxylic acid derivatives carrying keto side-chains, their production and use as endothelin-receptor antagonists

Info

Publication number
BG105236A
BG105236A BG105236A BG10523601A BG105236A BG 105236 A BG105236 A BG 105236A BG 105236 A BG105236 A BG 105236A BG 10523601 A BG10523601 A BG 10523601A BG 105236 A BG105236 A BG 105236A
Authority
BG
Bulgaria
Prior art keywords
endothelin
production
carboxylic acid
acid derivatives
receptor antagonists
Prior art date
Application number
BG105236A
Other languages
Bulgarian (bg)
Inventor
Wilhelm Amberg
Rolf Jansen
Georg Kettschau
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of BG105236A publication Critical patent/BG105236A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention relates to new carboxylic acid derivatives of formula where the substituents have the meaning given in the description, their production and their use as endothelin-receptor antagonists. 11 claims
BG105236A 1998-08-10 2001-02-09 New carboxylic acid derivatives carrying keto side-chains, their production and use as endothelin-receptor antagonists BG105236A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19836044A DE19836044A1 (en) 1998-08-10 1998-08-10 New 2-(hetero)aryl-alkanoic acid derivatives, useful as mixed endothelin receptor antagonists, e.g. for treating cardiac insufficiency, restenosis, hypertension or prostate cancer
PCT/EP1999/005728 WO2000009489A1 (en) 1998-08-10 1999-08-07 New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists

Publications (1)

Publication Number Publication Date
BG105236A true BG105236A (en) 2001-12-29

Family

ID=7876981

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105236A BG105236A (en) 1998-08-10 2001-02-09 New carboxylic acid derivatives carrying keto side-chains, their production and use as endothelin-receptor antagonists

Country Status (22)

Country Link
EP (1) EP1104410A1 (en)
JP (1) JP2002522531A (en)
KR (1) KR20010072378A (en)
CN (1) CN1323298A (en)
AR (1) AR020147A1 (en)
AU (1) AU5374199A (en)
BG (1) BG105236A (en)
BR (1) BR9912889A (en)
CA (1) CA2340167A1 (en)
CO (1) CO5261504A1 (en)
DE (1) DE19836044A1 (en)
HK (1) HK1042086A1 (en)
HR (1) HRP20010164A2 (en)
HU (1) HUP0104007A3 (en)
ID (1) ID27965A (en)
IL (1) IL140915A0 (en)
NO (1) NO20010622L (en)
PL (1) PL345998A1 (en)
SK (1) SK832001A3 (en)
TR (1) TR200100427T2 (en)
WO (1) WO2000009489A1 (en)
ZA (1) ZA200101975B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (en) * 1999-06-01 2000-12-07 Basf Ag New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636046A1 (en) * 1996-09-05 1998-03-12 Basf Ag New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists

Also Published As

Publication number Publication date
AR020147A1 (en) 2002-04-10
ID27965A (en) 2001-05-03
PL345998A1 (en) 2002-01-14
JP2002522531A (en) 2002-07-23
CA2340167A1 (en) 2000-02-24
NO20010622D0 (en) 2001-02-06
ZA200101975B (en) 2002-03-11
AU5374199A (en) 2000-03-06
KR20010072378A (en) 2001-07-31
HUP0104007A3 (en) 2002-12-28
HUP0104007A2 (en) 2002-05-29
CO5261504A1 (en) 2003-03-31
BR9912889A (en) 2001-05-08
EP1104410A1 (en) 2001-06-06
WO2000009489A1 (en) 2000-02-24
SK832001A3 (en) 2001-11-06
HK1042086A1 (en) 2002-08-02
NO20010622L (en) 2001-02-06
TR200100427T2 (en) 2001-07-23
IL140915A0 (en) 2002-02-10
DE19836044A1 (en) 2000-02-17
CN1323298A (en) 2001-11-21
HRP20010164A2 (en) 2002-04-30

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