HUP0102854A2 - (Ciano-imino)-kinoxalin-származékok, eljárás az előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
(Ciano-imino)-kinoxalin-származékok, eljárás az előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP0102854A2 HUP0102854A2 HU0102854A HUP0102854A HUP0102854A2 HU P0102854 A2 HUP0102854 A2 HU P0102854A2 HU 0102854 A HU0102854 A HU 0102854A HU P0102854 A HUP0102854 A HU P0102854A HU P0102854 A2 HUP0102854 A2 HU P0102854A2
- Authority
- HU
- Hungary
- Prior art keywords
- cyano
- group
- compounds
- optionally substituted
- cyanoiminoquinoxaline
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- MORUUIHTOGRZPK-UHFFFAOYSA-N quinoxalin-2-ylcyanamide Chemical class C1=CC=C2NC(=NC#N)C=NC2=C1 MORUUIHTOGRZPK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano-imino) groups Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010001497 Agitation Diseases 0.000 abstract 1
- 102000018899 Glutamate Receptors Human genes 0.000 abstract 1
- 108010027915 Glutamate Receptors Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004468 heterocyclylthio group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgyát a glutamátreceptorok túlzott izgalmi állapotakövetkeztében fellépő betegségek megelőzésére vagy terápiájáraszolgáló általános képletű vegyületek - ahol X és Y oxigénatom vagy(ciano-imino)-csoport, de legalább egyikük ciano-imino-csoport; R1,R2, R3 és R4 hidrogén- vagy halogénatom, nitro-, ciano- vagyhidroxicsoport, adott esetben szubsztituált amino-, alkil-,cikloalkil-, alkil-karbonil-, karbamoil-, szulfamoil-, aril-,heteroaril- vagy heterociklil-tio-csoport; R5 hidrogénatom,hidroxicsoport, adott esetben szubsztituált alkil-, alkoxi- vagycikloalkilcsoport; R1 és R2, R2 és R3, R3 és R4, valamint R4 és R5mindegyike a velük szomszédos atomokkal együtt karbociklustképezhetnek, amely szubsztituált lehet vagy heteroatomo(ka)ttartalmazhat - és gyógyszerészetileg elfogadható sóik vagy hidrátjaik,intermediereik és előállításuk képezik. A találmány kiterjed avegyületeket tartalmazó gyógyászati készítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15101798 | 1998-06-01 | ||
| PCT/JP1999/002822 WO1999062887A1 (en) | 1998-06-01 | 1999-05-28 | Cyanoiminoquinoxaline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102854A2 true HUP0102854A2 (hu) | 2002-03-28 |
| HUP0102854A3 HUP0102854A3 (en) | 2002-07-29 |
Family
ID=15509486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102854A HUP0102854A3 (en) | 1998-06-01 | 1999-05-28 | Cyanoiminoquinoxaline derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6525054B1 (hu) |
| EP (1) | EP1097927B1 (hu) |
| JP (1) | JP3231338B2 (hu) |
| KR (1) | KR20010043981A (hu) |
| CN (1) | CN1304404A (hu) |
| AT (1) | ATE333447T1 (hu) |
| AU (1) | AU744274B2 (hu) |
| BR (1) | BR9910859A (hu) |
| CA (1) | CA2333515A1 (hu) |
| DE (1) | DE69932441T2 (hu) |
| HU (1) | HUP0102854A3 (hu) |
| ID (1) | ID26809A (hu) |
| IL (1) | IL139783A0 (hu) |
| NO (1) | NO20006065L (hu) |
| NZ (1) | NZ508280A (hu) |
| PL (1) | PL344406A1 (hu) |
| RU (1) | RU2217426C2 (hu) |
| TR (1) | TR200003572T2 (hu) |
| WO (1) | WO1999062887A1 (hu) |
| ZA (1) | ZA200006838B (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100581344B1 (ko) * | 2003-05-02 | 2006-05-23 | 주식회사디엔에이링크 | 텔로머라제 활성 억제용 조성물 |
| EP2241557A1 (de) | 2009-04-02 | 2010-10-20 | Æterna Zentaris GmbH | Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen |
| CN104177595A (zh) * | 2013-05-28 | 2014-12-03 | 海洋王照明科技股份有限公司 | 含喹喔啉基的聚合物及其制备方法和有机太阳能电池器件 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6369057B1 (en) | 1991-04-15 | 2002-04-09 | Aventis Pharma Deutschland Gmbh | Quinoxalines, processes for their preparation and their use |
| AU688459B2 (en) | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
| ES2168383T3 (es) | 1994-09-27 | 2002-06-16 | Yamanouchi Pharma Co Ltd | Derivados de 1,2,3,4-tetrahidroquinoxalindiona y su utilizacion como antagonistas del glutamato receptor. |
| HUT76302A (en) * | 1995-11-30 | 1997-07-28 | Chinoin Gyogyszer Es Vegyeszet | Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them |
| AUPN842196A0 (en) | 1996-03-05 | 1996-03-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| JP2000506170A (ja) | 1996-03-05 | 2000-05-23 | メデイノックス，インコーポレイテッド | 酸化窒素スキャベンジャーを用いる複合治療方法とそのために有用な組成物 |
-
1999
- 1999-05-28 TR TR2000/03572T patent/TR200003572T2/xx unknown
- 1999-05-28 US US09/701,383 patent/US6525054B1/en not_active Expired - Fee Related
- 1999-05-28 BR BR9910859-3A patent/BR9910859A/pt not_active IP Right Cessation
- 1999-05-28 CA CA002333515A patent/CA2333515A1/en not_active Abandoned
- 1999-05-28 RU RU2001101155/04A patent/RU2217426C2/ru not_active IP Right Cessation
- 1999-05-28 HU HU0102854A patent/HUP0102854A3/hu unknown
- 1999-05-28 PL PL99344406A patent/PL344406A1/xx not_active Application Discontinuation
- 1999-05-28 CN CN99806926A patent/CN1304404A/zh active Pending
- 1999-05-28 EP EP99922540A patent/EP1097927B1/en not_active Expired - Lifetime
- 1999-05-28 JP JP55654899A patent/JP3231338B2/ja not_active Expired - Fee Related
- 1999-05-28 KR KR1020007013611A patent/KR20010043981A/ko not_active Application Discontinuation
- 1999-05-28 AU AU39553/99A patent/AU744274B2/en not_active Ceased
- 1999-05-28 IL IL13978399A patent/IL139783A0/xx unknown
- 1999-05-28 NZ NZ508280A patent/NZ508280A/xx unknown
- 1999-05-28 WO PCT/JP1999/002822 patent/WO1999062887A1/ja active IP Right Grant
- 1999-05-28 ID IDW20002390A patent/ID26809A/id unknown
- 1999-05-28 DE DE69932441T patent/DE69932441T2/de not_active Expired - Fee Related
- 1999-05-28 AT AT99922540T patent/ATE333447T1/de not_active IP Right Cessation
-
2000
- 2000-11-22 ZA ZA200006838A patent/ZA200006838B/en unknown
- 2000-11-29 NO NO20006065A patent/NO20006065L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69932441D1 (de) | 2006-08-31 |
| EP1097927A1 (en) | 2001-05-09 |
| NO20006065D0 (no) | 2000-11-29 |
| NO20006065L (no) | 2001-01-31 |
| NZ508280A (en) | 2002-09-27 |
| AU3955399A (en) | 1999-12-20 |
| KR20010043981A (ko) | 2001-05-25 |
| EP1097927B1 (en) | 2006-07-19 |
| RU2217426C2 (ru) | 2003-11-27 |
| US6525054B1 (en) | 2003-02-25 |
| HUP0102854A3 (en) | 2002-07-29 |
| EP1097927A4 (en) | 2002-08-07 |
| ID26809A (id) | 2001-02-08 |
| BR9910859A (pt) | 2001-03-13 |
| PL344406A1 (en) | 2001-11-05 |
| DE69932441T2 (de) | 2007-03-15 |
| AU744274B2 (en) | 2002-02-21 |
| JP3231338B2 (ja) | 2001-11-19 |
| IL139783A0 (en) | 2002-02-10 |
| CN1304404A (zh) | 2001-07-18 |
| TR200003572T2 (tr) | 2001-06-21 |
| ZA200006838B (en) | 2001-05-23 |
| ATE333447T1 (de) | 2006-08-15 |
| WO1999062887A1 (en) | 1999-12-09 |
| CA2333515A1 (en) | 1999-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |