HUP0100879A2 - Nukleozidok és alkalmazásuk vírusellenes gyógyszerkészítmények előállítására - Google Patents
Nukleozidok és alkalmazásuk vírusellenes gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0100879A2 HUP0100879A2 HU0100879A HUP0100879A HUP0100879A2 HU P0100879 A2 HUP0100879 A2 HU P0100879A2 HU 0100879 A HU0100879 A HU 0100879A HU P0100879 A HUP0100879 A HU P0100879A HU P0100879 A2 HUP0100879 A2 HU P0100879A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- nucleosides
- antiviral
- antiviral medicaments
- medicaments
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
A tal lm ny t rgya (I) ltal nos képletű - ahol R jelentése egym stólfüggetlenül hidrogénatom vagy metilcsoport - vegyület vagy gyógy szatiszempontból alkalmazható sói. Az előny"s farmakológiai tulajdons ggalrendelkező említett vegyületek vírusellenes hat súak, és felhasznlhatók a HBV- vagy HIV- fertőzés kezelésére, illetve az ilyenkezelésekre szolg ló gyógyszerkészítmények elő llít s ra. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9800452A SE9800452D0 (sv) | 1998-02-13 | 1998-02-13 | Antivirals |
ZA987267A ZA987267B (en) | 1997-08-15 | 1998-08-13 | Nucleosides |
PCT/SE1998/001467 WO1999009031A1 (en) | 1997-08-15 | 1998-08-14 | Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv) |
PCT/SE1999/000189 WO1999041268A1 (en) | 1998-02-13 | 1999-02-12 | Nucleosides |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0100879A2 true HUP0100879A2 (hu) | 2002-04-29 |
HUP0100879A3 HUP0100879A3 (en) | 2002-08-28 |
Family
ID=20410196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0100879A HUP0100879A3 (en) | 1998-02-13 | 1999-02-12 | Nucleosides and their use for preparation of antiviral medicaments |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1058687B1 (hu) |
JP (1) | JP4413427B2 (hu) |
KR (1) | KR100565388B1 (hu) |
CN (1) | CN1255422C (hu) |
AT (1) | ATE256140T1 (hu) |
AU (1) | AU732408B2 (hu) |
CA (1) | CA2318975A1 (hu) |
DE (1) | DE69913499T2 (hu) |
DK (1) | DK1058687T3 (hu) |
ES (1) | ES2211116T3 (hu) |
HK (1) | HK1035907A1 (hu) |
HU (1) | HUP0100879A3 (hu) |
IL (1) | IL137605A (hu) |
MY (1) | MY121813A (hu) |
NZ (1) | NZ506033A (hu) |
PL (1) | PL190284B1 (hu) |
PT (1) | PT1058687E (hu) |
SE (1) | SE9800452D0 (hu) |
SI (1) | SI1058687T1 (hu) |
TR (1) | TR200002318T2 (hu) |
WO (1) | WO1999041268A1 (hu) |
ZA (1) | ZA991148B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432966B2 (en) * | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
WO2004087140A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of a dipyridodiazepinone and a further antiretroviral compound |
WO2004087169A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of nevirapine and a further antiretroviral compound |
EP1610781A1 (en) * | 2003-03-27 | 2006-01-04 | Boehringer Ingelheim International GmbH | Antiviral combination of tipranavir and a further antiretroviral compound |
DE10321905A1 (de) * | 2003-05-05 | 2004-12-09 | Eberhard-Karls-Universität Tübingen | Verwendung von Kombinationen aus Hemmern der reversen Transkriptase und Hemmern der viruscodierten DNA-Polymerase |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8602981D0 (sv) * | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
IL100874A (en) * | 1991-02-08 | 1996-01-19 | Pro Neuron Inc | Oxiforin nucleosides and their composition, for use as medicines, their preparation and pharmaceutical preparations containing them |
DE4311801A1 (de) * | 1993-04-09 | 1994-10-13 | Hoechst Ag | Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung |
US5543414A (en) * | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
-
1998
- 1998-02-13 SE SE9800452A patent/SE9800452D0/xx unknown
- 1998-08-14 PL PL98366358A patent/PL190284B1/pl not_active IP Right Cessation
-
1999
- 1999-02-12 PT PT99932499T patent/PT1058687E/pt unknown
- 1999-02-12 ES ES99932499T patent/ES2211116T3/es not_active Expired - Lifetime
- 1999-02-12 KR KR1020007008862A patent/KR100565388B1/ko not_active IP Right Cessation
- 1999-02-12 SI SI9930467T patent/SI1058687T1/xx unknown
- 1999-02-12 DE DE69913499T patent/DE69913499T2/de not_active Expired - Fee Related
- 1999-02-12 JP JP2000531460A patent/JP4413427B2/ja not_active Expired - Fee Related
- 1999-02-12 CN CNB998028851A patent/CN1255422C/zh not_active Expired - Fee Related
- 1999-02-12 MY MYPI99000515A patent/MY121813A/en unknown
- 1999-02-12 HU HU0100879A patent/HUP0100879A3/hu unknown
- 1999-02-12 NZ NZ506033A patent/NZ506033A/en not_active IP Right Cessation
- 1999-02-12 DK DK99932499T patent/DK1058687T3/da active
- 1999-02-12 TR TR2000/02318T patent/TR200002318T2/xx unknown
- 1999-02-12 AU AU32819/99A patent/AU732408B2/en not_active Ceased
- 1999-02-12 CA CA002318975A patent/CA2318975A1/en not_active Abandoned
- 1999-02-12 ZA ZA9901148A patent/ZA991148B/xx unknown
- 1999-02-12 EP EP99932499A patent/EP1058687B1/en not_active Expired - Lifetime
- 1999-02-12 AT AT99932499T patent/ATE256140T1/de not_active IP Right Cessation
- 1999-02-12 WO PCT/SE1999/000189 patent/WO1999041268A1/en active IP Right Grant
-
2000
- 2000-07-31 IL IL137605A patent/IL137605A/en unknown
-
2001
- 2001-09-18 HK HK01106601A patent/HK1035907A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1035907A1 (en) | 2001-12-14 |
CA2318975A1 (en) | 1999-08-19 |
WO1999041268A1 (en) | 1999-08-19 |
TR200002318T2 (tr) | 2000-11-21 |
CN1255422C (zh) | 2006-05-10 |
ES2211116T3 (es) | 2004-07-01 |
KR20010074428A (ko) | 2001-08-04 |
JP4413427B2 (ja) | 2010-02-10 |
PT1058687E (pt) | 2004-03-31 |
ZA991148B (en) | 1999-08-12 |
AU3281999A (en) | 1999-08-30 |
DE69913499T2 (de) | 2004-10-28 |
NZ506033A (en) | 2002-02-01 |
AU732408B2 (en) | 2001-04-26 |
SI1058687T1 (en) | 2004-02-29 |
EP1058687B1 (en) | 2003-12-10 |
JP2002503670A (ja) | 2002-02-05 |
ATE256140T1 (de) | 2003-12-15 |
EP1058687A1 (en) | 2000-12-13 |
DK1058687T3 (da) | 2004-03-15 |
CN1290268A (zh) | 2001-04-04 |
HUP0100879A3 (en) | 2002-08-28 |
SE9800452D0 (sv) | 1998-02-13 |
KR100565388B1 (ko) | 2006-03-30 |
IL137605A (en) | 2006-12-31 |
MY121813A (en) | 2006-02-28 |
PL190284B1 (pl) | 2005-11-30 |
DE69913499D1 (en) | 2004-01-22 |
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