HUP0002554A2 - Új metalloproteáz inhibitorok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Új metalloproteáz inhibitorok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0002554A2 HUP0002554A2 HU0002554A HUP0002554A HUP0002554A2 HU P0002554 A2 HUP0002554 A2 HU P0002554A2 HU 0002554 A HU0002554 A HU 0002554A HU P0002554 A HUP0002554 A HU P0002554A HU P0002554 A2 HUP0002554 A2 HU P0002554A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- straight
- preparation
- atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
A tal lm ny t rgya (I) ltal nos képletű vegyületek, ahol R1 jelentésehidrogén- vagy halogénatom, vagy 1-6 szénatomos egyenes vagy el gazószénl ncú alkilcsoport vagy 1-6 szénatomos egyenes vagy el gazó szénlncú alkoxicsoport, R2 jelentése hidroxicsoport, egyenes vagy el gazószénl ncú 1-6 szénatomos alkoxicsoport vagy -NHOH csoport, Ar1jelentése fenilén- vagy bifeniléncsoport, X jelentése oxigén- vagykénatom vagy NR csoport vagy -C-C- csoport vagy vegyértékk"tés, Rjelentése hidrogénatom vagy egyenes vagy el gazó szénl ncú 1-6szénatomos alkilcsoport, n értéke 0 és 6 k"z"tti egész sz m a szélsőértékeket is beleértve, Ar2 jelentése - heteroarilcsoporttalszubsztitu lt fenilcsoport, - heteroarilcsoporttal szubsztitu ltbifenilcsoport, - heteroarilcsoporttal szubsztitu lt piridinilcsoportvagy - heterociklusos csoport, izomerjeik és gyógyszerészetilegalkalmazható savval vagy b zissal alkotott addíciós sóik. A tal lm nya vegyületek elő llít s ra szolg ló elj r st és a vegyületekettartalmazó gyógyszerkészítményeket is mag ban foglalja, amelyek r k,reum s megbetegedések, ateroszklerózis kezelésben alkalmazhatóak. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9908448A FR2795730B1 (fr) | 1999-07-01 | 1999-07-01 | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0002554D0 HU0002554D0 (en) | 2000-08-28 |
| HUP0002554A2 true HUP0002554A2 (hu) | 2002-04-29 |
| HUP0002554A3 HUP0002554A3 (en) | 2002-12-28 |
Family
ID=9547562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002554A HUP0002554A3 (en) | 1999-07-01 | 2000-06-30 | New metalloprotease inhibitors, a process for their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6339092B1 (hu) |
| EP (1) | EP1065209B1 (hu) |
| JP (1) | JP3330583B2 (hu) |
| KR (1) | KR100472521B1 (hu) |
| CN (1) | CN1147492C (hu) |
| AT (1) | ATE239021T1 (hu) |
| AU (1) | AU770168B2 (hu) |
| BR (1) | BR0002265A (hu) |
| CA (1) | CA2313302C (hu) |
| DE (1) | DE60002395T2 (hu) |
| DK (1) | DK1065209T3 (hu) |
| EA (1) | EA002527B1 (hu) |
| ES (1) | ES2198262T3 (hu) |
| FR (1) | FR2795730B1 (hu) |
| HK (1) | HK1034968A1 (hu) |
| HU (1) | HUP0002554A3 (hu) |
| NO (1) | NO20003431L (hu) |
| NZ (1) | NZ505522A (hu) |
| PL (1) | PL341134A1 (hu) |
| PT (1) | PT1065209E (hu) |
| SI (1) | SI1065209T1 (hu) |
| ZA (1) | ZA200003310B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770647B2 (en) * | 2001-08-17 | 2004-08-03 | Bristol-Myers Squibb Pharma Company | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| DE102005002500A1 (de) * | 2005-01-19 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen |
| US20110034526A1 (en) * | 2007-12-21 | 2011-02-10 | Wyeth Llc | Benzimidazole Compounds |
| KR100962022B1 (ko) | 2010-01-12 | 2010-06-08 | (주) 유니크코리아엔아이 | 정전용량형 압력센서 및 그 제조방법 |
| JP6280573B2 (ja) * | 2013-03-14 | 2018-02-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ブロモドメイン阻害薬としてのフロピリジン |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
| EP1003751A1 (en) * | 1997-08-04 | 2000-05-31 | Amgen Inc. | Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors |
-
1999
- 1999-07-01 FR FR9908448A patent/FR2795730B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-28 KR KR10-2000-0035946A patent/KR100472521B1/ko not_active IP Right Cessation
- 2000-06-29 JP JP2000195536A patent/JP3330583B2/ja not_active Expired - Fee Related
- 2000-06-30 AT AT00401864T patent/ATE239021T1/de not_active IP Right Cessation
- 2000-06-30 CA CA002313302A patent/CA2313302C/fr not_active Expired - Fee Related
- 2000-06-30 NZ NZ505522A patent/NZ505522A/en unknown
- 2000-06-30 DK DK00401864T patent/DK1065209T3/da active
- 2000-06-30 HU HU0002554A patent/HUP0002554A3/hu unknown
- 2000-06-30 EP EP00401864A patent/EP1065209B1/fr not_active Expired - Lifetime
- 2000-06-30 US US09/608,240 patent/US6339092B1/en not_active Expired - Fee Related
- 2000-06-30 AU AU43784/00A patent/AU770168B2/en not_active Ceased
- 2000-06-30 ES ES00401864T patent/ES2198262T3/es not_active Expired - Lifetime
- 2000-06-30 DE DE60002395T patent/DE60002395T2/de not_active Expired - Fee Related
- 2000-06-30 PT PT00401864T patent/PT1065209E/pt unknown
- 2000-06-30 ZA ZA200003310A patent/ZA200003310B/xx unknown
- 2000-06-30 SI SI200030088T patent/SI1065209T1/xx unknown
- 2000-06-30 NO NO20003431A patent/NO20003431L/no not_active Application Discontinuation
- 2000-06-30 CN CNB001199099A patent/CN1147492C/zh not_active Expired - Fee Related
- 2000-06-30 EA EA200000598A patent/EA002527B1/ru not_active IP Right Cessation
- 2000-06-30 PL PL00341134A patent/PL341134A1/xx not_active Application Discontinuation
- 2000-07-03 BR BR0002265-9A patent/BR0002265A/pt not_active IP Right Cessation
-
2001
- 2001-08-15 HK HK01105716A patent/HK1034968A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1034968A1 (en) | 2001-11-09 |
| NZ505522A (en) | 2001-12-21 |
| AU4378400A (en) | 2001-01-04 |
| CN1290703A (zh) | 2001-04-11 |
| ES2198262T3 (es) | 2004-02-01 |
| HUP0002554A3 (en) | 2002-12-28 |
| CA2313302A1 (fr) | 2001-01-01 |
| CA2313302C (fr) | 2004-06-15 |
| PL341134A1 (en) | 2001-01-02 |
| JP2001039983A (ja) | 2001-02-13 |
| NO20003431L (no) | 2001-01-02 |
| DE60002395T2 (de) | 2004-04-08 |
| HU0002554D0 (en) | 2000-08-28 |
| FR2795730A1 (fr) | 2001-01-05 |
| FR2795730B1 (fr) | 2001-08-31 |
| BR0002265A (pt) | 2001-03-13 |
| SI1065209T1 (en) | 2003-08-31 |
| EA200000598A1 (ru) | 2001-02-26 |
| PT1065209E (pt) | 2003-08-29 |
| DK1065209T3 (da) | 2003-08-25 |
| US6339092B1 (en) | 2002-01-15 |
| NO20003431D0 (no) | 2000-06-30 |
| EP1065209A1 (fr) | 2001-01-03 |
| CN1147492C (zh) | 2004-04-28 |
| DE60002395D1 (de) | 2003-06-05 |
| ATE239021T1 (de) | 2003-05-15 |
| AU770168B2 (en) | 2004-02-12 |
| EP1065209B1 (fr) | 2003-05-02 |
| KR100472521B1 (ko) | 2005-03-08 |
| EA002527B1 (ru) | 2002-06-27 |
| ZA200003310B (en) | 2001-01-25 |
| KR20010039689A (ko) | 2001-05-15 |
| JP3330583B2 (ja) | 2002-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |