HUP0001940A2 - Benzizotiazolszármazékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzizotiazolszármazékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0001940A2 HUP0001940A2 HU0001940A HUP0001940A HUP0001940A2 HU P0001940 A2 HUP0001940 A2 HU P0001940A2 HU 0001940 A HU0001940 A HU 0001940A HU P0001940 A HUP0001940 A HU P0001940A HU P0001940 A2 HUP0001940 A2 HU P0001940A2
- Authority
- HU
- Hungary
- Prior art keywords
- cr8r8
- alkenyl
- nr4r5
- alkoxy
- group
- Prior art date
Links
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 methylene, carbonyl Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány (I) általános képletű vegyületekre - amelyek képletében R-NH-C(X2)-NH-(CR13R14)v-Z csoport; X oxigénatom, karbonil-, C(X1)2vagy S(O)m csoport; A jelentése metilén-, karbonil- vagytiokarbonilcsoport; R1 hidrogén-, halogénatom, nitro-, ciano-,halogén-alkil-, alkil-, alkenil-, alkoxi-, halogén-alkoxi-, azido-, -(CR8R8)qS(O)tR4, hidroxi-, hidroxi-alkil-, aril-, aril-alkil-, aril-oxi-, aril-alkoxi-, heteroaril-, heteroaril-alkil-, heterociklil-,heterociklil-alkil-, heteroaril-alkil-, heterociklil-, heterociklil-alkil-, heteroaril-alkoxi-, aril-alkenil-, heteroaril-alkenil-,heterociklil-alkenil-, -(CR8R8)qNR4R5, -alkenil-C(O)NR4R5, -(CR8R8)qC(O)NR4R5, -(CR8R8)qC(O)NR4R10, -S(O)3R8, -(CR8R8)qC(O)R11, -alkenil-C(O)R11, -alkenil-C(O)OR11, -C(O)R11, -(CR8R8)qC(O)OR12, -(CR8R8)qOC(O)R11, -(CR8R8)qNR4C(O)R11, -(CR8R8)qC(NR4)NR4R5, -(CR8R8)qNR4C(NR5)R11, -(CR8R8)qNHS(O)2R17 vagy -(CR8R8)qS(O)2NR4R5csoport, vagy két R1 csoport együtt -O-(CH2)s-O- csoportot vagy egyciklusos csoportot képezhet; m értéke 1, 2vagy 3 - és a vegyületekettartalmazó, IL-8a vagy IL-8b receptorhoz kötődő kemokin által mediáltbetegségek kezelésére szolgáló gyógyszerkészítményekre vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3599097P | 1997-01-23 | 1997-01-23 | |
US4283097P | 1997-04-08 | 1997-04-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001940A2 true HUP0001940A2 (hu) | 2001-01-29 |
HUP0001940A3 HUP0001940A3 (en) | 2002-09-30 |
Family
ID=26712686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001940A HUP0001940A3 (en) | 1997-01-23 | 1998-01-23 | Benzisothiazole derivatives, their use and pharmaceutical compositions containing them |
Country Status (20)
Country | Link |
---|---|
US (1) | US6166055A (hu) |
EP (1) | EP1005341B1 (hu) |
JP (1) | JP2002515055A (hu) |
KR (1) | KR20000070369A (hu) |
CN (1) | CN1253501A (hu) |
AR (1) | AR008331A1 (hu) |
AT (1) | ATE381330T1 (hu) |
AU (1) | AU729893B2 (hu) |
BR (1) | BR9807085A (hu) |
CA (1) | CA2278427A1 (hu) |
DE (1) | DE69838874T2 (hu) |
ES (1) | ES2299200T3 (hu) |
HU (1) | HUP0001940A3 (hu) |
IL (1) | IL131005A0 (hu) |
NO (1) | NO313913B1 (hu) |
NZ (1) | NZ336859A (hu) |
PE (1) | PE103699A1 (hu) |
PL (1) | PL334774A1 (hu) |
TR (1) | TR199901761T2 (hu) |
WO (1) | WO1998032438A1 (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AR015426A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
EP1121360A4 (en) * | 1998-10-13 | 2002-01-23 | Smithkline Beecham Corp | INTERLEUKIN-8 (IL-8) RECEPTOR ANTAGONISTS |
WO2000069435A1 (en) * | 1999-05-18 | 2000-11-23 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
EP1196399A1 (en) * | 1999-07-16 | 2002-04-17 | Basf Aktiengesellschaft | Process for the preparation of substituted benzisothiazole compounds |
US6440993B1 (en) | 1999-10-12 | 2002-08-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
PE20011124A1 (es) | 2000-03-31 | 2001-10-28 | Upjohn Co | Nuevos agentes antibacterianos de benzosultam oxazolidinona |
DE10038709A1 (de) | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
CA2565519A1 (en) | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
PE20081785A1 (es) | 2007-02-19 | 2009-01-12 | Novartis Ag | Derivados de ciclohexil-amida del acido aril carboxilico |
TWI643845B (zh) | 2012-05-11 | 2018-12-11 | 重植治療公司 | 隱花色素調節劑之含咔唑磺醯胺類 |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09511998A (ja) * | 1994-04-15 | 1997-12-02 | グラクソ、ウェルカム、インコーポレーテッド | 1,4 − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法 |
JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
IL123939A (en) * | 1995-10-05 | 2001-11-25 | Kyoto Pharma Ind | The history of the heterocycles and the pharmaceutical preparations containing them |
US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AR015426A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
AU2234199A (en) * | 1998-01-16 | 1999-08-02 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
-
1998
- 1998-01-22 AR ARP980100284A patent/AR008331A1/es not_active Application Discontinuation
- 1998-01-23 KR KR1019997006602A patent/KR20000070369A/ko not_active Application Discontinuation
- 1998-01-23 CA CA002278427A patent/CA2278427A1/en not_active Abandoned
- 1998-01-23 CN CN98803564A patent/CN1253501A/zh active Pending
- 1998-01-23 AU AU58278/98A patent/AU729893B2/en not_active Ceased
- 1998-01-23 DE DE69838874T patent/DE69838874T2/de not_active Expired - Fee Related
- 1998-01-23 BR BR9807085-1A patent/BR9807085A/pt not_active Application Discontinuation
- 1998-01-23 AT AT98901852T patent/ATE381330T1/de not_active IP Right Cessation
- 1998-01-23 US US09/341,382 patent/US6166055A/en not_active Expired - Fee Related
- 1998-01-23 ES ES98901852T patent/ES2299200T3/es not_active Expired - Lifetime
- 1998-01-23 PL PL98334774A patent/PL334774A1/xx unknown
- 1998-01-23 EP EP98901852A patent/EP1005341B1/en not_active Expired - Lifetime
- 1998-01-23 JP JP53213998A patent/JP2002515055A/ja not_active Ceased
- 1998-01-23 IL IL13100598A patent/IL131005A0/xx unknown
- 1998-01-23 NZ NZ336859A patent/NZ336859A/xx unknown
- 1998-01-23 WO PCT/US1998/001292 patent/WO1998032438A1/en active IP Right Grant
- 1998-01-23 HU HU0001940A patent/HUP0001940A3/hu unknown
- 1998-01-23 TR TR1999/01761T patent/TR199901761T2/xx unknown
- 1998-07-22 PE PE1998000656A patent/PE103699A1/es not_active Application Discontinuation
-
1999
- 1999-07-22 NO NO19993585A patent/NO313913B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE381330T1 (de) | 2008-01-15 |
KR20000070369A (ko) | 2000-11-25 |
NZ336859A (en) | 2001-01-26 |
CN1253501A (zh) | 2000-05-17 |
DE69838874D1 (de) | 2008-01-31 |
ES2299200T3 (es) | 2008-05-16 |
AU5827898A (en) | 1998-08-18 |
DE69838874T2 (de) | 2008-12-04 |
US6166055A (en) | 2000-12-26 |
NO993585D0 (no) | 1999-07-22 |
BR9807085A (pt) | 2000-04-18 |
EP1005341B1 (en) | 2007-12-19 |
AR008331A1 (es) | 1999-12-29 |
EP1005341A4 (en) | 2004-09-08 |
PL334774A1 (en) | 2000-03-13 |
AU729893B2 (en) | 2001-02-15 |
TR199901761T2 (xx) | 1999-10-21 |
IL131005A0 (en) | 2001-01-28 |
CA2278427A1 (en) | 1998-07-30 |
WO1998032438A1 (en) | 1998-07-30 |
HUP0001940A3 (en) | 2002-09-30 |
NO313913B1 (no) | 2002-12-23 |
PE103699A1 (es) | 1999-12-30 |
JP2002515055A (ja) | 2002-05-21 |
EP1005341A1 (en) | 2000-06-07 |
NO993585L (no) | 1999-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |