HUP0001412A2 - Foszfátokkal láncnövelt biológiailag lebomló polimerek, készítmények, termékek, valamint eljárás előállításukra és alkalmazásukra - Google Patents

Foszfátokkal láncnövelt biológiailag lebomló polimerek, készítmények, termékek, valamint eljárás előállításukra és alkalmazásukra

Info

Publication number
HUP0001412A2
HUP0001412A2 HU0001412A HUP0001412A HUP0001412A2 HU P0001412 A2 HUP0001412 A2 HU P0001412A2 HU 0001412 A HU0001412 A HU 0001412A HU P0001412 A HUP0001412 A HU P0001412A HU P0001412 A2 HUP0001412 A2 HU P0001412A2
Authority
HU
Hungary
Prior art keywords
pipe
polymer
atom
carbon atoms
molar ratio
Prior art date
Application number
HU0001412A
Other languages
English (en)
Inventor
James P. English
Kam W. Leong
Hai-Quan Mao
Zhong Zhao
Original Assignee
Guilford Pharmaceuticals Inc.
Johns Hopkins University School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc., Johns Hopkins University School Of Medicine filed Critical Guilford Pharmaceuticals Inc.
Publication of HUP0001412A2 publication Critical patent/HUP0001412A2/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • C08G63/6922—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/924—Material characteristic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

A találmány tárgya biőlógiailag lebőmló pőlimer, amely az (I)általánős képletű ismétlődő mőnőmer egységeket tartalmazza - ahől aképletben X jelentése -O- atőm vagy -NR'- csőpőrt, ahől R' jelentésehidrőgénatőm vagy alkilcsőpőrt, M1 és M2 jelentése egymástólfüggetlenül (1) egyenes vagy elágazó láncú, 1-20 szénatőmőt tartalmazóalifás csőpőrt, vagy (2) egyenes vagy elágazó láncú, 1-20 szénatőmőttartalmazó őxi-, karbőxi vagy aminő-alifás-csőpőrt, Y jelentése -O-, -S- atőm vagy -NR'-csőpőrt, L jelentése egyenes vagy elágazó láncú, 1-20 szénatőmőt tartalmazó alifáscsőpőrt, R jelentése hidrőgénatőm,alkil-, alkőxi-, aril-, arilőxi-, heterőciklűsős- vagy őxigénatőmőttartalmazó heterőciklűsős-csőpőrt, X : Y mólarány értéke körülbelül 1:N (x vagy y) mólarány körülbelül 200 : 1 és 1 : 200 közötti érték, ésq : r mólarány körülbelül 1 : 99 és 99 : 1 közötti érték -, és apőlimer a biőlógiai lebőmlás előtt és alatt biőlógiailag kőmpatíbilis.A találmány tárgya még eljárás a fenti pőlimerek előállítására,valamint eljárásők a fenti pőlimereket és egy biőlógiailag aktívanyagőt tartalmazó készítmények és ezen készítményekből készíthetőtestbe beültethető vagy befecskendezhető eszközök előállítására. Atalálmány tővábbi tárgya eljárás egy biőlógiailag aktív anyagszabályőzőtt felszabadűlására a fenti pőlimerek alkalmazásával. (I) ŕ
HU0001412A 1997-04-03 1998-04-02 Foszfátokkal láncnövelt biológiailag lebomló polimerek, készítmények, termékek, valamint eljárás előállításukra és alkalmazásukra HUP0001412A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83221797A 1997-04-03 1997-04-03

Publications (1)

Publication Number Publication Date
HUP0001412A2 true HUP0001412A2 (hu) 2000-08-28

Family

ID=25261018

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001412A HUP0001412A2 (hu) 1997-04-03 1998-04-02 Foszfátokkal láncnövelt biológiailag lebomló polimerek, készítmények, termékek, valamint eljárás előállításukra és alkalmazásukra

Country Status (18)

Country Link
US (3) US6166173A (hu)
EP (1) EP0971969B1 (hu)
JP (1) JP4170399B2 (hu)
KR (1) KR20010006041A (hu)
CN (1) CN1107687C (hu)
AT (1) ATE271084T1 (hu)
AU (1) AU742110B2 (hu)
BR (1) BR9809390A (hu)
CA (1) CA2285909C (hu)
DE (1) DE69825040T2 (hu)
HK (1) HK1027366A1 (hu)
HU (1) HUP0001412A2 (hu)
IL (1) IL132122A0 (hu)
NO (1) NO994803L (hu)
NZ (1) NZ500674A (hu)
RU (1) RU2207350C2 (hu)
UA (1) UA54505C2 (hu)
WO (1) WO1998044020A1 (hu)

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Also Published As

Publication number Publication date
DE69825040T2 (de) 2005-09-08
AU742110B2 (en) 2001-12-20
NO994803L (no) 1999-12-03
CA2285909A1 (en) 1998-10-08
RU2207350C2 (ru) 2003-06-27
HK1027366A1 (en) 2001-01-12
US20020151617A1 (en) 2002-10-17
UA54505C2 (uk) 2003-03-17
AU6944998A (en) 1998-10-22
CN1107687C (zh) 2003-05-07
JP4170399B2 (ja) 2008-10-22
CN1256701A (zh) 2000-06-14
DE69825040D1 (de) 2004-08-19
JP2001521561A (ja) 2001-11-06
ATE271084T1 (de) 2004-07-15
US6376644B1 (en) 2002-04-23
BR9809390A (pt) 2000-06-13
NZ500674A (en) 2002-02-01
CA2285909C (en) 2008-07-29
US6166173A (en) 2000-12-26
IL132122A0 (en) 2001-03-19
KR20010006041A (ko) 2001-01-15
NO994803D0 (no) 1999-10-01
EP0971969B1 (en) 2004-07-14
WO1998044020A1 (en) 1998-10-08
EP0971969A1 (en) 2000-01-19

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