HUP0001386A2 - Pharmaceutical compositions containing n-sulphonyl indolin derivatives - Google Patents
Pharmaceutical compositions containing n-sulphonyl indolin derivativesInfo
- Publication number
- HUP0001386A2 HUP0001386A2 HU0001386A HUP0001386A HUP0001386A2 HU P0001386 A2 HUP0001386 A2 HU P0001386A2 HU 0001386 A HU0001386 A HU 0001386A HU P0001386 A HUP0001386 A HU P0001386A HU P0001386 A2 HUP0001386 A2 HU P0001386A2
- Authority
- HU
- Hungary
- Prior art keywords
- sulphonyl
- pharmaceutical compositions
- compositions containing
- surfactant
- amphiphilic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004094 surface-active agent Substances 0.000 abstract 4
- 150000002433 hydrophilic molecules Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A találmány tárgya vízmentes oldó/stabilizáló rendszer, amely vízbenemulgeálható vagy mikroemulgeálható (I) képletű N-szulfonil-indolinhidrofób származékának szolubilizálására, amelyre jellemző, hogy egyvagy több amfifil vegyületet, nemionos hidrofil felületaktív anyagotvagy nemionos hidrofil, mind amfifil és felületaktív tulajdonsággalrendelkező vegyületet tartalmaz, és a rendszer vagy legalább egyamfifil és egy nemionos hidrofil felületaktív anyag elegye, vagylegalább egy, mind felületaktív, mind amfifil tulajdonsággalrendelkező hidrofil vegyület. ÓThe subject of the invention is a water-free solvent/stabilizer system that can be water-emulsified or microemulsifiable for the solubilization of N-sulfonyl-indoline hydrophobic derivative of formula (I), which is characterized by containing one or more amphiphilic compounds, nonionic hydrophilic surfactants, or nonionic hydrophilic compounds with both amphiphilic and surfactant properties, and the system is a mixture of at least one amphiphile and a nonionic hydrophilic surfactant, or at least one hydrophilic compound with both surfactant and amphiphilic properties. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614957A FR2756736B1 (en) | 1996-12-05 | 1996-12-05 | PHARMACEUTICAL COMPOSITIONS CONTAINING N-SULFONYL INDOLINE DERIVATIVES |
| PCT/FR1997/002210 WO1998024430A1 (en) | 1996-12-05 | 1997-12-04 | Pharmaceutical compositions containing n-sulphonyl indolin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001386A2 true HUP0001386A2 (en) | 2001-04-28 |
| HUP0001386A3 HUP0001386A3 (en) | 2002-03-28 |
Family
ID=9498376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001386A HUP0001386A3 (en) | 1996-12-05 | 1997-12-04 | Pharmaceutical compositions containing n-sulphonyl indolin derivatives |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0941090A1 (en) |
| JP (1) | JP2000507618A (en) |
| KR (1) | KR20000069308A (en) |
| CN (1) | CN1239887A (en) |
| AR (1) | AR009651A1 (en) |
| AU (1) | AU716575B2 (en) |
| BR (1) | BR9712406A (en) |
| CA (1) | CA2273990A1 (en) |
| CO (1) | CO4910129A1 (en) |
| DZ (1) | DZ2362A1 (en) |
| EE (1) | EE9900206A (en) |
| FR (1) | FR2756736B1 (en) |
| HU (1) | HUP0001386A3 (en) |
| ID (1) | ID23373A (en) |
| IL (1) | IL129936A0 (en) |
| IS (1) | IS5062A (en) |
| MY (1) | MY132819A (en) |
| NO (1) | NO992724D0 (en) |
| NZ (1) | NZ335750A (en) |
| RU (1) | RU2174394C2 (en) |
| SK (1) | SK75599A3 (en) |
| TR (1) | TR199901702T2 (en) |
| WO (1) | WO1998024430A1 (en) |
| YU (1) | YU23099A (en) |
| ZA (1) | ZA9710919B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786486B3 (en) * | 1998-11-16 | 2000-12-08 | Sanofi Sa | PROCESS FOR THE PREPARATION OF (2S) -1 - [(2R, 3S) -5-CHLORO-3- (2- CHLOROPHENYL) -1- (3,4-DIMETHOXY BENZENESULFONYL) -3-HYDROXY- 2,3-DIHYDRO- 1H-INDOLE-2-CARBONYL] PYRROLIDINE-2-CARBOXAMIDE, ITS SOLVATES AND / OR HYDRATES |
| DE19913692A1 (en) * | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances |
| US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
| WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| FR2805992A1 (en) * | 2000-03-08 | 2001-09-14 | Sanofi Synthelabo | Oral administration of N-sulfonyl-indoline derivative to treat central nervous system, cardiovascular or gastric disorders, using polyethylene glycol, polysorbate and poloxamer as solubilizers for high bioavailability |
| DE10026698A1 (en) | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
| ITMI20011338A1 (en) * | 2001-06-26 | 2002-12-26 | Farmatron Ltd | ORAL PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE OF THE ACTIVE INGREDIENT |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| UA119324C2 (en) * | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Compositions of pharmaceutical actives containing diethylene glycol monoethyl ether or other alkyl derivatives |
| KR102139339B1 (en) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | Cosmetic composition which has improved solubility comprising indole compound |
| KR102139338B1 (en) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | Cosmetic composition which has improved solubility comprising indole compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237814A1 (en) * | 1982-10-12 | 1984-04-12 | Warner-Lambert Co., 07950 Morris Plains, N.J. | WATER-FREE EMULSIONS AND USE THEREOF |
| FR2679903B1 (en) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | DERIVATIVES OF N-SULFONYL INDOLINE CARRYING AN AMIDIC FUNCTION, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
-
1996
- 1996-12-05 FR FR9614957A patent/FR2756736B1/en not_active Expired - Fee Related
-
1997
- 1997-12-03 DZ DZ970212A patent/DZ2362A1/en active
- 1997-12-04 CA CA002273990A patent/CA2273990A1/en not_active Abandoned
- 1997-12-04 HU HU0001386A patent/HUP0001386A3/en unknown
- 1997-12-04 IL IL12993697A patent/IL129936A0/en unknown
- 1997-12-04 JP JP10525294A patent/JP2000507618A/en active Pending
- 1997-12-04 SK SK755-99A patent/SK75599A3/en unknown
- 1997-12-04 AR ARP970105696A patent/AR009651A1/en unknown
- 1997-12-04 EE EEP199900206A patent/EE9900206A/en unknown
- 1997-12-04 ID IDW990445D patent/ID23373A/en unknown
- 1997-12-04 BR BR9712406-0A patent/BR9712406A/en unknown
- 1997-12-04 KR KR1019997004983A patent/KR20000069308A/en not_active Application Discontinuation
- 1997-12-04 RU RU99114019/14A patent/RU2174394C2/en active
- 1997-12-04 WO PCT/FR1997/002210 patent/WO1998024430A1/en not_active Application Discontinuation
- 1997-12-04 AU AU53262/98A patent/AU716575B2/en not_active Ceased
- 1997-12-04 TR TR1999/01702T patent/TR199901702T2/en unknown
- 1997-12-04 EP EP97950228A patent/EP0941090A1/en not_active Withdrawn
- 1997-12-04 MY MYPI97005848A patent/MY132819A/en unknown
- 1997-12-04 CO CO97071118A patent/CO4910129A1/en unknown
- 1997-12-04 ZA ZA9710919A patent/ZA9710919B/en unknown
- 1997-12-04 CN CN97180304A patent/CN1239887A/en active Pending
- 1997-12-04 NZ NZ335750A patent/NZ335750A/en unknown
-
1999
- 1999-05-26 YU YU23099A patent/YU23099A/en unknown
- 1999-06-01 IS IS5062A patent/IS5062A/en unknown
- 1999-06-04 NO NO992724A patent/NO992724D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199901702T2 (en) | 1999-09-21 |
| NO992724L (en) | 1999-06-04 |
| CO4910129A1 (en) | 2000-04-24 |
| CA2273990A1 (en) | 1998-06-11 |
| WO1998024430A1 (en) | 1998-06-11 |
| CN1239887A (en) | 1999-12-29 |
| RU2174394C2 (en) | 2001-10-10 |
| YU23099A (en) | 1999-11-22 |
| FR2756736B1 (en) | 1999-03-05 |
| MY132819A (en) | 2007-10-31 |
| SK75599A3 (en) | 2000-08-14 |
| ID23373A (en) | 2000-04-20 |
| HUP0001386A3 (en) | 2002-03-28 |
| FR2756736A1 (en) | 1998-06-12 |
| NO992724D0 (en) | 1999-06-04 |
| NZ335750A (en) | 2001-06-29 |
| EP0941090A1 (en) | 1999-09-15 |
| DZ2362A1 (en) | 2002-12-28 |
| AU716575B2 (en) | 2000-03-02 |
| KR20000069308A (en) | 2000-11-25 |
| AU5326298A (en) | 1998-06-29 |
| EE9900206A (en) | 1999-12-15 |
| JP2000507618A (en) | 2000-06-20 |
| AR009651A1 (en) | 2000-04-26 |
| IS5062A (en) | 1999-06-01 |
| ZA9710919B (en) | 1999-06-04 |
| BR9712406A (en) | 1999-08-31 |
| IL129936A0 (en) | 2000-02-29 |
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