HUP0000795A2 - Budeszonidot tartalmazó, aeroszol formájú gyógyszerkészítmény - Google Patents
Budeszonidot tartalmazó, aeroszol formájú gyógyszerkészítményInfo
- Publication number
- HUP0000795A2 HUP0000795A2 HU0000795A HUP0000795A HUP0000795A2 HU P0000795 A2 HUP0000795 A2 HU P0000795A2 HU 0000795 A HU0000795 A HU 0000795A HU P0000795 A HUP0000795 A HU P0000795A HU P0000795 A2 HUP0000795 A2 HU P0000795A2
- Authority
- HU
- Hungary
- Prior art keywords
- budesonide
- aerosol formulations
- medicinal aerosol
- hfa
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title 1
- 239000000443 aerosol Substances 0.000 title 1
- 229960004436 budesonide Drugs 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 2
- 239000003380 propellant Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 abstract 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- 239000005642 Oleic acid Substances 0.000 abstract 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000005828 hydrofluoroalkanes Chemical class 0.000 abstract 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 229940049964 oleate Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000004753 textile Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány szerinti készítmény szemcsés bűdeszőnid szűszpenzióját,HFA 134a, HFA 227 és ezek elegye közül megválasztőtt hidrőflűőr-alkánhajtóanyagőt, és adőtt esetben egy vagy több (i) őlajsav, szőrbitán-őleát és lecitin közül megválasztőtt felületaktív anyagőt, és (ii) akészítmény tömegére vőnatkőztatva legfeljebb 2,5 tömeg% etanőlttartalmaz. A találmány kiterjed a hajtóanyagők alkalmazásárabűdeszőnid szemcsék szűszpendálására. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9620187.6A GB9620187D0 (en) | 1996-09-27 | 1996-09-27 | Medicinal aerosol formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0000795A2 true HUP0000795A2 (hu) | 2000-08-28 |
HUP0000795A3 HUP0000795A3 (en) | 2000-09-28 |
Family
ID=10800599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0000795A HUP0000795A3 (en) | 1996-09-27 | 1997-09-23 | Medicinal aerosol formulations comprising budesonide |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0932397B2 (hu) |
JP (1) | JP2001501209A (hu) |
KR (1) | KR20000048646A (hu) |
AR (1) | AR009370A1 (hu) |
AT (1) | ATE320246T1 (hu) |
AU (1) | AU732985B2 (hu) |
BR (1) | BR9712125A (hu) |
CA (1) | CA2266431A1 (hu) |
CZ (1) | CZ102799A3 (hu) |
DE (1) | DE69735497T2 (hu) |
ES (1) | ES2259447T3 (hu) |
GB (1) | GB9620187D0 (hu) |
HU (1) | HUP0000795A3 (hu) |
ID (1) | ID22523A (hu) |
MY (1) | MY130946A (hu) |
NO (1) | NO991407D0 (hu) |
PL (1) | PL332422A1 (hu) |
PT (1) | PT932397E (hu) |
SK (1) | SK38399A3 (hu) |
WO (1) | WO1998013031A2 (hu) |
ZA (1) | ZA978303B (hu) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863910A (en) * | 1996-01-12 | 1999-01-26 | Bolonick; Joel | Treatment of chronic inflammatory disorders of the gastrointestinal tract |
US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
GB9925934D0 (en) * | 1999-11-03 | 1999-12-29 | Glaxo Group Ltd | Novel apparatus and process |
IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
SK286694B6 (sk) | 2000-05-22 | 2009-03-05 | Chiesi Farmaceutici S.P.A. | Aerosólový farmaceutický prostriedok |
ES2222294T3 (es) | 2001-07-02 | 2005-02-01 | Chiesi Farmaceutici S.P.A. | Formulacion optimizada de tobramicina para administracion en forma de aerosol. |
TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
GB0311701D0 (en) * | 2003-05-21 | 2003-06-25 | Karib Kemi Pharm Liited | Improved metered dose inhaler product |
EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
EP1949891A1 (en) * | 2004-10-12 | 2008-07-30 | Generics (UK) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
WO2006040598A2 (en) * | 2004-10-12 | 2006-04-20 | Generics (Uk) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
ES2259915B1 (es) * | 2005-03-15 | 2007-12-16 | Laboratorio Aldo-Union, S.A. | Nueva formulacion estable de aerosoles en suspension y procedimiento de obtencion. |
TW201010708A (en) * | 2008-06-02 | 2010-03-16 | Intervet Int Bv | Composition comprising an antibiotic and a corticosteroid |
CN103655473A (zh) * | 2011-10-27 | 2014-03-26 | 江苏长风药业有限公司 | 以氢氟烷烃为抛射剂的布地奈德气雾剂制剂 |
CN102362859A (zh) * | 2011-10-27 | 2012-02-29 | 江阴长风医药科技有限公司 | 以氢氟烷烃为抛射剂的布地奈德气雾剂制剂 |
CN109646400A (zh) * | 2018-12-25 | 2019-04-19 | 上海信谊百路达药业有限公司 | 一种布地奈德吸入气雾剂及其制备方法 |
CN112891328A (zh) * | 2021-04-12 | 2021-06-04 | 上海方予健康医药科技有限公司 | 一种吸入用布地奈德混悬液的制备方法 |
CN113768906B (zh) * | 2021-10-25 | 2023-05-09 | 上海方予健康医药科技有限公司 | 新型糖皮质激素吸入气雾剂及药物组件 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8828477D0 (en) † | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
DE4003272A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
US5136107A (en) * | 1990-06-04 | 1992-08-04 | Ethyl Corporation | Process for halogenating aromatic compounds |
EP0504112A3 (en) † | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
ATE204743T1 (de) † | 1991-12-18 | 2001-09-15 | Minnesota Mining & Mfg | Aerosolzusammensetzungen für arzneimittelsuspensionen |
DE4230876A1 (de) † | 1992-03-17 | 1993-09-23 | Asta Medica Ag | Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten |
US5569450A (en) * | 1993-03-17 | 1996-10-29 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
DE4322703A1 (de) * | 1993-07-08 | 1995-01-12 | Asta Medica Ag | Druckgaspackungen unter Verwendung von Polyoxyethylen-glyceryl-fettsäureestern als Suspensionsstabilisatoren und Ventilschmiermittel |
TW283164B (hu) * | 1993-09-24 | 1996-08-11 | Du Pont | |
US5508023A (en) * | 1994-04-11 | 1996-04-16 | The Center For Innovative Technology | Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant |
GB9425160D0 (en) † | 1994-12-10 | 1995-02-08 | Glaxo Group Ltd | Medicaments |
MX9704550A (es) * | 1994-12-22 | 1997-10-31 | Astra Ab | Formulaciones de medicamentos en aerosol. |
-
1996
- 1996-09-27 GB GBGB9620187.6A patent/GB9620187D0/en active Pending
-
1997
- 1997-09-15 ZA ZA978303A patent/ZA978303B/xx unknown
- 1997-09-23 KR KR1019990702589A patent/KR20000048646A/ko not_active Application Discontinuation
- 1997-09-23 JP JP10515789A patent/JP2001501209A/ja active Pending
- 1997-09-23 PL PL97332422A patent/PL332422A1/xx unknown
- 1997-09-23 HU HU0000795A patent/HUP0000795A3/hu unknown
- 1997-09-23 CA CA002266431A patent/CA2266431A1/en not_active Abandoned
- 1997-09-23 ES ES97943453T patent/ES2259447T3/es not_active Expired - Lifetime
- 1997-09-23 BR BR9712125-8A patent/BR9712125A/pt unknown
- 1997-09-23 SK SK383-99A patent/SK38399A3/sk unknown
- 1997-09-23 AU AU44926/97A patent/AU732985B2/en not_active Ceased
- 1997-09-23 ID IDW990102D patent/ID22523A/id unknown
- 1997-09-23 PT PT97943453T patent/PT932397E/pt unknown
- 1997-09-23 CZ CZ991027A patent/CZ102799A3/cs unknown
- 1997-09-23 AT AT97943453T patent/ATE320246T1/de not_active IP Right Cessation
- 1997-09-23 WO PCT/US1997/016869 patent/WO1998013031A2/en active IP Right Grant
- 1997-09-23 DE DE69735497T patent/DE69735497T2/de not_active Expired - Lifetime
- 1997-09-23 EP EP97943453.7A patent/EP0932397B2/en not_active Expired - Lifetime
- 1997-09-26 AR ARP970104440A patent/AR009370A1/es not_active Application Discontinuation
- 1997-09-27 MY MYPI97004533A patent/MY130946A/en unknown
-
1999
- 1999-03-23 NO NO991407A patent/NO991407D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001501209A (ja) | 2001-01-30 |
HUP0000795A3 (en) | 2000-09-28 |
GB9620187D0 (en) | 1996-11-13 |
DE69735497D1 (de) | 2006-05-11 |
CA2266431A1 (en) | 1998-04-02 |
NO991407L (no) | 1999-03-23 |
KR20000048646A (ko) | 2000-07-25 |
SK38399A3 (en) | 1999-09-10 |
ID22523A (id) | 1999-10-28 |
MY130946A (en) | 2007-07-31 |
CZ102799A3 (cs) | 1999-07-14 |
NO991407D0 (no) | 1999-03-23 |
PT932397E (pt) | 2006-07-31 |
AU732985B2 (en) | 2001-05-03 |
ATE320246T1 (de) | 2006-04-15 |
AR009370A1 (es) | 2000-04-12 |
AU4492697A (en) | 1998-04-17 |
WO1998013031A2 (en) | 1998-04-02 |
EP0932397B2 (en) | 2014-04-02 |
WO1998013031A3 (en) | 1998-08-27 |
PL332422A1 (en) | 1999-09-13 |
DE69735497T2 (de) | 2006-08-24 |
BR9712125A (pt) | 1999-08-31 |
ZA978303B (en) | 1999-03-15 |
EP0932397B1 (en) | 2006-03-15 |
EP0932397A2 (en) | 1999-08-04 |
ES2259447T3 (es) | 2006-10-01 |
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