HUP0000766A2 - Eljárás benzo-tiazolon-származékok előállítására - Google Patents

Eljárás benzo-tiazolon-származékok előállítására

Info

Publication number
HUP0000766A2
HUP0000766A2 HU0000766A HUP0000766A HUP0000766A2 HU P0000766 A2 HUP0000766 A2 HU P0000766A2 HU 0000766 A HU0000766 A HU 0000766A HU P0000766 A HUP0000766 A HU P0000766A HU P0000766 A2 HUP0000766 A2 HU P0000766A2
Authority
HU
Hungary
Prior art keywords
ethyl
methoxy
amino
acetyl
phenyl
Prior art date
Application number
HU0000766A
Other languages
English (en)
Inventor
Christopher Goodwin
Original Assignee
Astra Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Ltd. filed Critical Astra Pharmaceuticals Ltd.
Publication of HUP0000766A2 publication Critical patent/HUP0000766A2/hu
Publication of HUP0000766A3 publication Critical patent/HUP0000766A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Abstract

A találmány tárgya új eljárás az (I) képletű vegyület ésintermedierjei előállítására. A találmány szerint 2-(4-metoxi-fenil)-etil-amint acetileznek N-[2-(4-metoxi-fenil)-etil]-acetamiddá, ezt N-[2-(4-metoxi-3-nitro-fenil)-etil]-acetamiddá (VII) nitrálják, melyetsavas közegben katalitikusan hidrogénezve N-[2-(3-amino-4-metoxi-fenil)-etil]-acetamid-hidrokloriddá (VI) redukálnak, majd benzoil-izo-cianáttal N-benzoil-N' -{2-metoxi-5-[2-(acetil-amino)-etil]-fenil}-tiokarbamiddá (V) kapcsolnak, utána vizes, lúgos közegben N-{2-metoxi-5-[2-(acetil-amino)-etil] -fenil}-tiokarbamiddá (IV) hidrolizálnak,savas közegben egy halogénező/oxidálószerrel 2-amino-4-metoxi-7-[2-(acetil-amino)-etil]-benzotiazollá (III) ciklizálják, réz (I) réz (II)-halogenid jelenlétében 2-klór-4-metoxi-7-[2-(acetil-amino)-etil]-benzo-tiazollá (II) alakítják, majd végül ezt az (I) képletűvegyületté konvertálják. A (II) (III) (IV) (V) (VI) és (VII)intermedierek új vegyületek. Ó
HU0000766A 1997-02-27 1998-02-17 Process for the preparation of benzothiazolone derivatives HUP0000766A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9700706A SE9700706D0 (sv) 1997-02-27 1997-02-27 Process for the preparation of benzothiazoline compounds
PCT/SE1998/000274 WO1998038180A1 (en) 1997-02-27 1998-02-17 Process for the preparation of benzothiazolone compounds

Publications (2)

Publication Number Publication Date
HUP0000766A2 true HUP0000766A2 (hu) 2000-10-28
HUP0000766A3 HUP0000766A3 (en) 2001-12-28

Family

ID=20405955

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000766A HUP0000766A3 (en) 1997-02-27 1998-02-17 Process for the preparation of benzothiazolone derivatives

Country Status (20)

Country Link
US (6) US6087508A (hu)
EP (1) EP0970064A1 (hu)
JP (1) JP2001513770A (hu)
KR (1) KR20000075720A (hu)
CN (1) CN1083447C (hu)
AU (1) AU724616B2 (hu)
BR (1) BR9807785A (hu)
CA (1) CA2280010A1 (hu)
EE (1) EE9900373A (hu)
HU (1) HUP0000766A3 (hu)
ID (1) ID22430A (hu)
IL (1) IL131121A0 (hu)
IS (1) IS5162A (hu)
NO (1) NO994131D0 (hu)
NZ (1) NZ336877A (hu)
PL (1) PL334901A1 (hu)
SE (1) SE9700706D0 (hu)
SK (1) SK111499A3 (hu)
TR (1) TR199902057T2 (hu)
WO (1) WO1998038180A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7158870B2 (en) * 2002-01-24 2007-01-02 Ford Global Technologies, Llc Post collision restraints control module
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
US7270805B1 (en) * 2006-03-30 2007-09-18 Conopco, Inc. Skin lightening agents, compositions and methods
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
EP2303873A4 (en) 2008-06-18 2012-01-04 Astrazeneca Ab BENZOXAZINE DERIVATIVES AS A BETA2 ADRENORE RECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISEASES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832365A (en) * 1972-03-14 1974-08-27 Hoffmann La Roche Quinone intermediates for synthesis of 6-hydroxydopamine
CH592644A5 (hu) * 1975-01-22 1977-10-31 Lonza Ag
DE2631163B2 (de) * 1976-07-10 1978-06-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 2-Iminobenzothiazolen
DE3231885A1 (de) * 1982-08-27 1984-03-01 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung halogensubstituierter 2-aminobenzthiazole
DE3507824A1 (de) * 1985-03-06 1986-09-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten styrolen
DE3522941A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag Verfahren zur herstellung von 2-aminobenzthiazolen
EP0529600B1 (de) * 1991-08-30 1996-11-06 Hoechst Aktiengesellschaft Verfahren zur Herstellung von 2-Aminobenzthiazolen
JPH0558998A (ja) * 1991-09-06 1993-03-09 Taisho Pharmaceut Co Ltd カルバゾール誘導体
DE4313930A1 (de) * 1993-04-28 1994-11-03 Hoechst Ag Verfahren zur Herstellung von 2(3H)-Benzothiazolen

Also Published As

Publication number Publication date
CA2280010A1 (en) 1998-09-03
IS5162A (is) 1999-08-23
AU724616B2 (en) 2000-09-28
TR199902057T2 (xx) 2000-02-21
US6114578A (en) 2000-09-05
SE9700706D0 (sv) 1997-02-27
ID22430A (id) 1999-10-14
SK111499A3 (en) 2000-05-16
CN1248252A (zh) 2000-03-22
HUP0000766A3 (en) 2001-12-28
NZ336877A (en) 2001-07-27
CN1083447C (zh) 2002-04-24
NO994131L (no) 1999-08-26
BR9807785A (pt) 2000-02-22
JP2001513770A (ja) 2001-09-04
US6087508A (en) 2000-07-11
US6147219A (en) 2000-11-14
EE9900373A (et) 2000-04-17
US6118024A (en) 2000-09-12
US6194614B1 (en) 2001-02-27
US6124468A (en) 2000-09-26
WO1998038180A1 (en) 1998-09-03
KR20000075720A (ko) 2000-12-26
EP0970064A1 (en) 2000-01-12
IL131121A0 (en) 2001-01-28
PL334901A1 (en) 2000-03-27
NO994131D0 (no) 1999-08-26
AU6640798A (en) 1998-09-18

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