HUP0202963A2 - Új benzol-szulfonamidok, valamint új eljárás ismert benzol-szulfonamid származék előállítására - Google Patents

Új benzol-szulfonamidok, valamint új eljárás ismert benzol-szulfonamid származék előállítására

Info

Publication number
HUP0202963A2
HUP0202963A2 HU0202963A HUP0202963A HUP0202963A2 HU P0202963 A2 HUP0202963 A2 HU P0202963A2 HU 0202963 A HU0202963 A HU 0202963A HU P0202963 A HUP0202963 A HU P0202963A HU P0202963 A2 HUP0202963 A2 HU P0202963A2
Authority
HU
Hungary
Prior art keywords
propyl
benzyl
benzenesulfonamides
novel
preparation
Prior art date
Application number
HU0202963A
Other languages
English (en)
Inventor
Tibor Gizur
József Törley
Elemér Fogassy
József Bálint
Gabriella Egri
Ádám Demeter
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0202963A priority Critical patent/HU225505B1/hu
Publication of HU0202963D0 publication Critical patent/HU0202963D0/hu
Priority to DE60327220T priority patent/DE60327220D1/de
Priority to EP03793925A priority patent/EP1539684B1/en
Priority to PCT/HU2003/000071 priority patent/WO2004022532A1/en
Priority to AT03793925T priority patent/ATE428689T1/de
Priority to AU2003263378A priority patent/AU2003263378A1/en
Publication of HUP0202963A2 publication Critical patent/HUP0202963A2/hu
Publication of HU225505B1 publication Critical patent/HU225505B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Az R-(-)-Tamsulosin HCl új előállítási eljárásában (R,S)-5-[2- (N-benzil-amino)propil)-2-metoxi.benzolszulfonsav-amid savaddiciós sói,valamint enantiomerjei, és az R-5-[2-[N-(2-etoxi-fenoxi)-etil)-N-benzil)-amino]-propil-2-metoxi-benzolszulfonamid új intermedierek. AzR-(-)-Tamsulosin HCl-t (I) úgy állítják elő, hogy a szekunderbenzilamint valamely alkilezőszerrel reagáltatva R-5-[2-[N-(2-etoxi-fenoxi)-etil]-N-benzil]-amino)-propil-2-metoxi-benzolszulfonamiddá N-alkilezik, ezt követően a benzil védőcsoportot eltávolítják, majd aHCl sót leválasztják. Az optikailag aktív vegyületet (4-metoxi-3-szulfamoil-fenil)-aceton és benzil-amin reduktív kondenzációjávalállítják elő, miután a kapott racémvegyületet királis savvalreszolválják. Ó
HU0202963A 2002-09-09 2002-09-09 Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates HU225505B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
HU0202963A HU225505B1 (en) 2002-09-09 2002-09-09 Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates
DE60327220T DE60327220D1 (de) 2002-09-09 2003-09-08 Benzolsulfonamide und verfahren zu ihrer herstellung
EP03793925A EP1539684B1 (en) 2002-09-09 2003-09-08 Benzenesulphonamides and process for their preparation
PCT/HU2003/000071 WO2004022532A1 (en) 2002-09-09 2003-09-08 Benzenesulphonamides and process for their preparation
AT03793925T ATE428689T1 (de) 2002-09-09 2003-09-08 Benzolsulfonamide und verfahren zu ihrer herstellung
AU2003263378A AU2003263378A1 (en) 2002-09-09 2003-09-08 Benzenesulphonamides and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0202963A HU225505B1 (en) 2002-09-09 2002-09-09 Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates

Publications (3)

Publication Number Publication Date
HU0202963D0 HU0202963D0 (hu) 2002-10-28
HUP0202963A2 true HUP0202963A2 (hu) 2004-10-28
HU225505B1 HU225505B1 (en) 2007-01-29

Family

ID=89980754

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202963A HU225505B1 (en) 2002-09-09 2002-09-09 Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates

Country Status (6)

Country Link
EP (1) EP1539684B1 (hu)
AT (1) ATE428689T1 (hu)
AU (1) AU2003263378A1 (hu)
DE (1) DE60327220D1 (hu)
HU (1) HU225505B1 (hu)
WO (1) WO2004022532A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100545148C (zh) 2004-08-16 2009-09-30 神隆新加坡私人有限公司 一种抗良性前列腺肥大药物坦索罗辛之合成方法
US8273918B2 (en) 2005-09-12 2012-09-25 Avrobindo Pharma Ltd. Process for preparing tamsulosin hydrochloride

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1429306A (fr) * 1964-11-23 1966-02-25 Soc Ind Fab Antibiotiques Sifa Nouvelles benzylamines substituées et leurs sels, et procédé de préparation
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines
JPH066565B2 (ja) * 1986-07-21 1994-01-26 山之内製薬株式会社 光学活性なベンゼンスルホンアミド誘導体の製造法
JP4342101B2 (ja) * 1998-02-27 2009-10-14 キッセイ薬品工業株式会社 インドール誘導体および当該誘導体を含有する医薬品組成物
JP2000029901A (ja) * 1998-07-14 2000-01-28 Canon Inc 画像検索装置及び方法

Also Published As

Publication number Publication date
HU0202963D0 (hu) 2002-10-28
DE60327220D1 (de) 2009-05-28
HU225505B1 (en) 2007-01-29
ATE428689T1 (de) 2009-05-15
AU2003263378A1 (en) 2004-03-29
EP1539684B1 (en) 2009-04-15
EP1539684A1 (en) 2005-06-15
WO2004022532A1 (en) 2004-03-18

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

MH4A Lapse of definitive patent protection due to relinquishment