HUE062293T2 - Magas glukózamin 3-o-szulfációs arányú heparan-szulfát - Google Patents

Magas glukózamin 3-o-szulfációs arányú heparan-szulfát

Info

Publication number
HUE062293T2
HUE062293T2 HUE16881651A HUE16881651A HUE062293T2 HU E062293 T2 HUE062293 T2 HU E062293T2 HU E16881651 A HUE16881651 A HU E16881651A HU E16881651 A HUE16881651 A HU E16881651A HU E062293 T2 HUE062293 T2 HU E062293T2
Authority
HU
Hungary
Prior art keywords
heparan sulfate
glucosamine residues
sulfation rate
sulfation
rate
Prior art date
Application number
HUE16881651A
Other languages
English (en)
Inventor
Kenichi Mori
Yuriko Tokura
Shunsuke Yamazaki
Tomoko Shimizu
Yasuhiro Mihara
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of HUE062293T2 publication Critical patent/HUE062293T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
HUE16881651A 2015-12-28 2016-12-16 Magas glukózamin 3-o-szulfációs arányú heparan-szulfát HUE062293T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015257022 2015-12-28

Publications (1)

Publication Number Publication Date
HUE062293T2 true HUE062293T2 (hu) 2023-10-28

Family

ID=59225733

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16881651A HUE062293T2 (hu) 2015-12-28 2016-12-16 Magas glukózamin 3-o-szulfációs arányú heparan-szulfát

Country Status (8)

Country Link
US (1) US10889656B2 (hu)
EP (1) EP3399045B9 (hu)
JP (2) JP7006275B2 (hu)
CN (1) CN108699580B (hu)
ES (1) ES2947291T3 (hu)
HR (1) HRP20230820T1 (hu)
HU (1) HUE062293T2 (hu)
WO (1) WO2017115675A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117417912A (zh) 2017-09-05 2024-01-19 味之素株式会社 2-o-硫酸化酶突变体和3-o-硫酸化酶突变体及其使用方法
EP3816279A4 (en) 2018-06-27 2022-04-20 Ajinomoto Co., Inc. ADDITIVE FOR CULTIVATION OF STEM CELLS, CULTURE MEDIUM AND CULTIVATION PROCEDURE
CN109321508B (zh) * 2018-10-12 2022-12-27 北京化工大学 产heparosan的基因工程菌及其应用
JP7540168B2 (ja) 2019-04-16 2024-08-27 東ソー株式会社 強酸性陽イオン交換体及びその製造方法
CN116103275B (zh) * 2022-12-01 2024-03-08 上海兴糖生物技术有限公司 一种葡萄糖醛酸c5-差向异构酶、其核苷酸序列、表达载体、细胞株及其构建方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
AU2003293122A1 (en) 2002-11-27 2004-06-23 Massachusetts Institute Of Technology Methods for synthesizing polysaccharides
EP1885865A4 (en) 2005-05-12 2010-12-22 Univ North Carolina ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES
CN101531723A (zh) 2009-02-27 2009-09-16 江南大学 一种用生物酶对肝素进行选择性结构修饰制备肝素衍生物的方法
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
ES2910476T3 (es) * 2010-12-23 2022-05-12 Univ North Carolina Chapel Hill Síntesis quimioenzimática de heparinas de peso molecular ultra bajo estructuralmente homogéneas
JP6569530B2 (ja) 2013-10-02 2019-09-04 味の素株式会社 ヘパロサン生産細菌及びヘパロサンの製造法

Also Published As

Publication number Publication date
JPWO2017115675A1 (ja) 2018-10-18
EP3399045B1 (en) 2023-06-07
EP3399045C0 (en) 2023-06-07
US10889656B2 (en) 2021-01-12
JP7006275B2 (ja) 2022-02-10
EP3399045B9 (en) 2023-10-04
EP3399045A4 (en) 2019-08-28
EP3399045A1 (en) 2018-11-07
US20180298117A1 (en) 2018-10-18
WO2017115675A1 (ja) 2017-07-06
ES2947291T3 (es) 2023-08-04
CN108699580B (zh) 2022-09-23
HRP20230820T1 (hr) 2023-11-10
CN108699580A (zh) 2018-10-23
JP2022003136A (ja) 2022-01-11

Similar Documents

Publication Publication Date Title
HK1252454A1 (zh) 清潔組合物
HRP20181692T1 (hr) Liječenje fibroze
IL256183A (en) Coatings
PL3085748T3 (pl) Powłoki
GB201513626D0 (en) Mitigating blockchain attack
HUE062293T2 (hu) Magas glukózamin 3-o-szulfációs arányú heparan-szulfát
IL258876B (en) Treatment of fatty liver associated with low ovulation
ZA201800219B (en) Cleaning composition
HUE057703T2 (hu) Eljárás poliszacharidok elõállítására
IL248608A0 (en) Sulphites of hyperane
ZA201703804B (en) Cleansing compositions
SG11201705969VA (en) Non-thermal soft plasma cleaning
HK1255221A1 (zh) 使用卡多曲組合物進行治療的方法
GB201501799D0 (en) Methods of producing liquid compositions
GB201507289D0 (en) Method of cleaning tableware
ZA201803870B (en) Coatings
PT3125867T (pt) Composição hiperosmolar de ácido hialurónico
GB2556537B (en) Superhydrophobic additive
GB201412604D0 (en) Glassware corrosion reduction
ZA201803447B (en) Cleansing compositions
SG10201710885QA (en) Cleaning properties structure
GB201502574D0 (en) Depostion process
GB201501636D0 (en) Pair of planes
GB201405155D0 (en) Theory of entertainment