HUE059493T2 - Eljárás optikailag aktív Beraprost elõállítására - Google Patents
Eljárás optikailag aktív Beraprost elõállításáraInfo
- Publication number
- HUE059493T2 HUE059493T2 HUE17714464A HUE17714464A HUE059493T2 HU E059493 T2 HUE059493 T2 HU E059493T2 HU E17714464 A HUE17714464 A HU E17714464A HU E17714464 A HUE17714464 A HU E17714464A HU E059493 T2 HUE059493 T2 HU E059493T2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- optically active
- active beraprost
- beraprost
- optically
- Prior art date
Links
- CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 title 1
- 229960002890 beraprost Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1600232A HU231080B1 (hu) | 2016-04-05 | 2016-04-05 | Eljárás optikailag aktív Beraprost előállítására |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE059493T2 true HUE059493T2 (hu) | 2022-11-28 |
Family
ID=89992131
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1600232A HU231080B1 (hu) | 2016-04-05 | 2016-04-05 | Eljárás optikailag aktív Beraprost előállítására |
| HUE17714464A HUE059493T2 (hu) | 2016-04-05 | 2017-03-30 | Eljárás optikailag aktív Beraprost elõállítására |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1600232A HU231080B1 (hu) | 2016-04-05 | 2016-04-05 | Eljárás optikailag aktív Beraprost előállítására |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10421737B2 (hu) |
| EP (1) | EP3440065B1 (hu) |
| JP (1) | JP6925366B2 (hu) |
| KR (1) | KR102373051B1 (hu) |
| CN (1) | CN109219601B (hu) |
| ES (1) | ES2925739T3 (hu) |
| HU (2) | HU231080B1 (hu) |
| TW (1) | TWI698431B (hu) |
| WO (1) | WO2017174439A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11560363B2 (en) * | 2018-10-22 | 2023-01-24 | United Therapeutics Corporation | Synthesis of esuberaprost prodrugs |
| US10577341B1 (en) * | 2018-11-26 | 2020-03-03 | Chirogate International Inc. | Beraprost-314d monohydrate crystals and methods for preparation thereof |
| US10577340B1 (en) * | 2018-11-26 | 2020-03-03 | Chirogate International Inc. | Beraprost-314d crystals and methods for preparation thereof |
| CN111087284A (zh) * | 2019-12-27 | 2020-05-01 | 安庆润科生物医药科技有限公司 | 一种贝前列环素中间体的制备方法 |
| CN113493430B (zh) * | 2020-03-19 | 2024-09-10 | 江西科睿药业有限公司 | 一种贝前列素及其盐的中间体及其制备方法 |
| US11884640B2 (en) | 2021-06-02 | 2024-01-30 | Chirogate International Inc. | Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227158B1 (en) | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective reduction |
| HU227157B1 (en) * | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective oxidation |
| JP5271272B2 (ja) * | 2006-11-16 | 2013-08-21 | ジェンムス ファーマ インコーポレイティド | Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬 |
| EP3461817B1 (en) | 2011-06-16 | 2020-11-04 | Lung Biotechnology Inc. | Potassium salt of beraprost |
| WO2013040068A2 (en) | 2011-09-12 | 2013-03-21 | Irix Pharmaceuticals, Inc. | Process for preparing synthetic prostacyclins |
| KR20150132440A (ko) * | 2013-03-15 | 2015-11-25 | 젬머스 파마 인코포레이티드 | 바이러스 감염의 치료제로서의 베라프로스트 이성질체 |
| JP6263604B2 (ja) | 2013-03-25 | 2018-01-17 | ユナイテッド セラピューティクス コーポレイション | チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法 |
| WO2015179427A1 (en) | 2014-05-20 | 2015-11-26 | Lung Biotechnology Pbc | Methods for producing beraprost and its derivatives |
-
2016
- 2016-04-05 HU HU1600232A patent/HU231080B1/hu unknown
-
2017
- 2017-03-30 KR KR1020187031751A patent/KR102373051B1/ko active IP Right Grant
- 2017-03-30 EP EP17714464.9A patent/EP3440065B1/en active Active
- 2017-03-30 TW TW106110689A patent/TWI698431B/zh active
- 2017-03-30 JP JP2018552171A patent/JP6925366B2/ja active Active
- 2017-03-30 US US16/091,019 patent/US10421737B2/en active Active
- 2017-03-30 CN CN201780034423.7A patent/CN109219601B/zh active Active
- 2017-03-30 ES ES17714464T patent/ES2925739T3/es active Active
- 2017-03-30 WO PCT/EP2017/057582 patent/WO2017174439A1/en active Application Filing
- 2017-03-30 HU HUE17714464A patent/HUE059493T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017174439A1 (en) | 2017-10-12 |
| US20190062295A1 (en) | 2019-02-28 |
| CN109219601A (zh) | 2019-01-15 |
| CN109219601B (zh) | 2022-08-09 |
| JP6925366B2 (ja) | 2021-08-25 |
| TWI698431B (zh) | 2020-07-11 |
| EP3440065B1 (en) | 2022-06-08 |
| EP3440065A1 (en) | 2019-02-13 |
| JP2019513729A (ja) | 2019-05-30 |
| HU231080B1 (hu) | 2020-07-28 |
| US10421737B2 (en) | 2019-09-24 |
| HUP1600232A2 (en) | 2017-10-30 |
| TW201808927A (zh) | 2018-03-16 |
| ES2925739T3 (es) | 2022-10-19 |
| KR102373051B1 (ko) | 2022-03-11 |
| KR20180131596A (ko) | 2018-12-10 |
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