HUE053379T2 - Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására - Google Patents

Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására

Info

Publication number
HUE053379T2
HUE053379T2 HUE14862555A HUE14862555A HUE053379T2 HU E053379 T2 HUE053379 T2 HU E053379T2 HU E14862555 A HUE14862555 A HU E14862555A HU E14862555 A HUE14862555 A HU E14862555A HU E053379 T2 HUE053379 T2 HU E053379T2
Authority
HU
Hungary
Prior art keywords
ketone
methods
genetically modified
amine compounds
reductive amination
Prior art date
Application number
HUE14862555A
Other languages
English (en)
Hungarian (hu)
Inventor
Nicholas J Agard
Oscar Alvizo
Melissa Ann Mayo
Minor Stefanie Ng
James Nicholas Riggins
Jeffrey C Moore
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of HUE053379T2 publication Critical patent/HUE053379T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01028—Opine dehydrogenase (1.5.1.28)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HUE14862555A 2013-11-13 2014-11-12 Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására HUE053379T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361903772P 2013-11-13 2013-11-13
US201462022315P 2014-07-09 2014-07-09
US201462022323P 2014-07-09 2014-07-09

Publications (1)

Publication Number Publication Date
HUE053379T2 true HUE053379T2 (hu) 2021-06-28

Family

ID=53044107

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14862555A HUE053379T2 (hu) 2013-11-13 2014-11-12 Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására

Country Status (9)

Country Link
US (5) US9822346B2 (enExample)
EP (1) EP3068793B1 (enExample)
JP (1) JP6643987B2 (enExample)
CN (1) CN106232619B (enExample)
CA (1) CA2929664C (enExample)
DK (1) DK3068793T3 (enExample)
HU (1) HUE053379T2 (enExample)
IL (1) IL245453B (enExample)
WO (1) WO2015073555A1 (enExample)

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CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
KR101761830B1 (ko) 2015-10-21 2017-07-26 주식회사 엘지화학 리간드 화합물, 올레핀 올리고머화용 촉매계, 및 이를 이용한 올레핀 올리고머화 방법
WO2018038906A1 (en) 2016-08-26 2018-03-01 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN107384885B (zh) * 2017-09-05 2019-12-24 武汉大学 亚胺还原酶及其突变体在合成(s)-1-芳基-1，2，3，4-四氢异喹啉中的应用
CN108504701B (zh) * 2018-04-26 2021-05-14 中南林业科技大学 一种异丙甲草胺中间体的合成方法
HUE051799T2 (hu) 2018-11-16 2021-03-29 Zanoprima Lifesciences Ltd Eljárás (S)-nikotin elõállítására myosmine vegyületbõl
EP3963057A4 (en) * 2019-05-01 2023-06-14 Codexis, Inc. MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
CN116286700B (zh) * 2021-10-18 2025-10-03 迪嘉药业集团股份有限公司 一种亚胺还原酶突变体及用途
CN114717211B (zh) * 2022-03-23 2023-06-02 江苏集萃分子工程研究院有限公司 亚胺还原酶突变体m5及其在合成氮杂环手性胺中的应用
CN116814569B (zh) * 2023-05-30 2025-07-25 华东理工大学 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用
CN119931979B (zh) * 2024-11-27 2026-06-23 南京药石科技股份有限公司 一种亚胺还原酶突变体及其应用

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Also Published As

Publication number Publication date
US20180030419A1 (en) 2018-02-01
CN106232619B (zh) 2022-09-09
US20210301266A1 (en) 2021-09-30
IL245453A0 (en) 2016-06-30
CN106232619A (zh) 2016-12-14
EP3068793B1 (en) 2021-02-17
EP3068793A1 (en) 2016-09-21
US20190345458A1 (en) 2019-11-14
US12312609B2 (en) 2025-05-27
IL245453B (en) 2021-04-29
US11060072B2 (en) 2021-07-13
US10407668B2 (en) 2019-09-10
CA2929664A1 (en) 2015-05-21
US20150132807A1 (en) 2015-05-14
CA2929664C (en) 2023-01-24
US9822346B2 (en) 2017-11-21
JP6643987B2 (ja) 2020-02-12
EP3068793A4 (en) 2017-09-20
WO2015073555A1 (en) 2015-05-21
US20250304924A1 (en) 2025-10-02
DK3068793T3 (da) 2021-03-22
JP2016536990A (ja) 2016-12-01

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