HUE052098T2 - Prohemosztatikus fehérjék vérzés kezelésére - Google Patents

Prohemosztatikus fehérjék vérzés kezelésére

Info

Publication number
HUE052098T2
HUE052098T2 HUE15731411A HUE15731411A HUE052098T2 HU E052098 T2 HUE052098 T2 HU E052098T2 HU E15731411 A HUE15731411 A HU E15731411A HU E15731411 A HUE15731411 A HU E15731411A HU E052098 T2 HUE052098 T2 HU E052098T2
Authority
HU
Hungary
Prior art keywords
bleeding
treatment
prohemostatic
proteins
prohemostatic proteins
Prior art date
Application number
HUE15731411A
Other languages
English (en)
Inventor
Daniël Verhoef
Pieter H Reitsma
Mettine H A Bos
Original Assignee
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Publication of HUE052098T2 publication Critical patent/HUE052098T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE15731411A 2014-05-26 2015-05-26 Prohemosztatikus fehérjék vérzés kezelésére HUE052098T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14169895 2014-05-26

Publications (1)

Publication Number Publication Date
HUE052098T2 true HUE052098T2 (hu) 2021-04-28

Family

ID=50774744

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15731411A HUE052098T2 (hu) 2014-05-26 2015-05-26 Prohemosztatikus fehérjék vérzés kezelésére

Country Status (25)

Country Link
US (4) US10537618B2 (hu)
EP (2) EP3149163B1 (hu)
JP (3) JP6640198B2 (hu)
KR (2) KR102351728B1 (hu)
CN (1) CN106536566A (hu)
AU (2) AU2015268149B2 (hu)
BR (1) BR112016027649A2 (hu)
CA (1) CA2949349A1 (hu)
DK (1) DK3149163T3 (hu)
EA (2) EA037991B1 (hu)
ES (1) ES2813440T3 (hu)
HR (1) HRP20201311T1 (hu)
HU (1) HUE052098T2 (hu)
IL (2) IL249132B (hu)
LT (1) LT3149163T (hu)
MA (2) MA40042B1 (hu)
MX (2) MX2016015567A (hu)
NZ (1) NZ727444A (hu)
PL (1) PL3149163T3 (hu)
PT (1) PT3149163T (hu)
RS (1) RS60706B1 (hu)
SG (2) SG10201906329VA (hu)
SI (1) SI3149163T1 (hu)
WO (1) WO2015183085A1 (hu)
ZA (1) ZA201608017B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3149163T (lt) * 2014-05-26 2020-09-25 Academisch Ziekenhuis Leiden Prohemostatiniai baltymai, skirti kraujavimo gydymui
CN108486197B (zh) * 2018-03-06 2021-10-22 爱斯特（成都）生物制药股份有限公司 高纯度依度沙班中间体的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
CA2096418C (en) 1990-11-26 2001-11-20 Philip J. Barr Expression of pace in host cells and methods of use thereof
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
DE4203965A1 (de) 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
AT404357B (de) 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
DE19605126A1 (de) 1996-02-12 1997-08-14 Basf Ag Thrombinmuteine als Antidot für Thrombininhibitoren
US6200955B1 (en) 1996-06-11 2001-03-13 Commonwealth Biotechnologies, Inc. Heparin binding peptides
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
WO2008127702A2 (en) * 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypetides and uses thereof
HUE052423T2 (hu) * 2007-09-28 2021-04-28 Alexion Pharma Inc Az XA faktor inhibitorok antidótumai és ezek alkalmazási módszerei
TWI538916B (zh) * 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
CN104755492A (zh) * 2012-07-25 2015-07-01 催化剂生物科学公司 修饰的因子x多肽及其应用
EP2950813B1 (en) 2013-01-31 2019-09-04 Pfizer Inc Compositions and methods for counteracting factor xa inhibition
US10119101B2 (en) 2014-04-28 2018-11-06 Ecolab Usa Inc. Method of minimizing enzyme based aerosol mist using a pressure spray system
LT3149163T (lt) * 2014-05-26 2020-09-25 Academisch Ziekenhuis Leiden Prohemostatiniai baltymai, skirti kraujavimo gydymui

Also Published As

Publication number Publication date
WO2015183085A1 (en) 2015-12-03
JP2017522900A (ja) 2017-08-17
RS60706B1 (sr) 2020-09-30
IL277377A (en) 2020-11-30
ES2813440T3 (es) 2021-03-23
IL277377B (en) 2021-10-31
EP3149163A1 (en) 2017-04-05
AU2015268149A1 (en) 2016-12-08
CN106536566A (zh) 2017-03-22
MA51688A (fr) 2020-12-02
KR20210054573A (ko) 2021-05-13
ZA201608017B (en) 2019-04-24
US11304995B2 (en) 2022-04-19
US20200138917A1 (en) 2020-05-07
EP3744840A1 (en) 2020-12-02
KR20170020332A (ko) 2017-02-22
EA037991B1 (ru) 2021-06-21
US20200138916A1 (en) 2020-05-07
JP2022134139A (ja) 2022-09-14
BR112016027649A2 (pt) 2017-08-15
EA202190813A1 (ru) 2021-12-31
NZ727444A (en) 2021-12-24
EA201692161A1 (ru) 2017-08-31
LT3149163T (lt) 2020-09-25
IL249132A0 (en) 2017-01-31
AU2021203838B2 (en) 2023-03-02
US10537618B2 (en) 2020-01-21
SI3149163T1 (sl) 2020-10-30
US11357836B2 (en) 2022-06-14
EP3149163B1 (en) 2020-06-03
MA40042B1 (fr) 2020-08-31
KR102245264B1 (ko) 2021-04-28
CA2949349A1 (en) 2015-12-03
JP2020062039A (ja) 2020-04-23
HRP20201311T1 (hr) 2020-12-11
SG10201906329VA (en) 2019-08-27
KR102351728B1 (ko) 2022-01-14
US20170157223A1 (en) 2017-06-08
AU2021203838A1 (en) 2021-07-08
MX2020013410A (es) 2021-02-26
US20220288172A1 (en) 2022-09-15
AU2015268149B2 (en) 2021-03-11
JP6640198B2 (ja) 2020-02-05
PT3149163T (pt) 2020-09-03
SG11201609811TA (en) 2016-12-29
MX2016015567A (es) 2017-06-29
DK3149163T3 (da) 2020-08-31
IL249132B (en) 2020-09-30
PL3149163T3 (pl) 2020-12-28

Similar Documents

Publication Publication Date Title
HK1231400A1 (zh) 蛋白質的選擇性還原
GB201502305D0 (en) Protein
GB201502306D0 (en) Protein
IL252696A0 (en) protein production
SG11201704010UA (en) Fibroin-derived protein composition
HK1244485A1 (zh) 用於治療神經母細胞瘤的組合物
HUE050893T2 (hu) Protein
GB201415344D0 (en) Protein
PT3122349T (pt) Composições para o tratamento da autodigestão
GB201519450D0 (en) Novel treatment
PL3099793T3 (pl) Białko
IL277377B (en) Prohemostatic proteins for the treatment of bleeding
EP3145525A4 (en) Use of microperoxidases for the treatment of carboxyhemoglobinemia
GB201522610D0 (en) Protein
GB201414371D0 (en) Protein modification
GB201412797D0 (en) Proteins
GB201412646D0 (en) Proteins
GB201412649D0 (en) Proteins
GB201412648D0 (en) Proteins
GB201406894D0 (en) Proteins
GB201405955D0 (en) Proteins
GB201405952D0 (en) Proteins
GB201403913D0 (en) Proteins
GB201403912D0 (en) Proteins
GB201403914D0 (en) Proteins