HUE050705T2 - A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai - Google Patents

A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai

Info

Publication number
HUE050705T2
HUE050705T2 HUE15756888A HUE15756888A HUE050705T2 HU E050705 T2 HUE050705 T2 HU E050705T2 HU E15756888 A HUE15756888 A HU E15756888A HU E15756888 A HUE15756888 A HU E15756888A HU E050705 T2 HUE050705 T2 HU E050705T2
Authority
HU
Hungary
Prior art keywords
diolaxane
uridine
analogues
cancer
treatment
Prior art date
Application number
HUE15756888A
Other languages
English (en)
Hungarian (hu)
Inventor
Richard Bethell
Anders Eneroth
Bjoern Klasson
Fredrik Oeberg
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of HUE050705T2 publication Critical patent/HUE050705T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE15756888A 2014-08-25 2015-08-24 A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai HUE050705T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1450983 2014-08-25
SE1550858 2015-06-22

Publications (1)

Publication Number Publication Date
HUE050705T2 true HUE050705T2 (hu) 2020-12-28

Family

ID=54014804

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE15756888A HUE050705T2 (hu) 2014-08-25 2015-08-24 A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai
HUE19177824A HUE059640T2 (hu) 2014-08-25 2015-08-24 A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE19177824A HUE059640T2 (hu) 2014-08-25 2015-08-24 A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai

Country Status (24)

Country Link
US (7) US10144750B2 (cg-RX-API-DMAC7.html)
EP (2) EP3186244B1 (cg-RX-API-DMAC7.html)
JP (2) JP6663424B2 (cg-RX-API-DMAC7.html)
KR (2) KR102398714B1 (cg-RX-API-DMAC7.html)
CN (4) CN110804072B (cg-RX-API-DMAC7.html)
AU (2) AU2015308988C1 (cg-RX-API-DMAC7.html)
BR (1) BR112017003898B1 (cg-RX-API-DMAC7.html)
CA (2) CA2956251C (cg-RX-API-DMAC7.html)
CY (1) CY1122945T1 (cg-RX-API-DMAC7.html)
DK (2) DK3572410T3 (cg-RX-API-DMAC7.html)
EA (2) EA033300B1 (cg-RX-API-DMAC7.html)
ES (2) ES2927212T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20201023T1 (cg-RX-API-DMAC7.html)
HU (2) HUE050705T2 (cg-RX-API-DMAC7.html)
IL (2) IL250344B (cg-RX-API-DMAC7.html)
MX (1) MX369649B (cg-RX-API-DMAC7.html)
MY (2) MY188089A (cg-RX-API-DMAC7.html)
NZ (2) NZ729118A (cg-RX-API-DMAC7.html)
PH (2) PH12017500184B1 (cg-RX-API-DMAC7.html)
PL (2) PL3186244T3 (cg-RX-API-DMAC7.html)
PT (2) PT3186244T (cg-RX-API-DMAC7.html)
SG (3) SG10201911558UA (cg-RX-API-DMAC7.html)
WO (1) WO2016030335A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201802864B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA033300B1 (ru) * 2014-08-25 2019-09-30 Медивир Аб Диоксолановые аналоги уридина для лечения рака
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
KR20180101370A (ko) * 2015-12-11 2018-09-12 뉴카나 피엘씨 인산염 유도체 및 젬시타빈 전구약물 nuc-1031의 부분입체 이성질체 선별적 합성
RS66090B1 (sr) * 2016-03-02 2024-11-29 Medivir Ab Kombinovana terapija sa sorafenibom ili regorafenibom i fosforamidatnim prolekom troksacitabina
CN106432328B (zh) * 2016-09-14 2019-03-22 江苏福瑞生物医药有限公司 一种索非布韦中间体的制备方法
MX2019005675A (es) * 2016-11-18 2019-08-14 Neurovive Pharmaceutical Ab Profarmacos hepaticos de ionoforos de protones mitocondriales.
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
ES2973104T3 (es) 2019-02-18 2024-06-18 Medivir Ab Combinación de fármacos para su uso en un método de tratamiento de cáncer de hígado
CN110964057B (zh) * 2019-12-25 2022-05-06 东南大学 一种利用微流体反应装置制备索非布韦中间体的方法
CN113402546A (zh) * 2020-03-17 2021-09-17 浙江四维医药科技有限公司 一种瑞德西韦磷酸中间体尾链动态动力学拆分方法
EP4135849B1 (en) * 2020-04-15 2025-03-19 Medivir AB Miv-818/lenvatinib combination therapy for liver cancer
CN113754692B (zh) * 2020-06-03 2022-06-10 上海交通大学 瑞德西韦中间体(s,s)-氨基磷酸酯的不对称催化合成方法
CN114685558A (zh) * 2020-12-28 2022-07-01 尚科生物医药（上海）有限公司 一种瑞德西韦中间体的制备方法
CN114249764A (zh) * 2021-11-10 2022-03-29 宁波大学 一种磷酰胺酯类前药的中间体及其制备方法与应用
WO2025155547A1 (en) * 2024-01-17 2025-07-24 University Of Georgia Research Foundation, Inc. An efficient synthesis of beta-l-5-[(e)-2-bromovinyl)-1-((2s,4s)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil)] (l-bhdu) via chiral pure l-dioxolane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US6022876A (en) 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections
CA2425359A1 (en) * 2000-10-13 2002-04-18 Shire Biochem Inc. Dioxolane analogs for improved inter-cellular delivery
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
WO2007106450A2 (en) * 2006-03-10 2007-09-20 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase in combination therapy
US20100266674A1 (en) * 2006-09-01 2010-10-21 University Of Georgia Research Foundation, Inc. L-oddc prodrugs for cancer
PL216525B1 (pl) * 2006-10-17 2014-04-30 Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk 5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
US20130143835A1 (en) * 2011-12-05 2013-06-06 Medivir Ab HCV Polymerase Inhibitors
KR20160099090A (ko) * 2013-11-27 2016-08-19 아이데닉스 파마슈티칼스 엘엘씨 간암의 치료를 위한 뉴클레오티드
EA033300B1 (ru) * 2014-08-25 2019-09-30 Медивир Аб Диоксолановые аналоги уридина для лечения рака

Also Published As

Publication number Publication date
BR112017003898A2 (pt) 2017-12-05
PT3186244T (pt) 2020-05-29
KR20200035482A (ko) 2020-04-03
AU2015308988B2 (en) 2018-04-26
CN107074826B (zh) 2020-05-22
PH12017500184A1 (en) 2017-06-28
US20210054008A1 (en) 2021-02-25
US10654877B2 (en) 2020-05-19
US11447511B2 (en) 2022-09-20
CN110804072A (zh) 2020-02-18
AU2015308988A1 (en) 2017-02-23
CN111269264A (zh) 2020-06-12
CA2956251A1 (en) 2016-03-03
EA201890648A2 (ru) 2018-08-31
EP3572410A1 (en) 2019-11-27
PL3572410T3 (pl) 2022-10-03
WO2016030335A1 (en) 2016-03-03
KR102398714B1 (ko) 2022-05-17
EA033300B1 (ru) 2019-09-30
MX2017002328A (es) 2017-05-22
IL250344A0 (en) 2017-03-30
MX369649B (es) 2019-11-15
JP6905609B2 (ja) 2021-07-21
IL266766B (en) 2020-05-31
ES2796089T3 (es) 2020-11-25
CA3128645C (en) 2023-06-27
IL250344B (en) 2020-01-30
EP3186244B1 (en) 2020-04-22
NZ762628A (en) 2023-04-28
DK3186244T3 (da) 2020-07-13
CN110790789A (zh) 2020-02-14
CN110804072B (zh) 2023-05-12
EP3186244A1 (en) 2017-07-05
JP2017526677A (ja) 2017-09-14
PT3572410T (pt) 2022-09-15
MY188089A (en) 2021-11-17
NZ729118A (en) 2022-02-25
SG11201701172SA (en) 2017-03-30
US10144750B2 (en) 2018-12-04
SG10202001117YA (en) 2020-04-29
CA2956251C (en) 2022-10-25
CA3128645A1 (en) 2016-03-03
IL266766A (en) 2019-07-31
US20190100541A1 (en) 2019-04-04
US20200239502A1 (en) 2020-07-30
CN110790789B (zh) 2023-05-12
ES2927212T3 (es) 2022-11-03
PH12019501919A1 (en) 2020-09-14
PH12017500184B1 (en) 2017-06-28
PL3186244T3 (pl) 2020-11-16
ZA201802864B (en) 2019-07-31
JP6663424B2 (ja) 2020-03-11
AU2018201980A1 (en) 2018-04-12
US10336780B2 (en) 2019-07-02
MY198325A (en) 2023-08-24
HUE059640T2 (hu) 2022-12-28
EA201890648A3 (ru) 2019-02-28
EA031106B1 (ru) 2018-11-30
BR112017003898B1 (pt) 2022-10-18
HRP20201023T1 (hr) 2020-10-16
AU2015308988C1 (en) 2018-09-06
US10822360B2 (en) 2020-11-03
EA201790328A1 (ru) 2017-08-31
DK3572410T3 (da) 2022-08-29
US20230382931A1 (en) 2023-11-30
US20190389890A1 (en) 2019-12-26
US20170267705A1 (en) 2017-09-21
US20230117570A1 (en) 2023-04-20
SG10201911558UA (en) 2020-01-30
JP2020090535A (ja) 2020-06-11
KR102396905B1 (ko) 2022-05-13
CN107074826A (zh) 2017-08-18
EP3572410B1 (en) 2022-07-20
AU2018201980B2 (en) 2019-05-16
CY1122945T1 (el) 2021-10-29
KR20170046736A (ko) 2017-05-02

Similar Documents

Publication Publication Date Title
IL296080B1 (en) Method for treating cancer
HUE050705T2 (hu) A rákos megbetegedések kezelésére szolgáló uridin diolaxán analógjai
IL255261A0 (en) Methods for treating cancer
DK3240801T3 (da) Kombinationstumorimmunterapi
EP3344318A4 (en) Patient interfaces
HUE054012T2 (hu) Kombinációs terápia rák ellen
HUE059694T2 (hu) Készítmény rák kezelésére
HUE042087T2 (hu) Inhalátor
FI20155008A7 (fi) Ajoneuvoavusteinen työlaite
HUE040167T2 (hu) Rákkezelés
DK3393478T3 (da) Kombinationsterapi
EP4205699C0 (en) Inhaler
EP3362091A4 (en) COMBINATION THERAPY
KR20180084983A (ko) 암의 치료를 위한 피리미도-피리미다지논의 용도
DK3407909T5 (da) Cancerbehandling
DK3250168T3 (da) Forbedringer vedrørende nethindebehandling
NO20141516A1 (no) Plaster
TH1501007353A (th) สารประกอบชนิดใหม่สำหรับการบำบัดโรคมะเร็ง
ES1141057Y (es) Tejido
UA28393S (uk) Пластир медичний riverplast
TH1601000759A (th) การทรีทเม้นท์แก๊ส
ES1117280Y (es) Pieza Quirúrgica
UA28866S (uk) Маска марлева
TH144620B (th) โครงสร้างของที่กันเเดด
TH144615B (th) โครงสร้างของที่บังเเดด