HUE047172T2 - Újfajta gyógyszerészeti készítmény, mely egy kétszálú poli-ribonukleotid és egy polialkilén-imin egy komplexét tartalmazó részecskéket tartalmaz - Google Patents

Újfajta gyógyszerészeti készítmény, mely egy kétszálú poli-ribonukleotid és egy polialkilén-imin egy komplexét tartalmazó részecskéket tartalmaz

Info

Publication number
HUE047172T2
HUE047172T2 HUE16805990A HUE16805990A HUE047172T2 HU E047172 T2 HUE047172 T2 HU E047172T2 HU E16805990 A HUE16805990 A HU E16805990A HU E16805990 A HUE16805990 A HU E16805990A HU E047172 T2 HUE047172 T2 HU E047172T2
Authority
HU
Hungary
Prior art keywords
polyalkyleneimine
particles
complex
double
pharmaceutical composition
Prior art date
Application number
HUE16805990A
Other languages
English (en)
Inventor
Rubio Mercedes Pozuelo
Ortiz Marisol Quintero
Garcia Ana Villanueva
Original Assignee
Bioncotech Therapeutics S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54557307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE047172(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioncotech Therapeutics S L filed Critical Bioncotech Therapeutics S L
Publication of HUE047172T2 publication Critical patent/HUE047172T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
HUE16805990A 2015-11-17 2016-11-17 Újfajta gyógyszerészeti készítmény, mely egy kétszálú poli-ribonukleotid és egy polialkilén-imin egy komplexét tartalmazó részecskéket tartalmaz HUE047172T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15194864 2015-11-17

Publications (1)

Publication Number Publication Date
HUE047172T2 true HUE047172T2 (hu) 2020-04-28

Family

ID=54557307

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16805990A HUE047172T2 (hu) 2015-11-17 2016-11-17 Újfajta gyógyszerészeti készítmény, mely egy kétszálú poli-ribonukleotid és egy polialkilén-imin egy komplexét tartalmazó részecskéket tartalmaz

Country Status (20)

Country Link
US (2) US10568971B2 (hu)
EP (3) EP3319587B1 (hu)
JP (2) JP6710415B6 (hu)
KR (1) KR102317281B1 (hu)
CN (3) CN112294757B (hu)
AU (2) AU2016355972B2 (hu)
CA (1) CA3005492C (hu)
CH (1) CH713097B1 (hu)
DE (2) DE112016003047B4 (hu)
DK (1) DK3319587T3 (hu)
EA (1) EA037117B1 (hu)
ES (2) ES2755418T3 (hu)
GB (1) GB2555364A (hu)
HU (1) HUE047172T2 (hu)
IL (2) IL257393B (hu)
MX (1) MX2018005971A (hu)
PL (1) PL3319587T3 (hu)
PT (1) PT3319587T (hu)
SG (2) SG11201803949RA (hu)
WO (1) WO2017085228A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015260725B2 (en) 2014-05-14 2021-02-25 Targimmune Therapeutics Ag Improved polyethyleneimine polyethyleneglycol vectors
ES2746340T3 (es) 2015-04-22 2020-03-05 Curevac Ag Composición que contiene ARN para el tratamiento de enfermedades tumorales
WO2017027216A1 (en) * 2015-08-13 2017-02-16 The Johns Hopkins University Methods of preparing polyelectrolyte complex nanoparticles
EP3448363B1 (en) 2017-05-17 2022-05-11 Highlight Therapeutics, S.L. Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine
CN107693789B (zh) * 2017-07-31 2021-08-13 华中科技大学同济医学院附属协和医院 一种包含细胞靶向抗体及Poly(I：C)的化合物及其制备方法和应用
CN107550885B (zh) * 2017-07-31 2021-08-13 华中科技大学同济医学院附属协和医院 一种包含模式识别受体中tlr3配体的纳米颗粒载体及其制备方法和应用
US20210396737A1 (en) * 2018-11-21 2021-12-23 Highlight Therapeutics, S.L. Nanoplexed poly(i:c) formulations and uses thereof
EP3960287A4 (en) * 2019-04-26 2023-01-18 Toray Industries, Inc. SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR ADSORPTIBLE MATERIAL
US20220313724A1 (en) * 2021-05-17 2022-10-06 Highlight Therapeutics, S.L. Compositions for intratumoral administration and related methods
US20240091348A1 (en) 2022-09-20 2024-03-21 Highlight Therapeutics, S.L. Novel compositions based on polyinosinic-polycytidylic acid

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1820588A (en) * 1987-07-17 1989-01-19 Hem Research, Inc. Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function
ATE535231T1 (de) 2002-07-03 2011-12-15 Oncovir Inc Verfahren zur herstellung von poly-iclc und seine verwendung
WO2004045491A2 (en) 2002-11-18 2004-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Targeted double stranded rna mediated cell killing
EP1886688A4 (en) 2005-05-30 2013-01-09 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING PREPARATION OF A NUCLEIC ACID-CONTAINING COMPLEX
CN103405762A (zh) * 2005-06-08 2013-11-27 依生生物制药(新加坡)私人有限公司 以聚肌苷酸-聚胞苷酸为主的佐剂
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
JP4861036B2 (ja) 2006-03-31 2012-01-25 リンテック株式会社 剥離シートおよびその製造方法
WO2008057696A2 (en) 2006-10-10 2008-05-15 Juvaris Biotherapeutics, Inc. Compositions of pattern recognition receptor-ligand: lipid complexes and methods of use thereof
EP2047858A1 (en) * 2007-10-10 2009-04-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Combination products for treating cancer
KR100958293B1 (ko) 2008-03-27 2010-05-19 단국대학교 산학협력단 테오필린에 의해 표적 특이적 ｒｎａ 치환 활성이 조절되는알로스테릭 트랜스―스플라이싱 그룹 ｉ 리보자임
CA2748125A1 (en) * 2008-12-22 2010-07-01 Alexander Levitzki Egfr-homing double-stranded rna vector for systemic cancer treatment
ES2368963B1 (es) 2009-07-04 2012-10-10 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Procedimiento de identificación de agentes terapéuticos contra el melanoma y uso de agente identificado.
ES2525487T3 (es) 2009-07-07 2014-12-23 Syngenta Participations Ag Nuevos microbiocidas
CN102988303A (zh) 2011-09-15 2013-03-27 天津泽世德生物医药有限公司 一种多聚肌苷酸多聚胞苷酸冻干粉针的制备方法
US20140234373A1 (en) 2011-09-16 2014-08-21 Georfia Regents University Methods of Promoting Immune Tolerance
US9226936B2 (en) 2011-10-28 2016-01-05 The Wistar of Anatomy and Biology Methods and compositions for enhancing the therapeutic effect of anti-tumor T cells
US9636414B2 (en) * 2011-12-15 2017-05-02 Biontech Ag Particles comprising single stranded RNA and double stranded RNA for immunomodulation
CA2866230C (en) 2012-05-03 2020-08-18 Janssen R&D Ireland Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections
ITRM20120480A1 (it) 2012-10-09 2014-04-10 Uni Degli Studi Camerino Nanoparticelle lipidiche multicomponenti e procedimenti per la loro preparazione.
WO2014165296A1 (en) 2013-03-12 2014-10-09 Multicell Immunotherapeutics, Inc. Methods and formulations to achieve tumor targeted double stranded rna mediated cell death
JP6629216B2 (ja) 2013-11-06 2020-01-15 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 上気道感染症の治療のためのポリイノシン酸−ポリシチジル酸（ポリ（ｉ：ｃ））製剤
CN103599071B (zh) 2013-11-08 2016-01-27 杭州美亚药业股份有限公司 一种双链聚肌胞干粉的制备方法
AU2015260725B2 (en) * 2014-05-14 2021-02-25 Targimmune Therapeutics Ag Improved polyethyleneimine polyethyleneglycol vectors

Also Published As

Publication number Publication date
EP3319587A1 (en) 2018-05-16
CA3005492C (en) 2023-01-10
US10568971B2 (en) 2020-02-25
JP6896914B2 (ja) 2021-06-30
KR102317281B1 (ko) 2021-10-25
CN112294757A (zh) 2021-02-02
ES2715251R1 (es) 2019-11-28
EA201891115A1 (ru) 2018-10-31
EP3639811B1 (en) 2024-03-20
ES2715251A2 (es) 2019-06-03
US20230116048A1 (en) 2023-04-13
EP3639811A1 (en) 2020-04-22
DK3319587T3 (da) 2019-11-25
JP2020143088A (ja) 2020-09-10
GB201801932D0 (en) 2018-03-21
WO2017085228A1 (en) 2017-05-26
CN112294758A (zh) 2021-02-02
AU2016355972A2 (en) 2018-07-19
US20180243444A1 (en) 2018-08-30
EA037117B1 (ru) 2021-02-09
AU2020201605A1 (en) 2020-03-19
CN107920993B (zh) 2020-11-20
EP4183386A1 (en) 2023-05-24
GB2555364A (en) 2018-04-25
CH713097B1 (de) 2019-07-15
ES2755418T3 (es) 2020-04-22
MX2018005971A (es) 2019-01-31
JP6710415B2 (ja) 2020-06-17
DE202016008594U1 (de) 2018-08-23
SG11201803949RA (en) 2018-06-28
PT3319587T (pt) 2019-11-20
AU2016355972B2 (en) 2019-12-05
CN112294758B (zh) 2022-09-30
ES2715251B1 (es) 2020-09-07
DE112016003047B4 (de) 2022-10-27
DE112016003047T5 (de) 2018-03-29
IL257393B (en) 2020-02-27
AU2016355972A1 (en) 2018-07-05
EP3319587B1 (en) 2019-08-21
JP6710415B6 (ja) 2020-07-29
IL257393A (en) 2018-06-28
CA3005492A1 (en) 2017-05-26
JP2018537398A (ja) 2018-12-20
SG10202110138TA (en) 2021-10-28
PL3319587T3 (pl) 2020-05-18
AU2020201605B2 (en) 2022-05-26
CN107920993A (zh) 2018-04-17
IL272238A (en) 2020-02-27
KR20180074781A (ko) 2018-07-03
CN112294757B (zh) 2024-02-13

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