HUE046089T2 - Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához - Google Patents

Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához

Info

Publication number
HUE046089T2
HUE046089T2 HUE12795954A HUE12795954A HUE046089T2 HU E046089 T2 HUE046089 T2 HU E046089T2 HU E12795954 A HUE12795954 A HU E12795954A HU E12795954 A HUE12795954 A HU E12795954A HU E046089 T2 HUE046089 T2 HU E046089T2
Authority
HU
Hungary
Prior art keywords
biocatalysts
hydroxy
preparation
substituted carbamates
carbamates
Prior art date
Application number
HUE12795954A
Other languages
English (en)
Hungarian (hu)
Inventor
Fabien Cabirol
Haibin Chen
Anupam Gohel
Steven Collier
Derek Smith
Birgit Kosjek
Jacob Janey
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of HUE046089T2 publication Critical patent/HUE046089T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184Carbonyl reductase (NADPH) (1.1.1.184)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HUE12795954A 2011-11-18 2012-11-14 Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához HUE046089T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161561665P 2011-11-18 2011-11-18

Publications (1)

Publication Number Publication Date
HUE046089T2 true HUE046089T2 (hu) 2020-01-28

Family

ID=47295185

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12795954A HUE046089T2 (hu) 2011-11-18 2012-11-14 Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához

Country Status (8)

Country Link
US (8) US9139819B2 (show.php)
EP (1) EP2780448B1 (show.php)
CN (2) CN106479990B (show.php)
HU (1) HUE046089T2 (show.php)
IL (1) IL232621B (show.php)
IN (1) IN2014CN04470A (show.php)
SG (1) SG11201402401TA (show.php)
WO (1) WO2013074650A1 (show.php)

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JP6088535B2 (ja) 2011-10-27 2017-03-08 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. ベータ3アゴニストおよび中間体を製造するプロセス
WO2013062881A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Process for making beta 3 agonists and intermediates
EP2780448B1 (en) 2011-11-18 2019-09-11 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
US10287289B2 (en) 2013-03-15 2019-05-14 Merck Sharp & Dohme Corp. Process for preparing beta 3 agonists and intermediates
WO2014150633A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
EP3256577B1 (en) 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN106011095B (zh) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
WO2018224989A1 (en) 2017-06-06 2018-12-13 Urovant Sciences Gmbh Use of vibegron to treat overactive bladder
EP3890743A1 (en) 2018-12-05 2021-10-13 Urovant Sciences GmbH Vibegron for the treatment of overactive bladder symptoms
CN109943543B (zh) * 2019-03-28 2020-12-11 上海健康医学院 醇脱氢酶突变体及其制备方法和应用
CN114410599B (zh) * 2022-01-29 2023-08-18 浙江工业大学 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用
CN116814569B (zh) * 2023-05-30 2025-07-25 华东理工大学 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用

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Also Published As

Publication number Publication date
US12241093B2 (en) 2025-03-04
US9803178B2 (en) 2017-10-31
US10253303B2 (en) 2019-04-09
EP2780448A1 (en) 2014-09-24
US20190177702A1 (en) 2019-06-13
EP2780448B1 (en) 2019-09-11
US20180371427A1 (en) 2018-12-27
US9422531B2 (en) 2016-08-23
US20140322769A1 (en) 2014-10-30
US9139819B2 (en) 2015-09-22
US20150344850A1 (en) 2015-12-03
IL232621B (en) 2019-10-31
US20210071151A1 (en) 2021-03-11
IL232621A0 (en) 2014-06-30
CN104053771A (zh) 2014-09-17
SG11201402401TA (en) 2014-06-27
US20180010100A1 (en) 2018-01-11
US11713451B2 (en) 2023-08-01
CN106479990A (zh) 2017-03-08
US20240018489A1 (en) 2024-01-18
IN2014CN04470A (show.php) 2015-09-04
US10851351B2 (en) 2020-12-01
WO2013074650A1 (en) 2013-05-23
CN106479990B (zh) 2020-09-18
CN104053771B (zh) 2016-11-09
US20160319247A1 (en) 2016-11-03
US10100287B2 (en) 2018-10-16

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