HUE039689T2 - Proteolitikus extraktum bromelainból kötõszöveti rendellenességek kezelésére - Google Patents

Proteolitikus extraktum bromelainból kötõszöveti rendellenességek kezelésére

Info

Publication number
HUE039689T2
HUE039689T2 HUE12815526A HUE12815526A HUE039689T2 HU E039689 T2 HUE039689 T2 HU E039689T2 HU E12815526 A HUE12815526 A HU E12815526A HU E12815526 A HUE12815526 A HU E12815526A HU E039689 T2 HUE039689 T2 HU E039689T2
Authority
HU
Hungary
Prior art keywords
bromelain
treatment
connective tissue
tissue disorders
proteolytic extract
Prior art date
Application number
HUE12815526A
Other languages
English (en)
Inventor
Lior Rosenberg
Guy Rubin
Eilon Asculai
Original Assignee
Mediwound Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediwound Ltd filed Critical Mediwound Ltd
Publication of HUE039689T2 publication Critical patent/HUE039689T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1732Lectins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22Cysteine endopeptidases (3.4.22)
    • C12Y304/22031Ananain (3.4.22.31)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22Cysteine endopeptidases (3.4.22)
    • C12Y304/22032Stem bromelain (3.4.22.32)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
HUE12815526A 2011-07-20 2012-07-19 Proteolitikus extraktum bromelainból kötõszöveti rendellenességek kezelésére HUE039689T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161509612P 2011-07-20 2011-07-20

Publications (1)

Publication Number Publication Date
HUE039689T2 true HUE039689T2 (hu) 2019-01-28

Family

ID=47557739

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12815526A HUE039689T2 (hu) 2011-07-20 2012-07-19 Proteolitikus extraktum bromelainból kötõszöveti rendellenességek kezelésére

Country Status (17)

Country Link
US (2) US9511126B2 (hu)
EP (1) EP2734216B1 (hu)
JP (1) JP6049714B2 (hu)
KR (1) KR101921363B1 (hu)
CN (1) CN103687607B (hu)
AU (1) AU2012285378B2 (hu)
BR (1) BR112014001439B1 (hu)
CA (1) CA2842291C (hu)
DK (1) DK2734216T3 (hu)
ES (1) ES2690568T3 (hu)
HU (1) HUE039689T2 (hu)
MX (1) MX350145B (hu)
PL (1) PL2734216T3 (hu)
PT (1) PT2734216T (hu)
RU (1) RU2625726C2 (hu)
WO (1) WO2013011514A1 (hu)
ZA (1) ZA201400946B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3210619A2 (en) * 2014-10-24 2017-08-30 HPRD-Health Products Research and Development LDA Topical formulation for treating skin or mucosal infections, preparation method and uses thereof
CN108884453B (zh) * 2016-01-31 2022-07-29 麦迪伍德有限公司 用于治疗伤口的清创组合物
EP3445389B1 (en) * 2016-04-18 2022-10-26 Mediwound Ltd Formulations for debridement of chronic wounds
KR101800788B1 (ko) * 2017-03-31 2017-11-27 박영오 켈로이드 흉터 개선용 화장료 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
GB8724728D0 (en) 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
JP3054190B2 (ja) 1989-01-27 2000-06-19 イムノリティックス・インコーポレイテッド 良性前立腺肥大処置のための組成物および方法
IL103969A (en) 1991-12-03 1997-01-10 Gerold K V Klein Proteolytic mixture containing escharase and method of isolating same
US5589171A (en) 1994-08-22 1996-12-31 Advance Biofactures Of Curacao Treatment of Dupuytren's disease with collagenase
US6086872A (en) 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
US6031005A (en) 1998-08-03 2000-02-29 Easterling; W. Jerry Composition and method for treating Peyronie's disease and related connective tissue disorders
US6022539A (en) 1999-06-03 2000-02-08 Advance Biofactures Of Curacao Amelioration of peyronie's disease
WO2002074329A1 (en) * 2001-03-19 2002-09-26 Ribeiro Santana Cristiano Albe Pharmaceutical composition applied to the treatment of the peyronie disease and corresponding obtention process
US20030026794A1 (en) * 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
WO2004037183A2 (en) 2002-10-22 2004-05-06 Harbor-Ucla Research And Education Institute Phosphodiester inhibitors and nitric oxide modulators for treating peyronie’s disease, arteriosclerosis and other fibrotic diseases
US20060240037A1 (en) * 2003-06-04 2006-10-26 Edward Fey Methods and compositions for the treatment and prevention of degenerative joint disorders
CA2536096A1 (en) * 2004-01-30 2005-08-18 Angiotech International Ag Compositions and methods for treating contracture
IL165334A0 (en) * 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
ITPD20050207A1 (it) 2005-07-07 2007-01-08 Fidia Farmaceutici Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere
US7811560B2 (en) 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
BRPI0801929A2 (pt) * 2008-05-13 2010-01-12 Santana Cristiano Alberto Ribeiro processo e composição farmacêutica compreendendo enzimas proteolìticas vegetais em nanopartìculas supramoleculares, para tratamento da doença de peyronie, colagenoses e patologias fibróticas e uso

Also Published As

Publication number Publication date
PT2734216T (pt) 2018-11-07
EP2734216A1 (en) 2014-05-28
DK2734216T3 (en) 2018-11-19
WO2013011514A1 (en) 2013-01-24
US10293033B2 (en) 2019-05-21
ZA201400946B (en) 2015-11-25
AU2012285378A1 (en) 2014-01-23
AU2012285378B2 (en) 2017-03-02
CN103687607B (zh) 2018-01-30
CA2842291C (en) 2020-09-15
EP2734216B1 (en) 2018-07-25
JP2014520881A (ja) 2014-08-25
RU2014106299A (ru) 2015-08-27
CA2842291A1 (en) 2013-01-24
KR20140079757A (ko) 2014-06-27
CN103687607A (zh) 2014-03-26
JP6049714B2 (ja) 2016-12-21
US9511126B2 (en) 2016-12-06
KR101921363B1 (ko) 2018-11-22
BR112014001439A2 (pt) 2017-07-18
US20170049865A1 (en) 2017-02-23
PL2734216T3 (pl) 2018-12-31
MX2014000748A (es) 2014-10-15
US20140154229A1 (en) 2014-06-05
EP2734216A4 (en) 2015-03-11
MX350145B (es) 2017-08-28
BR112014001439B1 (pt) 2021-05-25
RU2625726C2 (ru) 2017-07-18
ES2690568T3 (es) 2018-11-21

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