HUE033713T2 - Terápiás és diagnosztikai cél - Google Patents

Terápiás és diagnosztikai cél Download PDF

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HUE033713T2
HUE033713T2 HUE12770215A HUE12770215A HUE033713T2 HU E033713 T2 HUE033713 T2 HU E033713T2 HU E12770215 A HUE12770215 A HU E12770215A HU E12770215 A HUE12770215 A HU E12770215A HU E033713 T2 HUE033713 T2 HU E033713T2
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bst1
antibody
cancer
antibodies
protein
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Christian Rohlff
Alasdair Stamps
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Oxford Biotherapeutics Ltd
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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Claims (10)

  1. TERÁPIÁS ÉS DIAGNOSZTIKAI CÉL Szabadalmi igénypontok l. Antitest, annak funkcionális fragmense vagy antuesí-mímeükum, ameís kötődik a BSTl·· hez, alkalmazás céljából egy betegségnek a kezelésére vagy megelőzésére, amely a következőkből álló listából van választva: akut mieloid leukémia (AML), B-sejtes krónikus lim foci tás Oímfoid) leukémia, emlőrák, koíorektáíis rák, veserák., fej- és nyakí-rák, tüdőrák vagy hasnyálmirigyrák. 2» Antitest, annak funkcionális fragmense vagy amitest-mimetikum alkalmazás céljából az 1. igénypont szerint, ahol a nevezett betegség az akut mieloid leukémia (AML).
  2. 3, Antitest alkalmazás céljából az 1. igénypont vagy a 2. igénypont, szerint, ahol az antitest egy monokionálís antitest.
  3. 4, Antitest, annak funkcionális fragmense vagy amitest-mimetikum alkalmazás céljából az l.-töí 3,-ág igénypontok bármelyike szerint, ahol az antitest, annak funkcionális iragmense vagy antiiest-mimetikum egy kiinéra antitest, egy humán antitest, egy humanizált antitest, egy egyláncú antitest, egy defukozilált (angolul: „defucosylated") antitest vagy egy btspecífifcas antitest,:
  4. 5, Antitest, annak funkcionális fragmense vagy antitest-mhneiikum alkalmazás céljából az l.-töí 4.-ig igénypontok bármelyike szerint, ahol az antitest, annak funkcionális fragmense vagy antitest-mínietikum tartalmaz egy terápiás molekularészt (csoportot) vagy ahhoz konjugálva van; előnyösen ahol a terápiás molekularész (csoport) egy citot.os.ikus molektilarész (csoport) vagy egy radioaktív izotóp; opcionálisan ahol az antitest, annak funkcionális fragmense vagy antiiest-mimetikum egy antitest-gyógyszer-konjugutuui.
  5. 6, Antitest, unnak funkcionális fragmense vagy antitest-miineükum alkalmazás céljából az 1.-től 4,-ig igénypontok bármelyike szerint, ahol az affinitást reagens (angolul; „affinity reagent") előidéz egyet vagy többet a következők közül: antitest-függő celluláris (sejt-közvetített) citotoxicitás (ADCC), komplement-függő citotoxicitás (CDC) és/vagy T-sejtes citotoxicitás.
  6. 7, Antitest, annak funkcionális fragmense vagy anüíest-mimeltkum alkalmazás céljából az 1 tol 6, ig igénypontok bármelyike szerint, ahol az antitest, annak funkcionális fragmense vagy amitest-mimetíkum indukálja a ráksejtek apoptózísát, elpusztítja a rákos őssejteket vagy csökkenti azoknak a számát és/vagy elpusztítja a keringő ráksejteket vagy csökkenti azoknak a számát.
  7. 8, Antitest, annak funkcionális fragmense vagy antitesf-rnímeükum alkalmazás céljából az 1 .-töl 6.-ig igénypontok bármelyike szerint, ahol az antitest, annak funkcionális fragmense vagy antitest-mirnetíkum modulálja a 8ST1 egy fiziológiai funkcióját, gátolja a ligandum-kötődést. a BSTí-hez és/vagy,- gátol egy a BSTl· által közvetített szignál-transzdukcíós (jelátviteli) útvonalat (angolul: „signal transduction pathway"). 9, kijárás egy betegségnek a kimutatására, diagnosztizálására és/vagy szkrínelésére (szűrésére, angolul: „screening”), ahol a BSTl expressziül va van a nevezett betegségben, vagy egy gyógyszer vagy terápia hatásának a monitorozására, ahol a BSTl expresszálva van a nevezett betegségben, egy mintában, amely egy alanytól van kapva, ahol az magában foglalja a következőket: a következők jelenlétének vagy szintjének a kimutatását: BSTl-nek, vagy annak egy vagy több fragmensének, ami magában foglalja azok szintjének egy elváltozásának a kimutatását a nevezett, alanyban; alvói a nevezet* betegség -a kővetkezőkből áilé csoportból van választva: akut mieloid leukémia í AjvíL), B-sejtes krónikus limfocitás (limfbid) leukémia, emlőrák, kolorektális rák, veserák, fej- és nyakí~rák, tüdőrák és hasnyáimirigyrűk,
  8. 10, Eljárás a 9, igénypont szerint, amely magában foglalja a kővetkezők jelenlétének a kimutatását; a BSTl~nek< vagy annak egy vagy több fragmensének, ahol vagy (a) a BSTI-nek, vagy annak a nevezett egy vagy több fragmensének, egy megemelkedett szintjének a jelenléte az alanyban, összehasonlítva a szinttel egy egészséges alanyban, vagy (b) a BSTl-nek, vagy annak a nevezett egy vagy több fragmensének, egy kimutatható szántjének a jelenléte az alanyban, összehasonlítva egy megfelelő, nem kimutatható szinttel egy egészséges alanyban, a ráknak a jelenlétét jelzi (arra utalj a nevezett alanyban, ahol a BSTI express/álvu um a nevezett rákban, H, Eljárás a 9. vagy 10. igénypont szerint, ahol a BSTl-nck. vagy altnak egy vagy több fragmensének, a jelenléte a következők alkalmazásával um kimutatva: egy antitest, annak funkcionális fragmense vagy antitesi-mimefíkum, amely kötődik a BSTl-hez; ahol előnyösen az; antitest, annak funkcionális fragmense vagy aniiiest-mimeükum a 3. vagy 4, igénypontok bármelyikében meghatározottak szerint áll rendelkezésre.
  9. 12. Eljárás a II, igénypont szerint, ahol az. antitest, annak funkcionális i'ragmense vagy antiteswnimeükum tartalmaz egy kimutatható jeioioanyagoí (detektálható jelölést, angolul; „detectable label") vagy konjugálva van ahhoz.
  10. 13. Alkalmazás az 1.-től 8.-ig igénypontok bármelyike szerint, vagy eljárás a 9.~iői 12,-ig igénypontok bármelyike szerint, ahol az alany egy ember.
HUE12770215A 2011-06-28 2012-06-28 Terápiás és diagnosztikai cél HUE033713T2 (hu)

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US9175092B2 (en) 2011-06-28 2015-11-03 Oxford Biotherapeutics Ltd Antibodies to bone marrow stromal antigen 1
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CN110393790B (zh) * 2018-04-24 2023-03-28 中国科学院分子细胞科学卓越创新中心 促黄体生成素在抑制髓系白血病发展的用途
WO2023135177A1 (en) 2022-01-14 2023-07-20 T.J.Smith And Nephew, Limited Self-calibration with dynamic therapy performance for negative pressure wound therapy devices
WO2023187790A1 (en) * 2022-03-31 2023-10-05 Ramot At Tel-Aviv University Ltd. Targeting immune infiltration to the central nervous system (cns)

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
JP2532858B2 (ja) 1985-04-01 1996-09-11 セルテツク リミテツド 形質転換したミエロ―マ細胞系
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
AU622426B2 (en) 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
EP0814159B1 (en) 1990-08-29 2005-07-27 GenPharm International, Inc. Transgenic mice capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
GB9106048D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccines
ES2098377T3 (es) 1990-10-22 1997-05-01 Abbott Lab Reactivo de diagnostico anoxico estabilizado en solucion.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
JP3672306B2 (ja) 1991-04-10 2005-07-20 ザ スクリップス リサーチ インスティテュート ファージミドを使用するヘテロ二量体受容体ライブラリー
CA2110799A1 (en) 1991-06-14 1992-12-23 Arnold H. Horwitz Microbially-produced antibody fragments and their conjugates
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU665221B2 (en) 1991-12-02 1995-12-21 Cambridge Antibody Technology Limited Production of anti-self antibodies from antibody segment repertoires and displayed on phage
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
US6765087B1 (en) 1992-08-21 2004-07-20 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
CA2148252C (en) 1992-10-30 2007-06-12 Roger Brent Interaction trap system for isolating novel proteins
US5807683A (en) 1992-11-19 1998-09-15 Combichem, Inc. Combinatorial libraries and methods for their use
US6838254B1 (en) 1993-04-29 2005-01-04 Conopco, Inc. Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
DE69534347T2 (de) 1994-01-31 2006-05-24 Trustees Of Boston University, Boston Bibliotheken aus Polyklonalen Antikörpern
WO1995026204A1 (en) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US5738996A (en) 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
GB9608510D0 (en) 1996-04-25 1996-07-03 Medical Res Council Calcium dependent binding ligands
US6555310B1 (en) 1997-04-04 2003-04-29 Biosite Diagnostics, Inc. Polyclonal libraries
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
ES2340112T3 (es) 1998-04-20 2010-05-28 Glycart Biotechnology Ag Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos.
JPH11310596A (ja) * 1998-04-28 1999-11-09 Seibutsu Bunshi Kogaku Kenkyusho:Kk 骨髄間質細胞抗原結合蛋白質
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Hakko Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
EP2149604A1 (en) 2000-09-08 2010-02-03 Universität Zürich Collections of repeat proteins comprising repeat modules
EP1331266B1 (en) 2000-10-06 2017-01-04 Kyowa Hakko Kirin Co., Ltd. Cells producing antibody compositions
US20060223114A1 (en) 2001-04-26 2006-10-05 Avidia Research Institute Protein scaffolds and uses thereof
US20050048512A1 (en) 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20030082630A1 (en) 2001-04-26 2003-05-01 Maxygen, Inc. Combinatorial libraries of monomer domains
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
US20050089932A1 (en) 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding
US6989452B2 (en) 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
WO2003002609A2 (en) 2001-06-28 2003-01-09 Domantis Limited Dual-specific ligand and its use
US20040110226A1 (en) 2002-03-01 2004-06-10 Xencor Antibody optimization
CN102911987B (zh) 2002-04-09 2015-09-30 协和发酵麒麟株式会社 基因组被修饰的细胞
CN1678634A (zh) 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
EP1558645B1 (en) 2002-11-08 2011-07-27 Ablynx N.V. Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
EP1578801A2 (en) 2002-12-27 2005-09-28 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
EP1627062A1 (en) 2003-05-14 2006-02-22 Domantis Limited A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
ES2315664T3 (es) 2003-06-30 2009-04-01 Domantis Limited Anticuerpos de dominio unico (dab) pegilados.
US20050164301A1 (en) 2003-10-24 2005-07-28 Avidia Research Institute LDL receptor class A and EGF domain monomers and multimers
JP2005295921A (ja) 2004-04-14 2005-10-27 Pharma Design Inc 新規ｂｓｔ１選択的スプライシング変異体及びその用途
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
US20060234299A1 (en) 2004-11-16 2006-10-19 Avidia Research Institute Protein scaffolds and uses thereof
EP1844073A1 (en) 2005-01-31 2007-10-17 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
CA2605781A1 (en) 2005-05-09 2007-04-12 Glycart Biotechnology Ag Antigen binding molecules having modified fc regions and altered binding to fc receptors
US7521195B1 (en) * 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
WO2007038619A2 (en) 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
EP1973576B1 (en) 2005-11-28 2019-05-15 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
EP2235055A2 (en) 2007-12-24 2010-10-06 Oxford Biotherapeutics Ltd. Ephrin type-a receptor 10 protein
WO2011027310A1 (en) 2009-09-03 2011-03-10 Koninklijke Philips Electronics N.V. Novel tumor markers
US9002545B2 (en) 2011-01-07 2015-04-07 Wabtec Holding Corp. Data improvement system and method
US9175092B2 (en) 2011-06-28 2015-11-03 Oxford Biotherapeutics Ltd Antibodies to bone marrow stromal antigen 1

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US20140193333A1 (en) 2014-07-10
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US9447178B2 (en) 2016-09-20

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