HUE033384T2 - Primer amin-tartalmú szilikon-hidrogél kontaktlencsék, valamint ezekkel kapcsolatos kompozíciók és eljárások - Google Patents
Primer amin-tartalmú szilikon-hidrogél kontaktlencsék, valamint ezekkel kapcsolatos kompozíciók és eljárások Download PDFInfo
- Publication number
- HUE033384T2 HUE033384T2 HUE14722703A HUE14722703A HUE033384T2 HU E033384 T2 HUE033384 T2 HU E033384T2 HU E14722703 A HUE14722703 A HU E14722703A HU E14722703 A HUE14722703 A HU E14722703A HU E033384 T2 HUE033384 T2 HU E033384T2
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- HU
- Hungary
- Prior art keywords
- monomer
- primary amine
- agent
- contact lens
- polymerizable composition
- Prior art date
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- ILHMPZFVDISGNP-UHFFFAOYSA-N ethenyl n-[3-tris(trimethylsilyloxy)silylpropyl]carbamate Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCNC(=O)OC=C ILHMPZFVDISGNP-UHFFFAOYSA-N 0.000 description 1
- KRAZQXAPJAYYJI-UHFFFAOYSA-N ethenyl trimethylsilylmethyl carbonate Chemical compound C[Si](C)(C)COC(=O)OC=C KRAZQXAPJAYYJI-UHFFFAOYSA-N 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
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- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B25/00—Packaging other articles presenting special problems
- B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
- B29K2033/04—Polymers of esters
- B29K2033/12—Polymers of methacrylic acid esters, e.g. PMMA, i.e. polymethylmethacrylate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2011/00—Optical elements, e.g. lenses, prisms
- B29L2011/0016—Lenses
- B29L2011/0041—Contact lenses
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Eyeglasses (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Ophthalmology & Optometry (AREA)
- General Health & Medical Sciences (AREA)
- Materials For Medical Uses (AREA)
Claims (5)
- FRIMER AMIN-TARTALMÛ SZfUKON-HiDROGÉL KONTAKTLENCSÉK, VALAMINT EZEKKEL KAPCSOLATOS KOMPOZÍCIÓK Ê$ EUÀRÀSOK SiibádiM Igénypontok:1, Szilikon-hktrogéi kontaktlencse, amely tartalmaz; polimer íenesetistii amelynek hidratált állapotban egyensúlyi víztartalma legalább 30 %, oxigén-áteresztő képessége legalább 30 barrer, és modulusa 0,3-·· 1,2 MPa, és amely égy elegyedd polimerizálható kompozíció roákciótérméke. az említett elegyedő polimerizálható kompozíció tartalmaz (a) !||jaiébb egy sziioxáii monomert 20*80 íómegszázalék mennyiségben; (0) legalább egy hidrofil monomert tel legalább egy térhaíósdo szert. Cd) legalább egy poíimermiüió-iniciétort; és (e) legalább egy pflmér amindariaímú metakriiát monomert vagy legalább egy primer amín-tartalmú meiakrilamid monomert ahol a polimer len esetést tartalmazza a legalább egy primer amm-tartaimo monomer polimerizált e|pipl yify a legalább egy primer amln-tartaimu métikrilamícl monomer polimerizált egységei által biztosított primer anno funkciós csoportok sokaságat és a primer amin funkciós csoportok sokasága kovalensen lifidrk komplementer funkciós csoportokhoz annak eredményeként, hogy a; polimer lepoeeteÄt olyan vizes old atban bocsátjuk rendelkezésre, améif tartalmaz olyan szert, amely rendeikezik: kapóséit egy kagy több említett kbnipléndenter funkciós csoporttal.
- 2, Az 1. igénypont szerinti kontaktlencse, ahol a legalább egy primer amín-tartalmú metakriiát monomer vagy a jégaíéhb egy primer amfortartalmö roetáiriUmid mopomer: (a) szabad bázis formában van jelen; (b) a polimerizálható kompozícióban legalább 0.2 tomigszizaíék mennyiségben van jelen: és/vagy (c) ÉÈiSnôÂSffné primer aminiaiâfmâ MtaferÄmii monomer, és ahol az aikanlánc 2él szénatom hosszúságú.
- 3, Az 1. vagy 2. igénypont szerinti kontaktlencse, ahol az elegyedő polimerizálható kompozíció szerves oldószertől vagy «ryis higltószertoi mentes;
- 4, Az 'Ki igénypontok bármelyike szerinti kontaktlencse, ahol a legalább egy hidrofil monomer tartalmaz N - v i n i I - a m Id - ta ft a Im 0 hidrofil monomert % A 4. igénypont szerinti kontaktlencse, ahol a legalább egy primer amin-tartalmú rnetakrüát monomer fagy a legalább egy primer amin-tartalmú metakrilamití monomer legalább egy primer amin-tartaimú metakolamid monomer: amelyet m N~{2"amlnoetif)metakrilamld (AEMAA) monomer egy formája* az prgpíl)metakrilimíd (APMAA) monomer agy íormáp: |a ezek bármilyen kombinápl^eÜfal alkotott csoportból választunk.
- 8, Az 1~ő. igénypontok bármelyike szerinti kontaktlencse, ahol a legalább egy sziloxán monomert a szilícium-tartalmú vinit-karbonát monomer, szilidum-tartalmú vlml-karbamát monomer, monometakriioxipropil-vègü polldimefliszHoxán monomer, rnonometaknloxipropil'Végü mono-n-butil-végö poiidimetij-szlioxÉft monomer és ezek bármilyen kombinációié által alkotott csoportból választjuk; és/vagy tartalmaz (1) képiéin sziloxán monomert:(1) ahol m jelentése az (1) képletben egész szám, értéke 3 - 10. n jelentése az (1) képletben egész szám. értéke 1 - 10, R1 jelentése az (1) képletbén 1-4 szénatomos aikliosoport és mindegyik R3 jelentése az (1) képletben, függetlenül, hidrogénatom vagy metilosoport. 1A Ä*: 1*0. Igénypontok bármelyike szerinti kontaktlencse, ahol (a) az említett szer komplementer funkciós csoportja tartalmaz észter, aldehid, keton vagy karbonsav jfaMó* csoportot; &: polimer ienoaetest: púmét amie irmkofe ^csoportjainak sokasig# kevifensen kdiódik a szerrtéi kapcsolt komplementer funkció^: csoportokhoz amín-észter, amio-afdehíd, amin-Reton, le» amio-karbonsav kötéssel; if a per így a polimer tenoseiestbez van kapcsolva, vagy :(b) a szer komplementer funkció« csoportja bí-hidmzt! izgkcinímtd PHS) csoport, ás a koyejeos kötés arnin-ozokolnirncl-észter kötés, E A ? Igénypont szertal kontakitenose,: alól a szar nidvaeftlszef vagy klpesgiiszen 7. vagy 8. igénypont szerinti kontaktlencse* ápol a .szer laialmaz olyan polimert, amelynek; van legalább egy kapcsolt komplementer funkciós csoportja; és/vagy artöl a széf nedvesitoszer, és a polimer lencsetest kontakt szép 70 foknál kisebb, % HjÉréf előállításéra, amely során: gondoskodunk agy eíeiyedó poiímstlzélbafó kompozieiöröl m amlett elegyedő polimerizálható kompozíció tartalmaz (a) legalább egy: szllosén monomért 20-80 íömegszázalék mennyiségben; (b) legalább egv hidrofil monomert 20-80 tömegszázafék mennyiségben; (c) legalább egy térrtálositö szert (d) legalább egy pelmenzáciö-inlaitort; és (e) legalább egy primer amimtartalmű metakrilát monomert vagy legalább egy primer amin-tartalmű metakrkamld monomert polimerizáljuk a polimerizálható kompozíciót kontaktlencse öntlformo-Isiieállttlsban polimer lencseiest előállításira:, amelynek Hidratált állapotban az égpnsÉp víztartalma legalább 3D %, oxigèrviteresætd képessege legalább 80 barrertás nmdulusa 0,3 -1,2 MPa, a polimer leneseiéi! tartalmazza a legalább egy primer amín-tartaímú metakríléi monomer polimerizált egységéi vagy a legalább egy primer amin-tartalmű metakrilamid monomer polimerizált egységei Éttel biztosított pnmer amin funkciós csoportok sokaságát; el vieszfjy ki potlmer iencsetestit érintkezésbe nézzük at elválasztott;: ;pőtaef: ímmÚmM' olyan si Oldattal. amely tartalmaz olyan szert, amely rendelkezik kapcsolt egy vagy több komplementer' funkciós csoporttal. így kovalens kötések alakulnak kl a szer egy vagy ti» komplementer funkciós csoportja: is a polimer tenesetes! frimer amin funkciós csoportjainak sokasága között ezáltal bozzikápoSÖÉá a szert..m érintkezésbe hozott polimer lencseiesthez; és csomagoljuk az érintkezésbe hozott polimer lenesetestet kontaktlencse csomagoló oldatot tartalmazó kontaktlencse csomagolásba a kész kontaktlencse 11, A 10. igénypont szérlnf efirls, ahol a pollilét tencsétéél öntőforma' összeáHHástól való elválasztása mechanikai öntőforma-összeállítás szétválasztásának olyan eljárását tartalmazza, amely nem foglalja magában folyadéknak a polimer lencseiestre vagy az őntőforma-összeállitásra való felvitelét, vagy a polimer lencsetest öntófcrms-osizeilfításiól való; ÄifasÄsa olyan mechanikai lencse-eltávolító eljárást tartalmaz, amely nem foglalja magában folyadék felvitelét a polimer tencsefestre vagy egy onfMommrèSÂ 12, A 10. vagy 11. igénypont szénné eljárás, ahol az énntkeztetést 20-60 X-on vagy pH 5,0--9,0 értéknél vagy 20#^rf# pH 5,0-9,0 érlilhit: »pzzlte 13, A 10-12. igénypontok bármelyike szerinti eljárás, amely faialmaz Ä az elválasztok polimer íencsetestfei végzett extrákéról, vagy az érínfkeztetetf polimer lencsetesttel végzett extrakciéf. vagy mindkettőt a reagáiatian monomer eltávolítására, és/vagy tartalmazza továbbá az érlnfkezietett polimer fencsetest mosását a csomagolást megelőzően. liv É 10-13, igénypontok bármelyike szerinti eljárás, ahol a kész kontaktlencse kontakt szöge legalább 10 fokkal alacsonyabb, mint annak a kontaktlencsének a konlaktszöge, amelyet ugyanazon polimerizálható kompozíció alkalmazáséval és ugyanazgpelöáilífási eljárás alkalmazásával állítunk elő. de az elválasztott polimer lencsetestnek a szer vizes oldatával való érintkeztetésének lépése nélkül. Az 1-9. igénypontok bármelyike szerinti kontaktlencse vagy a 1Ct-l4, igénypontok bármelyike szerinti eljárás« ahoi a legalább agy primer amlrviaftiirii mêiaknlâî monomer vagy a legalább egy primer aroirvtartalmú metakrilamid monomer (a) jelen van (b) alkárdánoAartalmú primer iaminAartatmé: melakÉárpll rponMip ahol az: atkáplÉne 2-6 szénatom bosszúságig és ahol az elegyedd pblmerizalhato kompozlpö szerves oldószertől vagy szerves higltôszertôl mentes.
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| US201361817606P | 2013-04-30 | 2013-04-30 |
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| HUE14722703A HUE033384T2 (hu) | 2013-04-30 | 2014-04-30 | Primer amin-tartalmú szilikon-hidrogél kontaktlencsék, valamint ezekkel kapcsolatos kompozíciók és eljárások |
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| EP (1) | EP2992366B1 (hu) |
| JP (1) | JP2016524178A (hu) |
| KR (1) | KR101640725B1 (hu) |
| CN (1) | CN105164555B (hu) |
| AU (1) | AU2014261220B2 (hu) |
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| MX (1) | MX347214B (hu) |
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| US10209534B2 (en) | 2012-03-27 | 2019-02-19 | Johnson & Johnson Vision Care, Inc. | Increased stiffness center optic in soft contact lenses for astigmatism correction |
| WO2016161144A1 (en) * | 2015-04-01 | 2016-10-06 | The Regents Of The University Of Colorado, A Body Corporate | Nanogels for ophthalmic applications |
| US10371964B2 (en) | 2015-09-15 | 2019-08-06 | Largan Medical Co., Ltd. | Contact lens product |
| CN106526888B (zh) | 2015-09-15 | 2019-08-06 | 星欧光学股份有限公司 | 隐形眼镜产品 |
| US10845622B2 (en) | 2015-09-15 | 2020-11-24 | Largan Medical Co., Ltd. | Multifocal contact lens and contact lens product |
| US11125916B2 (en) * | 2016-07-06 | 2021-09-21 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising N-alkyl methacrylamides and contact lenses made thereof |
| CN109476987A (zh) * | 2016-07-20 | 2019-03-15 | 3M创新有限公司 | 用于量子点的稳定苯乙烯系聚合物 |
| CN110740855B (zh) | 2017-06-07 | 2021-10-22 | 爱尔康公司 | 用于生产硅氧烷水凝胶隐形眼镜的方法 |
| CA3061585C (en) | 2017-06-07 | 2021-11-16 | Alcon Inc. | Silicone hydrogel contact lenses |
| AU2018282054B2 (en) | 2017-06-07 | 2021-01-14 | Alcon Inc. | Silicone hydrogel contact lenses |
| US11067831B2 (en) * | 2017-10-30 | 2021-07-20 | Coopervision International Limited | Methods of manufacturing coated contact lenses |
| CN111919141B (zh) | 2018-02-26 | 2023-11-14 | 爱尔康公司 | 硅氧烷水凝胶隐形眼镜 |
| EP3774310B1 (en) | 2018-03-28 | 2022-07-06 | Alcon Inc. | Method for making silicone hydrogel contact lenses |
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- 2014-04-30 US US14/781,041 patent/US9429684B2/en active Active
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- 2014-04-30 MY MYPI2015703848A patent/MY175265A/en unknown
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| US20160054475A1 (en) | 2016-02-25 |
| KR20150140851A (ko) | 2015-12-16 |
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| MY175265A (en) | 2020-06-17 |
| US9429684B2 (en) | 2016-08-30 |
| JP2016524178A (ja) | 2016-08-12 |
| EP2992366A1 (en) | 2016-03-09 |
| CN105164555B (zh) | 2016-12-21 |
| MX2015014072A (es) | 2016-07-07 |
| EP2992366B1 (en) | 2016-12-07 |
| WO2014177871A1 (en) | 2014-11-06 |
| AU2014261220A1 (en) | 2015-11-26 |
| CA2909899C (en) | 2016-04-12 |
| HK1214368A1 (zh) | 2016-07-22 |
| MX347214B (es) | 2017-04-19 |
| KR101640725B1 (ko) | 2016-07-18 |
| CN105164555A (zh) | 2015-12-16 |
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