HUE032074T2 - Aktív, nagymértékben foszforilált, emberi liszoszomális szulfatáz enzimek elõállítása és alkalmazása - Google Patents

Aktív, nagymértékben foszforilált, emberi liszoszomális szulfatáz enzimek elõállítása és alkalmazása Download PDF

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Publication number
HUE032074T2
HUE032074T2 HUE09702074A HUE09702074A HUE032074T2 HU E032074 T2 HUE032074 T2 HU E032074T2 HU E09702074 A HUE09702074 A HU E09702074A HU E09702074 A HUE09702074 A HU E09702074A HU E032074 T2 HUE032074 T2 HU E032074T2
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Hungary
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galns
enzyme
lake
sulfatase
lysosomal
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HUE09702074A
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English (en)
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Michel Claude Vellard
Vish Koppaka
Melita Dvorak-Ewell
Erno Pungor
Charles Hague
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Biomarin Pharm Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40451345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE032074(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of HUE032074T2 publication Critical patent/HUE032074T2/hu

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001—Arylsulfatase (3.1.6.1)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004—N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06014—N-Acetylglucosamine-6-sulfatase (3.1.6.14)
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
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Claims (2)

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VÍC :gjÿ tó* s; C :F' v>; -ÖSs ^ ^ ^ XI ^ ’<: F g iá ® p ' ' tó B -tó: S ® :» tó ä é -í*i· 8 í * 1 I 1- I I: s S i 1 J I Ï 8: f i € * Ç f Ψ í if S. s s: i * I ? I r I = 50. A ?. igénypont szerinti készítmény az oit meghatározott alkalmazásra vagy a 8. igéttypom szerlnu alkalmazás. ahol a CiALMS enzim redukáló körolmények között vág»«» SOS·· F A GO. voran Coenumie Slue îVÿ-· ’|5:S^ifíl0i|;:í>íí^í!i^i^ ϊΐ·ίI, έί:«>όϊ>ί·;;?ί-:lá.íMií;íí proteinek. legalább 90Η-3 ||||||||||||||||, j!!Í:'''::|||||Í. t. î. kés/.itmény nz ctt :^:::^ÎÎ;^-iiiiiiiiii^ !!l eiéoypomok bálibbΙΑ:5í ΐίΐ5¾¾ iíH|||.:GÁl:iP:S ehzlm IBIpil^ií&amp;íáíjSít levő tisztein legalább Am ä Cso-fotmilgilcmne (FCUy) kö|yéÍÍtíl 1:2; A 7-50, igénypontok bármelyike szerint! készítmény az. ott megbatározott alkalmazásra vagy ah-ltl igénypontok-bármelyike szerinti alkalmazás, ahol a GAIMS enzim S3, pozickiíabtt« íévö -tisztem J.egaí-áb.b.-9Uk«* á.Cö-íomulgHcinné (FQIy) -konvertált:.· 13. A 7-12. igénypontok bármelyike szerinti készítmény az-ott meghatározott .alkat ntázásra vagy a 1M2. Igénypontok bánttciyíke szerinti alkalmam, ahol a kezeié?; hatásosságát az MÍ>.S iVavban vagy .Montul» A szindróntában szenvedd alanyban a ksratán-szatiat vizelettel-tÖrténiVkiválasZtáaán&amp;k mérésével határozzak öreg. aha! a* MFS IVa-ban vagy Morcom Ä szbidmmábast szenvedő alany vizeleten mért KS-sxntbéi ittíroíál alany vízek'tben mert ΗΛ .-cmtH'rtd e* vagy MFh. iVa-ban vagy Morquio A szindrómába» -szenvedő, kezeletlen alany vizeletben'»}«« K^szmíjéval vagy a« azonos alany GALMS~enzimnse|:.td«éná-lctÍzeiéat megeJ&amp;riie« a vizeletben mén KS-srJntjévcl hasonlítjuk össze, vagy ahoi a kezelés hatásosságát az alany fttnkekmáíis vizsgálatával tárástesztekkel, lépcsőzéssé! mért állóképesség vagy polmonáliaAesptratorifcua funkció alapján határozzuk meg, ahol adok esetben a járásieszt « 6'vágy ' 12 'pere alatt sétál· 'távolságot ntéo ystgyl!! :$hb:|:Í;$á^ .pöSpilliält: meglesi lépcsők s/asnüt méri vagy ahol a puimonáii.Vre-piratorrki.i!·: inrskdot korökhis funkció íeehokardmcram} vagy putmanálss fenkció íl'VC, FFV llkhiy «íiííiíSa^^mléiä|S|íiíáís M. A 13. igénypont szerinti készítmény az ott meghatározott alkalmazásra. vagy tt 1:1 igénypont szentül alkalmazás, ahol GAUNS-enzimtuel történő kezelést követően a vizeletben mért KS csökkenése nagyobb, miot 201(, vagy ahol tiALNS-enstmmel történő kezdést követően a vizeletben mert KS csökkenése nagyobb, mint lil!
  2. 15, Az t-<S, igénypontok bármelyike szerinti O A LNS^eîtzimkészJîtnény. a 7-14. igénypontok bármelyike szerinti készítmény az ott meghatározót} alkalmazásra vagy a l-M. igénypontok bármelyike szét inti alkalmazás, ahol a sebes irányítószígnái tartalmaz, osont iíáavlrópeptidei.
HUE09702074A 2008-01-18 2009-01-16 Aktív, nagymértékben foszforilált, emberi liszoszomális szulfatáz enzimek elõállítása és alkalmazása HUE032074T2 (hu)

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US2217908P 2008-01-18 2008-01-18
US9937308P 2008-09-23 2008-09-23
US11024608P 2008-10-31 2008-10-31

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HUE16203748A HUE066911T2 (hu) 2008-01-18 2009-01-16 Aktív, erõsen foszforilált humán lizoszomális szulfatáz enzimek elõállítása és alkalmazásai
HUE09702074A HUE032074T2 (hu) 2008-01-18 2009-01-16 Aktív, nagymértékben foszforilált, emberi liszoszomális szulfatáz enzimek elõállítása és alkalmazása
HUS1700022C HUS1700022I1 (hu) 2008-01-18 2017-05-18 Aktív, nagymértékben foszforilált, emberi liszoszomális szulfatáz enzimek elõállítása és alkalmazása

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