CY2017018I2 - Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων - Google Patents

Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων

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Publication number
CY2017018I2
CY2017018I2 CY2017018C CY2017018C CY2017018I2 CY 2017018 I2 CY2017018 I2 CY 2017018I2 CY 2017018 C CY2017018 C CY 2017018C CY 2017018 C CY2017018 C CY 2017018C CY 2017018 I2 CY2017018 I2 CY 2017018I2
Authority
CY
Cyprus
Prior art keywords
lysosomic
human
active
preparation
highly phosphorylated
Prior art date
Application number
CY2017018C
Other languages
English (en)
Other versions
CY2017018I1 (el
Original Assignee
Biomarin Pharmaceutical Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40451345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2017018(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharmaceutical Inc. filed Critical Biomarin Pharmaceutical Inc.
Publication of CY2017018I2 publication Critical patent/CY2017018I2/el
Publication of CY2017018I1 publication Critical patent/CY2017018I1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001—Arylsulfatase (3.1.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004—N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06014—N-Acetylglucosamine-6-sulfatase (3.1.6.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
CY2017018C 2008-01-18 2017-05-19 Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων CY2017018I1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2217908P 2008-01-18 2008-01-18
US9937308P 2008-09-23 2008-09-23
US11024608P 2008-10-31 2008-10-31
PCT/US2009/031276 WO2009091994A2 (en) 2008-01-18 2009-01-16 Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof

Publications (2)

Publication Number Publication Date
CY2017018I2 true CY2017018I2 (el) 2017-11-14
CY2017018I1 CY2017018I1 (el) 2017-11-14

Family

ID=40451345

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20171100313T CY1118984T1 (el) 2008-01-18 2017-03-13 Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων
CY2017018C CY2017018I1 (el) 2008-01-18 2017-05-19 Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων

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CY20171100313T CY1118984T1 (el) 2008-01-18 2017-03-13 Παρασκευη ενεργων, ακρως φωσφορυλιωμενων, ανθρωπινων λυσοσωμικων ενζυμων σουλφατασης και χρησεις αυτων

Country Status (28)

Country Link
US (7) US8128925B2 (el)
EP (2) EP2245145B1 (el)
JP (1) JP5687069B2 (el)
KR (1) KR101744142B1 (el)
CN (2) CN105274072A (el)
AR (1) AR070198A1 (el)
AU (1) AU2009205978B2 (el)
BR (1) BRPI0906948B1 (el)
CA (2) CA3112632A1 (el)
CL (1) CL2009000091A1 (el)
CY (2) CY1118984T1 (el)
DK (1) DK2245145T3 (el)
HK (1) HK1244505A1 (el)
HR (1) HRP20170366T1 (el)
HU (2) HUE032074T2 (el)
IL (1) IL206975A (el)
LT (2) LT2245145T (el)
MX (1) MX2010007846A (el)
NL (1) NL300874I2 (el)
NO (1) NO2017024I1 (el)
PE (2) PE20091319A1 (el)
PL (1) PL2245145T3 (el)
PT (1) PT2245145T (el)
RU (1) RU2510820C2 (el)
SI (1) SI2245145T1 (el)
TW (1) TWI395816B (el)
WO (1) WO2009091994A2 (el)
ZA (1) ZA201004674B (el)

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Also Published As

Publication number Publication date
PT2245145T (pt) 2017-03-14
NL300874I2 (nl) 2018-04-12
CY2017018I1 (el) 2017-11-14
KR101744142B1 (ko) 2017-06-07
EP2245145B1 (en) 2016-12-14
BRPI0906948B1 (pt) 2023-05-16
WO2009091994A3 (en) 2009-10-29
LT2245145T (lt) 2017-04-10
CY1118984T1 (el) 2017-11-14
CL2009000091A1 (es) 2009-03-27
HRP20170366T1 (hr) 2017-05-05
US9873867B2 (en) 2018-01-23
CA2711590A1 (en) 2009-07-23
AR070198A1 (es) 2010-03-17
JP2011509674A (ja) 2011-03-31
NO2017024I1 (no) 2017-05-30
BRPI0906948A2 (pt) 2015-07-14
TW200934869A (en) 2009-08-16
PE20091319A1 (es) 2009-09-23
TWI395816B (zh) 2013-05-11
JP5687069B2 (ja) 2015-03-18
CA3112632A1 (en) 2009-07-23
KR20100108438A (ko) 2010-10-06
EP2245145A2 (en) 2010-11-03
US10563183B2 (en) 2020-02-18
US20120208221A1 (en) 2012-08-16
IL206975A (en) 2013-06-27
RU2510820C2 (ru) 2014-04-10
HK1244505A1 (zh) 2018-08-10
DK2245145T3 (en) 2017-03-20
US8128925B2 (en) 2012-03-06
EP3219795A1 (en) 2017-09-20
US20090186011A1 (en) 2009-07-23
LTC2245145I2 (lt) 2019-04-25
CN102027110A (zh) 2011-04-20
IL206975A0 (en) 2010-12-30
ZA201004674B (en) 2011-09-28
RU2010134412A (ru) 2012-02-27
US20210189357A1 (en) 2021-06-24
US10934534B2 (en) 2021-03-02
WO2009091994A2 (en) 2009-07-23
PL2245145T3 (pl) 2017-07-31
US20130236921A1 (en) 2013-09-12
CA2711590C (en) 2021-03-23
US20160201039A1 (en) 2016-07-14
MX2010007846A (es) 2010-10-05
LTPA2017016I1 (lt) 2017-06-12
HUE032074T2 (en) 2017-08-28
HUS1700022I1 (hu) 2017-06-28
US9200264B2 (en) 2015-12-01
US20180208913A1 (en) 2018-07-26
US20200181590A1 (en) 2020-06-11
SI2245145T1 (sl) 2017-05-31
EP3219795B1 (en) 2024-03-13
US8420368B2 (en) 2013-04-16
PE20140841A1 (es) 2014-08-03
AU2009205978A1 (en) 2009-07-23
WO2009091994A9 (en) 2009-12-03
AU2009205978B2 (en) 2014-04-10
CN105274072A (zh) 2016-01-27

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