HUE031924T2 - Peptidek, konjugátumok és eljárás oltóanyag immunogenitásának fokozására - Google Patents
Peptidek, konjugátumok és eljárás oltóanyag immunogenitásának fokozására Download PDFInfo
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- HUE031924T2 HUE031924T2 HUE11712343A HUE11712343A HUE031924T2 HU E031924 T2 HUE031924 T2 HU E031924T2 HU E11712343 A HUE11712343 A HU E11712343A HU E11712343 A HUE11712343 A HU E11712343A HU E031924 T2 HUE031924 T2 HU E031924T2
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Classifications
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- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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Landscapes
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- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (7)
- FËP I IOEK, «IMJÜOÀttîËîfâKM ElJitó ÖETÖAMYAÓ: FOKOZÁSÁRA Szab»(hi 1 ntl igénypot) f «k J.aftfely antigénhez,it^tnano^nbçK vagy a«Őgét«· vagylítruttönogént:t»r$a!ro»zô ImofeÄoz konjugàît pepiidet tartalmaz, ahol n pepdd SEQ ID NO: 8, 9. 12, 13, 16, 17, 19-2.4, 151-158, 163-t 66. 168, Î 7:2-i?6, 179-182, Î 85- I 97, i 98-208 és 2 1 0-2 i 6 ï/erir.ii atîriaosav^^y.ek veîiclâk bármelyikéből álkésahof az antigén, immtmogén vagy az: antigént vagy immunogént tártálmázé hordozó a peptíü C-iermináHsához konjugáíl. 2. A?. I. igénypont szerinti fconjugâtumFÂd & ^ptlidiiëï:: a SEQ ID HO: 12, Π. 16, 17 cs 19-24 szerinti anuuosav-szekvenciák bármelyike alkotja. À 2- Igénypont szerinti konjugátum. ahol a pepttd a SEQ ID NO:2a szerinti aminosav-szekverteiéből ál],
- 4, Ag: i-3. igénypontok bármelyike szét inti konjugátum, ahol az antigénhez. immöbopÄg vggy a» ántg géht: vafyJïOttjanogéHt tartalmazó hotdozóhoz 2-20 popod kötődik.
- 5, Az 1.-4. igénypontok bármelyike szerinti: konjugáíutn. ahol: tsz antigéo vagy ínmuöíögÉi: flmtőmniigén vagy tamotit»«iöö6gén. vagy paíngébisiijgén vagy pat< >gen imnmoogéu.
- 6, Az 1:-1. igénypontok bármelyiké szermti koitjogátum gyógyszerként tór.eno «dkuimvs/Aira.
- 7, Az: 1-1. Igéíxvp^^Sők’ al^üSÜ^;. £§&: llAgf Jfertözö betegség megelőzésé-ben vagy kezelésében történő alkalmazást».
- 8, Ak 1-1, igébypöiitök bámtelyike szénáit rnegelŐzöséfe vagy kezelésére szolgáló gyógyszer előállítására, fl M ? igénypont sgérind kftojngáturn vagy a S. jgéőypbnt szerinti alkalmazás, ahöí az alanynak van téia-nusrzioxtn vagy telanmtztoxoid sileai ellenanyaga. |0. A 7, igénypt»AF^Hhtlkoxtj«gâiMm:iyagy a 8, igénypont szerinti alkalmazás;,; abíÓ Jz alany olyan alany, akíttek a komugáinm beadása előtt legalább kél héttel tefanuszSoxin elleni, keringő ellenanyagok képzésére szollá íő oltóanyagot adiak be. H. A ?. igényporti szedni) keítjugáliu wtgs a 8 mène pont szeneit akahnizas ahol a )et tozo b^Ugsvg vitális, bakteriális, gomba- vagy parazitás betegség. 12. A 7 igénypont szeríttri kunjugátnm vagy a 8. igénypont szerinti pznl választott: ttklö-, vastágMh nyelőé#-, petefészek-, hasnyálmirigy-. bőr-, gyomon-, fej- és Hpk|Í.o{yag-rák, szarkóma, proszkua-, líépaíoeelteláns. agy-, adrenáhs, emlő-, eMörnelriális rák, mezotetíómá, vese^, mirigy-, hematológiai, kardnoki rák, melanoma, mellékpajzsmirigy-, méhnyakrák, nettroblaszióms, Wiims-tumor, hererák, hipofizísrák vagy íeokromociíóma.
- 13. Peptid, amely SEQ ID NO: 8. <>, 12. 13, ló, 17, 19-24, 151-158, 163-1őő, 168, 172-176. 179-182. 185. p?* 198-208 és 210-216 szerinfi aptinosav-szekveneiak bárőielylkéböliíí, 14. A 13, igén>£ő«tSä^«&$bpf«k.;ptely SEQ ÍD MO: 2|, 13,46, 1? és f9-24 szériáit atninosay-szefe-vendák bármelyikéből áll. 15. A 14. Igénypont szerinti pepiid, amely SEQ SD NO; 8.mfeos«y**lsékvendiÜ#14Í&
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10156505 | 2010-03-15 | ||
| US31793010P | 2010-03-26 | 2010-03-26 |
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| Publication Number | Publication Date |
|---|---|
| HUE031924T2 true HUE031924T2 (hu) | 2017-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11712343A HUE031924T2 (hu) | 2010-03-15 | 2011-03-15 | Peptidek, konjugátumok és eljárás oltóanyag immunogenitásának fokozására |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9522962B2 (hu) |
| EP (1) | EP2547364B1 (hu) |
| CN (1) | CN102892431A (hu) |
| CA (1) | CA2793087C (hu) |
| CY (1) | CY1118801T1 (hu) |
| DK (1) | DK2547364T3 (hu) |
| ES (1) | ES2616258T3 (hu) |
| HR (1) | HRP20170251T1 (hu) |
| HU (1) | HUE031924T2 (hu) |
| LT (1) | LT2547364T (hu) |
| PL (1) | PL2547364T3 (hu) |
| PT (1) | PT2547364T (hu) |
| RS (1) | RS55670B1 (hu) |
| SI (1) | SI2547364T1 (hu) |
| WO (1) | WO2011115483A1 (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014111724A1 (en) | 2013-01-18 | 2014-07-24 | London School Of Hygiene And Tropical Medicine | Glycosylation method |
| GB201301085D0 (en) * | 2013-01-22 | 2013-03-06 | London School Hygiene & Tropical Medicine | Glycoconjugate Vaccine |
| CA2943334A1 (en) * | 2014-03-19 | 2015-09-24 | Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital | Immunogenic glycopeptides, composition comprising the glycopeptides and use thereof |
| CN106986923B (zh) * | 2017-04-10 | 2021-01-26 | 新疆农垦科学院 | GnRH抗原及其在主动免疫对公牛的去势效果及肉品质影响中的应用 |
| KR20200143422A (ko) | 2018-04-10 | 2020-12-23 | 에이씨 이뮨 에스.에이. | 항-aveta 치료적 백신 |
| BR112021001520A2 (pt) * | 2018-07-31 | 2021-04-20 | Snoretox Pty Ltd | neurotoxinas tetânicas peguiladas e tratamento de hipotonia |
| KR20210095891A (ko) | 2018-11-23 | 2021-08-03 | 스트라이크 파마 아베 | 이중 특이적 접합체 |
| GB201917699D0 (en) | 2019-12-04 | 2020-01-15 | Ultimovacs Ab | Vaccine conjugates |
| US20230057367A1 (en) * | 2020-02-03 | 2023-02-23 | Snoretox Ltd | Composition and method |
| CN113318225B (zh) * | 2020-02-28 | 2024-01-19 | 无锡派列博生物医药科技有限公司 | 肿瘤免疫增强剂及其制法和应用 |
| GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
| US20220118079A1 (en) * | 2020-10-20 | 2022-04-21 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic Antigens |
| WO2022187132A1 (en) * | 2021-03-04 | 2022-09-09 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| WO2022258794A2 (en) * | 2021-06-09 | 2022-12-15 | Ultimovacs Ab | A conjugate |
| WO2024121411A1 (en) | 2022-12-09 | 2024-06-13 | Strike Pharma Ab | Optimized tag moiety |
| WO2024126758A2 (en) | 2022-12-14 | 2024-06-20 | Ultimovacs Ab | A nucleic acid molecule and a chimeric polypeptide |
| WO2024126737A1 (en) | 2022-12-14 | 2024-06-20 | Ultimovacs Ab | A core and a conjugate |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| AU693437B2 (en) * | 1993-12-28 | 1998-07-02 | Chiron Mimotopes Pty Ltd | T-cell epitopes |
| DE69731357T2 (de) * | 1996-03-23 | 2006-02-02 | The Research Foundation For Microbial Diseases Of Osaka University, Suita | Funktionelles antigenfragment von tetanustoxin und tetanusvakzine |
| ES2257771T3 (es) | 1996-10-28 | 2006-08-01 | Amersham Health As | Agentes de contraste. |
| US6180084B1 (en) | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
| FR2806727A1 (fr) * | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| AU2002219711B8 (en) | 2000-12-08 | 2006-03-02 | Academisch Ziekenhuis Leiden | Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses |
| US20040101534A1 (en) | 2002-06-25 | 2004-05-27 | Diamond Don J. | Adjuvant-free peptide vaccine |
| WO2008118487A2 (en) | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
-
2011
- 2011-03-15 SI SI201131107A patent/SI2547364T1/sl unknown
- 2011-03-15 EP EP11712343.0A patent/EP2547364B1/en active Active
- 2011-03-15 US US13/635,384 patent/US9522962B2/en active Active
- 2011-03-15 CA CA2793087A patent/CA2793087C/en active Active
- 2011-03-15 WO PCT/NL2011/050180 patent/WO2011115483A1/en active Application Filing
- 2011-03-15 PT PT117123430T patent/PT2547364T/pt unknown
- 2011-03-15 DK DK11712343.0T patent/DK2547364T3/en active
- 2011-03-15 RS RS20170170A patent/RS55670B1/sr unknown
- 2011-03-15 PL PL11712343T patent/PL2547364T3/pl unknown
- 2011-03-15 CN CN2011800240921A patent/CN102892431A/zh active Pending
- 2011-03-15 LT LTEP11712343.0T patent/LT2547364T/lt unknown
- 2011-03-15 ES ES11712343.0T patent/ES2616258T3/es active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| HRP20170251T1 (hr) | 2017-04-21 |
| EP2547364A1 (en) | 2013-01-23 |
| DK2547364T3 (en) | 2017-02-27 |
| US20130071428A1 (en) | 2013-03-21 |
| SI2547364T1 (sl) | 2017-05-31 |
| CA2793087A1 (en) | 2011-09-22 |
| CA2793087C (en) | 2019-07-23 |
| PL2547364T3 (pl) | 2017-06-30 |
| RS55670B1 (sr) | 2017-06-30 |
| WO2011115483A1 (en) | 2011-09-22 |
| LT2547364T (lt) | 2017-03-27 |
| US9522962B2 (en) | 2016-12-20 |
| CY1118801T1 (el) | 2018-01-10 |
| PT2547364T (pt) | 2017-02-21 |
| ES2616258T3 (es) | 2017-06-12 |
| CN102892431A (zh) | 2013-01-23 |
| EP2547364B1 (en) | 2016-12-14 |
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