CY1118801T1 - Πεπτιδια, προϊοντα συζευξης και μεθοδος για την αυξηση της ανοσογονικοτητας ενος εμβολιου - Google Patents
Πεπτιδια, προϊοντα συζευξης και μεθοδος για την αυξηση της ανοσογονικοτητας ενος εμβολιουInfo
- Publication number
- CY1118801T1 CY1118801T1 CY20171100217T CY171100217T CY1118801T1 CY 1118801 T1 CY1118801 T1 CY 1118801T1 CY 20171100217 T CY20171100217 T CY 20171100217T CY 171100217 T CY171100217 T CY 171100217T CY 1118801 T1 CY1118801 T1 CY 1118801T1
- Authority
- CY
- Cyprus
- Prior art keywords
- vaccine
- peptides
- relates
- coupling products
- increasing immunogenicity
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000008878 coupling Effects 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 238000005859 coupling reaction Methods 0.000 title 1
- 230000005847 immunogenicity Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000024932 T cell mediated immunity Effects 0.000 abstract 1
- 108010055044 Tetanus Toxin Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000028996 humoral immune response Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940021993 prophylactic vaccine Drugs 0.000 abstract 1
- 229940118376 tetanus toxin Drugs 0.000 abstract 1
- 229940021747 therapeutic vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε προϊόντα σύζευξης που περιλαμβάνουν ένα πεπτίδιο τουλάχιστον 10 υπολειμμάτων αμινοξέων που περιλαμβάνουν την αλληλουχία αμινοξέων GITELKKL για την επαγωγή ισχυρών χυμικών και κυτταρικών ανοσοαποκρίσεων, όταν χορηγούνται σε υποκείμενα που έχουν αντισώματα έναντι της ανατοξίνης του τετάνου. Σε μία ενσωμάτωση η εφεύρεση αναφέρεται σε ένα προφυλακτικό και θεραπευτικό εμβόλιο και σε μία περαιτέρω ενσωμάτωση η εφεύρεση σχετίζεται με την θεραπεία ή την πρόληψη του καρκίνου ή μιας μολυσματικής ασθένειας.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10156505 | 2010-03-15 | ||
US31793010P | 2010-03-26 | 2010-03-26 | |
PCT/NL2011/050180 WO2011115483A1 (en) | 2010-03-15 | 2011-03-15 | Peptides, conjugates and method for increasing immunogenicity of a vaccine |
EP11712343.0A EP2547364B1 (en) | 2010-03-15 | 2011-03-15 | Peptides, conjugates and method for increasing immunogenicity of a vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118801T1 true CY1118801T1 (el) | 2018-01-10 |
Family
ID=43430699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100217T CY1118801T1 (el) | 2010-03-15 | 2017-02-16 | Πεπτιδια, προϊοντα συζευξης και μεθοδος για την αυξηση της ανοσογονικοτητας ενος εμβολιου |
Country Status (15)
Country | Link |
---|---|
US (1) | US9522962B2 (el) |
EP (1) | EP2547364B1 (el) |
CN (1) | CN102892431A (el) |
CA (1) | CA2793087C (el) |
CY (1) | CY1118801T1 (el) |
DK (1) | DK2547364T3 (el) |
ES (1) | ES2616258T3 (el) |
HR (1) | HRP20170251T1 (el) |
HU (1) | HUE031924T2 (el) |
LT (1) | LT2547364T (el) |
PL (1) | PL2547364T3 (el) |
PT (1) | PT2547364T (el) |
RS (1) | RS55670B1 (el) |
SI (1) | SI2547364T1 (el) |
WO (1) | WO2011115483A1 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014111724A1 (en) | 2013-01-18 | 2014-07-24 | London School Of Hygiene And Tropical Medicine | Glycosylation method |
GB201301085D0 (en) * | 2013-01-22 | 2013-03-06 | London School Hygiene & Tropical Medicine | Glycoconjugate Vaccine |
CN106456766B (zh) * | 2014-03-19 | 2020-03-10 | 台湾基督长老教会马偕医疗财团法人马偕纪念医院 | 抗免疫原性糖肽的抗体、包含其的组合物及其用途 |
CN106986923B (zh) * | 2017-04-10 | 2021-01-26 | 新疆农垦科学院 | GnRH抗原及其在主动免疫对公牛的去势效果及肉品质影响中的应用 |
MX2020010621A (es) | 2018-04-10 | 2020-10-20 | Ac Immune Sa | Vacunas terapeuticas anti-abeta. |
AU2019315327B2 (en) * | 2018-07-31 | 2024-05-09 | Snoretox Pty Ltd | Pegylated tetanus neurotoxins and treatment of hypotonia |
CA3119865A1 (en) | 2018-11-23 | 2020-05-28 | Strike Pharma Ab | Bi-specific conjugates |
GB201917699D0 (en) | 2019-12-04 | 2020-01-15 | Ultimovacs Ab | Vaccine conjugates |
AU2021216611A1 (en) * | 2020-02-03 | 2022-08-25 | Snoretox Ltd | Composition and method |
US20240245763A9 (en) * | 2020-02-06 | 2024-07-25 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the Treatment and Prevention of Zoonotic Infections |
CN113318225B (zh) * | 2020-02-28 | 2024-01-19 | 无锡派列博生物医药科技有限公司 | 肿瘤免疫增强剂及其制法和应用 |
GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
US20220296696A1 (en) * | 2020-10-20 | 2022-09-22 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic Antigens |
CA3222077A1 (en) * | 2021-06-09 | 2022-12-15 | Dana Michel | A conjugate |
WO2024121411A1 (en) | 2022-12-09 | 2024-06-13 | Strike Pharma Ab | Optimized tag moiety |
WO2024126737A1 (en) | 2022-12-14 | 2024-06-20 | Ultimovacs Ab | A core and a conjugate |
WO2024126758A2 (en) | 2022-12-14 | 2024-06-20 | Ultimovacs Ab | A nucleic acid molecule and a chimeric polypeptide |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
JPH09510437A (ja) * | 1993-12-28 | 1997-10-21 | カイロン ミモトープス プロプライエトリー リミテッド | T細胞エピトープ |
US6372225B1 (en) * | 1996-03-23 | 2002-04-16 | The Research Foundation Of Microbial Diseases Of Osaka University | Tetanus toxin functional fragment antigen and tetanus vaccine |
WO1998018496A2 (en) | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
US6180084B1 (en) | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
FR2806727A1 (fr) * | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
AU2002219711B8 (en) | 2000-12-08 | 2006-03-02 | Academisch Ziekenhuis Leiden | Long peptides of 22-45 amino acid residues that induce and/or enhance antigen specific immune responses |
JP2005535627A (ja) * | 2002-06-25 | 2005-11-24 | シティ・オブ・ホープ | アジュバント不含ペプチド・ワクチン |
US9662383B2 (en) | 2007-03-26 | 2017-05-30 | University Of Massachusetts | Compositions and methods for increasing immunogenicity of glycoprotein vaccines |
-
2011
- 2011-03-15 US US13/635,384 patent/US9522962B2/en active Active
- 2011-03-15 SI SI201131107A patent/SI2547364T1/sl unknown
- 2011-03-15 EP EP11712343.0A patent/EP2547364B1/en active Active
- 2011-03-15 RS RS20170170A patent/RS55670B1/sr unknown
- 2011-03-15 PT PT117123430T patent/PT2547364T/pt unknown
- 2011-03-15 CN CN2011800240921A patent/CN102892431A/zh active Pending
- 2011-03-15 WO PCT/NL2011/050180 patent/WO2011115483A1/en active Application Filing
- 2011-03-15 ES ES11712343.0T patent/ES2616258T3/es active Active
- 2011-03-15 DK DK11712343.0T patent/DK2547364T3/en active
- 2011-03-15 LT LTEP11712343.0T patent/LT2547364T/lt unknown
- 2011-03-15 CA CA2793087A patent/CA2793087C/en active Active
- 2011-03-15 PL PL11712343T patent/PL2547364T3/pl unknown
- 2011-03-15 HU HUE11712343A patent/HUE031924T2/en unknown
-
2017
- 2017-02-15 HR HRP20170251TT patent/HRP20170251T1/hr unknown
- 2017-02-16 CY CY20171100217T patent/CY1118801T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2011115483A1 (en) | 2011-09-22 |
PT2547364T (pt) | 2017-02-21 |
ES2616258T3 (es) | 2017-06-12 |
LT2547364T (lt) | 2017-03-27 |
EP2547364B1 (en) | 2016-12-14 |
CA2793087A1 (en) | 2011-09-22 |
CA2793087C (en) | 2019-07-23 |
SI2547364T1 (sl) | 2017-05-31 |
US20130071428A1 (en) | 2013-03-21 |
HRP20170251T1 (hr) | 2017-04-21 |
RS55670B1 (sr) | 2017-06-30 |
PL2547364T3 (pl) | 2017-06-30 |
HUE031924T2 (en) | 2017-08-28 |
DK2547364T3 (en) | 2017-02-27 |
CN102892431A (zh) | 2013-01-23 |
EP2547364A1 (en) | 2013-01-23 |
US9522962B2 (en) | 2016-12-20 |
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