HU911648D0 - Kyralic synthesis for producing 1-aryl-aminopropane-1-oles - Google Patents

Kyralic synthesis for producing 1-aryl-aminopropane-1-oles

Info

Publication number
HU911648D0
HU911648D0 HU911648A HU164891A HU911648D0 HU 911648 D0 HU911648 D0 HU 911648D0 HU 911648 A HU911648 A HU 911648A HU 164891 A HU164891 A HU 164891A HU 911648 D0 HU911648 D0 HU 911648D0
Authority
HU
Hungary
Prior art keywords
kyralic
oles
aminopropane
aryl
synthesis
Prior art date
Application number
HU911648A
Other languages
English (en)
Other versions
HUT57760A (en
Inventor
Michael Alexander Staszak
Gilbert Stanley Staten
Leland Otto Weigel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU911648D0 publication Critical patent/HU911648D0/hu
Publication of HUT57760A publication Critical patent/HUT57760A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU911648A 1990-05-17 1991-05-16 Process for producing chiral 1-aryl-3-amino-1-propanol derivatives HUT57760A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52451290A 1990-05-17 1990-05-17

Publications (2)

Publication Number Publication Date
HU911648D0 true HU911648D0 (en) 1991-11-28
HUT57760A HUT57760A (en) 1991-12-30

Family

ID=24089523

Family Applications (1)

Application Number Title Priority Date Filing Date
HU911648A HUT57760A (en) 1990-05-17 1991-05-16 Process for producing chiral 1-aryl-3-amino-1-propanol derivatives

Country Status (8)

Country Link
EP (1) EP0457559A3 (hu)
JP (1) JPH04226948A (hu)
KR (1) KR910019960A (hu)
CA (1) CA2042346A1 (hu)
FI (1) FI912280A (hu)
HU (1) HUT57760A (hu)
IE (1) IE911677A1 (hu)
IL (1) IL98108A0 (hu)

Families Citing this family (48)

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EP0571685A1 (en) * 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamines, their preparation and use
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
US6090950A (en) * 1996-08-23 2000-07-18 Zeeland Chemicals, Inc. Chiral hydride complexes
US6008412A (en) * 1997-10-14 1999-12-28 Eli Lilly And Company Process to make chiral compounds
TW514634B (en) * 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds
US5936124A (en) * 1998-06-22 1999-08-10 Sepacor Inc. Fluoxetine process from benzoylpropionic acid
US6025517A (en) * 1998-08-03 2000-02-15 Sepracor Inc. Fluoxetine process from benzoylacetonitrile
DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
AU2003221028A1 (en) * 2002-03-19 2003-09-29 Mitsubishi Chemical Corporation 3-hydroxy-3-(2-thienyl)propionamide compound, process for producing the same, and process for producing 3-amino-1-(2-thienyl)-1-propanol compound therefrom
WO2003097632A1 (fr) * 2002-05-20 2003-11-27 Mitsubishi Rayon Co., Ltd. Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine
WO2004005239A1 (en) * 2002-07-09 2004-01-15 Lonza Ag PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS
DK1852415T3 (da) * 2002-07-09 2010-01-25 Lonza Ag Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer
DE10235206A1 (de) * 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
KR101017884B1 (ko) * 2002-08-27 2011-03-04 메르크 파텐트 게엠베하 아미노 알콜의 거울상이성질 선택성 수소화 반응을 위한 제조방법
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
US6846957B2 (en) 2002-11-22 2005-01-25 Board Of Regents, The University Of Texas System Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
DE10345772A1 (de) 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
BRPI0506796A (pt) * 2004-02-19 2007-05-22 Lonza Ag processo para a preparação de 1-substituìdos-3-aminoálcoois enantiomericamentente puros
CN1300137C (zh) * 2004-03-31 2007-02-14 上海医药工业研究院 (s)－(+)－n,n－二甲基－3－(1－萘氧基)－3－(2－噻吩基)丙胺的制备方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
JP2007523213A (ja) * 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
EP1868983A1 (en) 2005-02-21 2007-12-26 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
MX2007010931A (es) 2005-03-08 2007-10-16 Teva Pharma Formas cristalinas de (s)-(+)-n,n-dimetil-3-(1-naftaleniloxi)-3-(2 -tienil)propanamina oxalato y la preparacion ellas.
EP1874754A1 (en) 2005-03-14 2008-01-09 Teva Pharmaceutical Industries Ltd Pure duloxetine hydrochloride
US7842717B2 (en) 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
US7759500B2 (en) 2005-12-05 2010-07-20 Teva Pharmaceutical Industries Ltd. 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
DE102005062662A1 (de) 2005-12-23 2007-06-28 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005062661A1 (de) 2005-12-23 2007-08-16 Basf Ag Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol
WO2007077580A2 (en) 2006-01-06 2007-07-12 Msn Laboratories Limited Improved process for pure duloxetine hydrochloride
MX2007011727A (es) * 2006-01-23 2007-11-15 Teva Pharma Dnt-succinato y metodos de preparacion de el.
EP1856088A1 (en) * 2006-01-23 2007-11-21 Teva Pharmaceutical Industries Ltd Dnt-benzenesulfonate and methods of preparation thereof
MX2007011611A (es) * 2006-01-23 2007-10-18 Teva Pharma Fumarato de dnt y metodos de preparacion de ellos.
EP1976845A2 (en) * 2006-02-13 2008-10-08 Teva Pharmaceutical Industries Ltd A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
US7560573B2 (en) 2006-02-21 2009-07-14 Teva Pharmaceutical Industries Ltd Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
CN101484435A (zh) 2006-07-03 2009-07-15 兰贝克赛实验室有限公司 制备n-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺及其纯对应异构体盐的方法
EP2114912B1 (en) 2006-12-22 2012-04-04 Synthon B.V. Process for making duloxetine and related compounds
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
HU230480B1 (hu) * 2008-07-25 2016-07-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás N-metil-ariloxi-propánamin származékok előállítására
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
CA2758736A1 (en) * 2009-01-06 2010-07-15 Alembic Pharmaceuticals Limited An improved process for the reparation of duloxetine and salts thereof
JPWO2011118625A1 (ja) 2010-03-24 2013-07-04 住友精化株式会社 光学活性なｎ−モノアルキル−３−ヒドロキシ−３−アリールプロピルアミン化合物の製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
DK630987D0 (da) * 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
CA1337128C (en) * 1988-04-08 1995-09-26 David Wayne Robertson Propanamine derivatives

Also Published As

Publication number Publication date
EP0457559A3 (en) 1993-05-12
KR910019960A (ko) 1991-12-19
JPH04226948A (ja) 1992-08-17
FI912280A0 (fi) 1991-05-10
HUT57760A (en) 1991-12-30
IE911677A1 (en) 1991-11-20
IL98108A0 (en) 1992-06-21
EP0457559A2 (en) 1991-11-21
FI912280A (fi) 1991-11-18
CA2042346A1 (en) 1991-11-18

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Legal Events

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DFC4 Cancellation of temporary protection due to refusal