HU230655B1 - Eljárás fingolimod előállítására - Google Patents

Eljárás fingolimod előállítására Download PDF

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Publication number
HU230655B1
HU230655B1 HU1500023A HUP1500023A HU230655B1 HU 230655 B1 HU230655 B1 HU 230655B1 HU 1500023 A HU1500023 A HU 1500023A HU P1500023 A HUP1500023 A HU P1500023A HU 230655 B1 HU230655 B1 HU 230655B1
Authority
HU
Hungary
Prior art keywords
formula
mmol
reaction
iodine
group
Prior art date
Application number
HU1500023A
Other languages
English (en)
Hungarian (hu)
Inventor
Stanislav Radl
Jan DOUBSKY
Original Assignee
Zentiva K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva K.S. filed Critical Zentiva K.S.
Publication of HUP1500023A2 publication Critical patent/HUP1500023A2/hu
Publication of HU230655B1 publication Critical patent/HU230655B1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU1500023A 2012-06-15 2013-06-12 Eljárás fingolimod előállítására HU230655B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ2012-406A CZ2012406A3 (cs) 2012-06-15 2012-06-15 Způsob výroby fingolimodu založený na otevírání aziridinového kruhu
CZPV2012-406 2012-06-15
PCT/CZ2013/000075 WO2013185740A1 (en) 2012-06-15 2013-06-12 A method for the preparation of fingolimod

Publications (2)

Publication Number Publication Date
HUP1500023A2 HUP1500023A2 (en) 2015-04-28
HU230655B1 true HU230655B1 (hu) 2017-06-28

Family

ID=48740780

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1500023A HU230655B1 (hu) 2012-06-15 2013-06-12 Eljárás fingolimod előállítására

Country Status (3)

Country Link
CZ (1) CZ2012406A3 (cs)
HU (1) HU230655B1 (cs)
WO (1) WO2013185740A1 (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11696904B2 (en) * 2020-01-10 2023-07-11 The Regents Of The University Of California Prodrug for therapeutic applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2579602B2 (ja) * 1992-10-21 1997-02-05 吉富製薬株式会社 ２−アミノ−１，３−プロパンジオール化合物および免疫抑制剤
JP4079505B2 (ja) 1998-04-28 2008-04-23 田辺三菱製薬株式会社 ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法
CN100548968C (zh) 2006-03-01 2009-10-14 徐州师范大学 一种制备2-对辛基苯乙基-2-氨基丙二醇盐酸盐的方法
CA2717934C (en) 2008-03-19 2017-07-18 Novartis Ag Process for the preparation of 2-amino-2- [2-(4-c3-c21-alkyl-phenyl)ethyl] propane-1,3-diols
CN103313964A (zh) * 2010-10-28 2013-09-18 Mapi医药公司 用于制备芬戈莫德的中间化合物和方法
CN102120720B (zh) * 2011-01-25 2013-05-22 上海华升生物科技有限公司 盐酸芬戈莫德的合成新方法

Also Published As

Publication number Publication date
CZ304188B6 (cs) 2013-12-18
CZ2012406A3 (cs) 2013-12-27
WO2013185740A1 (en) 2013-12-19
HUP1500023A2 (en) 2015-04-28

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MM4A Lapse of definitive patent protection due to non-payment of fees