HU220611B1 - Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások - Google Patents

Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások Download PDF

Info

Publication number
HU220611B1
HU220611B1 HU9300468A HU46893A HU220611B1 HU 220611 B1 HU220611 B1 HU 220611B1 HU 9300468 A HU9300468 A HU 9300468A HU 46893 A HU46893 A HU 46893A HU 220611 B1 HU220611 B1 HU 220611B1
Authority
HU
Hungary
Prior art keywords
formula
phosphoric acid
decyloxy
propyl ester
group
Prior art date
Application number
HU9300468A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9300468D0 (en
HUT62910A (en
Inventor
Dieter Herrmann
Herbert Leinert
Alfred Mertens
Harald Zilch
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4026265A external-priority patent/DE4026265A1/de
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of HU9300468D0 publication Critical patent/HU9300468D0/hu
Publication of HUT62910A publication Critical patent/HUT62910A/hu
Publication of HU220611B1 publication Critical patent/HU220611B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HU9300468A 1990-08-20 1991-08-14 Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások HU220611B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4026265A DE4026265A1 (de) 1990-08-20 1990-08-20 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Publications (3)

Publication Number Publication Date
HU9300468D0 HU9300468D0 (en) 1993-05-28
HUT62910A HUT62910A (en) 1993-06-28
HU220611B1 true HU220611B1 (hu) 2002-03-28

Family

ID=6412536

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9300468A HU220611B1 (hu) 1990-08-20 1991-08-14 Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások

Country Status (10)

Country Link
JP (1) JP3032576B2 (US07026469-20060411-C00007.png)
KR (1) KR970011307B1 (US07026469-20060411-C00007.png)
CZ (1) CZ287942B6 (US07026469-20060411-C00007.png)
HU (1) HU220611B1 (US07026469-20060411-C00007.png)
MX (1) MX9100676A (US07026469-20060411-C00007.png)
NZ (1) NZ239422A (US07026469-20060411-C00007.png)
RO (1) RO115163B1 (US07026469-20060411-C00007.png)
RU (1) RU2104282C1 (US07026469-20060411-C00007.png)
TW (1) TW207544B (US07026469-20060411-C00007.png)
ZA (1) ZA916542B (US07026469-20060411-C00007.png)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
RU2293739C2 (ru) * 2002-07-26 2007-02-20 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" 5`-холинфосфат 3`-азидо-3`-дезокситимидина как антивирусный агент

Also Published As

Publication number Publication date
ZA916542B (en) 1992-05-27
NZ239422A (en) 1993-09-27
HU9300468D0 (en) 1993-05-28
MX9100676A (es) 1992-04-01
KR970011307B1 (ko) 1997-07-09
RO115163B1 (ro) 1999-11-30
CZ287942B6 (cs) 2001-03-14
CZ18093A3 (en) 1993-06-16
KR930701470A (ko) 1993-06-11
JPH06500543A (ja) 1994-01-20
RU2104282C1 (ru) 1998-02-10
JP3032576B2 (ja) 2000-04-17
HUT62910A (en) 1993-06-28
TW207544B (US07026469-20060411-C00007.png) 1993-06-11

Similar Documents

Publication Publication Date Title
FI104176B (fi) Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi
CA1285935C (en) Therapeutic nucleosides
US5563257A (en) Phospholipid derivatives of nucleosides
US4963662A (en) Fluorinated nucleosides and method for treating retrovirus infections therewith
US5547941A (en) Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions
EP0322384B1 (en) Nucleosides for use in therapy
AU780879B2 (en) Anti-viral pyrimidine nucleoside analogues
HU220336B (hu) Nukleozid-monofoszfátok új lipidészterei, eljárás előállításukra és alkalmazásuk immunszuppresszív gyógyszerekben
EP0291917B1 (en) Novel oxetanocins
WO1990001036A1 (en) Nucleoside derivatives
WO1993016092A1 (de) Neue lipidphosphonsäure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel
PT821690E (pt) Análogos de nucleotídeos para tratamento de infeções virais
EP0196185A2 (en) Antiviral nucleosides
US5132291A (en) Antivirals and methods for increasing the antiviral activity of azt
WO1998038202A1 (en) Antiviral phosphonate prodrugs of nucleosides and nucleoside analogues
JPH06228186A (ja) 2’−デオキシ−(2’s)−アルキルピリミジンヌクレオシド誘導体
US5153180A (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
HU220611B1 (hu) Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások
JPH08512040A (ja) デオキシヌクレオシドのリポヌクレオチド、それらの製造方法および抗ウイルス薬としてのそれらの用途
US6080734A (en) Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
CA1303032C (en) Antiviral nucleosides
IE56504B1 (en) Antiviral nucleosides