HU218850B - Eljárás polipeptidek előállítására - Google Patents

Eljárás polipeptidek előállítására Download PDF

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Publication number
HU218850B
HU218850B HU9303580A HU9303580A HU218850B HU 218850 B HU218850 B HU 218850B HU 9303580 A HU9303580 A HU 9303580A HU 9303580 A HU9303580 A HU 9303580A HU 218850 B HU218850 B HU 218850B
Authority
HU
Hungary
Prior art keywords
yeast
cup1
plasmid
gene
promoter
Prior art date
Application number
HU9303580A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT68578A (en
HU9303580D0 (en
Inventor
Peter Fürst
Jutta Heim
Thomas Hottiger
Gabriele Pohlig
Original Assignee
Novartis Ag.
Ucp Gen-Pharma Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag., Ucp Gen-Pharma Ag. filed Critical Novartis Ag.
Publication of HU9303580D0 publication Critical patent/HU9303580D0/hu
Publication of HUT68578A publication Critical patent/HUT68578A/hu
Publication of HU218850B publication Critical patent/HU218850B/hu

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/102Plasmid DNA for yeast
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/15Peptidyl-dipeptidases (3.4.15)
    • C12Y304/15001Peptidyl-dipeptidase A (3.4.15.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
HU9303580A 1992-12-15 1993-12-14 Eljárás polipeptidek előállítására HU218850B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92811005 1992-12-15

Publications (3)

Publication Number Publication Date
HU9303580D0 HU9303580D0 (en) 1994-04-28
HUT68578A HUT68578A (en) 1995-06-28
HU218850B true HU218850B (hu) 2000-12-28

Family

ID=8212051

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9303580A HU218850B (hu) 1992-12-15 1993-12-14 Eljárás polipeptidek előállítására

Country Status (15)

Country Link
US (1) US5922569A (fi)
EP (1) EP0603128A1 (fi)
JP (1) JPH06343471A (fi)
KR (1) KR940014784A (fi)
AU (1) AU673384B2 (fi)
CA (1) CA2111321A1 (fi)
FI (1) FI935592A (fi)
HU (1) HU218850B (fi)
IL (1) IL108015A0 (fi)
MX (1) MX9308031A (fi)
NO (1) NO934602L (fi)
NZ (1) NZ250442A (fi)
SG (1) SG49865A1 (fi)
TW (1) TW282490B (fi)
ZA (1) ZA939359B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004263900A1 (en) * 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
DK1684719T3 (da) * 2003-11-14 2012-01-30 Baxter Int Alfa-1-antitrypsin-sammensætninger og behandlingsfremgangsmåder, der anvender sådanne sammensætninger
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
KR100672745B1 (ko) * 2005-04-20 2007-01-24 재단법인 목암생명공학연구소 효모 발현시스템에서의 재조합 외래단백질의 분비효율을향상시키는 방법
JP2009543560A (ja) * 2006-07-14 2009-12-10 ノボザイムス,インコーポレイティド 真菌細胞中の遺伝子発現を上昇させる方法
JP5751609B2 (ja) * 2010-08-24 2015-07-22 株式会社豊田中央研究所 特性が改変された細胞の生産方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3163784A (en) * 1983-08-08 1985-02-14 Smithkline Beckman Corporation Yeast copper - metallothionein gene
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4940661A (en) * 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US4935350A (en) * 1985-11-18 1990-06-19 Amgen Materials and methods for controlling plasmid copy number and stability
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
PT88556B (pt) * 1987-09-28 1992-11-30 Smithkline Biolog Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche

Also Published As

Publication number Publication date
AU673384B2 (en) 1996-11-07
HUT68578A (en) 1995-06-28
JPH06343471A (ja) 1994-12-20
FI935592A0 (fi) 1993-12-13
NO934602L (no) 1994-06-16
NZ250442A (en) 1995-12-21
SG49865A1 (en) 1999-10-19
CA2111321A1 (en) 1994-06-16
ZA939359B (en) 1994-06-15
HU9303580D0 (en) 1994-04-28
EP0603128A1 (en) 1994-06-22
IL108015A0 (en) 1994-04-12
AU5207193A (en) 1994-06-30
US5922569A (en) 1999-07-13
KR940014784A (ko) 1994-07-19
FI935592A (fi) 1994-06-16
TW282490B (fi) 1996-08-01
NO934602D0 (no) 1993-12-14
MX9308031A (es) 1994-08-31

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Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: NOVARTIS AG, CH

Owner name: UCP GEN-PHARMA AG., CH

HMM4 Cancellation of final prot. due to non-payment of fee