HU216300B - Elektrolitikus cella, és eljárás proteinek és peptidek jelölésére - Google Patents
Elektrolitikus cella, és eljárás proteinek és peptidek jelölésére Download PDFInfo
- Publication number
- HU216300B HU216300B HU9302925A HU9302925A HU216300B HU 216300 B HU216300 B HU 216300B HU 9302925 A HU9302925 A HU 9302925A HU 9302925 A HU9302925 A HU 9302925A HU 216300 B HU216300 B HU 216300B
- Authority
- HU
- Hungary
- Prior art keywords
- electrolytic cell
- electrode
- cell
- working electrode
- separator
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 69
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 36
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 36
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 28
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 23
- 238000002372 labelling Methods 0.000 claims abstract description 43
- 239000000463 material Substances 0.000 claims abstract description 43
- 239000000700 radioactive tracer Substances 0.000 claims abstract description 36
- 239000000126 substance Substances 0.000 claims abstract description 29
- 238000012360 testing method Methods 0.000 claims abstract description 25
- 239000011148 porous material Substances 0.000 claims abstract description 16
- 230000002285 radioactive effect Effects 0.000 claims description 62
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 60
- 239000004065 semiconductor Substances 0.000 claims description 54
- 230000008569 process Effects 0.000 claims description 36
- 150000002367 halogens Chemical class 0.000 claims description 35
- 229910052736 halogen Inorganic materials 0.000 claims description 34
- 239000012528 membrane Substances 0.000 claims description 29
- 229910052697 platinum Inorganic materials 0.000 claims description 29
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 20
- 229910052737 gold Inorganic materials 0.000 claims description 19
- 239000010931 gold Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- 238000005341 cation exchange Methods 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 14
- 239000003011 anion exchange membrane Substances 0.000 claims description 10
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 238000005349 anion exchange Methods 0.000 claims description 7
- 239000010935 stainless steel Substances 0.000 claims description 7
- 239000012857 radioactive material Substances 0.000 claims description 5
- 229910052705 radium Inorganic materials 0.000 claims description 5
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 229910052703 rhodium Inorganic materials 0.000 claims description 3
- 239000000941 radioactive substance Substances 0.000 claims description 2
- 239000010948 rhodium Substances 0.000 claims 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 1
- 239000007772 electrode material Substances 0.000 claims 1
- 239000012858 resilient material Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 44
- 238000005868 electrolysis reaction Methods 0.000 description 33
- 239000000243 solution Substances 0.000 description 32
- 238000006243 chemical reaction Methods 0.000 description 25
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 24
- 229910052740 iodine Inorganic materials 0.000 description 24
- 239000011630 iodine Substances 0.000 description 24
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 21
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 21
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000006192 iodination reaction Methods 0.000 description 14
- 230000026045 iodination Effects 0.000 description 13
- 239000002904 solvent Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 11
- 229910052751 metal Inorganic materials 0.000 description 11
- 239000002184 metal Substances 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 239000003792 electrolyte Substances 0.000 description 10
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 229960004441 tyrosine Drugs 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 229910021607 Silver chloride Inorganic materials 0.000 description 8
- 239000011521 glass Substances 0.000 description 8
- 150000004820 halides Chemical class 0.000 description 8
- 238000003760 magnetic stirring Methods 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- -1 polypropylene Polymers 0.000 description 8
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000872 buffer Substances 0.000 description 7
- 239000010970 precious metal Substances 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229960005309 estradiol Drugs 0.000 description 6
- 239000000741 silica gel Substances 0.000 description 6
- 229910002027 silica gel Inorganic materials 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 229960003399 estrone Drugs 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000003014 ion exchange membrane Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000000163 radioactive labelling Methods 0.000 description 4
- 235000009518 sodium iodide Nutrition 0.000 description 4
- 238000004809 thin layer chromatography Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- HETCEOQFVDFGSY-UHFFFAOYSA-N Isopropenyl acetate Chemical compound CC(=C)OC(C)=O HETCEOQFVDFGSY-UHFFFAOYSA-N 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 229930182833 estradiol Natural products 0.000 description 3
- 102000015694 estrogen receptors Human genes 0.000 description 3
- 108010038795 estrogen receptors Proteins 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000004792 oxidative damage Effects 0.000 description 3
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229910003446 platinum oxide Inorganic materials 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229910052713 technetium Inorganic materials 0.000 description 3
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- UQTZMGFTRHFAAM-ZETCQYMHSA-N 3-iodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(I)=C1 UQTZMGFTRHFAAM-ZETCQYMHSA-N 0.000 description 2
- 239000010963 304 stainless steel Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 229920000557 Nafion® Polymers 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 229910000589 SAE 304 stainless steel Inorganic materials 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000011089 carbon dioxide Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- YADSGOSSYOOKMP-UHFFFAOYSA-N dioxolead Chemical compound O=[Pb]=O YADSGOSSYOOKMP-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 230000005518 electrochemistry Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000003818 flash chromatography Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002140 halogenating effect Effects 0.000 description 2
- 238000005658 halogenation reaction Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 150000004694 iodide salts Chemical class 0.000 description 2
- 239000010857 liquid radioactive waste Substances 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229910052702 rhenium Inorganic materials 0.000 description 2
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 239000004296 sodium metabisulphite Substances 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- UOZVHDAXQMQYHZ-FPPVNLLCSA-N (8R,9S,13S,14S)-15-bromo-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4Br)O)[C@@H]4[C@@H]3CCC2=C1 UOZVHDAXQMQYHZ-FPPVNLLCSA-N 0.000 description 1
- DQQMDOLPKAVVIE-HASHYOOPSA-N (8r,9s,13s,14s)-17-[(e)-2-iodanylethenyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)(O)\C=C\[125I])[C@@H]4[C@@H]3CCC2=C1 DQQMDOLPKAVVIE-HASHYOOPSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000270722 Crocodylidae Species 0.000 description 1
- 229910003771 Gold(I) chloride Inorganic materials 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000010405 anode material Substances 0.000 description 1
- 229940046836 anti-estrogen Drugs 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000010425 asbestos Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 238000000170 chemical ionisation mass spectrum Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 238000010961 commercial manufacture process Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- FDWREHZXQUYJFJ-UHFFFAOYSA-M gold monochloride Chemical compound [Cl-].[Au+] FDWREHZXQUYJFJ-UHFFFAOYSA-M 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 1
- 150000002496 iodine Chemical class 0.000 description 1
- SNHMUERNLJLMHN-UHFFFAOYSA-N iodobenzene Chemical compound IC1=CC=CC=C1 SNHMUERNLJLMHN-UHFFFAOYSA-N 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000002661 non steroidal estrogen Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002901 radioactive waste Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
- C25B9/17—Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
- C25B9/19—Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof with diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Metallurgy (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/701,438 US5230783A (en) | 1991-05-15 | 1991-05-15 | Electrolytic cell and process for the labeling of proteins and peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9302925D0 HU9302925D0 (en) | 1993-12-28 |
| HUT67029A HUT67029A (en) | 1995-01-30 |
| HU216300B true HU216300B (hu) | 1999-06-28 |
Family
ID=24817377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9302925A HU216300B (hu) | 1991-05-15 | 1992-05-12 | Elektrolitikus cella, és eljárás proteinek és peptidek jelölésére |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5230783A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0514187B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2612145B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR0164876B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1036866C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE171483T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU650337B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2068804C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69227065T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0514187T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2120990T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI108371B (cg-RX-API-DMAC7.html) |
| HU (1) | HU216300B (cg-RX-API-DMAC7.html) |
| IE (1) | IE921540A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL101893A (cg-RX-API-DMAC7.html) |
| MX (1) | MX9202260A (cg-RX-API-DMAC7.html) |
| NO (1) | NO309497B1 (cg-RX-API-DMAC7.html) |
| SA (1) | SA92130072B1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG45300A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW225560B (cg-RX-API-DMAC7.html) |
| UA (1) | UA27771C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1992021019A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA923559B (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5590264A (en) * | 1991-04-10 | 1996-12-31 | International Business Machines Corporation | Method and apparatus for graphic association of user dialog displays with primary applications in a data processing system |
| GB9226840D0 (en) * | 1992-12-23 | 1993-02-17 | Unilever Plc | Improvements in or relating to electrochemical reactions |
| US6482309B1 (en) | 1999-10-20 | 2002-11-19 | Oxibio, Inc. | Electrolytic generation of nascent iodine as a method of treatment and for the prevention of infections associated with medical implant devices |
| CN109055968B (zh) * | 2018-07-12 | 2020-07-24 | 芜湖职业技术学院 | 有机电合成电解装置 |
| JP7166531B2 (ja) * | 2018-12-21 | 2022-11-08 | 国立大学法人東京工業大学 | 電気化学的手法を用いたハロゲン化物の製造方法 |
| DE102020122324A1 (de) | 2020-08-26 | 2022-03-03 | Gottfried Wilhelm Leibniz Universität Hannover, Körperschaft des öffentlichen Rechts | Elektrolysezelle, Elektrolysetestsystem und Teststand zum Testen von dichtungsfreien Elektrolysezellen und/oder Elektrolysetestsystemen |
| JPWO2023171617A1 (cg-RX-API-DMAC7.html) * | 2022-03-08 | 2023-09-14 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US341490A (en) * | 1886-05-11 | billings | ||
| DE1187308B (de) * | 1961-10-25 | 1965-02-18 | Licentia Gmbh | Anordnung zur Entregung von Synchronmaschinen |
| US3441490A (en) * | 1964-11-13 | 1969-04-29 | Jungner Instrument Ab | Coulometric titration apparatus |
| US3784453A (en) * | 1970-12-16 | 1974-01-08 | H Dworkin | Process and apparatus for making radioactive labeled protein material |
| BE795902A (fr) * | 1972-02-25 | 1973-08-23 | Rhone Poulenc Sa | Procede de preparation du diiodo-3,5 hydroxy-4benzonitrile et de l'iodo-3 hydroxy-4 nitro-5benzonitrile |
| SU535271A1 (ru) * | 1974-10-22 | 1976-11-15 | Предприятие П/Я В-8046 | Способ получени иодбензола |
| SU517222A1 (ru) * | 1974-10-25 | 1977-06-25 | Институт Биофизики Министерства Здравохранения Ссср | Способ получени препарата бенгальска роза, меченного радиоизотопами йода |
| SU597744A2 (ru) * | 1976-01-09 | 1978-03-15 | Химико-Металлургический Институт Академии Наук Казахской Сср | Электрод с активным слоем |
| SU601925A1 (ru) * | 1976-04-19 | 1979-07-15 | Институт биофизики АН СССР | Способ получени пептидов, меченных изотопами йода |
| US4126034A (en) * | 1978-01-30 | 1978-11-21 | Rheem Manufacturing Company | Method and apparatus for container pressure testing |
| HU179001B (en) * | 1978-05-29 | 1982-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 5-halo-6,9alpha-oxido-prostaglandin derivatives |
| US4184937A (en) * | 1978-12-26 | 1980-01-22 | Catalyst Research Corporation | Electrochemical cell for the detection of chlorine |
| GB2081307A (en) * | 1980-07-08 | 1982-02-17 | Engelhard Min & Chem | Use of electrocatalytic anodes in photolysis |
| US4464236A (en) * | 1982-05-10 | 1984-08-07 | The Dow Chemical Company | Selective electrochemical oxidation of organic compounds |
| DE3234665A1 (de) * | 1982-09-18 | 1984-03-22 | Hoechst Ag | Verfahren zur markierung von organselektiven substanzen aus blutbestandteilen mit technetium-99m |
| DE3313655C2 (de) * | 1983-03-02 | 1995-03-23 | Euro Celtique Sa | Pharmazeutisches Jodophor-Präparat |
| DE3367631D1 (en) * | 1983-06-16 | 1987-01-02 | Rhone Poulenc Sante | Process for the electrochemical production of sulfoxides of thioformamide derivatives useful as medicines |
| AU569918B2 (en) * | 1983-10-13 | 1988-02-25 | Ici Australia Operations Proprietary Limited | Redox potential or ph electrode |
| US4859305A (en) * | 1984-08-30 | 1989-08-22 | Mine Safety Appliances Company | Electrochemical cell |
| JPS61106786A (ja) * | 1984-10-30 | 1986-05-24 | Asahi Chem Ind Co Ltd | ｐ−ヨ−ドアニリンの製造方法 |
| US4666570A (en) * | 1984-10-30 | 1987-05-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for producing aromatic compound with functional groups |
| JPS61257490A (ja) * | 1985-05-09 | 1986-11-14 | Asahi Chem Ind Co Ltd | 芳香族ジアミンの製造方法 |
| US4644237A (en) * | 1985-10-17 | 1987-02-17 | International Business Machines Corp. | Collision avoidance system |
| JPH01257490A (ja) * | 1988-04-08 | 1989-10-13 | Shiro Nagai | コバルトフリーコリノイドの製造法 |
| GB8817421D0 (en) * | 1988-07-21 | 1988-08-24 | Medisense Inc | Bioelectrochemical electrodes |
-
1991
- 1991-05-15 US US07/701,438 patent/US5230783A/en not_active Expired - Lifetime
-
1992
- 1992-05-12 KR KR1019930703450A patent/KR0164876B1/ko not_active Expired - Fee Related
- 1992-05-12 HU HU9302925A patent/HU216300B/hu not_active IP Right Cessation
- 1992-05-12 JP JP5500138A patent/JP2612145B2/ja not_active Expired - Fee Related
- 1992-05-12 UA UA93004034A patent/UA27771C2/uk unknown
- 1992-05-12 WO PCT/US1992/003943 patent/WO1992021019A1/en not_active Ceased
- 1992-05-14 MX MX9202260A patent/MX9202260A/es unknown
- 1992-05-15 CN CN92104560A patent/CN1036866C/zh not_active Expired - Lifetime
- 1992-05-15 SG SG1996003062A patent/SG45300A1/en unknown
- 1992-05-15 DE DE69227065T patent/DE69227065T2/de not_active Expired - Lifetime
- 1992-05-15 CA CA002068804A patent/CA2068804C/en not_active Expired - Fee Related
- 1992-05-15 TW TW081103818A patent/TW225560B/zh active
- 1992-05-15 AU AU16335/92A patent/AU650337B2/en not_active Ceased
- 1992-05-15 DK DK92304395T patent/DK0514187T3/da active
- 1992-05-15 EP EP92304395A patent/EP0514187B1/en not_active Expired - Lifetime
- 1992-05-15 ES ES92304395T patent/ES2120990T3/es not_active Expired - Lifetime
- 1992-05-15 AT AT92304395T patent/ATE171483T1/de not_active IP Right Cessation
- 1992-05-15 ZA ZA923559A patent/ZA923559B/xx unknown
- 1992-05-15 IL IL10189392A patent/IL101893A/en not_active IP Right Cessation
- 1992-07-01 IE IE154092A patent/IE921540A1/en not_active IP Right Cessation
- 1992-08-19 SA SA92130072A patent/SA92130072B1/ar unknown
-
1993
- 1993-01-26 US US08/008,954 patent/US5246561A/en not_active Expired - Lifetime
- 1993-10-14 NO NO933704A patent/NO309497B1/no unknown
- 1993-11-12 FI FI935023A patent/FI108371B/fi not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0725789A (ja) | 生物学的システムにおける測定方法 | |
| Antonio et al. | Design of spectroelectrochemical cell for in situ X-ray absorption fine structure measurements of bulk solution species | |
| De et al. | Kinetic Studies of the Electrochemical Treatment of Nitrate and Nitrite Ions on Iridium‐Modified Carbon Fiber Electrodes | |
| Evans et al. | The mechanism of demineralization at carbon electrodes | |
| Makrides | Hydrogen overpotential on nickel in alkaline solution | |
| HU216300B (hu) | Elektrolitikus cella, és eljárás proteinek és peptidek jelölésére | |
| Próchniak et al. | Electrochemical deposition of nickel from aqueous electrolytic baths prepared by dissolution of metallic powder | |
| Gamburg et al. | Electrodeposition, properties, and composition of rhenium–nickel alloys | |
| Neihof et al. | Simple non-gassing electrodes for use in electrophoresis | |
| Reischl et al. | Electrochemical transfer of [18F] fluoride from [18O] water into organic solvents ready for labeling reactions | |
| HK1016021B (en) | Electrolytic cell and process for the labeling of proteins and peptides | |
| NZ242735A (en) | Electrolytic cell having a half-cell with a working electrode and a reference electrode, a porous separator, and a half-cell with a counter-electrode; half-cells clamped together; use for labelling | |
| Russell et al. | Tracer electrochemistry of pertechnetate: Chelation of 99mTc by EDTA after controlled-potential reduction at mercury and platinum cathodes | |
| Chakravarty et al. | An electrochemical procedure to concentrate 99mTc availed from a zirconium [99Mo] molybdate gel generator | |
| Katoh et al. | A study of the cathode reaction in Karl Fischer coulometric titration | |
| Peters et al. | Chronopotentiometric determination of halides and analysis of halide mixtures with silver anodes | |
| Ismail et al. | Separation and purification of yttrium from strontium through barium sulfate membrane under electric potential | |
| Shinagawa et al. | Studies on Focusing Chromatography: Separation of Radioactive Nuclides in Neutron Irradiated Uranium | |
| Bruchertseifer et al. | Preparation of samples for the α—Spectrometry of transplutonium elements: Electrolytic deposition of rare earth and transplutonium elements from α—Hydroxyisobutyrate solutions | |
| Klein et al. | Electrolytic preparation of isotopically enriched hard chromium layers on gold backings for nuclear reaction studies | |
| Beronius et al. | Iodine 125 as A Radiation Source with Special Emphasis on its Applications in Medical Radiology: II. Agl and Cul as point roentgen sources | |
| Ambe et al. | In and Ex Situ Emission Mössbauer Spectra of No‐Carrier‐Added 119Sb Electrodeposited on Gold | |
| JPH1039096A (ja) | 陽電子放射同位元素の製造方法 | |
| Koželj et al. | Labelling of some enzymes by electrolytic iodination a comparative study | |
| Więckowski | Kinetic isotope effects between light and heavy water in HCOOH and CH3OH adsorption and oxidation on Pt: Mechanistic considerations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |