HU211121B - Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde - Google Patents
Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde Download PDFInfo
- Publication number
- HU211121B HU211121B HU9303667A HU9303667A HU211121B HU 211121 B HU211121 B HU 211121B HU 9303667 A HU9303667 A HU 9303667A HU 9303667 A HU9303667 A HU 9303667A HU 211121 B HU211121 B HU 211121B
- Authority
- HU
- Hungary
- Prior art keywords
- nitrobenzaldehyde
- dihydroxy
- preparation
- reaction
- hours
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 12
- BBFJODMCHICIAA-UHFFFAOYSA-N 3,4-dihydroxy-5-nitrobenzaldehyde Chemical compound OC1=CC(C=O)=CC([N+]([O-])=O)=C1O BBFJODMCHICIAA-UHFFFAOYSA-N 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title description 4
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 claims description 12
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 10
- YXIWHUQXZSMYRE-UHFFFAOYSA-N 1,3-benzothiazole-2-thiol Chemical compound C1=CC=C2SC(S)=NC2=C1 YXIWHUQXZSMYRE-UHFFFAOYSA-N 0.000 claims description 6
- -1 aromatic mercapto compound Chemical class 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000002798 polar solvent Substances 0.000 claims description 3
- 239000012298 atmosphere Substances 0.000 claims description 2
- CMWKITSNTDAEDT-UHFFFAOYSA-N 2-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC=C1C=O CMWKITSNTDAEDT-UHFFFAOYSA-N 0.000 claims 1
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical class 0.000 claims 1
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- ZEHYRTJBFMZHCY-UHFFFAOYSA-N 5-nitrovanillin Chemical compound COC1=CC(C=O)=CC([N+]([O-])=O)=C1O ZEHYRTJBFMZHCY-UHFFFAOYSA-N 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000012299 nitrogen atmosphere Substances 0.000 description 3
- 229940054266 2-mercaptobenzothiazole Drugs 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000017858 demethylation Effects 0.000 description 2
- 238000010520 demethylation reaction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000012434 nucleophilic reagent Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- BLZNSXFQRKVFRP-UHFFFAOYSA-N 1-bromo-4-methoxy-2-methylbenzene Chemical compound COC1=CC=C(Br)C(C)=C1 BLZNSXFQRKVFRP-UHFFFAOYSA-N 0.000 description 1
- SCSROOBIOOCHHI-UHFFFAOYSA-N 2,3-dihydroxy-5-nitrobenzaldehyde Chemical compound OC1=CC([N+]([O-])=O)=CC(C=O)=C1O SCSROOBIOOCHHI-UHFFFAOYSA-N 0.000 description 1
- RFCQDOVPMUSZMN-UHFFFAOYSA-N 2-Naphthalenethiol Chemical compound C1=CC=CC2=CC(S)=CC=C21 RFCQDOVPMUSZMN-UHFFFAOYSA-N 0.000 description 1
- VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 description 1
- RCCIQDAGHPKBOM-UHFFFAOYSA-N 2-bromo-3,4-dihydroxy-5-nitrobenzaldehyde Chemical compound OC1=C(O)C([N+]([O-])=O)=CC(C=O)=C1Br RCCIQDAGHPKBOM-UHFFFAOYSA-N 0.000 description 1
- KFFUEVDMVNIOHA-UHFFFAOYSA-N 3-aminobenzenethiol Chemical compound NC1=CC=CC(S)=C1 KFFUEVDMVNIOHA-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- WCDSVWRUXWCYFN-UHFFFAOYSA-N 4-aminobenzenethiol Chemical compound NC1=CC=C(S)C=C1 WCDSVWRUXWCYFN-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 150000008378 aryl ethers Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical class OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- SEXOVMIIVBKGGM-UHFFFAOYSA-N naphthalene-1-thiol Chemical compound C1=CC=C2C(S)=CC=CC2=C1 SEXOVMIIVBKGGM-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000002341 toxic gas Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919113431A GB9113431D0 (en) | 1991-06-20 | 1991-06-20 | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9303667D0 HU9303667D0 (en) | 1994-04-28 |
| HUT66450A HUT66450A (en) | 1994-11-28 |
| HU211121B true HU211121B (en) | 1995-10-30 |
Family
ID=10697088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9303667A HU211121B (en) | 1991-06-20 | 1992-06-18 | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5382699A (ro) |
| EP (1) | EP0589948B1 (ro) |
| JP (1) | JP3048639B2 (ro) |
| KR (1) | KR100241132B1 (ro) |
| AT (1) | ATE142192T1 (ro) |
| AU (1) | AU650149B2 (ro) |
| BG (1) | BG62163B1 (ro) |
| CA (1) | CA2110583C (ro) |
| CZ (1) | CZ281933B6 (ro) |
| DE (1) | DE69213452T2 (ro) |
| DK (1) | DK0589948T3 (ro) |
| EE (1) | EE03068B1 (ro) |
| ES (1) | ES2091472T3 (ro) |
| FI (1) | FI104715B (ro) |
| GB (1) | GB9113431D0 (ro) |
| GR (1) | GR3021052T3 (ro) |
| HU (1) | HU211121B (ro) |
| NO (1) | NO178298C (ro) |
| PL (1) | PL169522B1 (ro) |
| RO (1) | RO115157B1 (ro) |
| RU (1) | RU2098405C1 (ro) |
| SK (1) | SK281800B6 (ro) |
| WO (1) | WO1993000323A1 (ro) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9419274D0 (en) * | 1994-09-23 | 1994-11-09 | Orion Yhtymae Oy | New method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde |
| US7339060B2 (en) | 2005-03-23 | 2008-03-04 | Resolution Chemicals, Ltd. | Preparation of cabergoline |
| US20070197576A1 (en) * | 2006-02-08 | 2007-08-23 | Resolution Chemicals Limited | Production of Cabergoline and Novel Polymorphic Form Thereof |
| EP2251323B1 (en) | 2009-05-14 | 2014-04-23 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Method for the purification of entacapone |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO107714C (ro) * | 1961-06-21 | |||
| US4009210A (en) * | 1975-05-07 | 1977-02-22 | Gulf Oil Corporation | Process for manufacturing 3,5-ditert.butyl-4-hydroxybenzaldehyde by formylation of 2,6-ditert.butylphenol |
| DK175069B1 (da) * | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
| YU213587A (en) * | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| FI864875A0 (fi) * | 1986-11-28 | 1986-11-28 | Orion Yhtymae Oy | Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa. |
| GB2238047B (en) * | 1989-11-03 | 1993-02-10 | Orion Yhtymae Oy | Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation |
-
1991
- 1991-06-20 GB GB919113431A patent/GB9113431D0/en active Pending
-
1992
- 1992-06-18 DK DK92911745.5T patent/DK0589948T3/da active
- 1992-06-18 JP JP4510758A patent/JP3048639B2/ja not_active Expired - Fee Related
- 1992-06-18 US US08/162,198 patent/US5382699A/en not_active Expired - Lifetime
- 1992-06-18 ES ES92911745T patent/ES2091472T3/es not_active Expired - Lifetime
- 1992-06-18 EP EP92911745A patent/EP0589948B1/en not_active Expired - Lifetime
- 1992-06-18 KR KR1019930703777A patent/KR100241132B1/ko not_active Expired - Fee Related
- 1992-06-18 DE DE69213452T patent/DE69213452T2/de not_active Expired - Fee Related
- 1992-06-18 CZ CS932804A patent/CZ281933B6/cs not_active IP Right Cessation
- 1992-06-18 CA CA002110583A patent/CA2110583C/en not_active Expired - Fee Related
- 1992-06-18 PL PL92301827A patent/PL169522B1/pl not_active IP Right Cessation
- 1992-06-18 RO RO93-01717A patent/RO115157B1/ro unknown
- 1992-06-18 WO PCT/FI1992/000192 patent/WO1993000323A1/en not_active Ceased
- 1992-06-18 SK SK1446-93A patent/SK281800B6/sk unknown
- 1992-06-18 RU RU9393058510A patent/RU2098405C1/ru not_active IP Right Cessation
- 1992-06-18 AU AU18980/92A patent/AU650149B2/en not_active Ceased
- 1992-06-18 AT AT92911745T patent/ATE142192T1/de not_active IP Right Cessation
- 1992-06-18 HU HU9303667A patent/HU211121B/hu not_active IP Right Cessation
-
1993
- 1993-12-10 BG BG98285A patent/BG62163B1/bg unknown
- 1993-12-16 NO NO934664A patent/NO178298C/no unknown
- 1993-12-16 FI FI935657A patent/FI104715B/fi active
-
1994
- 1994-11-01 EE EE9400168A patent/EE03068B1/xx not_active IP Right Cessation
-
1996
- 1996-09-17 GR GR960402420T patent/GR3021052T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: ORION CORPORATION (BUSINESS ID KOD: 1999212-6), FI Free format text: FORMER OWNER(S): ORION-YHTYMAE OY, FI |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |