HU193290B - Cinditioning cosmetical composition containing blood plasma concentrate as active agent - Google Patents

Abstract

Skin treatment agent intended to be used in the different fields of treatment of the skin with known conventional substances such as carriers, additives, perfumes, preservation agents and optionally protection agents and dye stuffs. The skin treatment agent may be presented as a product for the bath, in other words as a cream for the bath, a bath-shower gel, a body milk, in the form of creams, that is to say as a cream for the face, a night cream, a mask for the face, and furthermore as a solar protection agent, for example a sun milk, a sun protection foam, an after sun lotion, as well as a lipstick or an eyelid shade; in addition to all these above-mentioned forms, many other applications may be found. This skin care agent contains as active substance blood plasma extract from slaughter blood in an amount of at least 0.3 and at the most 6% by weight. To prepare this skin care agent, the blood plasma extract, conveniently blood plasma extract obtained by ultra-filtration with a low salt contents is soaked in water or an emulsion before mixing it in the soaked state with other components.

Description

FIELD OF THE INVENTION The present invention relates to a composition for skin care which can be used in a wide variety of skin care applications, together with known carrier additives, fragrances, preservatives and optionally preservatives and colorants. The skin care composition of the invention may thus be in the form of bath products, such as a cream bath, lotion or lotion, as well as creams, such as face cream, night cream, face mask, in addition to sunscreen, i.e. sun cream, sunblock, sunblock, lip gloss or , but there are many other forms of presentation besides those listed here.

The main purpose of various skin care products, or the second purpose, but not secondary to their main purpose, is to nourish, conserve, restore elasticity and maintain its natural state. This is the main purpose of applying cream products, the purification of floral products or sunscreen products, or the supplementary purpose besides my sun protection.

It is known that human skin has a protective film layer which is a suspension or emulsion. The protective jacket has a pH of 4.5 to 6.5 and is therefore mainly acidic. The components of the acid mantle are sebum, water, various amino acids, proteins and minerals. When cleaning, the jacket may be damaged and dry out, so it should be returned to its original condition.

Preparations for nourishing, preserving or restoring the skin contain extracts of plant or animal origin as active ingredients which are rich in proteins and amino acids and thereby have a beneficial effect on the skin. Reference is made, by way of example only, to the English patent specification 1 038 145, which discloses the applicability of blood serum in cosmetic compositions, to the German Patent Application No. 1 467 952, which discloses the use of nucleotides in cosmetic compositions. German Patent Publication No. 167,919; and Japanese Patent Publication No. 118,817/74, which discloses cosmetic preparations containing placental protein. It is further known from Polish Patent No. 51007 that bovine blood plasma is added to cosmetic compositions as an additional active ingredient. The main disadvantage of this solution is that the use of plasma does not provide a natural protein spectrum since the plasma does not contain fibrinogen and albunirir. It is known from Japanese Patent Application No. 7949/59 (Chemical Abstracts, 54, 3873f) that a concentrate of saliva can be used as an active ingredient in a skin care composition, but for the reasons detailed below, the concentrate prepared as described herein is so high in salt that its cosmetic use is detrimental. Although many excellent skincare formulations are known today, there is always a real need for new formulations that are more effective than at least some of the existing formulations, or provide benefits in a broader range of applications.

It is also known that, from the known natural-based active ingredients, the protein and amino acid composition in the blood contains all the ingredients that would allow to fulfill the above purposes. In its natural form, the use of blood for cosmetic purposes is hindered by many circumstances. These include coagulation, decay, color, etc.

Slaughterhouse blood for industrial use is already widely known. After being treated with anticoagulant, the slaughterhouse blood is separated into thick blood and blood plasma by a separator and the blood plasma is mainly used for food purposes. The major groups of proteins in the plasma are globular and lipoprotein type proteins and fibrinogen.

Plasma, in its natural state, is unsuitable for use as an active ingredient due to its high water content and its tendency to deteriorate. By drying from plasma, plasma concentrates can be prepared which can be used as an active ingredient in skin care compositions according to the invention. Plasma concentrates have a relatively high salt content. During drying and concentration, the salt concentration increases when the liquid leaves.

Below is the composition of the blood plasma, then the dried blood plasma, and the essential amino acid content of the blood plasma (Grant, RA: Applied Protein Chemistry, Applied Sci. Publishers, Ltd., London, 1980). composition

Water 90.8% Salt ^f 0.8% Fat 0.1% Other materials 0.4% proteins 7.9% Albumin 3.3% fibrinogen 0.4% Globulin , 4.2% Dried blood plasma average composition Water 7.0% Protein 71.9% Many 7.3% by volume of plasma 9.2% anticoagulant Fat 1.0% Other 3.6% Essential amino acid content of blood plasma (g amino acid / 100 g) lysine 9.2 Leucine 10.1 threonine 6.2 i-leucine 2.9

methionine 1.0 Tritofán 1.9 Valin 7.0 histidine 3.5 phenylalanine 5.6

From the above composition, it can be seen that the protein content of concentrated plasma is 71.9% by weight compared to 7.9% by volume in plasma. This almost tenfold amount is due to a significant decrease in water content. However, during drying, not only the relative protein content but also the salt content increases. 16.5% salt in concentrated plasma is a barrier in most cosmetic applications. Salts derived from anticoagulants are particularly dangerous here. They contain different phosphate salts, the presence of which coagulates and precipitates proteins on the skin surface. High salt content has a dehydrating effect, dries and sometimes irritates the skin. Because of its very high protein and amino acid composition, the plasma concentration is therefore only suitable for cosmetic purposes despite its very favorable protein and amino acid composition. It is an object of the present invention to provide a skin care composition free of the above disadvantages. It has been found that this object can be solved by using a plasma concentrate obtained by ultrafiltration in the composition. This technology, called ultrafiltration, allows fine filtration to separate particles of molecular weight 16,000-18,000 from the liquid phase. The valuable proteins and amino acids in the plasma have molecular weights above this range and can be separated from the liquid phase by ultrafiltration. In contrast to drying in ultrafiltration, not only the liquid but also the salt dissolved in it are removed from the filtrate so that the salt content of the concentrate is significantly lower. In contrast to the 16.5% salinity in the dried blood plasma, the plasma concentration of the ultrafiltrated condensed plasma is about 4.1% and the remainder of this anticoagulant is only about 2.5%. This amount of salt is already negligible. We have found that this ultrafiltrated condensed blood plasma is well suited as an active ingredient in skin care products.

The present invention relates to a skin care composition which is suitable for use in various areas of skin care, and includes carrier, additives, perfume and other substances specific to each area and comprising as an active ingredient a plasma concentration of 0.3 to 3% by weight in slaughterhouse blood. with a salt concentration of not more than 6% by weight, the residues resulting from the addition of anticoagulants to the shell up to a maximum salt content of 60% and with a protein concentration of not less than 60%. In addition to the amount described herein, the benefits of using protein components in the plasma can even compensate for the potential disadvantages of salt content in the dried plasma concentrate, moreover, the protein and amino acid composition of the concentrate substantially corresponds to the unconcentrated plasma.

Significantly more favorable results are obtained when the salt concentration in the plasma is below 4.5%. Such a concentration can therefore only be achieved by ultrafiltration from currently known technologies.

The benefits of using the plasma concentrate as an active ingredient can be understood by reference to the major properties of the protein groups contained therein, as analyzed below.

Of the globular proteins in particular, serum albumin and serum globulins have good water-binding properties and adsorb on the skin surface to protect against dehydration and exert a moisturizing effect. Globular proteins, especially histidine, also have anti-inflammatory properties. Gamma globulin, which is found only in the plasma, known as an antidote to acute diseases, increases the body's resistance. Lipoprotein is capable of stabilizing water / oil systems and its presence in skin care products considered emulsion systems has a stabilizing effect. Lipoprotein proteins also contain fat on their surface, thus replacing the fat content of the skin. The amino acid composition of plasma fibrinogen is more favorable for biologically active compounds than collagen and elastin. Thus, the threonine content is three and six times, respectively, the leucine and isoleucine content is nearly three times that of collagen. The tyrosine content is five times that of collagen, the content of lysine is more than twice that of collagen, and sixteen times that of elastin. Arginine is present in the plasma six times as much as elastin. Tryptophan is completely free of collagen and elastin, whereas it is found in significant amounts in fibrinogen. Collagen does not contain cystine, and elastin contains seven times the amount of cystine as fibrinogen. The other important sulfur-containing amino acid, methionine, is only trace in elastin and is one-quarter of fibrinogen relative to collagen. These ratios are further increased when one considers that the concentration of protein and amino acids in plasma is multiplied relative to plasma. The data described here reflect some of the benefits of the use of plasma compared to the two most preferred skin care active ingredients, namely collagen and elastin. It is not yet fully proven, but it is highly likely that, in addition to the presence of higher concentrations of valuable amino acids, they are more favorable for tethering than the same mother3.

-3193290 genes would be applied in adherence to a tissue foreign vehicle. In the known active substances, the latter conditions prevail. The presence of blood plasma is another source of advantage when used as an active ingredient in sunscreen products. The decarboxylation of histidine produces urocanic acid; which is also found in a small amount in normal skin and has a strong sunscreen. The versatile advantages mentioned here explain why the presence of plasma concentrate as an active ingredient in a variety of skin care formulations is beneficial. Although the compositions of the invention may be prepared in a manner known per se, it is desirable to combine the plasma concentrate with the other ingredients after steaming in water.

The following examples are intended to illustrate the invention. The plasma concentrate used in the examples was prepared according to the process described in Hungarian Patent Application No. 186,957, the characteristics of which are given therein.

Example 1

For the preparation of a cream bath, the following composition is prepared: sodium lauryl ether sulfate as the first phase surfactant (Henkel Düsseldorf 50% Texapon N-25), fragrance (IFF Hilversum Dutch company FAH 42095) 1% by volume and greasing agent (coconut fatty acid diethanolamide marketed by Henkel as Comperlan KD) 1% by volume, 42.5% by volume distilled water as a second phase, sodium chloride Phases containing 3% by weight and 3% by weight of plasma concentrate (with a dry matter content of 93.09% by weight, of which protein is 80.57%, sodium chloride 2.05%, ash content 4.44%) stirring until the ingredients are dissolved, and finally dissolving the first phase in the second phase.

Example 2

The following composition was prepared: 40% by weight of the sodium lauryl ether sulfate surfactant, 20% by weight of the betaine derivative marketed by Caola Hungarian under the trade name Zalabetain. coconut fatty acid diethanolamide 5% by weight, perfume 0.5% by weight as mentioned in example 1, methyl 4-hydroxybenzoic acid as preservative in 0.5% by weight, Example 1 2% and water 32%.

First, the blood plasma concentrate is steeped in water, and after gentle heating, each component is added to the water and cooled with stirring. The perfume is carried out at 30 ° C.

Example 3

In the manufacture of a sun-milk product, two phases are prepared, the first phase being 6% by weight of the final product of an oil-in-water emulsifier marketed by Dragoco (Holzminden, Federal Republic of Germany) under the trade name "Hydromiristenol", isopropyl myristate, 8 wt% paraffin oil, 0.5 wt% cetyl alcohol and 2 wt% sold by Dragoco under the tradename Prosolal S 9 (5-3,3-dimethyl). -2-norbornilidene, -3-penten-2-one). The second phase contains 1% by weight of a water soluble degreasing agent marketed by Dragoco under the brand name "Neo-PCL-wasserlöslich", 1% by volume of blood plasma concentrate in Example 1, 0.4% by weight of propylene glycol. A preservative (a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one) marketed by Rohm and Haas, Philadelphia, USA, under the trade name Kathon CG. % and distilled water 73.1%. The blood plasma concentrate is steeped in water and the materials of the second phase are mixed. Each phase is heated to 7075 ° C separately, the first phase is added to the second phase with vigorous stirring, and the resulting mixture is cooled to 30-35 ° C with slow stirring and mixed in 0.2% by weight according to Example 1. fragrance.

Example 4

Sun protection foam is also made in two phases. The first phase contains 10% by volume of the emulsifier of Example 3 quality, and 18% by weight of paraffin oil, 1.5% by volume of 1% alcohol, 0.5% by weight, according to Bayer, Germany. Silicone Oil, marketed under the trade name A ”and 2% by weight of the ultraviolet radiation filter material of Example 3. The second phase contains 70.7% distilled water, 1% by volume of the plasma concentration of Example 1, 5% by weight of propylene glycol, and a preservative (see Example 3 in 0.3% by weight). Plasma concentrate is first slurried in water, then the other ingredients are added, the second phase is mixed, the two phases are each heated to about 75 ° C and the second phase is poured into the system to emulsify and reduce the stirring rate to about 40. The mixture was perfumed at 0.5 ° C with the addition of 0.5% fragrance (see Example 1) and then charged with 85% and 15% Freon 12 (ICI, London, UK).

Example 5

For the preparation of a sunbathing product, the following composition is prepared: 15% by volume ethyl alcohol, 0.5% by volume perfume (see Example 1), 3.5% by weight water-soluble degreaser (see Example 3) -in; as a second phase, distilled water (67%), D-panthenol (1%), plasma concentration of Example 1 (1%), hydrating additive 4193290 (marketed by Dragoco under the brand name Hidroviton, (amino acids, sodium lactate, allantoin, a mixture of polyhydric alcohols and wetting agents) (2%), homogenizing the porous astringent extract (azulene) (5%), chamomile extract (product of Szilasmenti MGTSz) and the premixed first and second phases .

Example 6

Body milk is also prepared using two phases, the first phase emulsifier (see Example 3) using 7.5% paraffin oil 45%, the second phase distilled water 46.75% and the plasma concentration of Example 1. 0.5% by weight. The two phases are prepared separately, then heated to 70 ° C, and the second phase is poured into the first phase to form an emulsion. By reducing the stirring rate, the composition is cooled to 30-35 ° C and then perfumed with 0.25% by weight of perfume (see Example 1).

Example 7

There are two phases of night cream preparation. In the first phase emulsifier (see Example 3) was used in 25%, in isopropyl myristate in 5% and in paraffin oil in 5%, in the second phase 48.5% in distilled water and 5.5% in propylene glycol. wt%, moisturizer (see Example 5) 2%, magnesium sulfate 0.5% and the plasma concentration of Example 1 5%. The individual phases are mixed individually and heated to about 70 ° C, and the second phase is poured into the first phase with rapid mixing and the composition is cooled to about 35 ° C and 0.5% by weight of the fragrance (see Fig. 1). perfume is added.

Example 8

A face mask is prepared in the following composition: stearin 5%, triethanolamine 0.3%, bleach (mercuric amidochloride) 5%. The plasma concentration of Example 1 was 0.5%, water 71.2%, kaolin 15%, and titanium 2%. Blood plasma concentrate and bleach are dissolved in a portion of the water with stirring, and the stearin is melted at 75 ° C and the remaining water / triethanolamine mixture is added with vigorous stirring at about 80 ° C and finally cooled to 35 ° C with stirring. and adding kaolin and titanium dioxide.

Example 9

For the face mask, the following composition is used: fat phase component (Laurenic acid hexyl ester, marketed by Henkel as Cetiol HE) 5%, 86% glycerol 5%, 96% ethyl alcohol 23%, 1 The plasma concentration of Example 1 is 2%, triethanolamine 0.1%, fragrance (see Example 1) 0.2% and structuring agent (10% carboxymethylcellulose solution) 64.7% . The blood plasma concentrate is swollen into the structure loosener and further additives are added to this material.

Example 10

For the preparation of the face cream, we start with two phases, the first phase containing 16% by weight of the fat phase component (see Example 9), 13% by emulsifier (see Example 3), and 5% by weight of the second phase 61% water and 5% plasma concentration of Example 1. In this work, the pH of the system is adjusted to 3.7 to 6.5, the two phases are heated to 75-80 ° C and mixed with each other.

Example 11

The following compositions were used to make the lip gloss: lanolin 30%, polybutene 51 1% paraffin wax 4%, dye (strawberry food coloring) 9%, plasma concentration of Example 1 5%, aroma oil (eperaroma) I%. The materials were heated at 80-90 ° C and stirred until homogeneous, and filled in jars at 50-60 ° C.

Example 12

The following two-phase composition is used to prepare the eyelid. For the first phase, stearic acid at 10%, iron oxide at 10%, isopropyl myristate at 3.3%, a preservative (see Example 3) at 0.2% and an emulsifier (see Example 3). ) 2% by volume. The second phase - (fatty phase) triethanolamine 3.3%, magnesium aluminum silicate 10%, film-forming material [polyvinyl alcohol] 7.5%, 1.2%. propanediol at 2.5%, a preservative (see Example 3) at 0.2% and the remainder in deionized water. Both phases are heated to about 75 ° C, and the second (aqueous) phase is emulsified in the first phase with slow stirring, cooled after homogenization, and the resulting cream is mixed with 5% dye and 1 volume of blood plasma.

The above examples illustrate that a variety of skin care cosmetics can be prepared by the further solution of the invention. All of the products listed above were extremely beneficial in their effect and proved the benefits of the plasma concentration and outlined above in practice.

In each of the above examples, the most preferred percentages are given. As is well known in the cosmetics industry, a slight change, for example to + 10%, in the ratio of each ingredient is not significantly altered.

Claims (2)

I. Skincare product, in particular in the form of a cuticle, cream, sunscreen, lip gloss or eyeliner, in which the carrier and / or matrix is customarily used in the preparation of skin care products. -5193290 excipients, preferably distilled water as carrier, a physiologically acceptable organic solvent and / or a C12-C18 fatty alcohol, a fatty acid ester or oil, and preferably a perfume, coloring agent and / or preservative, based on 0,3% by weight of the total composition. Contains 3% by weight of a plasma concentration in the slaughterhouse blood of not more than 6% by weight, not more than 60% by weight of the anticoagulant salts added to the slaughterhouse blood and having a protein content of not less than 60%. 2. A composition according to claim 1, wherein the plasma concentration is less than 4.5% by weight. without figure