WO1986000224A1

WO1986000224A1 - Agent for the treatment of the skin and production method thereof

Info

Publication number: WO1986000224A1
Application number: PCT/HU1985/000037
Authority: WO
Inventors: István LACZKÓ; Eszter KOVÁCS; Erzsébet BASA; Jánosné CSELOVSKY; Péter BANETH; Miklósné GÁBOR; Lászlóné FÜLÖP; Györgyné VARRÓ; Béla HORVÁTH
Original assignee: Universal Vegyipari Szövetkezet; Élelmiszeripari Fo^"Iskola
Priority date: 1984-06-19
Filing date: 1985-06-19
Publication date: 1986-01-16
Also published as: EP0186681A1; HU193290B

Abstract

Skin treatment agent intended to be used in the different fields of treatment of the skin with known conventional substances such as carriers, additives, perfumes, preservation agents and optionally protection agents and dye stuffs. The skin treatment agent may be presented as a product for the bath, in other words as a cream for the bath, a bath-shower gel, a body milk, in the form of creams, that is to say as a cream for the face, a night cream, a mask for the face, and furthermore as a solar protection agent, for example a sun milk, a sun protection foam, an after sun lotion, as well as a lipstick or an eyelid shade; in addition to all these above-mentioned forms, many other applications may be found. This skin care agent contains as active substance blood plasma extract from slaughter blood in an amount of at least 0.3 and at the most 6% by weight. To prepare this skin care agent, the blood plasma extract, conveniently blood plasma extract obtained by ultra-filtration with a low salt contents is soaked in water or an emulsion before mixing it in the soaked state with other components.

Description

SKIN CARE PRODUCT AND METHOD FOR THE PRODUCTION THEREOF

The invention relates to a skin care product which can be used in the different areas of skin care together with the known carrier, additive, fragrance, preservative and optionally protective and coloring agents which are customary for this. The skin care product according to the invention can therefore be used as a bath product, i.e. as a cream bath, shower bath (gel), body care milk, also in the form of creams, i.e. as a face cream, night cream, face pack (mask), also as sunscreen such as sun milk, sunscreen foam, after-sun cream and also as lip gloss or eyeshadow, but numerous other manifestations are conceivable in addition to the forms listed here.

In addition to their main function or main purpose, the different skin care products have the non-secondary task of nourishing and protecting the skin, restoring its elasticity and giving it its natural condition. This is the main purpose for cream products, and a complementary function for bathing products or sunscreens.

It is known that human skin has a protective film which is in the form of a suspension or an emulsion. This protective film has a pH of 4.5-5.5, and is therefore also called the protective acid mantle of the skin. It consists of sebum, water, various amino acids, proteins and minerals. When cleaning the skin, this protective coat can be damaged and dry out, so it must be returned to its natural state.

The preparations produced to nourish the skin, to preserve or restore its natural state contain, as active ingredients, extracts of vegetable or animal origin, which are rich in proteins and amino acids and therefore exert an advantageous influence on the skin.

Although numerous excellent skin care products are already known, there is always a real need for more effective or at least in some respects more advantageous preparations or those which offer other advantages due to a broader range of applications.

The object of the invention is to meet this real need satisfy and accordingly to create a novel skin care product and a process for its preparation.

The invention is based on the knowledge that, among the natural active ingredients, all those that make it possible to achieve the stated goal are contained in the blood due to its protein and amino acid composition. The use of the hat in its natural form for cosmetic purposes is hampered by numerous circumstances, including its tendency to clot and spoil, its color, etc. The industrial use of blood from slaughterhouses is well known. It is treated with an anticoagulator and then separated into thick blood and blood plasma in the separator. The blood plasma is mainly used in the food industry. It mainly contains globulins, lipoproteins and fibrinogen as protein groups. In its natural form, the blood plasma seems unsuitable for use as an active ingredient due to its high water content and its perishability. A blood plasma extract which can be used according to the invention as an active ingredient for skin care products can be obtained from blood plasma by drying. The blood plasma extract contains a relatively large amount of salt, since the salt concentration increases with drying and concentration as the water emerges. The composition of the blood plasma, the dried blood plasma and the content of essential amino acids in the blood plasma are given below (Grant, R.A .: Applied protein chemistry, Applied Sei. Publishers, Ltd., London, 1980).

Average composition of the blood plasma making up 60% of the total blood

Water 90.8 mass%

Salt 0.8 mass%

Fat 0.1 mass% other substances 0.4 mass% protein 7.9 mass%

Albumin 3.3 mass% fibrinogen 0.4 mass% globulin 4.2 mass% Average composition of the dried blood plasma

Water 7.0 mass%

Protein 71.9 mass%

Salts (from the bluplasma) 7.3 mass%

(Anticoagolator) 9.2 mass%

Fat 1.0 mass% other 3.6 mass%

Blood plasma content of essential amino acids (g / 100 g plasma)

Lvsin 9.2 Leucine 10.1

Youronin 6.2 isoleucine 2.9

Methionine 1.0 tryptophan 1.9

Valine 7.0 histidine 3.5

Phenvlalanine 5.6

The protein content of the dried blood plasma is therefore 71.9% and that of the blood plasma is only 7.9%. This almost tenfold amount results from the considerable reduction in the water content. When drying, however, not only the relative protein content increases, but also the salt content. The 16.5% salt contained in the dried blood plasma is an obstacle for most cosmetic applications, primarily the salts originating from the anticoagulator pose a danger. These are different phosphates that coagulate the proteins on the surface of the skin. The high salt content has a dehydrating effect, dries out the skin and can also irritate it. Despite its ideal protein and amino acid composition, the blood plasma extract can therefore only be used in small quantities for cosmetic purposes. The thickening of the blood plasma, however, cannot be done only by drying. With the technology referred to in the industry as ultrafiltration, particles with a molecular weight of only 16000-18000 can be separated from the liquid phase. The molar mass of the valuable proteins and amino acids contained in the blood plasma is above this range, and they can therefore be separated from the liquid phase by ultrafiltration. In contrast to drying Ultrafiltration not only removes the liquid, but also the salts dissolved in it, ie the extract has a much lower salt content. Compared to the 16.5% salt content of the dried blood plasma, the blood plasma thickened by ultrafiltration only has a salt content of about 4.1%, of which only about 2.5% are residues originating from the anticoagulator. This amount of salt can already be described as negligible.

The invention relates to a skin care product which can be used in different areas of skin care and which contains carriers, additives, fragrances and other substances which are characteristic of these areas. The skin care agent according to the invention contains, as an active ingredient, blood plasma extract obtained from slaughterhouse blood in an amount of at least 0.3% by mass and at most 6% by mass.

In the stated amount, the advantages of the protein components contained in the blood plasma also compensate for the possible disadvantages of the salt content contained in the dried blood plasma extract. Much more favorable results are achieved, however, if the salt concentration in the blood plasma extract is at most 6%, in particular below 4.2%. This concentration can only be achieved by ultrafiltration. If the blood plasma extract is not broken down into fractions, it retains its original composition and the residues from the anticoagulant added to the slaughterhouse blood account for a maximum of 60% of the permissible salt content.

To achieve a mechanism of action with a broad spectrum, it is advantageous if the protein and amino acid composition of the blood plasma extract corresponds to that of the blood plasma and the protein concentration in the extract is at least 60%.

The advantages of using blood plasma extract as an active ingredient can be understood from the following main properties of the protein groups contained in the extract.

Of the globular proteins, serum albumin and serum globulins in particular have the property of adding water tie; they are adsorbed on the skin surface and protect the skin from drying out, have a hydrating effect. The globular proteins, especially histidine, also have an anti-inflammatory effect. The gamma globulin, which can only be found in the blood plasma, is known to be the antidote to acute diseases, it increases the resistance of the organism.

The lipoproteins are suitable for the stabilization of water / oil systems and their presence in the skin care products which represent emulsion systems has a stabilizing effect. The lipoproteins also contain fat on their surface, so they supplement the fat content of the skin.

The amino acid composition of the fibrinogen contained in the plasma is more favorable compared to that of other biologically active compounds (collagen, elastin). For example, the threonine content of the fibrinogen is three and six times as high, and the leucine and isoleucine content is about three times that of the collagen. Fibrinogen contains five times as much tyrosine and more than twice as much lysine as collagen, and its lysine content is sixteen times that of elastin. The arginine content of the blood plasma is six times that of the elastin. Tryptophan is not found at all in collagen and elastin, but in significant amounts in fibrinogen. Collagen contains no cystine, and elastin contains only one seventh of the cystine content of fibrinogen. The other important sulfur-containing amino acid, methionine, is only present in trace amounts in elastin, and collagen also contains only a quarter of the methionine content of fibrinogen. These relative numbers show even greater differences when one considers that the proteins and amino acids are contained in the blood plasma extract many times more concentrated than in the blood plasma.

Collagen and elastin are considered to be extremely advantageous as active ingredients in skin care products. The comparative figures given therefore show some of the advantages that result from the use of blood plasma.

The mechanism of action has not yet been fully clarified, but the fact that apart from the higher con concentration of the amino acids, their binding state for incorporation into the organism is more favorable than the binding of the same amino acids to non-body carriers. In the known preparations there is mostly binding to non-body carriers. When used as an active ingredient in sunscreens, blood plasma shows further advantages. The decarboxylation of histidine produces urokanic acid, which can also be found in small amounts in normal skin and has strong light protection properties. The many advantages explained here explain why the presence of blood plasma extract in skin care products is advantageous.

In the sense of the process for the production of skin care products containing blood plasma, the blood plasma is first swollen in water and then combined with the other components. Different advantageous application forms and the production of the skin care products according to the invention are explained in the following examples. Example 1 Two phases are prepared for the production of a cream bath. The first consists of sodium lauryl ether sulfate at 50% by mass, 1% by mass of fragrances and 1% by mass of refatting agent, the second from 42.5% by mass of distilled water, 3% by mass of sodium chloride and 3% by mass of blood plasma extract. The two phases are stirred separately until everything has dissolved, and then the first phase is dissolved in the second phase. Example 2

A shower bath (gel) has the following composition: 40% by weight of surface-active substance, preferably sodium lauryl ether sulfate, 20% by weight of betaine derivative, 5% by weight of fatty acid diethanolamide, 0.5% by weight of fragrances, 0.5% by weight of preservative, 2% by weight of blood plasma extract and 32% by weight Water. First the blood plasma extract is swelled in water, then the remaining components are added to the water with gentle warming, and the mixture is stirred with cooling. The fragrances are added at 30 ° C. Example 3 Two phases are used to produce sun milk rode. Based on the end product, the first phase contains 6 mass% emulsifier, 3 mass% isopropyl myristate, 8 mass% paraffin oil, 0.5 mass% cetyl alcohol and 2 mass% light protection substance against UV radiation. The second phase contains 1 mass% of water-soluble lipid-replenishing agent, 1 mass% of blood plasma extract, 0.4 mass% of propylene glycol and 5 mass% of preservative as well as 73.1 mass% of distilled water. The blood plasma extract is swollen in water, then the components of the second phase are added. Both phases are heated separately to 70-75 ° C, then the first phase is added to the second phase with vigorous stirring. With slow stirring, the mixture is cooled to 30-35 ° C. and fragrance is added in an amount of 0.2% by mass.

Example 4 Sun protection foam is also produced from two phases. The first phase contains 10 mass% emulsifier, 2.5 mass% fat phase component, and the second phase contains 70.7 mass% distilled water, 1 mass% blood plasma extract, 5 mass% propylene glycol and 0.3 mass% preservative. In the manner already described, the bluplasma extract is first swelled in water and then the other components of the second phase are added. The two phases are heated separately to about 75 ° C. Then the first phase is poured into the second and the system is emulsified. It is stirred more slowly and at a temperature of about 40 ° C 0.5% by weight of fragrances are added. 85% of the mass obtained are filled together with 15% propellant gas in spray containers.

Example 5

To produce an after-sun lotion, the first phase consists of 15% by mass of ethyl alcohol, 0.5% by mass of fragrances and 3.5% by mass of refatting agent and the second phase consists of 67% by mass of distilled water, 1% by weight of D-panthenol and 1% by mass % Blood plasma extract, 2 mass% hydrating additives, 5 mass% of an extract pulling the pores together and 5 mass% chamomile distillate. The phases are mixed and homogenized.

Example 6 Personal care milk is also prepared in two phases. The first phase consists of 7.5 mass% emulsifier and 45 mass% paraffin oil, and the second phase consists of 46.75 mass% distilled water and 0.5 mass% blood plasma extract. The two phases are heated separately to 70 ° C and an emulsion is prepared by pouring the second phase into the first. With slow stirring, the mixture is cooled back to 30-35 ° C. and then fragrance is added in an amount of 0.25% by mass. Example 7

Two phases are prepared for the production of a night cream. The first phase contains 25 mass% emulsifier, 5 mass% isopropyl myristate and 8 mass% paraffin oil and the second phase 48.5 mass% distilled water, 5.5 mass5 propylene glycol, 2 mass% hydrating additives, 0.5 mass% magnesium sulfate and 5 Mass% blood plasma extract. The phases are heated separately to 70 ° C, then the second phase is poured into the first with rapid stirring and the mixture is cooled to about 35 ° C with slow stirring. At this temperature, 0.5% by mass of fragrances are added. Example 8

A face pack (mask) is prepared according to the following recipe: 6 mass% stearin, 0.3 mass% triethanolamine, 5 mass% bleach, 0.5 mass% blood plasma extract, 71.2 mass% water, 15 mass% kaolin and 2 mass% Titanium dioxide. The blood plasma extract and the bleach are dissolved in part of the water with stirring. The stearin is melted at 75 ° C and added together with the mixture of the remaining water with the triethanolamine with vigorous stirring at 80 ° C. The mixture is cooled to 35 ° C. with stirring, and kaolin and titanium dioxide are added at this temperature. Example 9

A face pack is prepared according to the following recipe: 5 mass% fat phase component, 5 mass% 86% glycerol, 23 mass% 96% ethyl alcohol, 2 mass5 blood plasma extract, 0.1 mass% triethanolamine, 0.2 mass% fragrance and 64.7 Mass% consistency. In the latter, the blood plasma extract is dissolved and the other substances are added. Example 10

A face cream is prepared in two phases. The first phase contains 16 mass% fat phase component and 13 mass% emulsifier, while the second phase consists of 5 mass% 1,2-propylene glycol, 61 mass% water and 5 mass% blood plasma extract. The pH of the aqueous phase is adjusted to 3.7-6.5. Both phases are heated to 75-80 ° C and then mixed together.

Example 11 From 30% by mass of lanolin, 51% by mass of polybutene, 4% by mass

Paraffin wax, 9% by mass of dye, 5% by mass of blood plasma extract and 1% by mass of flavoring agents is used to produce lip gloss by melting the materials at 80-90 ° C, homogenizing them and then filling them into cans at 50-60 ° C. Example 12

Eye shadow is prepared from two phases. The first contains 10% by mass of stearic acid. 10 mass% iron oxide, 3.3 mass% isopropyl myristate, 0.2 mass% preservative and 2 mass% emulsifier, the second consists of 3.3 mass% triethanolamine, 10 mass% magnesium aluminum silicate, 7.5 mass% film former, 2.5 Mass% 1,2-propanediol, 0.2 mass% preservative, the rest is ion-free water. Both phases are heated to about 75 ° C, then the aqueous phase is emulsified in the fat phase with slow stirring. 5% by mass of dye and 1% by mass of blood plasma extract are added to the cream obtained.

The examples given show that a wide variety of skin care cosmetics can be produced according to the invention. In the examples, the blood plasma extract means the desalted extract produced by ultrafiltration. All of the products described had an excellent effect and proved the existence of the advantages already explained in practice.

The optimum compositions were given in the examples. It is known in the cosmetic industry that the conditions do not change very much if the proportion of a component is changed to a small extent, for example by +10%.

Claims

1. Skin care products, in particular in the form of bath products, creams, sunscreens, lip gloss or eyeshadow, by virtue of the fact that it contains, as an active ingredient, blood plasma extract obtained from slaughterhouse blood in an amount of at least 0.3% by mass and at most 6% by mass.

2. Skin care product according to claim 1, characterized g e k e nn z e i c hn e t that the salt concentration in the blood plasma extract is at most 6%.

3 «Skin care product according to claim 2, characterized in that the residues derived from the anticoagulant added to the slaughterhouse blood make up a maximum of 60% of the permissible salt content.

4. Skin care product according to one of claims 1-3, characterized g e k e nn z e i c hn e t that the protein composition of the blood plasma extract is in line with the protein composition of the blood plasma and the blood plasma extract contains at least 60% protein. 5. A process for the preparation of a skin care product according to any one of claims 1-4, in the form of a cream bath, characterized in that a first phase of 50% by weight sodium lauryl ether sulfate as a surface-active substance, 1% by weight perfume, 1% by weight refatting agent and a second phase from 42,

5 mass% distilled water, 3 mass% sodium chloride and 3 mass% blood plasma extract is prepared, and after all components have gone into solution, the first phase is dissolved in the second, and the amounts of each component with an accuracy of + 10% of specified values are observed.

6. A process for the preparation of a skin care product according to any one of claims 1-4, in the form of a shower bath, characterized in that a composition of 40% by mass of surface-active substance, preferably Na% trium lauryl ether sulfate, 20% by weight betaine derivative, 5% by mass

Fatty acid diethamide, 0.5 mass% perfume, 0.5 mass% preservative, 2 mass% blood plasma extract and 32 mass% water is used, first the blood plasma extract in water is swollen and after warming up the remaining components are added to the water, the mass is cooled with stirring and the fragrances are added at about 30 ° C, and the amounts of the individual components are maintained with an accuracy of +10% of the stated values.

7. A method for producing a skin care product according to any one of claims 1-4, in the form of sunscreen milk, characterized geke nn zeic hn et that two phases are prepared, the first of which based on the end product 6 mass% emulsifier, 3 mass% isopropyl myristate .8 mass%

Paraffin oil, 0.5% by mass of cetyl alcohol and 2% by mass of light protection against UV radiation, the second 1% by mass of water-soluble lipid-replenishing agent, 1% by mass of blood plasma extract, 0.4% by mass of propylene glycol and 5% by mass of preservative as well as 73.1% by mass of distilled water contains, the blood plasma extract is swollen in water, then the substances of the second phase are mixed and both phases are heated separately to 70-75 ° C, the first phase is added to the second with intensive stirring, the mass is slowly stirred to 30-35 ° C cooled and at this temperature fragrance is added in an amount of 0.2% by mass, and the amounts of the individual components are maintained with an accuracy of +10% of the stated values.

8. A method for producing a skin care product according to any one of claims 1-4, in the form of sun protection foam, characterized geke nn zeic hn et that two phases are prepared, of which the first 10 mass% emulsifier and 2.5 mass% fat phase component and second 70.7 mass% distilled water, 1 mass% blood plasma extract, 5 mass% propylene glycol and 0.3 mass% preservative, the blood plasma extract is swollen in water and mixed with the other components of the second phase, the two phases separately from each other to about 75 ° C are heated, then the first phase is poured into the second and the system is emulsified, 0.5% by mass fragrances are added with slow stirring at about 40 ° C, the finished mass in a mass ratio of 85:15 filled with propellant in spray containers and the quantities of the individual components with a Accuracy of +10% of the specified values are observed.

9. A method for producing a skin care product according to any one of claims 1-4, in the form of after-sun lotion, characterized in that two phases are prepared, the first of which consists of 15% by weight of ethyl alcohol and 0.5% by weight of fragrance and 3.5% by mass of refatting agent and the second consisting of 67% by weight of distilled water, 1% by weight of D-panthenol, 1% by weight of blood plasma extract, 2% by mass of hydrating additives, 5% by weight of an extract which contracts the pores and 5% by weight of chamomile distillate, the phases are mixed and homogenized and the quantities of the individual components are observed with an accuracy of +10% of the specified values.

10. A method for producing a skin care product according to any one of claims 1-4, in the form of a personal care product, characterized in that two phases are prepared, the first of which consists of 7.5% by mass of emulsifier and 45% by mass of paraffin oil and the second consists of 46.75% by mass of distilled water and 0.5% by mass of blood plasma extract, the two phases are heated separately to about 70 ° C., by pouring the second phase into the first, an emulsion is prepared with slow stirring at 30-35 ° C. cooled and mixed with fragrance in an amount of 0.25% by mass, and the amounts of the individual components are maintained with an accuracy of +10% of the stated values.

11. A method for producing a skin care product according to any one of claims 1-4, in the form of a night cream, characterized geke nn zeic hn et that two phases are prepared, the first of which 25% by mass emulsifier, 5% by mass isopropyl myristate and 8% by mass % Paraffin oil and the second consisting of 48.5 mass% distilled water, 5.5 mass% propylene glycol, 2 mass% hydrating additives, 0.5 mass% magnesium sulfate and 5 mass% blood plasma extract, the two phases separately heated to about 70 ° C are poured into the first phase with rapid stirring, the mixture is cooled to about 35 ° C. with slow stirring and fragrance is added at this temperature in an amount of 0.5% by mass, and the amounts of the individual Components with an accuracy of + 10% of the specified values are observed.

12. A process for the production of a skin care product according to any one of claims 1-4, in the form of a face pack, characterized in that a composition consisting of 6% by weight of stearin, 0.3% by weight of triethanolamine, 5% by weight of bleach, 5 mass% blood plasma extract, 71.2 mass% water, 15 mass% kaolin and 2 mass% titanium dioxide, the blood plasma extract and the bleaching agent are dissolved in part of the water, the stearin melted at about 75 C and together with the mixture of remaining water with the triethanolamine added with vigorous stirring at about 80 ° C. and then the mass is cooled to about 35 ° C., kaolin and titanium dioxide are added at this temperature and the amounts of the components are maintained with an accuracy of +10% of the stated values.

13. A method for producing a skin care product according to any one of claims 1-4, in the form of a face pack, characterized in that a composition consisting of 5 mass% fat phase component, 5

Mass% 86% glycerol, 23 mass% 96% ethyl alcohol, 2 mass% blood plasma extract, 0.1 mass% triethanolamine, 0.2 mass% fragrance and 64.7 mass% consistency agent and the blood plasma extract is swollen in the latter, which added to other components and the quantities of the individual components are maintained with an accuracy of +10% of the specified values.

14. A method for producing a skin care product according to any one of claims 1-4, in the form of a face cream, characterized in that two phases are prepared, one of which consists of 16% by mass fat phase component and 13% by mass emulsifier, the other from 5 Mass% 1,2-propylene glycol, 61 mass% water and 5 mass% blood plasma extract, the pH of the aqueous phase is adjusted to 3.7-6.5, both phases heated to 75-80 ° C, mixed together and the quantities of the individual components are maintained with an accuracy of +10% of the specified values.

15. A method for producing a skin care product according to any one of claims 1-4, in the form of lip gloss, characterized geke nn zeic hn et that 30 mass% lanolin, 51 mass% polybutene, 4 mass% paraffin wax, 9 mass% dye, 5 mass % Blood plasma extract and 1 mass% flavorings melted at 80-90 ° C, homogenized with each other and the amounts of the individual components are maintained with an accuracy of + 10% of the stated values.

16. A method for producing a skin care product according to any one of claims 1-4, in the form of eyeshadow, characterized geke nn zeic hn et that two phases are prepared, the first of which 10% by weight stearic acid, 10% by weight iron oxide, 3, 3 mass% isopropyl myristate, 0.2 mass% preservative and 2 mass% emulsifier, the second of 3.3 mass% triethanolamine, 10 mass% magnesium aluminum silicate, 7.5 mass% film former, 2.5 mass% 1,2-propanediol, 0.2% by mass of preservative and in the remaining part consists of ion-free water, both phases are heated to about 75 ° C., then, with slow stirring, the aqueous phase in the fat phase is emulsified, 5% by mass of dye and 1% by mass of blood plasma extract is obtained from the cream obtained added and the quantities of the individual components are maintained with an accuracy of +10% of the specified values.