HU188367B - Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof - Google Patents
Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof Download PDFInfo
- Publication number
- HU188367B HU188367B HU833061A HU306183A HU188367B HU 188367 B HU188367 B HU 188367B HU 833061 A HU833061 A HU 833061A HU 306183 A HU306183 A HU 306183A HU 188367 B HU188367 B HU 188367B
- Authority
- HU
- Hungary
- Prior art keywords
- chloro
- acid
- methylene
- oxytetracycline
- deoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/14—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU833061A HU188367B (en) | 1983-09-02 | 1983-09-02 | Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof |
| DE19843431009 DE3431009A1 (de) | 1983-09-02 | 1984-08-23 | Verfahren zur herstellung von 6-demethyl-6-desoxy-6-methylen-5-oxytetracyclin und dessen 11a-chlorderivat |
| IT8467863A IT1207343B (it) | 1983-09-02 | 1984-08-30 | 11a cloro derivato procedimento per la preparazione della 6 demetil 6 deossi 6 metilen5 ossitetraciclina e del relativo |
| KR1019840005370A KR910004668B1 (ko) | 1983-09-02 | 1984-08-31 | 6-데메틸-6-데옥시-6-메틸렌-5-옥시테트라 싸이클린 및 이의 IIa-클로로 유도체를 제조하는 방법 |
| JP59180882A JPS6094950A (ja) | 1983-09-02 | 1984-08-31 | ６−デメチル−６−デオキシ−６−メチレン−５−オキシテトラサイクリンおよびその１１ａ−クロロ−誘導体の製造方法 |
| US06/646,574 US4659515A (en) | 1983-09-02 | 1984-08-31 | Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof |
| PL1984249429A PL143307B1 (en) | 1983-09-02 | 1984-08-31 | Process for preparing 6-demethyl-6-desoxy-6-mtehylene-5-oxytetracycyline and its 11 a -chloroderivatives |
| BG8466763A BG44707A3 (US20030204162A1-20031030-M00001.png) | 1983-09-02 | 1984-08-31 | |
| GB08422041A GB2145722B (en) | 1983-09-02 | 1984-08-31 | Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11a-chloro-derivative thereof |
| FR8413504A FR2551435B1 (fr) | 1983-09-02 | 1984-08-31 | Procede de preparation de la 6-demethyl-6-deoxy-6-methylene-5-oxytetracycline et de son derive 11a-chloro |
| DD84266854A DD219186A5 (de) | 1983-09-02 | 1984-08-31 | Verfahren zur herstellung von 6-demethyl-6-desoxy-6-methylen-5-oxytetracyclin und dessen 11a-chlorderivaten |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU833061A HU188367B (en) | 1983-09-02 | 1983-09-02 | Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT35632A HUT35632A (en) | 1985-07-29 |
| HU188367B true HU188367B (en) | 1986-04-28 |
Family
ID=10962342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU833061A HU188367B (en) | 1983-09-02 | 1983-09-02 | Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof |
Country Status (11)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686634A (en) * | 1994-07-01 | 1997-11-11 | Pfizer, Inc. | Process for producing 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11A-chlorotetracycline |
| CN104163773B (zh) * | 2013-08-30 | 2016-04-27 | 郑州后羿制药有限公司 | 一种四环素的精制方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB887671A (en) * | 1958-03-05 | 1962-01-24 | American Cyanamid Co | Preparation of members of the tetracycline series |
| US2984686A (en) * | 1960-12-19 | 1961-05-16 | Pfizer & Co C | 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines |
| FR1430859A (US20030204162A1-20031030-M00001.png) * | 1960-05-23 | 1966-05-25 | ||
| US3842123A (en) * | 1969-08-08 | 1974-10-15 | L Bernardi | Methylenetetracycline formate ester |
| BE755678R (fr) * | 1969-09-04 | 1971-03-03 | Farmaceutici Italia | Esters de la methylenetetracycline et procede de leur fabrication |
| CA942743A (en) * | 1970-07-03 | 1974-02-26 | Ivan Villax | Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines |
| FR2136137A5 (en) * | 1971-04-05 | 1972-12-22 | Pliva Pharm & Chem Works | Tetracycline derivs prepn - by bromination followed by dehydration |
| GB1333900A (en) * | 1971-07-08 | 1973-10-17 | Farmaceutici Italia | 6-deimethyl-6-deoxytetracycline |
| ATA571275A (de) * | 1974-08-09 | 1976-06-15 | Pliva Pharm & Chem Works | Verfahren zur herstellung von 11a-chlor-6-methylen-5-hydroxy-tetracyclin-p-toluolsulfonat |
-
1983
- 1983-09-02 HU HU833061A patent/HU188367B/hu not_active IP Right Cessation
-
1984
- 1984-08-23 DE DE19843431009 patent/DE3431009A1/de active Granted
- 1984-08-30 IT IT8467863A patent/IT1207343B/it active
- 1984-08-31 BG BG8466763A patent/BG44707A3/xx unknown
- 1984-08-31 US US06/646,574 patent/US4659515A/en not_active Expired - Fee Related
- 1984-08-31 KR KR1019840005370A patent/KR910004668B1/ko not_active IP Right Cessation
- 1984-08-31 GB GB08422041A patent/GB2145722B/en not_active Expired
- 1984-08-31 FR FR8413504A patent/FR2551435B1/fr not_active Expired
- 1984-08-31 DD DD84266854A patent/DD219186A5/de not_active IP Right Cessation
- 1984-08-31 PL PL1984249429A patent/PL143307B1/pl unknown
- 1984-08-31 JP JP59180882A patent/JPS6094950A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2551435B1 (fr) | 1989-01-20 |
| JPH0344066B2 (US20030204162A1-20031030-M00001.png) | 1991-07-04 |
| DE3431009A1 (de) | 1985-03-21 |
| JPS6094950A (ja) | 1985-05-28 |
| US4659515A (en) | 1987-04-21 |
| DD219186A5 (de) | 1985-02-27 |
| DE3431009C2 (US20030204162A1-20031030-M00001.png) | 1990-07-26 |
| FR2551435A1 (fr) | 1985-03-08 |
| HUT35632A (en) | 1985-07-29 |
| BG44707A3 (US20030204162A1-20031030-M00001.png) | 1989-01-16 |
| GB2145722A (en) | 1985-04-03 |
| PL143307B1 (en) | 1988-02-29 |
| GB2145722B (en) | 1987-07-08 |
| GB8422041D0 (en) | 1984-10-03 |
| KR850002457A (ko) | 1985-05-13 |
| PL249429A1 (en) | 1985-05-07 |
| KR910004668B1 (ko) | 1991-07-09 |
| IT8467863A0 (it) | 1984-08-30 |
| IT1207343B (it) | 1989-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |