HU188173B - Process for preparing new carbacyclins and pharmaceutical compositions containing such compounds - Google Patents
Process for preparing new carbacyclins and pharmaceutical compositions containing such compounds Download PDFInfo
- Publication number
- HU188173B HU188173B HU821645A HU164582A HU188173B HU 188173 B HU188173 B HU 188173B HU 821645 A HU821645 A HU 821645A HU 164582 A HU164582 A HU 164582A HU 188173 B HU188173 B HU 188173B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- hydroxymethyl
- decarboxy
- compound
- tetradehydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/12—Alcohols containing rings other than six-membered aromatic rings containing five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Drawers Of Furniture (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813121155 DE3121155A1 (de) | 1981-05-22 | 1981-05-22 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU188173B true HU188173B (en) | 1986-03-28 |
Family
ID=6133385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU821645A HU188173B (en) | 1981-05-22 | 1982-05-21 | Process for preparing new carbacyclins and pharmaceutical compositions containing such compounds |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4497830A (en, 2012) |
| EP (1) | EP0069692B1 (en, 2012) |
| JP (1) | JPS57206655A (en, 2012) |
| AT (1) | ATE32705T1 (en, 2012) |
| AU (1) | AU559925B2 (en, 2012) |
| CA (1) | CA1223582A (en, 2012) |
| CS (1) | CS226448B2 (en, 2012) |
| DD (1) | DD202528A5 (en, 2012) |
| DE (2) | DE3121155A1 (en, 2012) |
| DK (1) | DK152750C (en, 2012) |
| ES (1) | ES8304056A1 (en, 2012) |
| FI (1) | FI821824A7 (en, 2012) |
| GR (1) | GR82685B (en, 2012) |
| HU (1) | HU188173B (en, 2012) |
| IE (1) | IE53888B1 (en, 2012) |
| IL (1) | IL65847A0 (en, 2012) |
| MX (1) | MX155864A (en, 2012) |
| NO (1) | NO155536C (en, 2012) |
| NZ (1) | NZ200633A (en, 2012) |
| PH (1) | PH20454A (en, 2012) |
| YU (1) | YU109082A (en, 2012) |
| ZA (1) | ZA823551B (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190964A (en) * | 1978-04-03 | 1993-03-02 | Schering Aktiengesellschaft | 5-fluorocarbacyclins, their preparation and pharmaceutical use |
| CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3306123A1 (de) * | 1983-02-18 | 1984-09-06 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| CA1241324A (en) * | 1984-03-08 | 1988-08-30 | Paul A. Aristoff | Interphenylene carbacyclin derivatives |
| US5801200A (en) * | 1984-03-19 | 1998-09-01 | The Picower Institute For Medical Research | Methods and materials for the diagnosis and treatment of conditions such as stroke |
| DE69019431T2 (de) * | 1989-07-27 | 1995-09-14 | Ueno Seiyaku Oyo Kenkyujo Kk | Verwendung von 15-Keto-Prostansäure-Derivaten zur Herstellung eines Medikaments für die Verbesserung der Ausscheidung des Kaliumions. |
| DE4104606C1 (en, 2012) * | 1991-02-12 | 1992-10-15 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032576A (en, 2012) * | 1976-01-08 | 1977-06-28 | ||
| JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
| GB2038333B (en) * | 1978-01-26 | 1982-10-06 | Erba Farmitalia | 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| US4238414A (en) * | 1978-02-13 | 1980-12-09 | The Upjohn Company | 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds |
| JPS54119441A (en) * | 1978-03-09 | 1979-09-17 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative |
| DE2912409A1 (de) * | 1978-03-31 | 1979-10-11 | Ono Pharmaceutical Co | 6,9-methano-pgi tief 2 -analoge |
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| US4306076A (en) * | 1980-04-23 | 1981-12-15 | The Upjohn Company | Inter-phenylene CBA compounds |
| US4349689A (en) * | 1980-12-22 | 1982-09-14 | The Upjohn Company | Methano carbacyclin analogs |
-
1981
- 1981-05-22 DE DE19813121155 patent/DE3121155A1/de not_active Ceased
-
1982
- 1982-05-14 PH PH27303A patent/PH20454A/en unknown
- 1982-05-17 NZ NZ200633A patent/NZ200633A/en unknown
- 1982-05-19 AT AT82730069T patent/ATE32705T1/de not_active IP Right Cessation
- 1982-05-19 EP EP82730069A patent/EP0069692B1/de not_active Expired
- 1982-05-19 DE DE8282730069T patent/DE3278159D1/de not_active Expired
- 1982-05-19 DD DD82239993A patent/DD202528A5/de unknown
- 1982-05-19 CA CA000403276A patent/CA1223582A/en not_active Expired
- 1982-05-20 GR GR68208A patent/GR82685B/el unknown
- 1982-05-21 JP JP57085082A patent/JPS57206655A/ja active Granted
- 1982-05-21 ES ES512441A patent/ES8304056A1/es not_active Expired
- 1982-05-21 IL IL65847A patent/IL65847A0/xx unknown
- 1982-05-21 FI FI821824A patent/FI821824A7/fi not_active Application Discontinuation
- 1982-05-21 CS CS823764A patent/CS226448B2/cs unknown
- 1982-05-21 HU HU821645A patent/HU188173B/hu unknown
- 1982-05-21 YU YU01090/82A patent/YU109082A/xx unknown
- 1982-05-21 ZA ZA823551A patent/ZA823551B/xx unknown
- 1982-05-21 DK DK230082A patent/DK152750C/da not_active IP Right Cessation
- 1982-05-21 NO NO821693A patent/NO155536C/no unknown
- 1982-05-21 IE IE1218/82A patent/IE53888B1/en unknown
- 1982-05-24 MX MX192833A patent/MX155864A/es unknown
- 1982-05-24 US US06/381,609 patent/US4497830A/en not_active Expired - Fee Related
- 1982-05-24 AU AU84072/82A patent/AU559925B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NO821693L (no) | 1982-11-23 |
| JPH0368849B2 (en, 2012) | 1991-10-30 |
| IL65847A0 (en) | 1982-08-31 |
| NO155536C (no) | 1987-04-15 |
| DE3278159D1 (en) | 1988-04-07 |
| DK152750C (da) | 1988-10-03 |
| NZ200633A (en) | 1986-08-08 |
| DK230082A (da) | 1982-11-23 |
| ES512441A0 (es) | 1983-03-01 |
| DK152750B (da) | 1988-05-09 |
| ZA823551B (en) | 1983-03-30 |
| CA1223582A (en) | 1987-06-30 |
| PH20454A (en) | 1987-01-14 |
| YU109082A (en) | 1984-12-31 |
| NO155536B (no) | 1987-01-05 |
| DD202528A5 (de) | 1983-09-21 |
| AU8407282A (en) | 1982-11-25 |
| IE53888B1 (en) | 1989-04-12 |
| US4497830A (en) | 1985-02-05 |
| EP0069692B1 (de) | 1988-03-02 |
| FI821824A0 (fi) | 1982-05-21 |
| CS226448B2 (en) | 1984-03-19 |
| ES8304056A1 (es) | 1983-03-01 |
| ATE32705T1 (de) | 1988-03-15 |
| MX155864A (es) | 1988-05-13 |
| FI821824A7 (fi) | 1982-11-23 |
| DE3121155A1 (de) | 1982-12-09 |
| AU559925B2 (en) | 1987-03-26 |
| JPS57206655A (en) | 1982-12-18 |
| EP0069692A1 (de) | 1983-01-12 |
| IE821218L (en) | 1982-11-22 |
| GR82685B (en, 2012) | 1985-11-25 |
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