HRP970714B1 - Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a - Google Patents

Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a

Info

Publication number
HRP970714B1
HRP970714B1 HR970714A HRP970714A HRP970714B1 HR P970714 B1 HRP970714 B1 HR P970714B1 HR 970714 A HR970714 A HR 970714A HR P970714 A HRP970714 A HR P970714A HR P970714 B1 HRP970714 B1 HR P970714B1
Authority
HR
Croatia
Prior art keywords
beta
homoerythromycin
deoxo
aza
ethenyl
Prior art date
Application number
HR970714A
Other languages
English (en)
Inventor
Kujundžić Nedjeljko
Pavlović Dina
Kobrehel Gabrijela
Lazarevski Gorjana
Kelnerić Aeeljko
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Priority to HR970714A priority Critical patent/HRP970714B1/xx
Priority to SK1777-98A priority patent/SK283163B6/sk
Priority to CZ19984311A priority patent/CZ294878B6/cs
Priority to JP10367774A priority patent/JPH11255793A/ja
Priority to DE69812059T priority patent/DE69812059T2/de
Priority to DK98124763T priority patent/DK0927722T3/da
Priority to ES98124763T priority patent/ES2195266T3/es
Priority to EP98124763A priority patent/EP0927722B1/en
Priority to SI9830432T priority patent/SI0927722T1/xx
Priority to PT98124763T priority patent/PT927722E/pt
Priority to AT98124763T priority patent/ATE234320T1/de
Priority to NO19986186A priority patent/NO312034B1/no
Priority to RU98123827/04A priority patent/RU2205185C2/ru
Priority to UA98127020A priority patent/UA58515C2/uk
Priority to CA002256017A priority patent/CA2256017C/en
Priority to PL98330616A priority patent/PL187390B1/pl
Priority to BG103045A priority patent/BG63572B1/bg
Priority to HU9803043A priority patent/HUP9803043A3/hu
Priority to CNB981240895A priority patent/CN1177858C/zh
Priority to US09/223,978 priority patent/US6071886A/en
Publication of HRP970714A2 publication Critical patent/HRP970714A2/hr
Publication of HRP970714B1 publication Critical patent/HRP970714B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR970714A 1997-12-31 1997-12-31 Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a HRP970714B1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
HR970714A HRP970714B1 (en) 1997-12-31 1997-12-31 Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
SK1777-98A SK283163B6 (sk) 1997-12-31 1998-12-22 Beta,beta-Disubstituované deriváty 9-deoxo-9a-N-aza-etenyl-9a- aza-9a-homoerytromycínu A, farmaceutický prostriedok ich obsahujúci a ich použitie
CZ19984311A CZ294878B6 (cs) 1997-12-31 1998-12-23 Beta,beta-Disubstituované deriváty 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerytromycinu A, farmaceutický prostředek je obsahující a jejich použití
JP10367774A JPH11255793A (ja) 1997-12-31 1998-12-24 ９−デオキソ−９ａ−Ｎ−エテニル−９ａ−アザ−９ａ−ホモエリスロマイシンＡのβ，β−ジ置換誘導体
DE69812059T DE69812059T2 (de) 1997-12-31 1998-12-28 Beta,beta-disubstituierte Derivate von 9-Deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A
DK98124763T DK0927722T3 (da) 1997-12-31 1998-12-28 Beta,beta-disubstituerede derivater af 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A
ES98124763T ES2195266T3 (es) 1997-12-31 1998-12-28 Derivados beta,beta-sustituidos de 9-desoxo-9a-n-etenil-9a-aza-9a-homoeritromicina a.
EP98124763A EP0927722B1 (en) 1997-12-31 1998-12-28 Beta, Beta-disubstituted derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A
SI9830432T SI0927722T1 (en) 1997-12-31 1998-12-28 Beta, Beta-disubstituted derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A
PT98124763T PT927722E (pt) 1997-12-31 1998-12-28 Derivados beta beta-dissubstituidos de 9-desoxo-9a-n-etenil-9a-aza-9aza-9a-homoeritromicina
AT98124763T ATE234320T1 (de) 1997-12-31 1998-12-28 Beta,beta-disubstituierte derivate von 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
NO19986186A NO312034B1 (no) 1997-12-31 1998-12-29 <beta>, <beta>-Disubstituerte derivater av 9-deokso-9a-N- etenyl-9a-aza-9a-homoerytromycin A
RU98123827/04A RU2205185C2 (ru) 1997-12-31 1998-12-29 β, β-ДИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 9-ДЕЗОКСО-9А-N-ЭТЕНИЛ-9А-АЗА-9А-ГОМОЭРИТРОМИЦИНА А
UA98127020A UA58515C2 (uk) 1997-12-31 1998-12-29 ДВОЗАМІЩЕНІ ПОХІДНІ 9-ДЕОКСО-9а-N-ЕТЕНІЛ-9а-АЗА-9а-ГОМОЕРИТРОМІЦИНУ А, СПОСІБ ЇХ ОТРИМАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ
CA002256017A CA2256017C (en) 1997-12-31 1998-12-29 .beta.,.beta.-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
PL98330616A PL187390B1 (pl) 1997-12-31 1998-12-30 Nowe związki beta,beta-dwupodstawione pochodne 9-dezoksy-9a-N-etenylo-9a-aza-9a-homoerytromycyny A,sposób ich wytwarzania, kompozycja farmaceutycznai zastosowanie tych pochodnych
BG103045A BG63572B1 (bg) 1997-12-31 1998-12-30 Бета,бета-дизаместени производни на 9-дезоксо-9а-n-етенил-9а-а3а-9а-хомоеритромицин а
HU9803043A HUP9803043A3 (en) 1997-12-31 1998-12-30 Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-azo-9a-homoerythromycin-a, process for preparing them and pharmaceutical compns. contg. them
CNB981240895A CN1177858C (zh) 1997-12-31 1998-12-30 9- 去氧-9a-N-乙烯基-9a-氮杂-9a-高红霉素A的β,β-二取代衍生物
US09/223,978 US6071886A (en) 1997-12-31 1998-12-31 β,β-distributed derivatives of 9-deoxo-9a-N-ethenyl-9a-aza-9a-homoerythromycin A

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR970714A HRP970714B1 (en) 1997-12-31 1997-12-31 Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a

Publications (2)

Publication Number Publication Date
HRP970714A2 HRP970714A2 (en) 1999-10-31
HRP970714B1 true HRP970714B1 (en) 2003-08-31

Family

ID=10946680

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970714A HRP970714B1 (en) 1997-12-31 1997-12-31 Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a

Country Status (20)

Country Link
US (1) US6071886A (pl)
EP (1) EP0927722B1 (pl)
JP (1) JPH11255793A (pl)
CN (1) CN1177858C (pl)
AT (1) ATE234320T1 (pl)
BG (1) BG63572B1 (pl)
CA (1) CA2256017C (pl)
CZ (1) CZ294878B6 (pl)
DE (1) DE69812059T2 (pl)
DK (1) DK0927722T3 (pl)
ES (1) ES2195266T3 (pl)
HR (1) HRP970714B1 (pl)
HU (1) HUP9803043A3 (pl)
NO (1) NO312034B1 (pl)
PL (1) PL187390B1 (pl)
PT (1) PT927722E (pl)
RU (1) RU2205185C2 (pl)
SI (1) SI0927722T1 (pl)
SK (1) SK283163B6 (pl)
UA (1) UA58515C2 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
WO1989004167A1 (en) * 1987-11-10 1989-05-18 Pfizer Inc. Antibacterial 9-deoxo-9a-allyl and propargyl-9a-aza-9a-homoerythromycin a derivatives
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Also Published As

Publication number Publication date
HUP9803043A2 (hu) 1999-08-30
CZ431198A3 (cs) 1999-07-14
JPH11255793A (ja) 1999-09-21
NO986186L (no) 1999-07-01
NO312034B1 (no) 2002-03-04
CN1177858C (zh) 2004-12-01
CN1229085A (zh) 1999-09-22
PT927722E (pt) 2003-07-31
CA2256017A1 (en) 1999-06-30
SK283163B6 (sk) 2003-03-04
PL187390B1 (pl) 2004-06-30
CA2256017C (en) 2004-04-27
EP0927722A1 (en) 1999-07-07
DE69812059D1 (de) 2003-04-17
PL330616A1 (en) 1999-07-05
EP0927722B1 (en) 2003-03-12
ES2195266T3 (es) 2003-12-01
HRP970714A2 (en) 1999-10-31
BG63572B1 (bg) 2002-05-31
UA58515C2 (uk) 2003-08-15
CZ294878B6 (cs) 2005-04-13
NO986186D0 (no) 1998-12-29
HUP9803043A3 (en) 1999-12-28
SI0927722T1 (en) 2003-08-31
BG103045A (en) 1999-09-30
HU9803043D0 (en) 1999-02-01
DK0927722T3 (da) 2003-05-19
US6071886A (en) 2000-06-06
SK177798A3 (en) 2000-06-12
RU2205185C2 (ru) 2003-05-27
DE69812059T2 (de) 2004-03-04
ATE234320T1 (de) 2003-03-15

Similar Documents

Publication Publication Date Title
BG103945A (en) Derivatives of 4&#34;-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
AU4869690A (en) Pyrazolopyridine compound and processes for preparation thereof
BG103969A (en) C-4&#34;-substituted macrolide derivatives
AU1398892A (en) Pyrazolopyridine compound and processes for preparation thereof
DK0992509T3 (da) Nye makrolid-derivater
HRP931480A2 (en) 9a-N-(N&#39;-CARBAMONYL) and 9a-N-(N&#39;-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP930014A2 (en) 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
CA2300289A1 (en) A pharmaceutical composition active in reducing production of mcp-1 protein
HU9803043D0 (en) Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-azo-9a-homoerythromycin-a
PL322862A1 (en) Novel compounds 9-n-ethenylic derivtives of 9(s)-erythromycilamine
AP9801235A0 (en) Erythromycin derivatives.
BG103985A (en) Multicyclic derivatives of erythromycin
MXPA99003849A (es) Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.
EE05219B1 (et) Amkomtsiin, meetod selle valmistamiseks, kasutamine ravimina ja seda sisaldav farmatseutiline kompositsioon
CA2056823A1 (en) Derivatives of 10,11,12,13-Tetrahydrodesmycosin Processes for Preparation, and Use Thereof in Pharmaceuticals

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

PPPP Transfer of rights

Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20071024

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20090101