HRP930353A2 - Acetic acid derivatives - Google Patents
Acetic acid derivativesInfo
- Publication number
- HRP930353A2 HRP930353A2 HR930353A HRP930353A HRP930353A2 HR P930353 A2 HRP930353 A2 HR P930353A2 HR 930353 A HR930353 A HR 930353A HR P930353 A HRP930353 A HR P930353A HR P930353 A2 HRP930353 A2 HR P930353A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- phenyl
- group
- conh
- coo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH77590 | 1990-03-09 | ||
CH11591 | 1991-01-17 | ||
YU41791A YU41791A (sh) | 1990-03-09 | 1991-03-08 | Derivati sirćetne kiseline |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP930353A2 true HRP930353A2 (en) | 1996-06-30 |
Family
ID=25683562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR930353A HRP930353A2 (en) | 1990-03-09 | 1993-03-12 | Acetic acid derivatives |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0445796B1 (fr) |
JP (1) | JP2501252B2 (fr) |
KR (1) | KR910016765A (fr) |
AT (1) | ATE167482T1 (fr) |
BR (1) | BR9100941A (fr) |
CA (1) | CA2037153A1 (fr) |
DE (1) | DE59109010D1 (fr) |
ES (1) | ES2118067T3 (fr) |
FI (1) | FI911148A (fr) |
HR (1) | HRP930353A2 (fr) |
HU (1) | HUT56582A (fr) |
IE (1) | IE910778A1 (fr) |
IL (1) | IL97401A (fr) |
IS (1) | IS3681A7 (fr) |
MC (1) | MC2221A1 (fr) |
MX (1) | MX24811A (fr) |
MY (1) | MY105375A (fr) |
NO (1) | NO301167B1 (fr) |
NZ (1) | NZ237269A (fr) |
PH (1) | PH30963A (fr) |
PT (1) | PT96983B (fr) |
RU (1) | RU2072359C1 (fr) |
TW (1) | TW219928B (fr) |
UY (1) | UY23197A1 (fr) |
ZA (1) | ZA911534B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5332726A (en) * | 1989-09-29 | 1994-07-26 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic peptides and pseudopeptides |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5545658A (en) * | 1991-03-26 | 1996-08-13 | Hoffman-La Roche Inc. | Amino acid derivatives |
UA39849C2 (uk) * | 1991-03-26 | 2001-07-16 | Ф.Хоффманн-Ля Рош Аг | ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ |
WO1992018117A1 (fr) * | 1991-04-11 | 1992-10-29 | Rhone-Poulenc Rorer International (Holdings), Inc. | Derives peptidiques et pseudopeptidiques antithrombotiques |
AU662522B2 (en) * | 1991-05-13 | 1995-09-07 | Fujisawa Pharmaceutical Co., Ltd. | New peptide compound and a process for the preparation thereof |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
ATE230398T1 (de) * | 1991-10-15 | 2003-01-15 | Searle & Co | Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe |
US5254573A (en) * | 1991-10-15 | 1993-10-19 | Monsanto Company | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
US5625093A (en) * | 1991-10-15 | 1997-04-29 | G. D. Searle & Co. | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors |
WO1993012103A1 (fr) * | 1991-12-13 | 1993-06-24 | G.D. Searle & Co. | Lactones d'amidines de phenyle utiles comme inhibiteurs d'agregation plaquettaire |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
WO1993018058A1 (fr) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Imitateurs peptidiques utiles comme inhibiteurs de l'agregation plaquettaire |
HUT63609A (en) * | 1992-03-10 | 1993-09-28 | Sandoz Ag | Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds |
WO1994000424A1 (fr) * | 1992-06-25 | 1994-01-06 | G.D. Searle & Co. | Acides alcanoiques de phenyle amidine et lactones utiles comme inhibiteurs de l'agregation plaquettaire |
US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US5354738A (en) * | 1992-09-04 | 1994-10-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
AU675689B2 (en) * | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
WO1994014775A1 (fr) * | 1992-12-29 | 1994-07-07 | Smithkline Beecham Corporation | Composes inhibant l'aggregation des plaquettes |
DE4301747A1 (de) * | 1993-01-23 | 1994-07-28 | Cassella Ag | Substituierte Aminoverbindungen, ihre Herstellung und ihre Verwendung |
US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
US5409939A (en) * | 1993-02-12 | 1995-04-25 | G. D. Searle & Co. | Phenyl amidine thio derivatives useful as platelet aggregation inhibitors |
US6268380B1 (en) * | 1993-02-19 | 2001-07-31 | G. D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
AU6267894A (en) * | 1993-03-02 | 1994-09-26 | G.D. Searle & Co. | N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors |
ZW4194A1 (en) * | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic compounds |
ES2159798T3 (es) * | 1993-03-29 | 2001-10-16 | Astrazeneca Ab | Derivados heterociclicos como inhibidores de la agregacion plaquetaria. |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5612355A (en) * | 1993-06-23 | 1997-03-18 | G. D. Searle & Co. | Phenyl amidine lactones useful as platelet aggregation inhibitors |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
US5430043A (en) * | 1993-08-24 | 1995-07-04 | G. D. Searle & Co. | Platelet aggregation inhibitors |
EP1106606A3 (fr) * | 1993-09-22 | 2003-10-22 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés de N-(3-pipéridinylcarbonyl)-bêta-alanine en tant qu'antagonistes du facteur d'agrégation plaquettaire |
US5780590A (en) * | 1993-10-15 | 1998-07-14 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5789595A (en) * | 1994-11-01 | 1998-08-04 | Terumo Kabushiki Kaisha | Tetrahydroisoquinoline derivative and medical preparation containing the same |
JPH10511357A (ja) * | 1994-12-22 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | フィブリノゲン受容体拮抗物質 |
JP3874438B2 (ja) * | 1994-12-28 | 2007-01-31 | 新日本製鐵株式会社 | 置換β−アミノ酸残基を有するフィブリノーゲン受容体拮抗物質およびそれを有効成分とする医薬製剤 |
JP3874455B2 (ja) * | 1996-06-27 | 2007-01-31 | 新日本製鐵株式会社 | フィブリノーゲン受容体拮抗物質およびそれを有効成分とする医薬製剤 |
AU4954296A (en) * | 1995-03-17 | 1996-10-08 | Fujisawa Pharmaceutical Co., Ltd. | N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iia antagonists and fibrinogen-blood platelets binding inhibitors |
US5811398A (en) * | 1995-04-11 | 1998-09-22 | G. D. Searle & Co. | Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues |
US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
US5942544A (en) * | 1996-02-22 | 1999-08-24 | Dupont Pharmaceuticals Company | α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors |
DK0892780T3 (da) * | 1996-02-22 | 2003-03-03 | Bristol Myers Squibb Pharma Co | m-Amidinophenylanaloger som faktor Xa-inhibitorer |
CA2248809A1 (fr) * | 1996-03-13 | 1997-09-18 | Fujisawa Pharmaceutical Co., Ltd. | N-[(r)-1-{3-(4-piperidyl)propionyl-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine utilisee comme antagoniste du recepteur du fibrinogene |
US5872122A (en) * | 1997-10-16 | 1999-02-16 | Monsanto Company | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation |
US6066651A (en) * | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
EP0928790B1 (fr) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Dérivés du thiazole |
US6100282A (en) * | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
US6037365A (en) * | 1998-09-25 | 2000-03-14 | G.D. Searle & Co. | Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation |
ATE266012T1 (de) | 1998-10-22 | 2004-05-15 | Hoffmann La Roche | Thiazole derivate |
AU2210400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using a cyclooxygenase-2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia |
GB0019008D0 (en) * | 2000-08-04 | 2000-09-27 | Astrazeneca Ab | Therapeutic compounds |
EP1193248A1 (fr) * | 2000-09-30 | 2002-04-03 | Aventis Pharma Deutschland GmbH | Dérivés de malonamide et d'ester malonamique possédant une activité antithrombotique, leur préparation et leur emploi |
US7317019B2 (en) | 2003-08-21 | 2008-01-08 | Bristol Myers Squibb Co. | N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3577700D1 (de) * | 1984-11-30 | 1990-06-21 | Shosuke Okamoto | Lysinderivat und proteinase-inhibitor. |
-
1991
- 1991-02-26 CA CA002037153A patent/CA2037153A1/fr not_active Abandoned
- 1991-02-27 TW TW080101540A patent/TW219928B/zh active
- 1991-03-01 ZA ZA911534A patent/ZA911534B/xx unknown
- 1991-03-01 NZ NZ237269A patent/NZ237269A/xx unknown
- 1991-03-04 IL IL9740191A patent/IL97401A/en not_active IP Right Cessation
- 1991-03-04 HU HU91186A patent/HUT56582A/hu unknown
- 1991-03-06 MC MC912175A patent/MC2221A1/fr unknown
- 1991-03-07 AT AT91103462T patent/ATE167482T1/de not_active IP Right Cessation
- 1991-03-07 JP JP3065316A patent/JP2501252B2/ja not_active Expired - Lifetime
- 1991-03-07 MX MX2481191A patent/MX24811A/es unknown
- 1991-03-07 ES ES91103462T patent/ES2118067T3/es not_active Expired - Lifetime
- 1991-03-07 FI FI911148A patent/FI911148A/fi unknown
- 1991-03-07 EP EP91103462A patent/EP0445796B1/fr not_active Expired - Lifetime
- 1991-03-07 RU SU914894657A patent/RU2072359C1/ru active
- 1991-03-07 MY MYPI91000363A patent/MY105375A/en unknown
- 1991-03-07 DE DE59109010T patent/DE59109010D1/de not_active Expired - Fee Related
- 1991-03-08 PT PT96983A patent/PT96983B/pt not_active IP Right Cessation
- 1991-03-08 KR KR1019910003736A patent/KR910016765A/ko not_active Application Discontinuation
- 1991-03-08 IE IE077891A patent/IE910778A1/en unknown
- 1991-03-08 BR BR919100941A patent/BR9100941A/pt not_active Application Discontinuation
- 1991-03-08 PH PH42106A patent/PH30963A/en unknown
- 1991-03-08 NO NO910934A patent/NO301167B1/no unknown
- 1991-03-08 UY UY23197A patent/UY23197A1/es not_active IP Right Cessation
- 1991-03-08 IS IS3681A patent/IS3681A7/is unknown
-
1993
- 1993-03-12 HR HR930353A patent/HRP930353A2/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI911148A (fi) | 1991-09-10 |
IL97401A (en) | 1995-03-15 |
EP0445796A3 (en) | 1991-10-30 |
JP2501252B2 (ja) | 1996-05-29 |
ATE167482T1 (de) | 1998-07-15 |
MY105375A (en) | 1994-09-30 |
BR9100941A (pt) | 1991-11-05 |
MC2221A1 (fr) | 1993-02-02 |
TW219928B (fr) | 1994-02-01 |
ZA911534B (en) | 1991-11-27 |
RU2072359C1 (ru) | 1997-01-27 |
NO301167B1 (no) | 1997-09-22 |
UY23197A1 (es) | 1991-09-04 |
CA2037153A1 (fr) | 1991-09-10 |
IE910778A1 (en) | 1991-09-11 |
NO910934L (no) | 1991-09-10 |
ES2118067T3 (es) | 1998-09-16 |
NO910934D0 (no) | 1991-03-08 |
JPH04217652A (ja) | 1992-08-07 |
HU910186D0 (en) | 1991-08-28 |
IS3681A7 (is) | 1991-09-10 |
EP0445796A2 (fr) | 1991-09-11 |
HUT56582A (en) | 1991-09-30 |
PH30963A (en) | 1997-12-23 |
EP0445796B1 (fr) | 1998-06-17 |
DE59109010D1 (de) | 1998-07-23 |
IL97401A0 (en) | 1992-06-21 |
PT96983A (pt) | 1991-10-31 |
FI911148A0 (fi) | 1991-03-07 |
KR910016765A (ko) | 1991-11-05 |
MX24811A (es) | 1993-11-01 |
NZ237269A (en) | 1993-05-26 |
PT96983B (pt) | 1998-07-31 |
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