HRP20250459T1 - Čvrsti oblici i kombinacijski pripravci koji sadrže inhibitor beta-laktamaze i njihove uporabe - Google Patents

Čvrsti oblici i kombinacijski pripravci koji sadrže inhibitor beta-laktamaze i njihove uporabe Download PDF

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Publication number
HRP20250459T1
HRP20250459T1 HRP20250459TT HRP20250459T HRP20250459T1 HR P20250459 T1 HRP20250459 T1 HR P20250459T1 HR P20250459T T HRP20250459T T HR P20250459TT HR P20250459 T HRP20250459 T HR P20250459T HR P20250459 T1 HRP20250459 T1 HR P20250459T1
Authority
HR
Croatia
Prior art keywords
pharmaceutical composition
composition according
crystalline form
cefepime
oxaborinine
Prior art date
Application number
HRP20250459TT
Other languages
English (en)
Croatian (hr)
Inventor
Christopher J. Burns
Daniel C. Pevear
Luigi XERRI
Timothy Henkel
Daniel Mcgarry
Lawrence Rosen
Gerald Brenner
Jean-Baptiste ARLIN
Ana FERNANDEZ CASARES
Original Assignee
VenatoRx Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VenatoRx Pharmaceuticals, Inc. filed Critical VenatoRx Pharmaceuticals, Inc.
Publication of HRP20250459T1 publication Critical patent/HRP20250459T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/027Organoboranes and organoborohydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRP20250459TT 2017-03-06 2018-03-05 Čvrsti oblici i kombinacijski pripravci koji sadrže inhibitor beta-laktamaze i njihove uporabe HRP20250459T1 (hr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762467752P 2017-03-06 2017-03-06
US201762467750P 2017-03-06 2017-03-06
US201762564990P 2017-09-28 2017-09-28
US201762564989P 2017-09-28 2017-09-28
EP18763383.9A EP3592362B1 (en) 2017-03-06 2018-03-05 Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof
PCT/US2018/020968 WO2018165048A1 (en) 2017-03-06 2018-03-05 Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof

Publications (1)

Publication Number Publication Date
HRP20250459T1 true HRP20250459T1 (hr) 2025-06-06

Family

ID=63448038

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20250459TT HRP20250459T1 (hr) 2017-03-06 2018-03-05 Čvrsti oblici i kombinacijski pripravci koji sadrže inhibitor beta-laktamaze i njihove uporabe

Country Status (16)

Country Link
US (4) US11091505B2 (https=)
EP (1) EP3592362B1 (https=)
JP (2) JP7634934B2 (https=)
KR (1) KR102603489B1 (https=)
CN (2) CN110678186A (https=)
AU (1) AU2018230991B2 (https=)
CA (1) CA3055253A1 (https=)
ES (1) ES3015371T3 (https=)
HR (1) HRP20250459T1 (https=)
IL (2) IL268981B2 (https=)
MA (1) MA47743A (https=)
MY (1) MY196966A (https=)
PH (1) PH12019502037B1 (https=)
PL (1) PL3592362T3 (https=)
SG (1) SG11201908181XA (https=)
WO (1) WO2018165048A1 (https=)

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EP3849562B1 (en) * 2018-09-12 2024-06-26 Venatorx Pharmaceuticals, Inc. Combination compositions comprising a beta-lactamase inhibitor
BR112021010095A2 (pt) 2018-11-29 2021-09-28 VenatoRx Pharmaceuticals, Inc. Composições de combinação que compreendem um inibidor de beta-lactamase e usos das mesmas

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EP3849562B1 (en) 2018-09-12 2024-06-26 Venatorx Pharmaceuticals, Inc. Combination compositions comprising a beta-lactamase inhibitor
BR112021010095A2 (pt) 2018-11-29 2021-09-28 VenatoRx Pharmaceuticals, Inc. Composições de combinação que compreendem um inibidor de beta-lactamase e usos das mesmas

Also Published As

Publication number Publication date
US11091505B2 (en) 2021-08-17
KR102603489B1 (ko) 2023-11-16
IL301591B2 (en) 2026-03-01
IL301591B1 (en) 2025-11-01
US12187752B2 (en) 2025-01-07
MY196966A (en) 2023-05-15
IL268981B2 (en) 2023-09-01
CN110678186A (zh) 2020-01-10
IL268981B1 (en) 2023-05-01
JP2023061946A (ja) 2023-05-02
AU2018230991A1 (en) 2019-09-19
BR112019018447A2 (pt) 2020-04-14
EP3592362A4 (en) 2020-09-02
PH12019502037A1 (en) 2020-03-09
KR20190117790A (ko) 2019-10-16
ES3015371T3 (en) 2025-05-05
EP3592362A1 (en) 2020-01-15
PH12019502037B1 (en) 2024-06-05
US20200010485A1 (en) 2020-01-09
SG11201908181XA (en) 2019-10-30
MA47743A (fr) 2020-01-15
AU2018230991B2 (en) 2023-07-13
WO2018165048A1 (en) 2018-09-13
EP3592362C0 (en) 2025-02-19
CA3055253A1 (en) 2018-09-13
JP2020510661A (ja) 2020-04-09
IL268981A (en) 2019-10-31
US20240101580A1 (en) 2024-03-28
PL3592362T3 (pl) 2025-06-23
EP3592362B1 (en) 2025-02-19
JP7634934B2 (ja) 2025-02-25
IL301591A (en) 2023-05-01
US20250320235A1 (en) 2025-10-16
US20220002322A1 (en) 2022-01-06
CN117398398A (zh) 2024-01-16
US11820784B2 (en) 2023-11-21

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