HRP20230595T1 - Inhibitori lizina specifične demetilaze-1 - Google Patents
Inhibitori lizina specifične demetilaze-1 Download PDFInfo
- Publication number
- HRP20230595T1 HRP20230595T1 HRP20230595TT HRP20230595T HRP20230595T1 HR P20230595 T1 HRP20230595 T1 HR P20230595T1 HR P20230595T T HRP20230595T T HR P20230595TT HR P20230595 T HRP20230595 T HR P20230595T HR P20230595 T1 HRP20230595 T1 HR P20230595T1
- Authority
- HR
- Croatia
- Prior art keywords
- optionally substituted
- thiazol
- benzonitrile
- aminopiperidin
- methyl
- Prior art date
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title claims 3
- 239000004472 Lysine Substances 0.000 title claims 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- -1 substituted Chemical class 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- OCFMGYAQRZHSCZ-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(3-hydroxy-3-methylbut-1-ynyl)-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C#CC(C)(C)O OCFMGYAQRZHSCZ-UHFFFAOYSA-N 0.000 claims 2
- HVAAKYTYLKMURM-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(3-methylimidazo[4,5-b]pyridin-6-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=C2C(=NC=1)N(C=N2)C HVAAKYTYLKMURM-UHFFFAOYSA-N 0.000 claims 2
- LIEGLPZXWIKCQW-OYRHEFFESA-N 4-[2-[(3aR,8aS)-2,3,3a,4,5,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepin-6-yl]-5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1,3-thiazol-4-yl]benzonitrile Chemical compound [H][C@@]12CNC[C@]1([H])CCN(CC2)C1=NC(=C(S1)C1=CN(CC2CC2)N=C1)C1=CC=C(C=C1)C#N LIEGLPZXWIKCQW-OYRHEFFESA-N 0.000 claims 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003053 piperidines Chemical class 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- VOBBXMCCNRNXSU-UHFFFAOYSA-N 4-[2-(1,2,3,3a,4,6,7,7a-octahydropyrrolo[3,2-c]pyridin-5-yl)-5-(1-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CN1N=CC2=C1C=CC(=C2)C1=C(N=C(S1)N1CCC2NCCC2C1)C1=CC=C(C=C1)C#N VOBBXMCCNRNXSU-UHFFFAOYSA-N 0.000 claims 1
- DZUQALOGEVWHDI-UHFFFAOYSA-N 4-[2-(1,2,3,3a,4,6,7,7a-octahydropyrrolo[3,4-c]pyridin-5-yl)-5-(1-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CN1N=CC2=C1C=CC(=C2)C1=C(N=C(S1)N1CCC2CNCC2C1)C1=CC=C(C=C1)C#N DZUQALOGEVWHDI-UHFFFAOYSA-N 0.000 claims 1
- BXZJNQWBJWOJDX-UHFFFAOYSA-N 4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepin-6-yl)-5-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1,3-thiazol-4-yl]benzonitrile Chemical compound C1NCC2C1CCN(CC2)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=NN(C=1)CC(F)(F)F BXZJNQWBJWOJDX-UHFFFAOYSA-N 0.000 claims 1
- YVYGHZOCUMQODE-UHFFFAOYSA-N 4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5-(1-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CN1N=CC2=C1C=CC(=C2)C1=C(N=C(S1)N1CCC2(CCNC2)CC1)C1=CC=C(C=C1)C#N YVYGHZOCUMQODE-UHFFFAOYSA-N 0.000 claims 1
- MVCLHSDOSZUKLP-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(1-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=C2C=NN(C2=CC=1)C MVCLHSDOSZUKLP-UHFFFAOYSA-N 0.000 claims 1
- VUXZYIFGFZLCJC-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(1-methylpyrazolo[3,4-b]pyridin-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=C2C(=NC=1)N(N=C2)C VUXZYIFGFZLCJC-UHFFFAOYSA-N 0.000 claims 1
- GBEJUPWOLJZFIG-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(1-methylpyrrolo[2,3-b]pyridin-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=C2C(=NC=1)N(C=C2)C GBEJUPWOLJZFIG-UHFFFAOYSA-N 0.000 claims 1
- WEJQYDJANZATDO-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(2-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CN1C=C2C=C(C=CC2=N1)C1=C(N=C(S1)N1CCC(N)CC1)C1=CC=C(C=C1)C#N WEJQYDJANZATDO-UHFFFAOYSA-N 0.000 claims 1
- TXYVVPAQNXJPDG-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-(3-methylimidazo[4,5-b]pyridin-6-yl)-1,3-thiazol-4-yl]-2-fluorobenzonitrile Chemical compound NC1CCN(CC1)C=1SC(=C(N=1)C1=CC(=C(C#N)C=C1)F)C=1C=C2C(=NC=1)N(C=N2)C TXYVVPAQNXJPDG-UHFFFAOYSA-N 0.000 claims 1
- KGRQUDOSXNACLK-UHFFFAOYSA-N 4-[2-(4-aminopiperidin-1-yl)-5-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1,3-thiazol-4-yl]benzonitrile Chemical compound NC1CCN(CC1)C1=NC(=C(S1)C1=CN(CC(F)(F)F)N=C1)C1=CC=C(C=C1)C#N KGRQUDOSXNACLK-UHFFFAOYSA-N 0.000 claims 1
- WENDNASXVWFXDR-UHFFFAOYSA-N 4-[2-(4-aminopiperidine-1-carbonyl)-5-(1-methylbenzimidazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CN1C=NC2=CC(=CC=C12)C1=C(N=C(S1)C(=O)N1CCC(N)CC1)C1=CC=C(C=C1)C#N WENDNASXVWFXDR-UHFFFAOYSA-N 0.000 claims 1
- MGIZMNQJAOCVPN-GOSISDBHSA-N 4-[2-[(3R)-3-aminopiperidine-1-carbonyl]-5-(1-methylbenzimidazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound N[C@H]1CN(CCC1)C(=O)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C1=CC2=C(N(C=N2)C)C=C1 MGIZMNQJAOCVPN-GOSISDBHSA-N 0.000 claims 1
- BCZXZJPTKSJCQL-QGZVFWFLSA-N 4-[2-[(3R)-3-aminopiperidine-1-carbonyl]-5-(3-methylimidazo[4,5-b]pyridin-6-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound N[C@H]1CN(CCC1)C(=O)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=C2C(=NC=1)N(C=N2)C BCZXZJPTKSJCQL-QGZVFWFLSA-N 0.000 claims 1
- BJZAFOZWSBOIEG-LJQANCHMSA-N 4-[2-[(3R)-3-aminopiperidine-1-carbonyl]-5-(4-methylphenyl)-1,3-thiazol-4-yl]benzonitrile Chemical compound CC1=CC=C(C=C1)C1=C(N=C(S1)C(=O)N1CCC[C@@H](N)C1)C1=CC=C(C=C1)C#N BJZAFOZWSBOIEG-LJQANCHMSA-N 0.000 claims 1
- RSSUIMQJXWJYPA-MRXNPFEDSA-N 4-[2-[(3R)-3-aminopiperidine-1-carbonyl]-5-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1,3-thiazol-4-yl]benzonitrile Chemical compound N[C@H]1CN(CCC1)C(=O)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=NN(C=1)CC(F)(F)F RSSUIMQJXWJYPA-MRXNPFEDSA-N 0.000 claims 1
- GWOQLHVLECDZED-LJQANCHMSA-N 4-[2-[(3R)-3-aminopiperidine-1-carbonyl]-5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1,3-thiazol-4-yl]benzonitrile Chemical compound N[C@H]1CN(CCC1)C(=O)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C=1C=NN(C=1)CC1CC1 GWOQLHVLECDZED-LJQANCHMSA-N 0.000 claims 1
- MGIZMNQJAOCVPN-SFHVURJKSA-N 4-[2-[(3S)-3-aminopiperidine-1-carbonyl]-5-(1-methylbenzimidazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound N[C@@H]1CN(CCC1)C(=O)C=1SC(=C(N=1)C1=CC=C(C#N)C=C1)C1=CC2=C(N(C=N2)C)C=C1 MGIZMNQJAOCVPN-SFHVURJKSA-N 0.000 claims 1
- HGTXJRHAUZKRJR-KDURUIRLSA-N 4-[2-[(3aR,8aS)-2,3,3a,4,5,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepin-6-yl]-5-(1-methylpyrazolo[3,4-b]pyridin-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound [H][C@@]12CNC[C@]1([H])CCN(CC2)C1=NC(=C(S1)C1=CC2=C(N=C1)N(C)N=C2)C1=CC=C(C=C1)C#N HGTXJRHAUZKRJR-KDURUIRLSA-N 0.000 claims 1
- IGAFPLDFQDDIKO-OYRHEFFESA-N 4-[2-[(3aS,8aR)-2,3,3a,4,5,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepin-6-yl]-5-(1-methylbenzimidazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound [H][C@@]12CNC[C@]1([H])CCN(CC2)C1=NC(=C(S1)C1=CC2=C(C=C1)N(C)C=N2)C1=CC=C(C=C1)C#N IGAFPLDFQDDIKO-OYRHEFFESA-N 0.000 claims 1
- XFPQLJHGYZUVNB-OYRHEFFESA-N 4-[2-[(3aS,8aR)-2,3,3a,4,5,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepin-6-yl]-5-(1-methylindazol-5-yl)-1,3-thiazol-4-yl]benzonitrile Chemical compound [H][C@@]12CNC[C@]1([H])CCN(CC2)C1=NC(=C(S1)C1=CC2=C(C=C1)N(C)N=C2)C1=CC=C(C=C1)C#N XFPQLJHGYZUVNB-OYRHEFFESA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 125000005602 azabenzimidazolyl group Chemical group 0.000 claims 1
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000005438 isoindazolyl group Chemical group 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical class NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462020886P | 2014-07-03 | 2014-07-03 | |
| EP19156976.3A EP3511319B1 (en) | 2014-07-03 | 2015-06-29 | Inhibitors of lysine specific demethylase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230595T1 true HRP20230595T1 (hr) | 2023-09-15 |
Family
ID=55019883
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220414TT HRP20220414T1 (hr) | 2014-07-03 | 2015-06-29 | Inhibitori lizin specifične demetilaze-1 |
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| WO2017013061A1 (en) | 2015-07-17 | 2017-01-26 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| CN109195593A (zh) | 2016-03-15 | 2019-01-11 | 奥莱松基因组股份有限公司 | 用于治疗实体瘤的lsd1抑制剂的组合 |
| WO2017158136A1 (en) | 2016-03-16 | 2017-09-21 | Oryzon Genomics, S.A. | Methods to determine kdm1a target engagement and chemoprobes useful therefor |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
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| SG11202000077RA (en) | 2017-08-03 | 2020-02-27 | Oryzon Genomics Sa | Methods of treating behavior alterations |
| JP2021534124A (ja) * | 2018-08-10 | 2021-12-09 | ナビール ファーマ，インコーポレイティド | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６−（４−アミノ−３−メチル−２−オキサ−８−アザスピロ［４．５］デカン−８−イル）−３−（２，３−ジクロロフェニル）−２−メチルピリミジン−４（３ｈ）−オン誘導体及び関連化合物 |
| CA3127993A1 (en) * | 2019-02-01 | 2020-08-06 | Hanmi Pharm. Co., Ltd. | Imidazopyridine derivative compounds and use of same |
| AU2020242302A1 (en) | 2019-03-20 | 2021-09-16 | Oryzon Genomics, S.A. | Methods of treating borderline personality disorder |
| WO2020188089A1 (en) | 2019-03-20 | 2020-09-24 | Oryzon Genomics, S.A. | Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat |
| EP3994280A1 (en) | 2019-07-05 | 2022-05-11 | Oryzon Genomics, S.A. | Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors |
| US11360505B2 (en) | 2020-02-11 | 2022-06-14 | Simmonds Precision Products, Inc. | Distributed network time synchronization |
| CN114105950B (zh) * | 2020-08-31 | 2022-09-06 | 南京明德新药研发有限公司 | 吡唑类化合物及其应用 |
| WO2022199662A1 (zh) * | 2021-03-24 | 2022-09-29 | 四川汇宇制药股份有限公司 | 一种多环化合物及其应用 |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| CN116102533A (zh) * | 2021-11-11 | 2023-05-12 | 中国科学院上海药物研究所 | 一种芳杂环类化合物及其应用 |
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| DE1963188A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | Neue Cyanphenyl-1,4-dihydropyridinderivate |
| AU2002214546A1 (en) * | 2000-09-29 | 2002-04-08 | Cor Therapeutics, Inc. | Bicyclic pyrimidin-4-one based inhibitors of factor xa |
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| US7652018B2 (en) | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
| PE20081803A1 (es) | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| WO2009132310A1 (en) * | 2008-04-25 | 2009-10-29 | Wisconsin Alumni Research Foundation | Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth |
| US20130096160A1 (en) | 2010-04-14 | 2013-04-18 | Secretary, Department Of Health And Human Services | Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production |
| WO2012009475A1 (en) * | 2010-07-14 | 2012-01-19 | Oregon Health & Science University | Methods of treating cancer with inhibition of lysine-specific demethylase 1 |
| SG11201405239WA (en) * | 2012-03-06 | 2014-09-26 | Lupin Ltd | Thiazole derivatives as alpha 7 nachr modulators |
| MX2016007585A (es) * | 2013-12-11 | 2016-12-16 | Celgene Quanticel Res Inc | Inhibidores de desmetilasa-1 especifica de lisina. |
| CA2939048A1 (en) * | 2014-02-14 | 2015-08-20 | The University Of British Columbia | Human androgen receptor dna-binding domain (dbd) compounds as therapeutics and methods for their use |
| US9255097B2 (en) * | 2014-05-01 | 2016-02-09 | Quanticel Pharmaceuticals, Inc. | Inhibitors of lysine specific demethylase-1 |
| FR3020945B1 (fr) | 2014-05-16 | 2016-05-06 | Oreal | Composition pour colorer les fibres keratiniques comprenant une base d'oxydation et un coupleur heteroaryle particulier |
| RS60658B1 (sr) * | 2014-06-27 | 2020-09-30 | Celgene Quanticel Research Inc | Inhibitori lizin specifične demetilaze-1 |
| BR112017000042B1 (pt) * | 2014-07-03 | 2021-11-03 | Celgene Quanticel Research, Inc | Composto inibidores de desmetilase-1 lisina-específica e uso do mesmo, composição farmacêutica e método in vitro para regular a transcrição gênica em uma célula |
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