HRP20220020T1 - Modificirane izvanstanične vezikule i njihova uporaba - Google Patents
Modificirane izvanstanične vezikule i njihova uporaba Download PDFInfo
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- HRP20220020T1 HRP20220020T1 HRP20220020TT HRP20220020T HRP20220020T1 HR P20220020 T1 HRP20220020 T1 HR P20220020T1 HR P20220020T T HRP20220020T T HR P20220020TT HR P20220020 T HRP20220020 T HR P20220020T HR P20220020 T1 HRP20220020 T1 HR P20220020T1
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Classifications
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- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
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| SG11202111290WA (en) * | 2019-04-17 | 2021-11-29 | Codiak Biosciences Inc | Compositions of exosomes and aav |
| EP3994158A1 (en) | 2019-07-03 | 2022-05-11 | Codiak BioSciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| KR20220070433A (ko) * | 2019-08-14 | 2022-05-31 | 코디악 바이오사이언시즈, 인크. | Stat6을 표적으로 하는 세포외 소포-aso 작제물 |
| CA3147366A1 (en) | 2019-08-14 | 2021-02-18 | Adam T. BOUTIN | Extracellular vesicles with stat3-antisense oligonucleotides |
| CA3147701A1 (en) | 2019-08-14 | 2021-02-18 | Codiak Biosciences, Inc. | Extracellular vesicles with antisense oligonucleotides targeting kras |
| AU2020330133A1 (en) * | 2019-08-14 | 2022-03-17 | Lonza Sales Ag | Extracellular vesicle-ASO constructs targeting CEBP/beta |
| MX2022003570A (es) | 2019-09-25 | 2022-07-11 | Codiak Biosciences Inc | Composiciones de vesícula extracelular. |
| KR20220094221A (ko) | 2019-09-25 | 2022-07-05 | 코디악 바이오사이언시즈, 인크. | 종양의 치료를 위한 il-12 디스플레잉 엑소좀과 조합된 sting 효능제 포함 엑소좀 |
| WO2021062290A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Methods of producing extracellular vesicles |
| WO2021062057A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Exogenous loading of exosomes via lyophilization |
| WO2021062058A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Sting agonist comprising exosomes for treating neuroimmunological disorders |
| KR20210116324A (ko) | 2020-03-12 | 2021-09-27 | 기초과학연구원 | 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법 |
| WO2021184020A1 (en) | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Methods of treating neuroinflammation |
| US20230114434A1 (en) | 2020-03-13 | 2023-04-13 | Codiak Biosciences, Inc. | Extracellular vesicles for treating neurological disorders |
| WO2021184021A1 (en) | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting pmp22 |
| JP2023518414A (ja) | 2020-03-20 | 2023-05-01 | コディアック バイオサイエンシーズ， インコーポレイテッド | 治療のための細胞外小胞 |
| US20230220068A1 (en) | 2020-06-05 | 2023-07-13 | Codiak Biosciences, Inc. | Anti-transferrin extracellular vesicles |
| WO2022032140A2 (en) * | 2020-08-07 | 2022-02-10 | Amicus Therapeutics, Inc. | Vesicle targeting proteins and uses of same |
| CA3193107A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| GB202015399D0 (en) * | 2020-09-29 | 2020-11-11 | Evox Therapeutics Ltd | Engineered extracellular vesicles displaying enhanced pharmacokinetics |
| US20230364127A1 (en) | 2020-10-06 | 2023-11-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
| CN112410304A (zh) * | 2020-11-12 | 2021-02-26 | 天津大学 | 一种基因修饰的外泌体及其制备方法和应用 |
| CN112899307A (zh) * | 2021-01-28 | 2021-06-04 | 苏州大学 | GluN1和/或GluN2亚基羧基末端豆蔻酰化的NMDA受体的应用 |
| JP2024506712A (ja) | 2021-02-17 | 2024-02-14 | ロンザ セールス アーゲー | 細胞外ベシクルを負荷する方法 |
| CA3207944A1 (en) * | 2021-02-17 | 2022-08-25 | Ajay Verma | Extracellular vesicle-nlrp3 antagonist |
| KR20230166101A (ko) | 2021-04-01 | 2023-12-06 | 론자 세일즈 아게 | 세포외 소포 조성물 |
| CN114057893B (zh) * | 2021-04-26 | 2022-12-30 | 苏州大学 | 一种编码线粒体定位的豆蔻酰化多肽及其制备方法与应用 |
| CN117126886A (zh) * | 2022-05-20 | 2023-11-28 | 谛邈生物科技(北京)有限公司 | 一种实现工程化EVs功能蛋白模块化装载的核酸构建体及其应用 |
| KR102788272B1 (ko) * | 2022-05-24 | 2025-04-01 | 주식회사 시프트바이오 | 표면-개질된 세포외 소포체 및 이의 치료학적 용도 |
| WO2024215711A1 (en) * | 2023-04-10 | 2024-10-17 | Wake Forest University Health Sciences | Modified mammalian vesicles and compositions and methods related thereto |
| CN116769718A (zh) * | 2023-04-21 | 2023-09-19 | 南京逸微健华生物科技有限公司 | 一种工程化细胞外囊泡及用途 |
| WO2024226723A1 (en) * | 2023-04-26 | 2024-10-31 | Northwestern University | Active loading of biomolecular cargo into engineered vesicles |
| CN118909084A (zh) * | 2023-05-08 | 2024-11-08 | 天津外泌体科技有限公司 | 细胞外囊泡支架蛋白及其应用 |
| EP4644537A1 (en) | 2024-04-30 | 2025-11-05 | ConvEyXo | Targeted extracellular vesicle |
| WO2025232431A1 (zh) * | 2024-05-08 | 2025-11-13 | 天津外泌体科技有限公司 | 筛选影响细胞外囊泡被摄取的基因的系统和方法 |
| WO2026055342A1 (en) | 2024-09-04 | 2026-03-12 | Arsenal Biosciences, Inc. | Synthetic pathway activators |
Family Cites Families (13)
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP2254586B1 (en) * | 2008-02-22 | 2015-04-08 | Agency For Science, Technology And Research (A*star) | Mesenchymal stem cell particles |
| FR2950350B1 (fr) | 2009-09-24 | 2013-12-13 | Centre Nat Rech Scient | Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations |
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| WO2016138525A1 (en) * | 2015-02-27 | 2016-09-01 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| WO2016172598A1 (en) * | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| EP3397264A4 (en) * | 2015-12-30 | 2019-06-05 | The Regents of The University of California | METHOD FOR IMPROVED PREPARATION AND INSULATION OF CELL-DERIVED VESICLES |
| US10617768B2 (en) * | 2016-07-12 | 2020-04-14 | Santa Clara University | Engineered exosomes for the delivery of bioactive cargo using transmembrane tetraspanins |
| US20210290556A1 (en) * | 2016-08-22 | 2021-09-23 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
| US20200025685A1 (en) * | 2016-12-15 | 2020-01-23 | Codiak Biosciences, Inc. | Methods of measuring exosomes using intrinsic fluorescence |
| IL272786B2 (en) | 2017-08-25 | 2025-03-01 | Codiak Biosciences Inc | Preparation of therapeutic exosomes using membrane proteins |
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| EP3841112A1 (en) * | 2018-08-24 | 2021-06-30 | Codiak BioSciences, Inc. | Extracellular vesicles targeting dendritic cells and uses thereof |
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