HRP20211711T1 - Postupak za više brzina i mješalica za očuvanje toplinski osjetljivih dijelova na toplinu šarže termokinetički otopljene smjese - Google Patents
Postupak za više brzina i mješalica za očuvanje toplinski osjetljivih dijelova na toplinu šarže termokinetički otopljene smjese Download PDFInfo
- Publication number
- HRP20211711T1 HRP20211711T1 HRP20211711TT HRP20211711T HRP20211711T1 HR P20211711 T1 HRP20211711 T1 HR P20211711T1 HR P20211711T T HRP20211711T T HR P20211711TT HR P20211711 T HRP20211711 T HR P20211711T HR P20211711 T1 HRP20211711 T1 HR P20211711T1
- Authority
- HR
- Croatia
- Prior art keywords
- agents
- time period
- shaft
- speed
- mixing chamber
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 16
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 239000004615 ingredient Substances 0.000 claims 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 230000007704 transition Effects 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- -1 vaccines Substances 0.000 claims 2
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000012886 Vertigo Diseases 0.000 claims 1
- 239000003732 agents acting on the eye Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002269 analeptic agent Substances 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001088 anti-asthma Effects 0.000 claims 1
- 239000000924 antiasthmatic agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940125681 anticonvulsant agent Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000939 antiparkinson agent Substances 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 238000004891 communication Methods 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- 239000002871 fertility agent Substances 0.000 claims 1
- 229940125695 gastrointestinal agent Drugs 0.000 claims 1
- 239000004083 gastrointestinal agent Substances 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005554 hypnotics and sedatives Substances 0.000 claims 1
- 239000000367 immunologic factor Substances 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000010755 mineral Nutrition 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229940125702 ophthalmic agent Drugs 0.000 claims 1
- 230000002445 parasympatholytic effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 1
- 239000002996 urinary tract agent Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
- 231100000889 vertigo Toxicity 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/071—Fixing of the stirrer to the shaft
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
- B01F27/0722—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis perpendicular with respect to the rotating axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
- B01F27/0724—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis directly mounted on the rotating axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/21—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts
- B01F27/2123—Shafts with both stirring means and feeding or discharging means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/211—Measuring of the operational parameters
- B01F35/2115—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/211—Measuring of the operational parameters
- B01F35/2115—Temperature
- B01F35/21151—Temperature using infrared radiation thermometer or pyrometer or infrared sensors for temperature measurement without contact
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/212—Measuring of the driving system data, e.g. torque, speed or power data
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/214—Measuring characterised by the means for measuring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/2201—Control or regulation characterised by the type of control technique used
- B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2214—Speed during the operation
- B01F35/22142—Speed of the mixing device during the operation
- B01F35/221422—Speed of rotation of the mixing axis, stirrer or receptacle during the operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0481—Numerical speed values
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Seasonings (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Accessories For Mixers (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Claims (13)
1. Postupak miješanja sastava od dvije ili više sastojaka, pri čemu sastojci sadrže jednu ili više termolabilnih komponenti, pri čemu je sastav dobiven kao rezultat amorfna ili heterogeno homogena, taj postupak sadrži miješanje sastojaka u termokinetičkoj komori (MC) za miješanje, pri čemu osovina (2, 23) termokinetičke mješalice radi pri prvoj brzini u prvom vremenskom razdoblju dok se ne dostigne unaprijed određena vrijednost, kada se brzina osovine podesi na drugu brzinu tokom drugog vremenskog, pri čemu postupak miješanja neprekinut između prvog i drugog vremenskog razdoblja,
pri čemu termolabilne komponente sadrže jedan ili više aktivnih farmaceutskih sastojaka i/ili jedan ili više polimernih farmaceutski prihvatljivih ekscipijensa, i
pri čemu je kraj prvog vremenskog razdoblja pretežno prije no što temperatura komore za miješanje (MC) dosegne temperaturu prijelaza na smicanje ili točku taljenja bilo koje komponente sastojaka, ili
pri čemu, je kraj prvog vremenskog razdoblja unaprijed određeno vremensko razdoblje i promjena druge brzine se napravi automatski pomoću termokinetičke mješalice na kraju prvog vremenskog razdoblja, ili
pri čemu je kraj prvog vremenskog razdoblja prije no što temperatura komore za miješanje (MC) dosegne temperaturu prijelaza na smicanje aktivnog farmaceutskog sastojka u sastojcima, ili
pri čemu kraj je prvog vremenskog razdoblja pretežno prije no što temperatura komore za miješanje (MC) dosegne temperaturu prijelaza na smicanje farmaceutski prihvatljivog ekscipijensa u sastojcima,
naznačen time što je druga brzina veća od prve brzine.
2. Taj postupak sukladno patentnom zahtjevu 1, pri čemu sastojci sadrže najmanje jedan polimer osjetljiv na toplinu.
3. Postupak sukladno patentnom zahtjevu 1, pri čemu drugo vremensko razdoblje je pet posto ili više, ili 10 posto ili više od prvog vremenskog razdoblja.
4. Postupak sukladno patentnom zahtjevu 1, pri čemu je na kraju drugog vremenskog razdoblja brzina vrtnje osovine promijenjena s druge brzine na treću brzinu tokom trećeg vremenskog razdoblja budući dostigne unaprijed određenu vrijednost, specifično, pri čemu taj postupak miješanja je neprekinut između drugog i trećeg vremenskog razdoblja.
5. Postupak sukladno patentnom zahtjevu 1, pri čemu je kraj drugog vremenskog razdoblja prije nego što se aktivni farmaceutski sastojak razgradi toplinom, posebno pri čemu su na kraju drugog vremenskog razdoblja taj aktivni farmaceutski sastojak i farmaceutski prihvatljiv ekscipijens tih sastojaka amorfni.
6. Postupak sukladno patentnom zahtjevu 1, pri čemu je prva brzina veća od 1000 obrtaja u minuti i druga brzina je 200 do 400, 200 do 1000 ili 200 do 2500 obrtaja u minuti veća od prve brzine.
7. Postupak sukladno patentnom zahtjevu 1, pri čemu termolabilne komponente sadrže najmanje jedan aktivni farmaceutski sastojak i najmanje jedan polimerni farmaceutski prihvatljiv ekscipijens, i pri čemu je kraj prvog vremenskog razdoblja prije nego što temperatura komore za miješanje (MC) dosegne prijelaznu temperaturu smicanja ili točku taljenja bilo kojeg aktivnog farmaceutskog sastojka ili polimernog farmaceutski prihvatljivog ekscipijensa u tim sastojcima.
8. Postupak sukladno patentnom zahtjevu 7, pri čemu je aktivni farmaceutski sastojak izabran od antibiotika, analgetika, cjepiva, antikonvulzivi, sredstva protiv dijabetesa, sredstva protiv gljivica, antineoplastičnih sredstva, antiparkinsonskih sredstva, antireumatskih sredstva, sredstva za suzbijanje apetita, modifikatora biološkog odgovora, kardiovaskularnih sredstava, stimulansa središnjeg živčanog sustava, sredstva za kontracepciju, dijetetskih suplemenata, vitamina, minerala, lipida, saharida, metala, aminokiselina (i prekursora), nukleinskih kiselina i prekursora, kontrastnih sredstava, dijagnostičkih sredstava, agonista receptora dopamina, sredstva protiv erektilne disfunkcije, sredstva za fertilitet, gastrointestinalnih sredstava, hormona, imunomodulatora, sredstva protiv hiperkalcemije, stabilizatora stanica mastocita, relaksanasa mišića, nutritivnih sredstava, oftalmoloških sredstava, osteoporoznih sredstava, fizioterapeutskih sredstva, parasimptomimetici, parasimpatolitici, respiratornih sredstava, umirujućih hipnotičkih sredstava, sredstva membrane kože i sluzokože, sredstva koji utječu na odvikavanje od pušenja, steroida, simpatolici, sredstva za urinarni trakt, relaksanti maternice, vaginalnih sredstva, vazodilatatora, antihipertenzivi, hipertireozna sredstva, antihipertireozna sredstva, antiastmatika i sredstva za vertigo.
9. Termokinetička mješalica za proizvodnju farmaceutskog pripravka koji sadrži sastojak osjetljiv na toplinu, ta mješalica sadrži:
(a) pretežno cilindričnu komoru za miješanje (MC);
(b) osovinu (23, 24) smještenu kroz središnju os komore za miješanje (MC);
(c) elektromotor (15) spojen na osovinu da bi učinkovito uticao na prijenos kretanja vrtnje na osovini (23, 24);
(d) jednu ili više izbočina (25) iz osovine i okomito na dugu os osovine (23, 24);
(e) jedan ili više termičkih senzora (20) spojenih na zid komore za miješanje (MC) i funkcionalan da otkrivaju toplinu ili temperaturu najmanje dijela unutrašnjosti komore za miješanje (MC);
(f) uređaj s promjenjive frekvencijom spojen na motor (15);
(g) vrata (6) smještena u zidu komore za miješanje (MC), učinkovita kada su otvorena tokom odvijanja postupka da sadržaj komore za miješanje (MC) prođe iz komore za miješanje (MC); i
(h) elektronički upravljač u komunikaciji sa senzorima temperature, vrata (6) i uređaj s promjenljivom frekvencijom;
pri čemu elektronički upravljač sadrži korisnički uređaj s ulaznim otvorom, mjerač vremena, elektronički memorijski uređaj konfiguriran za prihvaćanje korisničkog unosa procesnih parametara za dvije ili više faza ciklusa termokinetičkog miješanja, i monitor;
pri čemu se unaprijed određeni procesni parametri spremaju u memorijski uređaj i prikazani su na monitoru tokom jedne ili više faza odvijanja postupka; i pri čemu, kada se ispuni jedan od unaprijed određenih parametara tijekom neke faze ciklusa obrade, elektronički upravljač automatski pomjera ciklus rada na slijedeću fazu, i
pri čemu se unaprijed određene vrijednosti izabiru iz skupine koja sadrži temperaturu, brzinu vrtnje osovine, povučenu amperažu od strane elektromotora, vrijeme te faze ciklusa rada, i bilo koju kombinaciju navedenih,
naznačen time što spomenuta naknadna faza koristi višu brzinu miješanja nego prethodna faza.
10. Termokinetička mješalica sukladno patentnom zahtjevu 9, pri čemu najmanje jedan od senzora temperature (20) otkriva infracrveno zračenje i pri čemu je razina zračenja izlazna vrijednost kao temperatura na monitoru.
11. Termokinetička mješalica sukladno patentnom zahtjevu 9, pri čemu je komora za miješanje (MC) s unutarnje strane obložena dijelovima unutarnje obloge.
12. Termokinetička mješalica sukladno patentnom zahtjevu 9, pri čemu prikaz izlaznih vrijednosti sadrži temperaturu komore, obrtaje motora u minuti, povučenu amperažu motora, proteklo vrijeme ciklusa, ili bilo koju kombinaciju navedenih.
13. Termokinetička mješalica sukladno patentnom zahtjevu 9, pri čemu jedno ili više izbočina (25) osovine (23, 24) sadrži bazu i krajnji dio, krajnji dio se može ukloniti iz dijela osnove i dio osnove se može ukloniti iz osovine (23, 24), ili pri čemu jedno ili više izbočina (25) iz osovine (23, 24) sadrži jedan ili više glavnih dijelova lica sa širinom od najmanje 1,91 cm (0,75 inča), pod kutom od između 15 do 80 stupnjeva od ravnina osi osovine, ili pri čemu jedno ili više izbočina (25) iz osovine (23, 24) kontroliraju translaciju vrtnje energije osovine koja se isporučuje na izbočine (25) u toplinskoj energiji unutar čestica (26) koje utječu na izbočine (25).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14889332.4A EP3131667B1 (en) | 2014-04-18 | 2014-04-18 | Multiple speed process and mixer for preserving heat sensitive portions of a thermokinetically melt blended batch |
| PCT/US2014/034601 WO2015160358A1 (en) | 2014-04-18 | 2014-04-18 | Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211711T1 true HRP20211711T1 (hr) | 2022-02-18 |
Family
ID=54324401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211711TT HRP20211711T1 (hr) | 2014-04-18 | 2014-04-18 | Postupak za više brzina i mješalica za očuvanje toplinski osjetljivih dijelova na toplinu šarže termokinetički otopljene smjese |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP3131667B1 (hr) |
| JP (1) | JP6535085B2 (hr) |
| CN (1) | CN106413870A (hr) |
| AU (1) | AU2014391109B2 (hr) |
| CA (1) | CA2945955C (hr) |
| DK (1) | DK3131667T3 (hr) |
| ES (1) | ES2897702T3 (hr) |
| HR (1) | HRP20211711T1 (hr) |
| HU (1) | HUE057232T2 (hr) |
| LT (1) | LT3131667T (hr) |
| PL (1) | PL3131667T3 (hr) |
| PT (1) | PT3131667T (hr) |
| RS (1) | RS62607B1 (hr) |
| SI (1) | SI3131667T1 (hr) |
| WO (1) | WO2015160358A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069460A (zh) * | 2016-05-09 | 2018-12-21 | 分散技术有限责任公司 | 改进的药物制剂 |
| JP7376220B2 (ja) * | 2017-09-11 | 2023-11-08 | オースティンピーエックス リミテッド ライアビリティ カンパニー | 熱動力学的に溶融ブレンドされるバッチの熱感受性部分用の、直接プローブにより感知した温度による、速度変更のための方法 |
| LT3470133T (lt) * | 2017-10-13 | 2021-03-10 | Dispersol Technologies, Llc | Tiesioginio temperatūros matavimo jutikliu būdas termokinetiškai lydyto mišinio partijos karščiui jautrių dalių maišymo greičiui keisti |
| CN109663524B (zh) * | 2017-10-13 | 2022-07-15 | 分散技术有限责任公司 | 用于热动力学熔体共混批次的热敏部分的速度改变的直接进样探头感测温度方法 |
| CN112546936A (zh) * | 2020-11-30 | 2021-03-26 | 北京艾科美特新材料开发有限公司 | 无机有机复合物料混合设备用温度监测系统 |
| CN113616525B (zh) * | 2021-08-20 | 2024-04-30 | 拓凌机械(浙江)有限公司 | 一种包衣固体药片的注塑成型装备及成型方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1062502A (en) * | 1975-04-17 | 1979-09-18 | John P. Porter | Data acquisition system for an elastomer processor |
| SU889077A1 (ru) * | 1980-03-06 | 1981-12-15 | Специальное Конструкторско-Технологическое Бюро "Технолог" Ленинградского Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Технологического Института Им.Ленсовета | Способ управлени процессом перемешивани в реакторе полунепрерывного действи |
| US4789597A (en) * | 1987-01-12 | 1988-12-06 | Fetherstonhaugh & Co. | Incorporation of chemically reactive agents on resin particles |
| JPH0711148Y2 (ja) * | 1987-10-20 | 1995-03-15 | 日本エステル株式会社 | ポリエステルの連続重合装置 |
| US6214988B1 (en) * | 1999-01-03 | 2001-04-10 | Schlumberger Technology Corporation | Process for making an HMX product |
| US6709146B1 (en) * | 2000-07-28 | 2004-03-23 | David Little | Thermokinetic mixer and method of using |
| JP2007160721A (ja) * | 2005-12-14 | 2007-06-28 | David Little | サーモキネティック・ミキサ、組成物及び構造用製品 |
| WO2008052112A2 (en) * | 2006-10-25 | 2008-05-02 | Symyx Technologies, Inc. | Multiple pin mixing apparatus and methods of using |
| US8486423B2 (en) * | 2007-08-21 | 2013-07-16 | Board Of Regents, The University Of Texas System | Thermo-kinetic mixing for pharmaceutical applications |
| MY169340A (en) * | 2010-03-15 | 2019-03-21 | Phoenix Innovation Tech Inc | Method and apparatus for regenerating vulcanized rubber |
| US20140039031A1 (en) * | 2011-02-23 | 2014-02-06 | Dispersol Technologies. LLC | Pharmaceutical formulations of acetyl-11-keto-b-boswellic acid, diindolylmethane, and curcumin for pharmaceutical applications |
-
2014
- 2014-04-18 PL PL14889332T patent/PL3131667T3/pl unknown
- 2014-04-18 ES ES14889332T patent/ES2897702T3/es active Active
- 2014-04-18 WO PCT/US2014/034601 patent/WO2015160358A1/en active Application Filing
- 2014-04-18 CN CN201480079254.5A patent/CN106413870A/zh active Pending
- 2014-04-18 SI SI201431923T patent/SI3131667T1/sl unknown
- 2014-04-18 LT LTEPPCT/US2014/034601T patent/LT3131667T/lt unknown
- 2014-04-18 HR HRP20211711TT patent/HRP20211711T1/hr unknown
- 2014-04-18 CA CA2945955A patent/CA2945955C/en active Active
- 2014-04-18 RS RS20211387A patent/RS62607B1/sr unknown
- 2014-04-18 AU AU2014391109A patent/AU2014391109B2/en active Active
- 2014-04-18 JP JP2017506247A patent/JP6535085B2/ja active Active
- 2014-04-18 PT PT148893324T patent/PT3131667T/pt unknown
- 2014-04-18 EP EP14889332.4A patent/EP3131667B1/en active Active
- 2014-04-18 DK DK14889332.4T patent/DK3131667T3/da active
- 2014-04-18 HU HUE14889332A patent/HUE057232T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015160358A1 (en) | 2015-10-22 |
| CN106413870A (zh) | 2017-02-15 |
| EP3131667A4 (en) | 2018-02-21 |
| CA2945955A1 (en) | 2015-10-22 |
| ES2897702T3 (es) | 2022-03-02 |
| JP2017518880A (ja) | 2017-07-13 |
| RS62607B1 (sr) | 2021-12-31 |
| HUE057232T2 (hu) | 2022-04-28 |
| AU2014391109B2 (en) | 2019-01-17 |
| DK3131667T3 (da) | 2021-10-25 |
| SI3131667T1 (sl) | 2022-02-28 |
| EP3131667A1 (en) | 2017-02-22 |
| EP3131667B1 (en) | 2021-09-01 |
| JP6535085B2 (ja) | 2019-06-26 |
| LT3131667T (lt) | 2021-12-10 |
| PT3131667T (pt) | 2021-11-19 |
| PL3131667T3 (pl) | 2022-01-17 |
| CA2945955C (en) | 2020-10-27 |
| AU2014391109A1 (en) | 2016-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20211711T1 (hr) | Postupak za više brzina i mješalica za očuvanje toplinski osjetljivih dijelova na toplinu šarže termokinetički otopljene smjese | |
| JP6695938B2 (ja) | 半可塑性医薬投与単位の製造 | |
| WO2008045329A3 (en) | Bone cement mixing and delivery system and method | |
| RU2015129072A (ru) | Устройство и способ приготовления экструдируемых пищевых продуктов | |
| EP3107399B1 (en) | Automated on demand baking system | |
| KR101853145B1 (ko) | 디플렉터 표면을 구비한 믹서 | |
| CN211754217U (zh) | 一种多种饲料定比定量投放混合装置 | |
| BR112019009594A2 (pt) | processos e sistemas de composição farmacêutica | |
| CN102633580A (zh) | 一种高温速硬型乳化炸药及其制备方法 | |
| CN106070990A (zh) | 一种酥脆香甜米花糖 | |
| CN108635234A (zh) | 一种术后流食喂食装置 | |
| JP6021037B1 (ja) | ペットフード用組成物、ペットフード用フード粒、ペットフード、およびペットフード包装体 | |
| CN103877395A (zh) | 铁皮石斛速溶粉的制备方法 | |
| US20140227380A1 (en) | Injection molding machine | |
| AU2010212175A1 (en) | Process for preparing chocolate crumb | |
| CN108421497A (zh) | 药物连续化制粒的生产工艺和设备 | |
| JP7376220B2 (ja) | 熱動力学的に溶融ブレンドされるバッチの熱感受性部分用の、直接プローブにより感知した温度による、速度変更のための方法 | |
| US9821283B1 (en) | Direct probe sensed temperature method for speed change for heat sensitive portions of a thermokinetically melt blended batch | |
| CN203469042U (zh) | 炒药机 | |
| CN207362641U (zh) | 自落式沥青混合料搅拌装置 | |
| CN201894744U (zh) | 一种炒药锅 | |
| CN206980663U (zh) | 一种新型营养饲料混合机 | |
| CN215019632U (zh) | 一种清醒动物自身给药装置 | |
| CN210934714U (zh) | 一种纤维素助剂添加搅拌装置 | |
| CN207025145U (zh) | 一种高效钻山风合剂配制罐 |