HRP20211432T1 - Cjepiva protiv raka s ciljanim djelovanjem na matične stanice raka - Google Patents
Cjepiva protiv raka s ciljanim djelovanjem na matične stanice raka Download PDFInfo
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- HRP20211432T1 HRP20211432T1 HRP20211432TT HRP20211432T HRP20211432T1 HR P20211432 T1 HRP20211432 T1 HR P20211432T1 HR P20211432T T HRP20211432T T HR P20211432TT HR P20211432 T HRP20211432 T HR P20211432T HR P20211432 T1 HRP20211432 T1 HR P20211432T1
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- pharmaceutical
- peptide
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- 206010028980 Neoplasm Diseases 0.000 title claims 3
- 201000011510 cancer Diseases 0.000 title claims 2
- 229940022399 cancer vaccine Drugs 0.000 title 1
- 238000009566 cancer vaccine Methods 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000002955 immunomodulating agent Substances 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- 108010055196 EphA2 Receptor Proteins 0.000 claims 2
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 2
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 206010006143 Brain stem glioma Diseases 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- HZQDCMWJEBCWBR-UUOKFMHZSA-N Mizoribine Chemical compound OC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HZQDCMWJEBCWBR-UUOKFMHZSA-N 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 208000004064 acoustic neuroma Diseases 0.000 claims 1
- 238000011374 additional therapy Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 201000000387 brain stem ependymoma Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000012829 chemotherapy agent Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 150000002484 inorganic compounds Chemical class 0.000 claims 1
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- 229960000681 leflunomide Drugs 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims 1
- 229950000844 mizoribine Drugs 0.000 claims 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
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- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001122—Ephrin Receptors [Eph]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
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- Genetics & Genomics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
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- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Farmaceutski pripravak koji sadrži peptid IL-13Rα2; peptid EphA2; i samo jedan peptid survivin koji sadrži slijed aminokiselina SEQ ID NO: 9; i epitop toksoida tetanus, pri čemu je navedeni pripravak emulgiran montanidom ISA-51, za upotrebu u načinu liječenja, prevencije ili kontrole raka mozga na potrebitom ispitaniku, pri čemu se farmaceutski pripravak ispitaniku daje supkutano, i pri čemu se još farmaceutski pripravak daje usporedo s bevacizumabom.
2. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 1., pri čemu se peptid IL-13Rα2 sastoji od bilo kojeg od sljedova SEQ ID NO: 1 – 4.
3. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 1. ili 2., pri čemu se peptid EphA2 sastoji od slijeda SEQ ID NO:5.
4. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 3., pri čemu se epitop toksoida tetanusa sastoji od slijeda SEQ ID NO:10.
5. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 4., pri čemu se metoda dodatno sastoji od davanja navedenom ispitaniku drugog farmaceutskog pripravka koji sadrži jedan ili više imunomodulatora.
6. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 5., pri čemu jedan ili više imunomodulator sadrži bjelančevinasta sredstva, molekule nukleinske kiseline, male molekule, organske spojeve, anorganske spojeve, metotreksat, leflunomid, ciklofosfamid, Cytoxan, Immuran, ciklosporin A, minociklin, azatioprin, antibiotike, metilprednisolon, kortikosteroide, steroide, mikofenolat mofetil, rapamicin, mizoribin, deoksispergualin, brekinar, malononitriloamide, modulatore receptora T-stanica, modulatore receptora citokina, modulatore mastocita, kemoterapijska sredstva, GM-CSF, i/ili imikimod.
7. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 6., pri čemu jedan ili više imunomodulatora sadrži molekule nukleinske kiseline.
8. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 5., pri čemu se drugi navedeni farmaceutski pripravak ispitaniku daje intramuskularno ili supkutano.
9. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 8., pri čemu je navedeni rak mozga: a) gliom, astrocitom, glioblastom, oligodendrogliom, gliom moždanog debla, ependimom, ili kombinirani tumor koji sadrži više od jedne vrste glija-stanica; ili b) akustički švanom, kranijalni faringeom, meningiom ili meduloblastom.
10. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 9., pri čemu je navedeni ispitanik čovjek.
11. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 10., pri čemu je navedeni ispitanik u remisiji.
12. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 10., pri čemu je navedeni ispitanik bio u relapsu.
13. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 10., pri čemu je navedeni ispitanik prošao najmanje jedno neuspješno liječenje.
14. Farmaceutski pripravak za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 13., pri čemu se navedena metoda sastoji od davanja najmanje jedne dodatne terapije za rak.
15. Farmaceutski pripravak za upotrebu prema patentnom zahtjevu 14., pri čemu je najmanje jedna dodatna terapija za rak zračenje, kemoterapija ili kirurški zahvat.
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| US201261647615P | 2012-05-16 | 2012-05-16 | |
| EP18213178.9A EP3536334B1 (en) | 2012-05-16 | 2013-05-15 | Cancer stem cell targeted cancer vaccines |
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| EP (4) | EP4321218A3 (hr) |
| JP (4) | JP2015518835A (hr) |
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| WO2013173411A1 (en) | 2012-05-16 | 2013-11-21 | Stemline Therapeutics, Inc | Cancer stem cell targeted cancer vaccines |
| EP3522917A2 (en) | 2016-10-07 | 2019-08-14 | Enterome S.A. | Microbiota sequence variants of tumor-related antigenic epitopes |
| CN117801069A (zh) | 2016-10-07 | 2024-04-02 | 恩特罗姆公司 | 用于癌症疗法的免疫原性化合物 |
| KR20240007316A (ko) | 2016-10-07 | 2024-01-16 | 엔터롬 에스.에이. | 암 치료를 위한 면역원성 화합물 |
| EP3773673A2 (en) * | 2018-04-11 | 2021-02-17 | Enterome S.A. | Immunogenic compounds for treatment of fibrosis, autoimmune diseases and inflammation |
| BR112020020780A2 (pt) * | 2018-04-11 | 2021-03-02 | Enterome S.A. | peptídeos antigênicos para prevenção e tratamento do câncer |
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- 2013-05-15 HU HUE18213178A patent/HUE056350T2/hu unknown
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2018
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| JP2015518835A (ja) | 2015-07-06 |
| PT3536334T (pt) | 2021-09-27 |
| CY1124512T1 (el) | 2022-07-22 |
| JP2022130585A (ja) | 2022-09-06 |
| PL3536334T3 (pl) | 2021-12-06 |
| EP3912634B1 (en) | 2023-10-04 |
| US20150139939A1 (en) | 2015-05-21 |
| US11672847B2 (en) | 2023-06-13 |
| LT3536334T (lt) | 2021-10-11 |
| US10485858B2 (en) | 2019-11-26 |
| EP4321218A3 (en) | 2024-04-24 |
| EP4321218A2 (en) | 2024-02-14 |
| RS62406B1 (sr) | 2021-10-29 |
| EP2849772A1 (en) | 2015-03-25 |
| EP3536334A1 (en) | 2019-09-11 |
| JP2020117519A (ja) | 2020-08-06 |
| CA2911191A1 (en) | 2013-11-21 |
| EP2849772A4 (en) | 2016-03-02 |
| US20210093701A1 (en) | 2021-04-01 |
| CA3183703A1 (en) | 2013-11-21 |
| JP2018109004A (ja) | 2018-07-12 |
| WO2013173411A1 (en) | 2013-11-21 |
| EP3536334B1 (en) | 2021-06-23 |
| SI3536334T1 (sl) | 2021-11-30 |
| CA2911191C (en) | 2023-02-28 |
| ES2890529T3 (es) | 2022-01-20 |
| US20240115677A1 (en) | 2024-04-11 |
| ES2967342T3 (es) | 2024-04-29 |
| EP3912634A1 (en) | 2021-11-24 |
| HUE056350T2 (hu) | 2022-02-28 |
| DK3536334T3 (da) | 2021-09-13 |
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