HRP20210991T1 - Metoda i sustav za nedestruktivno in ovo određivanje spola peradi - Google Patents
Metoda i sustav za nedestruktivno in ovo određivanje spola peradi Download PDFInfo
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- HRP20210991T1 HRP20210991T1 HRP20210991TT HRP20210991T HRP20210991T1 HR P20210991 T1 HRP20210991 T1 HR P20210991T1 HR P20210991T T HRP20210991T T HR P20210991TT HR P20210991 T HRP20210991 T HR P20210991T HR P20210991 T1 HRP20210991 T1 HR P20210991T1
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- Croatia
- Prior art keywords
- biomarker
- eggs
- embryo
- viable
- sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 14
- 230000001066 destructive effect Effects 0.000 title 1
- 239000000090 biomarker Substances 0.000 claims 14
- 235000013601 eggs Nutrition 0.000 claims 12
- 210000001161 mammalian embryo Anatomy 0.000 claims 8
- 238000004949 mass spectrometry Methods 0.000 claims 4
- 230000002596 correlated effect Effects 0.000 claims 3
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 2
- 238000003795 desorption Methods 0.000 claims 2
- 210000002257 embryonic structure Anatomy 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- GYCUGHGNCMGICI-UHFFFAOYSA-N 3-(2-aminoethylsulfanyl)butanoic acid Chemical group OC(=O)CC(C)SCCN GYCUGHGNCMGICI-UHFFFAOYSA-N 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- -1 amino compound Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000001506 fluorescence spectroscopy Methods 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 238000004969 ion scattering spectroscopy Methods 0.000 claims 1
- 238000001646 magnetic resonance method Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 244000144977 poultry Species 0.000 claims 1
- 238000009774 resonance method Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000011524 similarity measure Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 238000004885 tandem mass spectrometry Methods 0.000 claims 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K43/00—Testing, sorting or cleaning eggs ; Conveying devices ; Pick-up devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/08—Eggs, e.g. by candling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Claims (10)
1. Metoda za nedestruktivno utvrđivanje obilježja embrija Gallus Gallus domesticus in ovo, metoda koja obuhvaća:
(a) dobivanje uzorka materijala povezanog s jajetom koje sadrži zametak, i
(b) mjerenje bodovne vrijednosti za prisutnost i koncentraciju najmanje prvog biomarkera u uzorku koji ukazuje na karakteristike embrija, i
(c) primjena praga na vrijednost rezultata i koncentraciju dobivenu u (b) radi identificiranja karakteristike embrija povezane s prisutnošću i koncentracijom prvog biomarkera, pri čemu prvi biomarker sadrži amino spoj molekularne težine u rasponu od 150 do 170 g / mol; pri čemu korak (c) nadalje obuhvaća:
(i) korelaciju svakog relevantnog signala biomarkera s referentnim biomarkerom usklađivanjem spektra svakog korelacijskog signala s očekivanim spektrom korelirajućeg referentnog biomarkera pomoću mjere sličnosti, kako bi se definirao barem jedan pozitivno korelirajući signal;
(ii) mjerenje intenziteta svakog pozitivno korelirajućeg signala i bodovanje njegovog apsolutnog i/ili relativnog intenziteta signala; i
(iii) primjenu praga na vrijednost rezultata dobivenu funkcijom sličnosti za određivanje korelirane karakteristike embrija;
pri čemu je prvi biomarker 3-[(2-aminoetil)sulfanil]butanska kiselina, a koncentracija prvog biomarkera u količini od 50 ng/ml ili više u alantoičnoj tekućini embrija 7, 8 ili 9 dan korelira sa ženskim zametkom, dok prisutnost prvog biomarkera prisutnog u manje od 50 ng/ml korelira s muškim embrijem.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time što se otkrivaju i analiziraju prvi i drugi biomarker, i pri čemu se apsolutne i relativne količine najmanje prvog i drugog markera koriste za određivanje jedne ili više karakteristika.
3. Postupak prema zahtjevu 1 ili 2, naznačen time što obuhvaća primjenu jedne ili više metoda magnetske rezonancije; metoda spektralne rezonancije; analitička kromatografska metoda povezana s jednim ili više prikladnih detektora; fluorescentna spektroskopija; i/ili metode ispitivanja koje uključuju reagense selektivne za biomarker, za mjerenje prisutnosti i koncentracije jednog ili više biomarkera, po mogućnosti gdje masena spektrometrijska analiza obuhvaća masenu spektroskopiju ionskom raspršivanjem (ESI), lasersku ionsku jonizaciju uz pomoć matrice - vrijeme leta (MALDI- TOF) masena spektroskopija ili površinski pojačana laserska desorpcijska ionizacija - masena spektroskopija vremena leta (SELDI-TOF), izvor iona SPE/MS/MS, LDTD (termalna desorpcija laserske diode) i/ili uporaba senzora pokretljivosti iona (IMS).
4. Metoda prema bilo kojem od prethodnih zahtjeva, naznačena time što se testni uzorak obrađuje prije analize, po mogućnosti gdje obrada uzorka uključuje odvajanje uzorka ekstrakcijom u čvrstoj fazi (SPE), plinskom kromatografijom, jednofaznom ili višefaznom visokotlačnom tekućinskom kromatografijom (HPLC).
5. Postupak prema bilo kojem od zahtjeva 3 ili 4, naznačen time, što se jedan ili više internih standarda referentnih biomarkera dodaje uzorku prije analize masenom spektrometrijom.
6. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time što se apsolutni intenzitet signala ocjenjuje mjerenjem intenziteta signala biomarkera i usporedbom s intenzitetom signala jednog ili više poznatih internih standarda.
7. Metoda prema bilo kojem od prethodnih zahtjeva, naznačena time što se mnoštvo jajašaca ispituje na jednu ili više embrionalnih karakteristika; i po mogućnosti dalje obuhvaća utvrđivanje je li embrij u jajetu održiv i muški, ili održiv i ženski, ili neživ, i odvajanje mnoštva održivih muških jajašaca od mnoštva održivih ženskih jajašaca i jedne ili više neživih jajnih stanica.
8. Metoda prema bilo kojem prethodnom zahtjevu, naznačena time što je metoda potpuno automatizirana.
9. Postupak u skladu s patentnim zahtjevom 8, naznačen time što nadalje uključuje sortiranje održivih jajašaca prema predviđenom vremenu dok se vjerojatnost da se ne izlegne.
10. Postupak selektivne inkubacije mladunaca vrsta peradi koje nesu jaja sa specifičnim karakteristikama, koji obuhvaća
a. pružanje mnoštva jaja iz vrste, i
b. podvrgavanje jaja postupku prema bilo kojem zahtjevu od 1 do 9 za određivanje karakteristike embrija, i
c. odabir jaja sa željenom karakteristikom za formiranje odabranog mnoštva jaja, i
d. inkubiranje odabranih jaja dok se ne izleže jedno ili više mladunaca.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2016818A NL2016818B1 (en) | 2016-05-24 | 2016-05-24 | Method, system and food product for the in ovo gender, viability and/or developmental stage determination of embryos of oviparian species. |
| NL2016819A NL2016819B1 (en) | 2016-05-24 | 2016-05-24 | Method and system for the non-destructive in ovo determination of fowl gender. |
| NL2017382 | 2016-08-29 | ||
| PCT/NL2017/050330 WO2017204636A2 (en) | 2016-05-24 | 2017-05-24 | Method and system for the non-destructive in ovo determination of fowl gender |
| EP17740802.8A EP3465222B1 (en) | 2016-05-24 | 2017-05-24 | Method and system for the non-destructive in ovo determination of fowl gender |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20210991T1 true HRP20210991T1 (hr) | 2021-09-17 |
| HRP20210991T8 HRP20210991T8 (hr) | 2022-01-21 |
Family
ID=59366469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210991TT HRP20210991T8 (hr) | 2016-05-24 | 2021-06-23 | Metoda i sustav za nedestruktivno in ovo određivanje spola peradi |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11686732B2 (hr) |
| EP (2) | EP3859341A3 (hr) |
| JP (1) | JP7320353B2 (hr) |
| KR (1) | KR102530639B1 (hr) |
| CN (1) | CN109477840B (hr) |
| AU (1) | AU2017269050B2 (hr) |
| BR (1) | BR112018074071A8 (hr) |
| CA (1) | CA3025127A1 (hr) |
| DK (1) | DK3465222T3 (hr) |
| ES (1) | ES2877368T3 (hr) |
| HR (1) | HRP20210991T8 (hr) |
| HU (1) | HUE055153T2 (hr) |
| IL (1) | IL263138B2 (hr) |
| MX (2) | MX2018014484A (hr) |
| PL (1) | PL3465222T3 (hr) |
| PT (1) | PT3465222T (hr) |
| RU (1) | RU2756447C2 (hr) |
| UA (1) | UA127784C2 (hr) |
| WO (1) | WO2017204636A2 (hr) |
| ZA (1) | ZA201807967B (hr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10798921B2 (en) * | 2017-02-07 | 2020-10-13 | Zoetis Services Llc | Method for reducing pathogens in poultry hatchery operations |
| WO2019154493A1 (en) * | 2018-02-07 | 2019-08-15 | Seleggt Gmbh | Method for sampling an egg |
| EP3599465A1 (en) * | 2018-07-24 | 2020-01-29 | Tronico | Method for determining a specific characteristic of an embryo in an unhatched egg |
| US12105062B2 (en) * | 2018-09-05 | 2024-10-01 | Bae Systems Information And Electronic Systems Integration Inc. | Carbide-derived carbon for solid-phase micro extraction media |
| KR102150837B1 (ko) * | 2019-02-22 | 2020-09-03 | 고려대학교 산학협력단 | 소변의 대사체 분석을 위한 소변 샘플 처리 방법 |
| NL2023176B1 (en) | 2019-05-22 | 2020-12-01 | In Ovo B V | Composition comprising eggs and use of such composition |
| WO2021119588A1 (en) * | 2019-12-13 | 2021-06-17 | The United States Of America, As Represented By The Secretary Of Agriculture | A system and method for determining the sex and viability of poultry eggs prior to hatching |
| US12105071B2 (en) | 2019-12-18 | 2024-10-01 | Bae Systems Information And Electronic Systems Integration Inc. | Multi-element, ultra-low SWaP chemical pre-concentrator |
| DE102020000214A1 (de) * | 2020-01-15 | 2021-07-15 | Technische Hochschule Ostwestfalen-Lippe | Vorrichtung und Verfahren zur in-ovo Geschlechtsbestimmung bei einem befruchteten Vogelei |
| NL2024699B1 (en) | 2020-01-17 | 2021-10-13 | In Ovo Holding B V | Egg Characteristic Determining Device |
| NL2026004B1 (en) | 2020-07-05 | 2022-03-11 | In Ovo Holding B V | Egg Determining Method and Device |
| CN112986451B (zh) * | 2021-05-06 | 2022-05-17 | 湖南师范大学 | 一种基于风味特征的杂交鱼类肉品质评价方法 |
| DE102021127696B3 (de) | 2021-10-25 | 2023-03-09 | Technische Universität Dresden, Körperschaft des öffentlichen Rechts | Verfahren und Anordnung zur in-ovo Geschlechtsbestimmung von Vogeleiern |
| KR102632163B1 (ko) | 2022-04-13 | 2024-02-01 | 오보젠 주식회사 | 가금류 알(卵)의 암수 검사 및 선별장치 그리고 이를 이용한 선별방법 |
| CN114755357A (zh) * | 2022-04-14 | 2022-07-15 | 武汉迈特维尔生物科技有限公司 | 一种色谱质谱自动积分方法、系统、设备、介质 |
| CN115015461A (zh) * | 2022-06-13 | 2022-09-06 | 聊城大学 | 一种肉类挥发性风味物质的鉴别方法及其应用 |
| CN115047129B (zh) * | 2022-06-16 | 2023-07-04 | 贵州茅台酒股份有限公司 | 一种基于挥发性物质组成特征的高粱品种鉴别方法 |
| CN115808414A (zh) * | 2023-01-18 | 2023-03-17 | 苏州贝康医疗器械有限公司 | 一种无创评估胚胎发育质量的拉曼光谱分析方法及其应用 |
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| WO1993014629A1 (en) | 1992-01-27 | 1993-08-05 | North Carolina State University | Gene transfer in birds by introduction of dna into muscle in ovo |
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| IL127931A (en) * | 1996-10-04 | 2001-01-28 | Embrex Inc | Method of sorting birds in ovo |
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| RU2406371C1 (ru) | 2009-07-21 | 2010-12-20 | Государственное учреждение Всероссийский научно-исследовательский институт птицеперерабатывающей промышленности (ГУ ВНИИПП) | Способ получения яичного белкового продукта |
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| DE102013205426A1 (de) * | 2013-03-27 | 2014-10-16 | Siemens Aktiengesellschaft | Verfahren zum Bestimmen des Geschlechts eines Embryos in einem Ei |
| DE102014010150A1 (de) | 2014-07-04 | 2016-01-07 | Technische Universität Dresden | Verfahren und Vorrichtung zur Raman-spektroskopischen in-ovo Geschlechtsbestimmung von befruchteten und bebrüteten Vogeleiern |
| JP7062652B2 (ja) * | 2016-07-29 | 2022-05-06 | ノヴァトランス グループ ソシエテ アノニム | 鶏胚の卵内雌雄鑑別システムおよび方法 |
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