HRP20210373T1 - Multivalentno pneumokokno konjugirano cjepivo - Google Patents
Multivalentno pneumokokno konjugirano cjepivo Download PDFInfo
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- HRP20210373T1 HRP20210373T1 HRP20210373TT HRP20210373T HRP20210373T1 HR P20210373 T1 HRP20210373 T1 HR P20210373T1 HR P20210373T T HRP20210373T T HR P20210373TT HR P20210373 T HRP20210373 T HR P20210373T HR P20210373 T1 HRP20210373 T1 HR P20210373T1
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- pneumococcal
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- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 title claims 12
- 150000004676 glycans Chemical class 0.000 claims 15
- 229920001282 polysaccharide Polymers 0.000 claims 15
- 239000005017 polysaccharide Substances 0.000 claims 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 8
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 229960002885 histidine Drugs 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 3
- 108010040473 pneumococcal surface protein A Proteins 0.000 claims 3
- 238000012371 Aseptic Filling Methods 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000021615 conjugation Effects 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000011176 pooling Methods 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229940124733 pneumococcal vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Otolaryngology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (8)
1. Pripravak multivalentnog konjugiranog pneumokoknog cjepiva (PCV) koji se sastoji od:
a1) najmanje 12 kapsularnih polisaharida odabranih između serotipova 1, 3, 4, 5, 6B, 7F, 9N, 9V, 15B, 14, 18C, 19A, 19F, 22F, 23F i 33F od S. pneumoniae aktiviranih CDAP-om i konjugiranim nosačem proteina odabranim između CRM197, pneumokoknog površinskog proteina A (PspA), pneumokoknog proteina adhezina (PsaA) ili njihove kombinacije, i izborno jednog ili više serotipova odabranih između 6C, 8, 10A, 11A, 12F, 15A, 23A, 23B i 35B od S. pneumoniae; ili
a2) najmanje 14 kapsularnih polisaharida odabranih između serotipova 1, 3, 4, 5, 6B, 7F, 9N, 9V, 14, 15B, 18C, 19A, 19F, 22F, 23F i 33F od S. pneumoniae aktiviranih CDAP-om i konjugiranih do CRM197, PspA, PsaA ili njihove kombinacije, i izborno jednog ili više serotipova odabranih između 6C, 8, 10A, 11A, 12F, 15A, 23A, 23B i 35B od S. pneumoniae; i
b) farmaceutski prihvatljivog nosača; i
izborno farmaceutski prihvatljivog razrjeđivača ili nosača; i
izborno sastojaka,
pri čemu pripravak sadrži kapsularne polisaharide serotipova 22F i 33F i ne sadrži kapsularne polisaharide serotipa 6A.
2. Pripravak prema zahtjevu 1, naznačen time što količina polisaharida iz svakog od serotipova iznosi 1 do 10 µg.
3. Pripravak prema zahtjevu 1, naznačen time što količina nosača proteina konjugiranog s polisaharidom iznosi 3 do 30 µg.
4. Pripravak prema zahtjevu 1, naznačen time što pojedinačna doza od 0,5 mL sadrži 2 µg svakog polisaharida; 30-40 µg CRM197 proteina nosača; 0,2 do 1 mg adjuvanta aluminij-fosfata; natrijev klorid i pufer.
5. Formulacija 14-valentnog sterilnog tekućeg pneumokoknog konjugiranog cjepiva (PCV) koja sadrži 2 µg svakog kapsularnog polisaharida serotipova 1, 3, 4, 5, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F i 33F, 4 µg serotipova 6B, svaki pojedinačno konjugiran na 32 µg CRM197; 0.125 mg elementarnog aluminij (0.5 mg aluminij-fosfata) adjuvanta; i pufer natrijevog klorida i L-histidina, pri čemu formulacija ne sadrži kapsularni polisaharid iz serotipa 6A.
6. Formulacija 13-valentnog sterilnog tekućeg pneumokoknog konjugiranog cjepiva (PCV) koja sadrži 2 µg svakog kapsularnog polisaharida serotipova 1, 3, 4, 5, 7F, 9V, 14, 18C, 19A, 19F, 22F i 33F, 4 µg serotipa 6B, svaki pojedinačno konjugiran na 32 µg CRM197; 0.125 mg elementarnog aluminij (0.5 mg aluminij-fosfata) adjuvanta; i pufer natrijevog klorida i L-histidina, pri čemu formulacija ne sadrži kapsularni polisaharid iz serotipa 6A.
7. Postupak za formuliranje 13-valentne PCV formulacije prema zahtjevu 6, sadrži korake:
a) konjugaciju pneumokoknih kapsularnih polisaharida poznate veličine iz serotipova 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F i 33F aktivirane pomoću CDAP-a, pojedinačno na imunogeni nosač proteina CRM197,
b) diafiltraciju pojedinačnih monovalentnih pneumokoknih konjugata, nakon čega slijedi pročišćavanje pomoću kromatografije isključivanja veličine,
c) analizu frakcija pomoću SEC-HPLC i udruživanje frakcija koje sadrže monovalentne pneumokokne konjugate prije sterilizacije filtra pomoću filtra od 0.2 µm,
d) formulaciju 13-valentnog PCV-a pomoću 13 monovalentnih pneumokoknih konjugata; 4.4 µg za serotip 6B; 2.2 µg za ostatak serotipova i adjuvant Adju-Phos® zajedno s odgovarajućim ekscipijentom uključujući natrijev klorid i pufer koji uključuje L-histidin, praćeno aseptičnim punjenjem,
naznačen time što navedena 13-valentna PCV formulacija ne sadrži kapsularni polisaharid iz serotipa 6A.
8. Postupak za formuliranje 14-valentne PCV formulacije prema zahtjevu 5 sadrži korake:
a) konjugaciju pneumokoknih kapsularnih polisaharida poznate veličine iz serotipova 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F i 33F aktiviranih pomoću CDAP-a, pojedinačno na imunogeni nosač proteina CRM197,
b) diafiltraciju pojedinačnih monovalentnih pneumokoknih konjugata, nakon čega slijedi pročišćavanje pomoću kromatografije isključivanja veličine,
c) analizu frakcija pomoću SEC-HPLC i udruživanje frakcija koje sadrže monovalentne pneumokokne konjugate prije sterilizacije filtra pomoću filtra od 0.2 µm i
d) formulaciju 14-valentnog PCV-a pomoću monovalentnih konjugata pneumokoka; 4.4 µg za serotip 6B; 2,2 µg za ostatak serotipova i adjuvant Adju-Phos®, zajedno s odgovarajućim ekscipijentom, uključujući natrijev klorid i pufer koji uključuje L-histidin, praćeno aseptičnim punjenjem,
naznačen time što navedena 14-valentna PCV formulacija ne sadrži kapsularni polisaharid iz serotipa 6A.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3140CH2015 | 2015-06-23 | ||
PCT/IN2016/000157 WO2016207905A2 (en) | 2015-06-23 | 2016-06-21 | Multivalent pneumococcal conjugate vaccine |
EP16753710.9A EP3313436B1 (en) | 2015-06-23 | 2016-06-21 | Multivalent pneumococcal conjugate vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210373T1 true HRP20210373T1 (hr) | 2021-04-30 |
Family
ID=56738144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210373TT HRP20210373T1 (hr) | 2015-06-23 | 2021-03-03 | Multivalentno pneumokokno konjugirano cjepivo |
Country Status (22)
Country | Link |
---|---|
US (1) | US11147863B2 (hr) |
EP (1) | EP3313436B1 (hr) |
JP (1) | JP6808658B2 (hr) |
CN (1) | CN107810010A (hr) |
AU (1) | AU2016285017B2 (hr) |
BR (1) | BR112017028130A2 (hr) |
CA (1) | CA2989230A1 (hr) |
CY (1) | CY1123838T1 (hr) |
DK (1) | DK3313436T3 (hr) |
EA (1) | EA037373B1 (hr) |
ES (1) | ES2857474T3 (hr) |
HR (1) | HRP20210373T1 (hr) |
HU (1) | HUE053272T2 (hr) |
LT (1) | LT3313436T (hr) |
MX (1) | MX2017016828A (hr) |
PL (1) | PL3313436T3 (hr) |
PT (1) | PT3313436T (hr) |
RS (1) | RS61440B1 (hr) |
SA (1) | SA517390539B1 (hr) |
SI (1) | SI3313436T1 (hr) |
WO (1) | WO2016207905A2 (hr) |
ZA (1) | ZA201708713B (hr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
RU2721128C2 (ru) * | 2015-07-21 | 2020-05-18 | Пфайзер Инк. | Иммуногенные композиции, содержащие конъюгированные антигены капсульного сахарида, наборы, содержащие эти композиции, и их применения |
US11058757B2 (en) | 2016-03-31 | 2021-07-13 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
EP3518965A1 (en) | 2016-09-30 | 2019-08-07 | Biological E Limited | Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
JP7186166B2 (ja) | 2016-12-30 | 2022-12-08 | バックスサイト・インコーポレイテッド | 非天然アミノ酸とのポリペプチド抗原接合体 |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
JP7132954B2 (ja) * | 2017-06-10 | 2022-09-07 | インベントプライズ リミテッド ライアビリティ カンパニー | 改善された免疫原性及び結合活性を提供する2価又は多価コンジュゲート多糖を含む多価コンジュゲートワクチン |
CN108003240B (zh) * | 2017-12-04 | 2020-06-05 | 西安德轩驰生物科技有限公司 | 一种海水养殖鱼多联抗独特型卵黄抗体疫苗及其制备方法 |
KR20230130153A (ko) | 2017-12-06 | 2023-09-11 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
AU2019215216A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
BR112020021296A2 (pt) | 2018-04-18 | 2021-01-26 | Sk Bioscience Co., Ltd. | polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo |
CN113194987A (zh) * | 2018-10-12 | 2021-07-30 | 生物E有限公司 | 多价肺炎球菌多糖-蛋白缀合的疫苗 |
US20220296695A1 (en) | 2018-12-19 | 2022-09-22 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
EP3900739A1 (en) | 2020-04-21 | 2021-10-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic streptococcus pneumoniae saccharide conjugates to conserved membrane protein |
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CN103623401A (zh) | 2012-08-23 | 2014-03-12 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
CN103656631B (zh) | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
CN103656632B (zh) | 2012-09-24 | 2016-01-13 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖组合物、其制备方法及应用 |
KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
KR20140075201A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
CN104069488A (zh) | 2013-03-29 | 2014-10-01 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
US10280409B2 (en) | 2014-11-20 | 2019-05-07 | Biological E Limited | Codon optimized polynucleotide for high level expression of CRM197 |
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2016
- 2016-06-21 PL PL16753710T patent/PL3313436T3/pl unknown
- 2016-06-21 US US15/772,771 patent/US11147863B2/en active Active
- 2016-06-21 WO PCT/IN2016/000157 patent/WO2016207905A2/en active Application Filing
- 2016-06-21 MX MX2017016828A patent/MX2017016828A/es unknown
- 2016-06-21 EP EP16753710.9A patent/EP3313436B1/en active Active
- 2016-06-21 SI SI201631120T patent/SI3313436T1/sl unknown
- 2016-06-21 BR BR112017028130A patent/BR112017028130A2/pt active Search and Examination
- 2016-06-21 ES ES16753710T patent/ES2857474T3/es active Active
- 2016-06-21 HU HUE16753710A patent/HUE053272T2/hu unknown
- 2016-06-21 CA CA2989230A patent/CA2989230A1/en active Pending
- 2016-06-21 RS RS20210164A patent/RS61440B1/sr unknown
- 2016-06-21 LT LTEP16753710.9T patent/LT3313436T/lt unknown
- 2016-06-21 JP JP2017566871A patent/JP6808658B2/ja active Active
- 2016-06-21 CN CN201680037079.2A patent/CN107810010A/zh active Pending
- 2016-06-21 DK DK16753710.9T patent/DK3313436T3/da active
- 2016-06-21 EA EA201890431A patent/EA037373B1/ru unknown
- 2016-06-21 PT PT167537109T patent/PT3313436T/pt unknown
- 2016-06-21 AU AU2016285017A patent/AU2016285017B2/en active Active
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2017
- 2017-12-13 SA SA517390539A patent/SA517390539B1/ar unknown
- 2017-12-20 ZA ZA2017/08713A patent/ZA201708713B/en unknown
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2021
- 2021-02-18 CY CY20211100136T patent/CY1123838T1/el unknown
- 2021-03-03 HR HRP20210373TT patent/HRP20210373T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
LT3313436T (lt) | 2021-06-10 |
WO2016207905A2 (en) | 2016-12-29 |
EP3313436A2 (en) | 2018-05-02 |
US20190240308A1 (en) | 2019-08-08 |
WO2016207905A3 (en) | 2017-02-09 |
PT3313436T (pt) | 2021-02-25 |
US11147863B2 (en) | 2021-10-19 |
DK3313436T3 (da) | 2021-03-08 |
JP6808658B2 (ja) | 2021-01-06 |
MX2017016828A (es) | 2018-09-18 |
CA2989230A1 (en) | 2016-12-29 |
SA517390539B1 (ar) | 2021-05-24 |
PL3313436T3 (pl) | 2021-06-14 |
CY1123838T1 (el) | 2022-05-27 |
CN107810010A (zh) | 2018-03-16 |
EA037373B1 (ru) | 2021-03-22 |
EA201890431A1 (ru) | 2018-06-29 |
AU2016285017A1 (en) | 2018-01-04 |
JP2018518512A (ja) | 2018-07-12 |
SI3313436T1 (sl) | 2021-09-30 |
ZA201708713B (en) | 2019-08-28 |
ES2857474T3 (es) | 2021-09-29 |
RS61440B1 (sr) | 2021-03-31 |
BR112017028130A2 (pt) | 2018-08-28 |
HUE053272T2 (hu) | 2021-06-28 |
EP3313436B1 (en) | 2020-12-23 |
AU2016285017B2 (en) | 2022-03-03 |
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