CY1123838T1 - Πολυσθενες εμβολιο πνευμονιοκοκκικου συζευγματος - Google Patents

Πολυσθενες εμβολιο πνευμονιοκοκκικου συζευγματος

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Publication number
CY1123838T1
CY1123838T1 CY20211100136T CY211100136T CY1123838T1 CY 1123838 T1 CY1123838 T1 CY 1123838T1 CY 20211100136 T CY20211100136 T CY 20211100136T CY 211100136 T CY211100136 T CY 211100136T CY 1123838 T1 CY1123838 T1 CY 1123838T1
Authority
CY
Cyprus
Prior art keywords
conjugate vaccine
polystenes
pneumococcal
pneumococcal conjugate
composition
Prior art date
Application number
CY20211100136T
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English (en)
Inventor
Ramesh Venkat Matur
Nagarajan THIRUMENI
Rajendar Burki
Narender Dev MANTENA
Mahima DATLA
Original Assignee
Biological E Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biological E Limited filed Critical Biological E Limited
Publication of CY1123838T1 publication Critical patent/CY1123838T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία σύνθεση πολυσθενούς εμβολίου Πνευμονιοκοκκικού συζεύγματος (PCV) που περιλαμβάνει: 1) τουλάχιστον 12 καψικούς πολυσακχαρίτες που επιλέγονται από ορότυπους 1, 3, 4, 5, 6Β, 7F, 9Ν, 9V, 15Β, 14, 18C, 19Α, 19F, 22F, 23F και 33F του S. pneumoniae ενεργοποιημένοι με CDAP και συζευγμένοι σε πρωτεΐνη φορέα που επιλέγεται από CRM197, πνευμονιοκοκκική πρωτεΐνη Α επιφανείας (PspA), πνευμονιοκοκκική πρωτεΐνη προσκολλητίνης (PsaA) ή συνδυασμό αυτών και 2) έναν φαρμακευτικά αποδεκτό φορέα, όπου η σύνθεση δεν περιέχει καψικό πολυσακχαρίτη από ορότυπο 6Α.
CY20211100136T 2015-06-23 2021-02-18 Πολυσθενες εμβολιο πνευμονιοκοκκικου συζευγματος CY1123838T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3140CH2015 2015-06-23
PCT/IN2016/000157 WO2016207905A2 (en) 2015-06-23 2016-06-21 Multivalent pneumococcal conjugate vaccine

Publications (1)

Publication Number Publication Date
CY1123838T1 true CY1123838T1 (el) 2022-05-27

Family

ID=56738144

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100136T CY1123838T1 (el) 2015-06-23 2021-02-18 Πολυσθενες εμβολιο πνευμονιοκοκκικου συζευγματος

Country Status (22)

Country Link
US (1) US11147863B2 (el)
EP (1) EP3313436B1 (el)
JP (1) JP6808658B2 (el)
CN (1) CN107810010A (el)
AU (1) AU2016285017B2 (el)
BR (1) BR112017028130A2 (el)
CA (1) CA2989230A1 (el)
CY (1) CY1123838T1 (el)
DK (1) DK3313436T3 (el)
EA (1) EA037373B1 (el)
ES (1) ES2857474T3 (el)
HR (1) HRP20210373T1 (el)
HU (1) HUE053272T2 (el)
LT (1) LT3313436T (el)
MX (1) MX2017016828A (el)
PL (1) PL3313436T3 (el)
PT (1) PT3313436T (el)
RS (1) RS61440B1 (el)
SA (1) SA517390539B1 (el)
SI (1) SI3313436T1 (el)
WO (1) WO2016207905A2 (el)
ZA (1) ZA201708713B (el)

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UA126385C2 (uk) * 2016-09-30 2022-09-28 Байолоджикал І Лімітед Композиції полівалентної пневмококової вакцини, що містять кон'югати полісахарид-білок
CA3048981A1 (en) 2016-12-30 2018-07-05 Sutrovax, Inc. Polypeptide-antigen conjugates with non-natural amino acids
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EA202191638A1 (ru) * 2018-10-12 2021-12-27 Байолоджикал И Лимитед Мультивалентная вакцина на основе конъюгата пневмококковый полисахарид-белок
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KR20140075196A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
CN104069488A (zh) 2013-03-29 2014-10-01 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法
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Also Published As

Publication number Publication date
HUE053272T2 (hu) 2021-06-28
US11147863B2 (en) 2021-10-19
EP3313436A2 (en) 2018-05-02
HRP20210373T1 (hr) 2021-04-30
WO2016207905A3 (en) 2017-02-09
BR112017028130A2 (pt) 2018-08-28
CA2989230A1 (en) 2016-12-29
RS61440B1 (sr) 2021-03-31
JP6808658B2 (ja) 2021-01-06
DK3313436T3 (da) 2021-03-08
SI3313436T1 (sl) 2021-09-30
US20190240308A1 (en) 2019-08-08
ZA201708713B (en) 2019-08-28
ES2857474T3 (es) 2021-09-29
AU2016285017B2 (en) 2022-03-03
EA037373B1 (ru) 2021-03-22
JP2018518512A (ja) 2018-07-12
WO2016207905A2 (en) 2016-12-29
SA517390539B1 (ar) 2021-05-24
EP3313436B1 (en) 2020-12-23
AU2016285017A1 (en) 2018-01-04
PL3313436T3 (pl) 2021-06-14
EA201890431A1 (ru) 2018-06-29
LT3313436T (lt) 2021-06-10
CN107810010A (zh) 2018-03-16
MX2017016828A (es) 2018-09-18
PT3313436T (pt) 2021-02-25

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