HRP20201861T1 - Sredstvo protiv tuberkuloze - Google Patents
Sredstvo protiv tuberkuloze Download PDFInfo
- Publication number
- HRP20201861T1 HRP20201861T1 HRP20201861TT HRP20201861T HRP20201861T1 HR P20201861 T1 HRP20201861 T1 HR P20201861T1 HR P20201861T T HRP20201861T T HR P20201861TT HR P20201861 T HRP20201861 T HR P20201861T HR P20201861 T1 HRP20201861 T1 HR P20201861T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- dimethylphenoxy
- piperidin
- dione
- methyl
- Prior art date
Links
- 229940121383 antituberculosis agent Drugs 0.000 title 1
- 239000000814 tuberculostatic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 12
- AZOFJHATIPDIER-UHFFFAOYSA-N 6-[[4-(2,3-dimethylphenoxy)piperidin-1-yl]methyl]-1h-pyrimidine-2,4-dione Chemical compound CC1=CC=CC(OC2CCN(CC=3NC(=O)NC(=O)C=3)CC2)=C1C AZOFJHATIPDIER-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 206010062207 Mycobacterial infection Diseases 0.000 claims 3
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- HBUJYEUPIIJJOS-PBHICJAKSA-N (5r)-3-[4-[1-[(2s)-2,3-dihydroxypropanoyl]-3,6-dihydro-2h-pyridin-4-yl]-3,5-difluorophenyl]-5-(1,2-oxazol-3-yloxymethyl)-1,3-oxazolidin-2-one Chemical compound C1N(C(=O)[C@@H](O)CO)CCC(C=2C(=CC(=CC=2F)N2C(O[C@@H](COC3=NOC=C3)C2)=O)F)=C1 HBUJYEUPIIJJOS-PBHICJAKSA-N 0.000 claims 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- ZLHZLMOSPGACSZ-NSHDSACASA-N (6s)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine Chemical compound O([C@H]1CN2C=C(N=C2OC1)[N+](=O)[O-])CC1=CC=C(OC(F)(F)F)C=C1 ZLHZLMOSPGACSZ-NSHDSACASA-N 0.000 claims 1
- QUIJNHUBAXPXFS-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C2=CC=CC=C2C=CC=1)C1=CC=CC=C1 QUIJNHUBAXPXFS-UHFFFAOYSA-N 0.000 claims 1
- KIMCGLHTSSZPNS-UHFFFAOYSA-N 2,3-dinitrobenzamide Chemical compound NC(=O)C1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O KIMCGLHTSSZPNS-UHFFFAOYSA-N 0.000 claims 1
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical compound C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 claims 1
- YVMGQODAKAHLHB-UHFFFAOYSA-N 3-nitroimidazo[4,5-e]oxazine Chemical compound O1N=C([N+](=O)[O-])C=C2N=CN=C21 YVMGQODAKAHLHB-UHFFFAOYSA-N 0.000 claims 1
- XZISSTDXPBUCJA-DYESRHJHSA-N ClC1=CC(=C(C(=C1)F)N1C[C@H]([C@](CC1)(O)COC1=C2CCC(NC2=C(C=C1)F)=O)O)F Chemical compound ClC1=CC(=C(C(=C1)F)N1C[C@H]([C@](CC1)(O)COC1=C2CCC(NC2=C(C=C1)F)=O)O)F XZISSTDXPBUCJA-DYESRHJHSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 229940124522 antiretrovirals Drugs 0.000 claims 1
- 239000003903 antiretrovirus agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 claims 1
- 229960004287 clofazimine Drugs 0.000 claims 1
- XDAOLTSRNUSPPH-XMMPIXPASA-N delamanid Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 XDAOLTSRNUSPPH-XMMPIXPASA-N 0.000 claims 1
- 229960000285 ethambutol Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229960003350 isoniazid Drugs 0.000 claims 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical group NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 1
- 229960003907 linezolid Drugs 0.000 claims 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical group O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims 1
- 229960003702 moxifloxacin Drugs 0.000 claims 1
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 claims 1
- JFIBVDBTCDTBRH-REZTVBANSA-N n'-(2-adamantyl)-n-[(2e)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine Chemical compound C1C(C2)CC3CC1C(NCCNC/C=C(C)/CCC=C(C)C)C2C3 JFIBVDBTCDTBRH-REZTVBANSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229950004447 posizolid Drugs 0.000 claims 1
- 229960005206 pyrazinamide Drugs 0.000 claims 1
- IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 claims 1
- BTTNOGHPGJANSW-IBGZPJMESA-N radezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C1=CC=C(C=2C=CC(CNCC=3NN=NC=3)=CC=2)C(F)=C1 BTTNOGHPGJANSW-IBGZPJMESA-N 0.000 claims 1
- 229950009965 radezolid Drugs 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 229960002599 rifapentine Drugs 0.000 claims 1
- WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 claims 1
- FNDDDNOJWPQCBZ-ZDUSSCGKSA-N sutezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCSCC1 FNDDDNOJWPQCBZ-ZDUSSCGKSA-N 0.000 claims 1
- 229960003879 tedizolid Drugs 0.000 claims 1
- XFALPSLJIHVRKE-GFCCVEGCSA-N tedizolid Chemical compound CN1N=NC(C=2N=CC(=CC=2)C=2C(=CC(=CC=2)N2C(O[C@@H](CO)C2)=O)F)=N1 XFALPSLJIHVRKE-GFCCVEGCSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-dion, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
2. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-dion, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju bolesti koja je posljedica mikobakterijske infekcije kod sisavca.
3. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-dion, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju mikobakterijske infekcije kod sisavca.
4. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-dion, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 2 ili 3, naznačen time što je mikobakterijska infekcija infekcija bakterijom Mycobacterium tuberculosis.
5. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(11H,3H)-dion, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 2, naznačen time što je bolest tuberkuloza.
6. 6-((4-(2,3-Dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H-dion, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 2 ili 3, naznačen time što je sisavac čovjek.
7. Sol, naznačena time što je sol 6-((4-(2,3-dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-diona.
8. Farmaceutski prihvatljiva sol, naznačena time što je farmaceutski prihvatljiva sol 6-((4-(2,3-dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-diona.
9. Kombinacija, naznačena time što je kombinacija
a) 6-((4-(2,3-dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-diona, ili njegove farmaceutski prihvatljive soli; i
b) drugog terapijskog sredstva.
10. Kombinacija u skladu s patentnim zahtjevom 9, naznačena time što se drugo terapijsko sredstvo bira između izoniazida, rifampina, pirazinamida, etambutola, moksifloksacina, rifapentina, klofazimina, bedakvilina (TMC207), nitroimidazo-oksazina PA-824, delamanida (OPC-67683), OPC-167832, oksazolidinona, analoga EMB SQ109, benzotiazinona, dinitrobenzamida i protuvirusnog sredstva, uključujući proturetrovirusno sredstvo.
11. Kombinacija u skladu s patentnim zahtjevom 10, naznačena time što je oksazolidinon linezolid, tedizolid, radezolid, sutezolid (PNU-100480) ili posizolid (AZD-5847).
12. Kombinacija u skladu s patentnim zahtjevom 9, naznačena time što je drugo terapijsko sredstvo terapijsko sredstvo odobreno ili preporučeno za liječenje tuberkuloze.
13. Farmaceutski pripravak, naznačen time što sadrži a) 6-((4-(2,3-dimetilfenoksi)piperidin-1-il)metil)pirimidin-2,4(1H,3H)-dion, ili njegova farmaceutski prihvatljiva sol; i b) farmaceutski prihvatljivo pomoćno sredstvo.
14. Farmaceutski pripravak u skladu s patentnim zahtjevom 13, naznačen time što sadrži drugo terapijsko sredstvo.
15. Farmaceutski pripravak u skladu s patentnim zahtjevom 14, naznačen time što je drugo terapijsko sredstvo u skladu s bilo kojim od patentnih zahtjeva 10-12.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382124 | 2016-03-22 | ||
| EP17710980.8A EP3432887B1 (en) | 2016-03-22 | 2017-03-20 | Antituberculosis agent |
| PCT/EP2017/056565 WO2017162591A1 (en) | 2016-03-22 | 2017-03-20 | Antituberculosis agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201861T1 true HRP20201861T1 (hr) | 2021-01-08 |
Family
ID=55752236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201861TT HRP20201861T1 (hr) | 2016-03-22 | 2020-11-23 | Sredstvo protiv tuberkuloze |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10624893B2 (hr) |
| EP (1) | EP3432887B1 (hr) |
| JP (1) | JP6961608B2 (hr) |
| KR (1) | KR102479358B1 (hr) |
| CN (1) | CN108883114B (hr) |
| AR (1) | AR107935A1 (hr) |
| AU (1) | AU2017237380B2 (hr) |
| CA (1) | CA3018611C (hr) |
| CY (1) | CY1123527T1 (hr) |
| DK (1) | DK3432887T3 (hr) |
| ES (1) | ES2833929T3 (hr) |
| HR (1) | HRP20201861T1 (hr) |
| HU (1) | HUE051349T2 (hr) |
| LT (1) | LT3432887T (hr) |
| PL (1) | PL3432887T3 (hr) |
| PT (1) | PT3432887T (hr) |
| RS (1) | RS61103B1 (hr) |
| RU (1) | RU2756208C2 (hr) |
| SI (1) | SI3432887T1 (hr) |
| TW (1) | TW201808295A (hr) |
| UY (1) | UY37161A (hr) |
| WO (1) | WO2017162591A1 (hr) |
| ZA (1) | ZA201806012B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110004074B (zh) * | 2019-02-28 | 2021-06-18 | 北京蛋白质组研究中心 | 一种利用silac标记耻垢分枝杆菌蛋白质的方法及其专用培养基 |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| CN115902217B (zh) * | 2023-03-08 | 2023-06-16 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 一种牛副结核病间接elisa检测试剂盒及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2188196C2 (ru) * | 1998-05-26 | 2002-08-27 | Ашкинази Римма Ильинична | N-замещенные производные 5-оксииминобарбитуровой кислоты |
| AU2964899A (en) * | 1998-12-04 | 2000-06-26 | Rimma Iliinichna Ashkinazi | 2,4-dioxo-5-arylidenimino-1,3-pyrimidines |
| EP1655288A1 (en) * | 2004-11-05 | 2006-05-10 | Institut Pasteur | Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents |
-
2017
- 2017-03-20 ES ES17710980T patent/ES2833929T3/es active Active
- 2017-03-20 JP JP2018549859A patent/JP6961608B2/ja active Active
- 2017-03-20 LT LTEP17710980.8T patent/LT3432887T/lt unknown
- 2017-03-20 WO PCT/EP2017/056565 patent/WO2017162591A1/en active Application Filing
- 2017-03-20 DK DK17710980.8T patent/DK3432887T3/da active
- 2017-03-20 US US16/087,161 patent/US10624893B2/en active Active
- 2017-03-20 KR KR1020187029956A patent/KR102479358B1/ko active IP Right Grant
- 2017-03-20 CA CA3018611A patent/CA3018611C/en active Active
- 2017-03-20 CN CN201780019751.XA patent/CN108883114B/zh active Active
- 2017-03-20 RU RU2018136747A patent/RU2756208C2/ru active
- 2017-03-20 SI SI201730508T patent/SI3432887T1/sl unknown
- 2017-03-20 PT PT177109808T patent/PT3432887T/pt unknown
- 2017-03-20 HU HUE17710980A patent/HUE051349T2/hu unknown
- 2017-03-20 AU AU2017237380A patent/AU2017237380B2/en active Active
- 2017-03-20 RS RS20201409A patent/RS61103B1/sr unknown
- 2017-03-20 EP EP17710980.8A patent/EP3432887B1/en active Active
- 2017-03-20 PL PL17710980T patent/PL3432887T3/pl unknown
- 2017-03-21 TW TW106109379A patent/TW201808295A/zh unknown
- 2017-03-21 AR ARP170100695A patent/AR107935A1/es unknown
- 2017-03-21 UY UY0001037161A patent/UY37161A/es unknown
-
2018
- 2018-09-07 ZA ZA2018/06012A patent/ZA201806012B/en unknown
-
2020
- 2020-11-20 CY CY20201101104T patent/CY1123527T1/el unknown
- 2020-11-23 HR HRP20201861TT patent/HRP20201861T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3432887T3 (pl) | 2021-05-17 |
| RS61103B1 (sr) | 2020-12-31 |
| UY37161A (es) | 2017-09-29 |
| AU2017237380B2 (en) | 2019-12-19 |
| KR20180122006A (ko) | 2018-11-09 |
| AU2017237380A1 (en) | 2018-09-27 |
| JP2019512524A (ja) | 2019-05-16 |
| AR107935A1 (es) | 2018-06-28 |
| RU2018136747A (ru) | 2020-04-22 |
| DK3432887T3 (da) | 2020-11-09 |
| SI3432887T1 (sl) | 2020-12-31 |
| EP3432887B1 (en) | 2020-09-02 |
| JP6961608B2 (ja) | 2021-11-05 |
| RU2018136747A3 (hr) | 2020-05-15 |
| PT3432887T (pt) | 2020-12-04 |
| LT3432887T (lt) | 2020-12-10 |
| US20190091224A1 (en) | 2019-03-28 |
| CN108883114B (zh) | 2021-08-24 |
| HUE051349T2 (hu) | 2021-03-01 |
| EP3432887A1 (en) | 2019-01-30 |
| ES2833929T3 (es) | 2021-06-16 |
| RU2756208C2 (ru) | 2021-09-28 |
| US10624893B2 (en) | 2020-04-21 |
| WO2017162591A1 (en) | 2017-09-28 |
| BR112018069487A2 (pt) | 2019-02-12 |
| KR102479358B1 (ko) | 2022-12-19 |
| CA3018611A1 (en) | 2017-09-28 |
| CN108883114A (zh) | 2018-11-23 |
| CY1123527T1 (el) | 2022-03-24 |
| ZA201806012B (en) | 2020-02-26 |
| TW201808295A (zh) | 2018-03-16 |
| CA3018611C (en) | 2024-02-27 |
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