HRP20201685T1 - Sastavi gama-hidroksibutirata i njihova upotreba za liječenje poremećaja - Google Patents
Sastavi gama-hidroksibutirata i njihova upotreba za liječenje poremećaja Download PDFInfo
- Publication number
- HRP20201685T1 HRP20201685T1 HRP20201685TT HRP20201685T HRP20201685T1 HR P20201685 T1 HRP20201685 T1 HR P20201685T1 HR P20201685T T HRP20201685T T HR P20201685TT HR P20201685 T HRP20201685 T HR P20201685T HR P20201685 T1 HRP20201685 T1 HR P20201685T1
- Authority
- HR
- Croatia
- Prior art keywords
- ghb
- gamma
- hydroxybutyrate
- pharmaceutical composition
- composition according
- Prior art date
Links
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 title claims 23
- 239000000203 mixture Substances 0.000 title claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000011575 calcium Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 239000011777 magnesium Substances 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 159000000003 magnesium salts Chemical class 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737695P | 2012-12-14 | 2012-12-14 | |
| EP17202548.8A EP3335709B1 (en) | 2012-12-14 | 2013-12-13 | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201685T1 true HRP20201685T1 (hr) | 2020-12-25 |
Family
ID=49596603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201685TT HRP20201685T1 (hr) | 2012-12-14 | 2020-10-19 | Sastavi gama-hidroksibutirata i njihova upotreba za liječenje poremećaja |
Country Status (24)
| Country | Link |
|---|---|
| US (9) | US8591922B1 (https=) |
| EP (3) | EP3335709B1 (https=) |
| JP (1) | JP6215347B2 (https=) |
| KR (1) | KR102180343B1 (https=) |
| CN (1) | CN105025892B (https=) |
| AU (1) | AU2013359114B2 (https=) |
| CA (1) | CA2894876C (https=) |
| CY (2) | CY1119918T1 (https=) |
| DK (2) | DK3335709T3 (https=) |
| ES (2) | ES2660056T3 (https=) |
| HR (1) | HRP20201685T1 (https=) |
| HU (1) | HUE051060T2 (https=) |
| IL (1) | IL239355A (https=) |
| IN (1) | IN342829B (https=) |
| LT (1) | LT3335709T (https=) |
| MX (1) | MX366681B (https=) |
| NO (1) | NO3027826T3 (https=) |
| PL (1) | PL2931268T3 (https=) |
| PT (2) | PT2931268T (https=) |
| SG (1) | SG11201504637TA (https=) |
| SI (1) | SI3335709T1 (https=) |
| TR (1) | TR201802271T4 (https=) |
| TW (2) | TWI639425B (https=) |
| WO (1) | WO2014093791A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX391660B (es) | 2010-03-24 | 2025-03-21 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| CN113061089A (zh) | 2015-09-23 | 2021-07-02 | 凯瑞康宁生物工程（武汉）有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| FR3049463B1 (fr) | 2016-04-01 | 2019-07-05 | Debregeas Et Associes Pharma | Doses unitaires a liberation immediate de ghb ou de l'un de ses sels therapeutiquement acceptables administrees par voie orale et leur utilisation pour maintenir l'abstinence alcoolique |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11000498B2 (en) | 2016-07-22 | 2021-05-11 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| WO2019126214A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release |
| EP3737353A1 (en) | 2017-12-18 | 2020-11-18 | Tris Pharma, Inc. | Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| US11337919B2 (en) | 2017-12-18 | 2022-05-24 | Tris Pharma, Inc. | Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release |
| WO2019126216A1 (en) | 2017-12-18 | 2019-06-27 | Tris Phama, Inc. | Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| BR112021006027A2 (pt) | 2018-11-19 | 2021-06-29 | Jazz Pharmaceuticals Ireland Limited | formulações de fármaco resistente a álcool |
| CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| US20210186907A1 (en) | 2019-12-24 | 2021-06-24 | Jazz Pharmaceuticals Ireland Limited | Ghb dosing |
| TW202139986A (zh) * | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| KR102436227B1 (ko) * | 2020-05-29 | 2022-08-24 | 주식회사 케이티앤지 | 기능성 물질이 코팅된 흡연물품용 팁페이퍼 및 상기 팁페이퍼의 코팅 방법 |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) * | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| KR20230058151A (ko) | 2020-10-05 | 2023-05-02 | 엑스더블유파마 리미티드 | 감마-하이드록시부티르산 유도체의 변형된 방출 조성물 |
| US12582622B2 (en) | 2020-10-08 | 2026-03-24 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| WO2022082105A2 (en) | 2020-10-16 | 2022-04-21 | Jazz Pharmaceuticals Ireland Limited | Treatment methods using ghb |
| EP4588471A3 (en) | 2021-03-19 | 2025-09-24 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
| AU2022246286A1 (en) * | 2021-03-20 | 2023-09-07 | Alkem Laboratories Limited | A process for the preparation of mixed oxybate salts and polymorphs thereof |
| US11877992B1 (en) | 2021-06-07 | 2024-01-23 | Kelly Kathleen Spinelli | Gamma-hydroxybutyrate salts for the treatment of learning disorders |
| US11877993B1 (en) | 2021-06-23 | 2024-01-23 | Kelly Kathleen Spinelli | Gamma-hydroxybutyrate salts for the treatment of psychological disorders |
| EP4415701A1 (en) | 2021-10-11 | 2024-08-21 | Jazz Pharmaceuticals Ireland Limited | Method of administering oxybate |
| WO2023135150A1 (en) | 2022-01-11 | 2023-07-20 | Jazz Pharmaceuticals Ireland Limited | Method of administering oxybate |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20230338543A1 (en) * | 2022-04-21 | 2023-10-26 | Zevra Therapeutics, Inc. | Gamma-hydroxybutyrate delivering compounds and processes for making and using them |
| WO2024163966A1 (en) | 2023-02-03 | 2024-08-08 | Tris Pharma, Inc. | Low sodium oxybate once nightly composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB922029A (en) | 1960-05-19 | 1963-03-27 | Equilibre Biolog L | Therapeutic composition |
| US4374441A (en) | 1980-05-23 | 1983-02-22 | Book Covers, Inc. | Method of making a book cover and pocket element therefor |
| ZA814854B (en) | 1980-07-17 | 1982-07-28 | J Klosa | Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts |
| EP0044801B1 (de) | 1980-07-17 | 1984-02-15 | Josef Dr. Klosa | Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel |
| EP0235408B1 (en) | 1984-08-06 | 1991-01-09 | The University Of Toronto Innovations Foundation | Pharmaceutical composition and treatment |
| US4738985A (en) | 1986-03-19 | 1988-04-19 | The University Of Toronto Innovations Foundations | Pharmaceutical composition and treatment |
| IT1217783B (it) | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| JP2564690B2 (ja) | 1990-06-14 | 1996-12-18 | 三省製薬 株式会社 | メラニン生成抑制外用剤 |
| DE4113984C2 (de) | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| IT1271403B (it) | 1993-03-26 | 1997-05-28 | Ct Lab Farm Srl | Sali dell'acido gamma-idrossibutirrico ad attivita' ansiolitica e per il trattamento degli stati depressivi |
| IT1266565B1 (it) | 1993-07-22 | 1997-01-09 | Ct Lab Farm Srl | Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico. |
| US5840331A (en) | 1995-06-07 | 1998-11-24 | Arch Development Corporation | Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin |
| IT1283782B1 (it) | 1996-08-09 | 1998-04-30 | Ct Lab Farm Srl | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
| US6495598B1 (en) | 1997-04-22 | 2002-12-17 | Ophtecs Corporation | Perfusate preparation for ophthalmic operation |
| US5990162A (en) | 1997-08-29 | 1999-11-23 | Orphan Medical, Inc. | Method for treatment of fibromyalgia and chronic fatigue syndrome |
| DK1140061T3 (da) | 1998-12-23 | 2003-08-25 | Orphan Medical Inc | Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi |
| ES2383673T3 (es) | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
| FR2817256B1 (fr) | 2000-11-27 | 2005-07-15 | Univ Pasteur | Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques |
| WO2006124609A2 (en) * | 2005-05-16 | 2006-11-23 | Joseph Johnson | Methods and compositions for treating arg |
| US8778398B2 (en) * | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US8771735B2 (en) | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| US8410304B2 (en) | 2009-04-15 | 2013-04-02 | Norac Pharma | Process for preparing gamma-hydroxybutyrate |
| CN102946869B (zh) * | 2010-05-04 | 2016-08-03 | 爵士制药有限公司 | γ-羟基丁酸的速释制剂及剂型 |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
-
2013
- 2013-01-11 US US13/739,886 patent/US8591922B1/en active Active
- 2013-10-03 US US14/045,673 patent/US9132107B2/en active Active
- 2013-12-13 TW TW102146274A patent/TWI639425B/zh active
- 2013-12-13 LT LTEP17202548.8T patent/LT3335709T/lt unknown
- 2013-12-13 TR TR2018/02271T patent/TR201802271T4/tr unknown
- 2013-12-13 EP EP17202548.8A patent/EP3335709B1/en active Active
- 2013-12-13 CA CA2894876A patent/CA2894876C/en active Active
- 2013-12-13 WO PCT/US2013/074954 patent/WO2014093791A1/en not_active Ceased
- 2013-12-13 KR KR1020157018947A patent/KR102180343B1/ko active Active
- 2013-12-13 PL PL13863231T patent/PL2931268T3/pl unknown
- 2013-12-13 MX MX2015007531A patent/MX366681B/es active IP Right Grant
- 2013-12-13 TW TW106143923A patent/TWI681770B/zh not_active IP Right Cessation
- 2013-12-13 JP JP2015547980A patent/JP6215347B2/ja active Active
- 2013-12-13 SI SI201331802T patent/SI3335709T1/sl unknown
- 2013-12-13 ES ES13863231.0T patent/ES2660056T3/es active Active
- 2013-12-13 CN CN201380072864.8A patent/CN105025892B/zh active Active
- 2013-12-13 DK DK17202548.8T patent/DK3335709T3/da active
- 2013-12-13 EP EP13863231.0A patent/EP2931268B1/en active Active
- 2013-12-13 SG SG11201504637TA patent/SG11201504637TA/en unknown
- 2013-12-13 PT PT138632310T patent/PT2931268T/pt unknown
- 2013-12-13 AU AU2013359114A patent/AU2013359114B2/en active Active
- 2013-12-13 IN IN3943CH2015 patent/IN342829B/en unknown
- 2013-12-13 EP EP20190343.2A patent/EP3799867A1/en not_active Withdrawn
- 2013-12-13 PT PT172025488T patent/PT3335709T/pt unknown
- 2013-12-13 ES ES17202548T patent/ES2827005T3/es active Active
- 2013-12-13 HU HUE17202548A patent/HUE051060T2/hu unknown
- 2013-12-13 DK DK13863231.0T patent/DK2931268T3/en active
-
2014
- 2014-02-04 US US14/172,751 patent/US8901173B2/en active Active
- 2014-07-22 NO NO14741895A patent/NO3027826T3/no unknown
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2015
- 2015-06-11 IL IL239355A patent/IL239355A/en active IP Right Grant
- 2015-08-07 US US14/821,384 patent/US9555017B2/en active Active
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2016
- 2016-12-20 US US15/385,447 patent/US10195168B2/en active Active
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2018
- 2018-02-14 CY CY20181100181T patent/CY1119918T1/el unknown
- 2018-12-21 US US16/230,460 patent/US10675258B2/en active Active
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2020
- 2020-05-12 US US15/930,295 patent/US11554102B2/en active Active
- 2020-10-19 HR HRP20201685TT patent/HRP20201685T1/hr unknown
- 2020-11-02 CY CY20201101030T patent/CY1123498T1/el unknown
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2021
- 2021-09-20 US US17/479,886 patent/US20220000815A1/en not_active Abandoned
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2023
- 2023-06-30 US US18/346,015 patent/US20240156759A1/en active Pending
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