HRP20201290T1 - Novi izooblici tripsina i njihova upotreba - Google Patents
Novi izooblici tripsina i njihova upotreba Download PDFInfo
- Publication number
- HRP20201290T1 HRP20201290T1 HRP20201290TT HRP20201290T HRP20201290T1 HR P20201290 T1 HRP20201290 T1 HR P20201290T1 HR P20201290T T HRP20201290T T HR P20201290TT HR P20201290 T HRP20201290 T HR P20201290T HR P20201290 T1 HRP20201290 T1 HR P20201290T1
- Authority
- HR
- Croatia
- Prior art keywords
- trypsin
- seq
- amino acid
- acid sequence
- cod
- Prior art date
Links
- 102000004142 Trypsin Human genes 0.000 title claims 19
- 108090000631 Trypsin Proteins 0.000 title claims 19
- 239000012588 trypsin Substances 0.000 title claims 19
- 102000001708 Protein Isoforms Human genes 0.000 title claims 10
- 108010029485 Protein Isoforms Proteins 0.000 title claims 10
- 239000000203 mixture Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 238000001042 affinity chromatography Methods 0.000 claims 3
- 208000010668 atopic eczema Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- WPANETAWYGDRLL-UHFFFAOYSA-N 4-aminobenzenecarboximidamide Chemical compound NC(=N)C1=CC=C(N)C=C1 WPANETAWYGDRLL-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 231100000397 ulcer Toxicity 0.000 claims 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010016717 Fistula Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040954 Skin wrinkling Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 208000000260 Warts Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 206010048038 Wound infection Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000038016 acute inflammation Diseases 0.000 claims 1
- 230000006022 acute inflammation Effects 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 239000003957 anion exchange resin Substances 0.000 claims 1
- 239000006286 aqueous extract Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003729 cation exchange resin Substances 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000003890 fistula Effects 0.000 claims 1
- 210000003953 foreskin Anatomy 0.000 claims 1
- 230000036074 healthy skin Effects 0.000 claims 1
- 208000014617 hemorrhoid Diseases 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001297 phlebitis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 201000010153 skin papilloma Diseases 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000004647 tinea pedis Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6408—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1706—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Pulmonology (AREA)
- Marine Sciences & Fisheries (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Claims (15)
1. Izolirani ZT izooblik tripsina bakalara koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:1.
2. Izolirani ZT izooblik tripsina bakalara prema zahtjevu 1, izabran između tripsina ZT-1 bakalara, koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:2; tripsina ZT-2 bakalara koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:3; tripsina ZT-3 bakalara koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:4; i tripsina ZT-4 bakalara koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:5.
3. Sastav koji sadrži najmanje jedan ZT izooblik tripsina bakalara prema zahtjevu 1 ili 2, zajedno s pogodnim pomoćnim tvarima i nosačima.
4. Sastav prema zahtjevu 3, gdje spomenuti ZT izooblik(ci) tripsina bakalara su prisutni u smjesi s drugim tripsinima bakalara.
5. Sastav prema zahtjevu 4, gdje spomenuti ZT izooblik(ci) tipsina bakalara sadrži najmanje 5% (mas/mas) ukupnog sadržaja tripsina bakalara u spomenutom sastavu.
6. Sastav prema bilo kojem od zahtjeva 3 do 5, koji se može davati lokalno, kao losion, hidrogel, sprej za usta ili sprej za nos.
7. Sastav prema bilo kojem od zahtjeva 3 do 6, koji dalje sadrži polivalentni alkohol, kao što je glicerol.
8. Sastav prema bilo kojem od zahtjeva 3 do 7, za upotrebu u terapiji.
9. Sastav prema bilo kojem od zahtjeva 3 do 7, za upotrebu u (a) liječenju ili prevenciji bolesti uzrokovane patogenim organizmom koji je izabran iz grupe koja se sastoji od virusa, bakterije, gljivice, parazita i protozoa;
(b) liječenju ili prevenciji bolesti u gornjem respiratornom traktu uzrokovane patogenim organizmima kao što su virusi, bakterije i gljivice;
(c) liječenju ili prevenciji boli, akutne upale, kronične upale, artritisa, upaljenih zglobova, burzitisa, osteoartritisa, reumatoidnog artritisa, juvenilnog reumatoidnog artritisa, artritisa uzrokovanog sepsom, fibromijalgije, sistemskog eritemskog lupusa, flebitisa, tendinitisa, osipa, psorijaze, akni, ekcema, seboroičnog ekcema na licu, ekcema ruku, lica ili vrata, infekcija prepucija, atletskog stopala, infekcije fistula, inficiranih lokalnih ulcera, infekcije pupka kod novorođenčadi, bora, ožiljaka, keloida, potkožnih čireva, bradavica i alergijskog svraba, hemoroida, gljivične infekcije i imunološkog poremećaja uključujući autoimuni poremećaj;
(d) liječenju infekcija rana i rana od opekotina; i/ili
(e) uklanjanju mrtve ili ljuštene kože od inače zdrave kože.
10. Sastav prema bilo kojem od zahtjeva 3 do 7, za kozmetičku upotrebu.
11. Sastav za kozmetičku upotrebu, prema zahtjevu 10, spomenuti sastav dalje sadrži dodatni kozmetički aktivni spoj.
12. Postupak za dobivanje ZT izooblika tripsina bakalara koji sadrže aminokiselinsku sekvencu prema bilo kojem od SEQ ID NO:2 do SEQ ID NO:5, koji obuhvaća
(i) dobivanje vodenog ekstrakta utrobe bakalara,
(ii) izlaganje vodenog ekstrakta najmanje jednom ili koraku kromatografije, uključujući korak afinitetne kromatografije upotrebom p-aminobenzamidinskog afinitetnog liganda, i
(iii) desorbiranje i eluiranje ZT izooblika tripsina bakalara vezanih sa p-aminobenzamidinskim afinitetnim ligandom.
13. Postupak prema zahtjevu 12, koji dalje sadrži najmanje jedan korak upotrebom anionske izmjenjivačke smole nakon spomenutog koraka afinitetne kromatografije (ii) i/ili
dalje sadrži najmanje jedan korak upotrebom kationske izmjenjivačke smole prije koraka afinitetne kromatografije (ii).
14. Postupak prema zahtjevu 12 ili 13, gdje spomenuti desorbirani i eluirani ZT izooblici tripsina bakalara su sterilno procijeđeni upotrebom filtera sa 0.45 µm ili manjom veličinom otvora.
15. Postupak prema bilo kojem od zahtjeva 12 do 14, gdje spomenuti ZT izooblici tripsina bakalara su izabrani između tripsina ZT-1, koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:2; tripsina ZT-2 koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:3; tripsina ZT-3 koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:4; i tripsina ZT-4, koji sadrži aminokiselinsku sekvencu prema SEQ ID NO:5, ili njihove smjese.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178208.3A EP3121272A1 (en) | 2015-07-24 | 2015-07-24 | Novel fish trypsin isoforms and their use |
| EP16745663.1A EP3325618B1 (en) | 2015-07-24 | 2016-07-22 | Novel trypsin isoforms and their use |
| PCT/EP2016/067531 WO2017017012A1 (en) | 2015-07-24 | 2016-07-22 | Novel trypsin isoforms and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201290T1 true HRP20201290T1 (hr) | 2020-11-13 |
Family
ID=53758073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201290TT HRP20201290T1 (hr) | 2015-07-24 | 2020-08-18 | Novi izooblici tripsina i njihova upotreba |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11179311B2 (hr) |
| EP (3) | EP3121272A1 (hr) |
| JP (2) | JP6869979B2 (hr) |
| KR (1) | KR20180032588A (hr) |
| CN (2) | CN113846079A (hr) |
| AU (1) | AU2016299760B2 (hr) |
| BR (1) | BR112018001404A2 (hr) |
| CA (1) | CA2992821A1 (hr) |
| DK (3) | DK3325618T3 (hr) |
| ES (1) | ES2813551T3 (hr) |
| HR (1) | HRP20201290T1 (hr) |
| HU (1) | HUE050121T2 (hr) |
| MX (1) | MX2018000570A (hr) |
| PL (1) | PL3325618T3 (hr) |
| PT (1) | PT3325618T (hr) |
| RS (1) | RS60711B1 (hr) |
| RU (1) | RU2739945C2 (hr) |
| SI (1) | SI3325618T1 (hr) |
| WO (1) | WO2017017012A1 (hr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3121272A1 (en) | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Novel fish trypsin isoforms and their use |
| GB201701315D0 (en) | 2017-01-26 | 2017-03-15 | Enzymatica Ab | Novel treatments |
| GB201800274D0 (en) | 2018-01-08 | 2018-02-21 | Enzymatica Ab | Novel treatments |
| GB201801982D0 (en) | 2018-02-07 | 2018-03-28 | Enzymatica Ab | Novel treatments |
| WO2020229145A1 (en) * | 2019-05-13 | 2020-11-19 | Bioseutica B.V. | Purified fish proteases with high specific activities and its process of production |
| US11441261B2 (en) | 2020-09-10 | 2022-09-13 | WABESO Enhanced Enzymatics, Inc. | Self-sterilizing fabrics incorporating anti-viral cold-active proteases |
| US20240173387A1 (en) * | 2021-08-03 | 2024-05-30 | Zymiq Technology Ab | Peptidase formulation for treatment of microbial infections in the upper respiratory tract |
| WO2024044679A2 (en) * | 2022-08-24 | 2024-02-29 | Ohio State Innovation Foundation | Methods of synthesizing peptides with free n-terminal cysteine and products thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8302268L (sv) | 1983-04-22 | 1984-10-23 | Lars G I Hellgren | Ny kombination av proteolytiska och lipolytiska enzymer lemplig som tvettkomposition |
| DE3379589D1 (en) | 1982-10-25 | 1989-05-18 | Hellgren Lars G I | Enzyme composition for cleaning, the use thereof and preparation of the composition |
| SE454566B (sv) | 1984-04-24 | 1988-05-16 | Lars G I Hellgren | Farmaceutisk komposition innehallande en verksam mengd av vattenlosliga proteinaser som extraherats fran ett vattenlevande djur valt av ordningen euphausiaceae eller slektet mallotus |
| JPS6130527A (ja) | 1984-07-20 | 1986-02-12 | Kao Corp | 血栓溶解剤 |
| US6030612A (en) | 1994-11-22 | 2000-02-29 | Phairson Medical Inc. | Antimicrobial uses of multifunctional enzyme |
| WO2000078332A2 (en) * | 1999-06-18 | 2000-12-28 | Jon Bragi Bjarnason | Fish serine proteinases and their pharmaceutical and cosmetic use |
| RU2286171C1 (ru) * | 2005-04-12 | 2006-10-27 | Эдуард Артемович Макарян | Препарат для профилактики и лечения респираторных и желудочно-кишечных инфекционных заболеваний бактериальной и вирусной этиологии сельскохозяйственных животных и способ профилактики и лечения респираторных и желудочно-кишечных инфекционных заболеваний бактериальной и вирусной этиологии сельскохозяйственных животных |
| US8211428B2 (en) * | 2006-07-05 | 2012-07-03 | Torrey Pines Institute For Molecular Studies | Protease screening methods and proteases identified thereby |
| CN101250574A (zh) * | 2007-03-22 | 2008-08-27 | 中国海洋大学 | 一种梯级分子量鳕鱼鱼皮胶原肽的制备方法 |
| WO2011063394A2 (en) | 2009-11-23 | 2011-05-26 | Olmstead Stephen F | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
| GB0921288D0 (en) * | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| CA3075772C (en) | 2011-05-31 | 2022-07-19 | Hutchison Biofilm Medical Solutions Limited | Dispersion and detachment of cell aggregates |
| CN102228126B (zh) * | 2011-06-10 | 2013-03-13 | 天津市虎豹调味品酿造有限公司何庄分公司 | 一种鳕鱼骨水解蛋白液的制备方法 |
| CN103320485B (zh) * | 2013-06-03 | 2015-12-23 | 王南平 | 一种医用级生物材料用鱼皮胶原的制备方法 |
| EP3121272A1 (en) | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Novel fish trypsin isoforms and their use |
-
2015
- 2015-07-24 EP EP15178208.3A patent/EP3121272A1/en not_active Withdrawn
-
2016
- 2016-07-22 CN CN202111184339.8A patent/CN113846079A/zh active Pending
- 2016-07-22 US US15/746,897 patent/US11179311B2/en active Active
- 2016-07-22 CN CN201680042929.8A patent/CN107849551B/zh active Active
- 2016-07-22 SI SI201630894T patent/SI3325618T1/sl unknown
- 2016-07-22 BR BR112018001404-4A patent/BR112018001404A2/pt active Search and Examination
- 2016-07-22 WO PCT/EP2016/067531 patent/WO2017017012A1/en active Application Filing
- 2016-07-22 EP EP20169710.9A patent/EP3736331A1/en active Pending
- 2016-07-22 AU AU2016299760A patent/AU2016299760B2/en active Active
- 2016-07-22 RS RS20201012A patent/RS60711B1/sr unknown
- 2016-07-22 RU RU2018106533A patent/RU2739945C2/ru active
- 2016-07-22 MX MX2018000570A patent/MX2018000570A/es unknown
- 2016-07-22 JP JP2018522869A patent/JP6869979B2/ja active Active
- 2016-07-22 EP EP16745663.1A patent/EP3325618B1/en active Active
- 2016-07-22 ES ES16745663T patent/ES2813551T3/es active Active
- 2016-07-22 HU HUE16745663A patent/HUE050121T2/hu unknown
- 2016-07-22 DK DK16745663.1T patent/DK3325618T3/da active
- 2016-07-22 CA CA2992821A patent/CA2992821A1/en active Pending
- 2016-07-22 PT PT167456631T patent/PT3325618T/pt unknown
- 2016-07-22 KR KR1020187004156A patent/KR20180032588A/ko not_active Application Discontinuation
- 2016-07-22 PL PL16745663T patent/PL3325618T3/pl unknown
-
2018
- 2018-01-24 DK DKPA201870049A patent/DK180405B1/en active IP Right Grant
-
2020
- 2020-08-18 HR HRP20201290TT patent/HRP20201290T1/hr unknown
- 2020-11-30 DK DKPA202070808A patent/DK181080B1/en active IP Right Grant
-
2021
- 2021-04-14 JP JP2021068447A patent/JP7116823B2/ja active Active
- 2021-10-15 US US17/502,921 patent/US11918674B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20201290T1 (hr) | Novi izooblici tripsina i njihova upotreba | |
| JP2018520707A5 (hr) | ||
| RU2002101125A (ru) | Сериновые протеиназы рыб и их фармацевтическое и косметическое применение | |
| HRP20161521T1 (hr) | Novi kozmetički i/ili farmaceutski pripravci i njihova primjena | |
| CN104434740B (zh) | 一种中药祛痘凝胶剂及其制备方法 | |
| CN103463953A (zh) | 一种甲醛去除剂 | |
| CN103463967A (zh) | 一种空气净化机专用甲醛清除剂 | |
| CN102766548A (zh) | 一种抗菌消炎、护肤美容的药皂及其制备方法 | |
| CN102861128B (zh) | 丹参多酚酸有效部位在制备治疗皮肤病制剂中的应用 | |
| CN102283899B (zh) | 一种中药外用制剂及其用途 | |
| EP2755670B1 (en) | Compositions for the treatment of peripheral ulcers of various origins | |
| CN103493850A (zh) | 一种空气净化机专用空气抗菌剂 | |
| CN108078868B (zh) | 一种用于护肤品的抗过敏组合物 | |
| CN107158051B (zh) | 一种治疗湿疹的鞣酸软膏及其制备方法 | |
| Dashtpeima et al. | The Effect (s) of Matricaria chamomilla on Leishmania major Ulcers in Balb/c Mice | |
| US9421161B2 (en) | Herbal composition and a method of making thereof | |
| CN105496858A (zh) | 一种促进伤口愈合精油 | |
| CN105878630A (zh) | 治疗跖疣的外敷膏体 | |
| Kathekaya et al. | Development, characterisation of menthol based non-alcoholic propolis extracts and its effect on flavonoid composition of propolis analysed using RP-HPLC | |
| CN103272045B (zh) | 一种治疗慢性毛囊炎的中药制剂 | |
| Magam et al. | Development, Characterisation of Menthol based non-alcoholic propolis extracts and its effect on chemical composition of propolis analysed using RP-HPLC | |
| CN101301368B (zh) | 一种治疗粉刺的药酒 | |
| CN105878629A (zh) | 治疗跖疣的搓粉 | |
| CN104984088A (zh) | 一种治疗外伤感染的中药药方 | |
| CN113318178A (zh) | 一种治疗痤疮、痈疖的中药外用制剂 |