HRP20200794T1 - Keramidaza i diferencijacija stanica - Google Patents

Keramidaza i diferencijacija stanica

Info

Publication number
HRP20200794T1
HRP20200794T1 HRP20200794TT HRP20200794T HRP20200794T1 HR P20200794 T1 HRP20200794 T1 HR P20200794T1 HR P20200794T T HRP20200794T T HR P20200794TT HR P20200794 T HRP20200794 T HR P20200794T HR P20200794 T1 HRP20200794 T1 HR P20200794T1
Authority
HR
Croatia
Prior art keywords
ceramidase
cell differentiation
differentiation
cell
Prior art date
Application number
HRP20200794TT
Other languages
English (en)
Inventor
Edward H. Schuchman
Calogera M. Simonaro
Original Assignee
Mount Sinai School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP12830086.0A external-priority patent/EP2753346B1/en
Application filed by Mount Sinai School Of Medicine filed Critical Mount Sinai School Of Medicine
Publication of HRP20200794T1 publication Critical patent/HRP20200794T1/hr
Publication of HRP20200794T8 publication Critical patent/HRP20200794T8/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
    • F16D3/00—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive
    • F16D3/50—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members
    • F16D3/64—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members comprising elastic elements arranged between substantially-radial walls of both coupling parts
    • F16D3/68—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members comprising elastic elements arranged between substantially-radial walls of both coupling parts the elements being made of rubber or similar material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
    • F16D41/00—Freewheels or freewheel clutches
    • F16D41/20—Freewheels or freewheel clutches with expandable or contractable clamping ring or band
    • F16D41/206—Freewheels or freewheel clutches with expandable or contractable clamping ring or band having axially adjacent coils, e.g. helical wrap-springs
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F15/00—Suppression of vibrations in systems; Means or arrangements for avoiding or reducing out-of-balance forces, e.g. due to motion
    • F16F15/10—Suppression of vibrations in rotating systems by making use of members moving with the system
    • F16F15/12—Suppression of vibrations in rotating systems by making use of members moving with the system using elastic members or friction-damping members, e.g. between a rotating shaft and a gyratory mass mounted thereon
    • F16F15/121—Suppression of vibrations in rotating systems by making use of members moving with the system using elastic members or friction-damping members, e.g. between a rotating shaft and a gyratory mass mounted thereon using springs as elastic members, e.g. metallic springs
    • F16F15/124—Elastomeric springs
    • F16F15/1245—Elastic elements arranged between substantially-radial walls of two parts rotatable with respect to each other, e.g. between engaging teeth
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H55/00—Elements with teeth or friction surfaces for conveying motion; Worms, pulleys or sheaves for gearing mechanisms
    • F16H55/32—Friction members
    • F16H55/36—Pulleys
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
    • F16D2300/00—Special features for couplings or clutches
    • F16D2300/06—Lubrication details not provided for in group F16D13/74
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H55/00—Elements with teeth or friction surfaces for conveying motion; Worms, pulleys or sheaves for gearing mechanisms
    • F16H55/32—Friction members
    • F16H55/36—Pulleys
    • F16H2055/366—Pulleys with means providing resilience or vibration damping

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Acoustics & Sound (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Aviation & Aerospace Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulleys (AREA)
HRP20200794TT 2011-09-07 2020-05-15 Keramidaza i diferencijacija stanica HRP20200794T8 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531937P 2011-09-07 2011-09-07
EP12830086.0A EP2753346B1 (en) 2011-09-07 2012-09-07 Ceramidase and cell differentiation
PCT/US2012/054316 WO2013036875A1 (en) 2011-09-07 2012-09-07 Ceramidase and cell differentiation

Publications (2)

Publication Number Publication Date
HRP20200794T1 true HRP20200794T1 (hr) 2020-10-16
HRP20200794T8 HRP20200794T8 (hr) 2021-12-10

Family

ID=47753575

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20200794TT HRP20200794T8 (hr) 2011-09-07 2020-05-15 Keramidaza i diferencijacija stanica

Country Status (3)

Country Link
US (1) US20130059685A1 (hr)
HR (1) HRP20200794T8 (hr)
PT (1) PT2753346T (hr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236812B2 (en) * 2012-09-10 2022-02-01 Zen S/A Industria Metalurgica Decoupler with one-way clutch and fail-safe system
JP6256013B2 (ja) * 2014-01-09 2018-01-10 株式会社ジェイテクト プーリユニット
FR3046823B1 (fr) * 2016-01-14 2019-09-27 Psa Automobiles Sa. Dispositif de transmission de mouvement et de filtrage
JP6756214B2 (ja) * 2016-09-26 2020-09-16 セイコーエプソン株式会社 ロボット、歯車装置および歯車装置の製造方法
DE102017005986A1 (de) * 2017-06-23 2018-12-27 Neumayer Tekfor Engineering Gmbh Schwingungsdämpfer für einen Antriebsstrang

Family Cites Families (37)

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US1410544A (en) * 1918-01-08 1922-03-28 United Shoe Machinery Corp Self-lubricating pulley
US2398261A (en) * 1941-11-24 1946-04-09 Deister Concentrator Company Flexible coupling
US2873590A (en) * 1955-12-16 1959-02-17 Louis P Croset Flexible couplings, dampers, gearwheels and like devices
US2995044A (en) * 1957-09-12 1961-08-08 Tann Corp Two-step pulley
US3140128A (en) * 1961-05-10 1964-07-07 Tann Corp Self-lubricating bearing
US4328879A (en) * 1978-04-27 1982-05-11 The Gates Rubber Company Shock-absorbing sprocket, drive assembly, and the like
US4486183A (en) * 1980-06-30 1984-12-04 The Gates Rubber Company Torsionally elastic power transmitting device and drive
DE3680628D1 (de) * 1985-10-04 1991-09-05 Vickers Shipbuilding & Eng Elastische wellenkupplung.
DE3621187A1 (de) * 1986-06-25 1988-01-21 Hackforth Gmbh & Co Kg Elastische wellenkupplung
US5452622A (en) * 1993-02-09 1995-09-26 Magi, L.P. Stress dissipation gear
EP0626523B1 (de) * 1993-03-26 1996-12-11 CENTA-ANTRIEBE KIRSCHEY GmbH Zweistufige elastische Wellenkupplung
US5474499A (en) * 1993-07-12 1995-12-12 The United States Of America As Represented By The Secretary Of The Navy Flexible drive shaft coupling
GB9420741D0 (en) * 1994-10-14 1994-11-30 Litens Automotive Inc Crankshaft decoupler
FR2734034B1 (fr) * 1995-05-12 1997-07-11 Hutchinson Dispositif de decouplage, notamment poulie decoupleuse, destine a un vehicule automobile
JP3671571B2 (ja) * 1996-02-29 2005-07-13 株式会社デンソー 動力伝達装置
US5956998A (en) * 1996-06-06 1999-09-28 Fenelon; Paul J. Stress reduction gear and apparatus using same
US5797540A (en) * 1997-01-27 1998-08-25 Generac Corporation Method of making a power-transmitting coupling
JP4087499B2 (ja) * 1998-05-11 2008-05-21 Ｎｓｋワーナー株式会社 ワンウェイクラッチ
JP2001343024A (ja) * 2000-03-29 2001-12-14 Toyota Industries Corp 動力伝達機構
JP2002098213A (ja) * 2000-09-22 2002-04-05 Toyota Industries Corp 動力伝達機構
US6802779B2 (en) * 2000-10-27 2004-10-12 Denso Corporation Pulley type torque transmitting apparatus
JP4590795B2 (ja) * 2000-11-22 2010-12-01 株式会社デンソー プーリユニット
DE10255913B4 (de) * 2002-11-29 2005-07-28 Timken Gmbh Vorrichtung zum Dämpfen von Drehschwingungen
US7549938B2 (en) * 2003-01-07 2009-06-23 Forbo Financial Services Ag Treadmill belt
US7093703B2 (en) * 2003-04-23 2006-08-22 Koyo Seiko Co., Ltd. One-way clutch integrated with a rolling bearing, and method of producing the same
JP2007517168A (ja) * 2003-12-09 2007-06-28 ライテンズ オートモーティブ パートナーシップ オルタネータデカプラのオーバランのためのスプリング移動制限器
JP4730580B2 (ja) * 2004-04-12 2011-07-20 日立工機株式会社 電動工具及び歯車装置
FR2878305B1 (fr) * 2004-11-24 2008-05-30 Hutchinson Sa Poulie d'organe de transmission de puissance, alterno-demarreur separe equipe d'une telle poulie et systeme d'entrainement de moteur thermique
FR2891039B1 (fr) * 2005-09-19 2009-05-22 Hutchinson Sa Poulie de transmission de puissance
CN101432541B (zh) * 2006-04-26 2012-07-04 利滕斯汽车合伙公司 高扭矩设备的单向隔离器
WO2008103683A1 (en) * 2007-02-19 2008-08-28 Conntechnical Industries Strut-based overrunning drives
US7651173B2 (en) * 2007-07-03 2010-01-26 The Gates Corporation Wheel isolator coupling
US7891475B2 (en) * 2007-10-25 2011-02-22 The Gates Corporation Isolator decoupler
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Also Published As

Publication number Publication date
US20130059685A1 (en) 2013-03-07
HRP20200794T8 (hr) 2021-12-10
PT2753346T (pt) 2020-05-22

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