HRP20200240T1 - Ekspresijsko punjenje za transformaciju eukariotske stanice, postupak za transformaciju eukariotske stanice, genetički modificirani organizam i postupak za proizvodnju biogoriva i/ili biokemikalija i biogoriva koja su proizvedena na taj način - Google Patents
Ekspresijsko punjenje za transformaciju eukariotske stanice, postupak za transformaciju eukariotske stanice, genetički modificirani organizam i postupak za proizvodnju biogoriva i/ili biokemikalija i biogoriva koja su proizvedena na taj način Download PDFInfo
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- HRP20200240T1 HRP20200240T1 HRP20200240TT HRP20200240T HRP20200240T1 HR P20200240 T1 HRP20200240 T1 HR P20200240T1 HR P20200240T T HRP20200240T T HR P20200240TT HR P20200240 T HRP20200240 T HR P20200240T HR P20200240 T1 HRP20200240 T1 HR P20200240T1
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- 238000000034 method Methods 0.000 title claims 9
- 210000003527 eukaryotic cell Anatomy 0.000 title claims 6
- 239000002551 biofuel Substances 0.000 title claims 3
- 230000009466 transformation Effects 0.000 title claims 3
- 235000003869 genetically modified organism Nutrition 0.000 title 1
- 230000001131 transforming effect Effects 0.000 title 1
- 244000005700 microbiome Species 0.000 claims 14
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 6
- 101150063973 tdh1 gene Proteins 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 125000002288 PGK1 group Chemical group 0.000 claims 3
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- FQVLRGLGWNWPSS-BXBUPLCLSA-N (4r,7s,10s,13s,16r)-16-acetamido-13-(1h-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide Chemical compound N1C(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CC1=CN=CN1 FQVLRGLGWNWPSS-BXBUPLCLSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 101150118141 GRE3 gene Proteins 0.000 claims 2
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 claims 2
- 101000780443 Homo sapiens Alcohol dehydrogenase 1A Proteins 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 241000722885 Brettanomyces Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 claims 1
- 101000729289 Homo sapiens Ribose-5-phosphate isomerase Proteins 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 101150012255 RKI1 gene Proteins 0.000 claims 1
- 102100031139 Ribose-5-phosphate isomerase Human genes 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 101100103120 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) XKS1 gene Proteins 0.000 claims 1
- 241000311449 Scheffersomyces Species 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000974808 Spathaspora Species 0.000 claims 1
- 101150052008 TKL-1 gene Proteins 0.000 claims 1
- 101150100773 XKS1 gene Proteins 0.000 claims 1
- 108700040099 Xylose isomerases Proteins 0.000 claims 1
- 241000235013 Yarrowia Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000002230 centromere Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 101150005492 rpe1 gene Proteins 0.000 claims 1
- 101150115276 tal1 gene Proteins 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
- C12Y503/01005—Xylose isomerase (5.3.1.5)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (15)
1. Ekspresijska kazeta za transformaciju eukariotske stanice naznačena time što sadrži kombinaciju sljedećih ekspresijskih kazeta:
a) ekspresijsku kazetu koja sadrži gen koji kodira ksiloza izomerazu sekvence SEQ ID NO: 1, promotor TDH1 nukleotidne sekvence SEQ ID NO: 2 i terminator TDH1 nukleotidne sekvence SEQ ID NO: 3;
b) ekspresijsku kazetu koja sadrži promotor ADH1 predstavljen sekvencom SEQ ID NO: 8, gen XKS1 predstavljen sekvencom SEQ ID NO: 9 i terminator ADH1 predstavljen sekvencom SEQ ID NO: 10;
c) ekspresijsku kazetu koja sadrži promotor TDH1 nukleotidne sekvence SEQ ID NO: 2, gen TAL1 sekvence SEQ ID NO: 5, gen terminator TDH1 sekvence SEQ ID NO: 3, nakon koga slijedi promotor PGK1 sekvence SEQ ID NO: 6, gen RKI1 (SEQ ID NO: 7) i terminator nukleotidne sekvence SEQ ID NO: 13; i
d) ekspresijsku kazetu koja sadrži promotor TDH1 sekvence SEQ ID NO: 02, gen TKL1 sekvence SEQ ID NO: 11, gen koji kodira riboza 5-fosfat epimerazu (SEQ ID NO: 7), terminator TDH1 sekvence SEQ ID NO: 3, nakon koga slijedi promotor PGK1 sekvence SEQ ID NO: 6, gen RPE1 sekvence SEQ ID NO: 12 i terminator PGK1 sekvence SEQ ID NO: 13;
pri čemu je navedena ekspresijska kazeta funkcionalna u eukariotskoj stanici.
2. Ekspresijska kazeta, prema patentnom zahtjevu 1, naznačena time što je navedeni promotor(i) konstitutivni ili prirodno inducibilni.
3. Postupak za transformaciju eukariotske stanice, naznačen uvođenjem, u stanicu koja se transformiše, najmanje ekspresione kasete kao što je definirana u bilo kojem od patentnih zahtjeva 1-2.
4. Postupak, prema patentnom zahtjevu 3, dodatno naznačen time što sadrži inaktivaciju ili deleciju GRE3 gena (SEQ ID NO: 14) u genomu navedene eukariotske stanice.
5. Genetički modificirani mikroorganizam, naznačen time što sadrži najmanje ekspresijsku kazetu kao što je definirana u bilo kojem od patentnih zahtjeva 1-2.
6. Mikroorganizam, prema patentnom zahtjevu 5, naznačen time što su jedna ili više navedenih ekspresijskih kazeta prisutne u regiji od 5 tisuća prvih baznih parova brojanih od centromere kako u ushodnom tako i u nishodnom pravcu, i može biti čak samo ushodnom, samo nishodnom ili oba istovremeno.
7. Mikroorganizam, prema patentnom zahtjevu 6, naznačen time što promotorske sekvence, kodirajuće sekvence i terminatorske sekvence ekspresijskih kazeta su stabilne u genomu mikroorganizma i/ili su prisutne u najmanje 5 kopija u genomu mikroorganizma.
8. Mikroorganizam, prema bilo kojem od patentnih zahtjeva 6-7, naznačen time što gen GRE3 (SEQ ID NO: 14) je inaktiviran ili deletiran u/iz njegovog genoma.
9. Mikroorganizam, prema bilo kojem od patentnih zahtjeva 6-8, naznačen time što je to kvasac iz roda izabranog iz grupe koja se sastoji od: Saccharomyces, Scheffersomyces, Spathaspora, Pichia, Candida, Kluyveromyces, Schizosaccharomyces, Brettanomyces, Hansenula i Yarrowia.
10. Mikroorganizam, prema patentnom zahtjevu 9, naznačen time što mikroorganizam je Saccharomyces cerevisiae DSM28739.
11. Genetički modificirani mikroorganizam, naznačen time što je to Saccharomyces cerevisiae DSM28739.
12. Postupak za proizvodnju biogoriva i/ili biokemikalija, naznačen time što sadrži korak kultivacije mikroorganizma kao što je definiran u bilo kojem od patentnih zahtjeva 5-11.
13. Postupak, prema patentnom zahtjevu 12, naznačen time što je prinos postupka najmanje 0.45 grama etanola proizvedenog po gramu ksiloze potrošene od strane mikroorganizma u sintetičkom mediju koji sadrži ksilozu kao izvor ugljika.
14. Postupak, prema patentnom zahtjevu 12 ili 13, naznačen time što volumetrijska produktivnost je najmanje 0.67 grama etanola proizvedenog po litri svakog sata, kada je u sintetičkom mediju koji sadrži ksilozu kao izvor ugljika.
15. Postupak, prema bilo kojem od patentnih zahtjeva 12-14, naznačen time što mikroorganizam je mikroorganizam Saccharomyces cerevisiae DSM28739.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102014014407A BR102014014407A2 (pt) | 2014-06-12 | 2014-06-12 | cassete de expressão para transformar célula eucariótica, micro-organismo geneticamente modificado com eficiente consumo de xilose, processo para produção de biocombustíveis e bioquímicos e biocombustível e/ou bioquímico assim produzido |
| PCT/BR2015/050075 WO2015188244A1 (pt) | 2014-06-12 | 2015-06-12 | Cassete de expressão para a transformação de célula eucariótica, processo para a transformação de célula eucariótica, micro-organismo geneticamente modificado, processo de produção de biocombustíveis e/ou bioquímicos e biocombustível e/ou bioquímico assim produzidos |
| EP15806997.1A EP3165609B1 (en) | 2014-06-12 | 2015-06-12 | Expression cartridge for the transformation of a eukaryotic cell, method for transforming a eukaryotic cell, genetically modified organism, and process for producing biofuels and/or biochemicals and biofuels thus produced |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200240T1 true HRP20200240T1 (hr) | 2020-08-21 |
Family
ID=54832638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200240TT HRP20200240T1 (hr) | 2014-06-12 | 2020-02-12 | Ekspresijsko punjenje za transformaciju eukariotske stanice, postupak za transformaciju eukariotske stanice, genetički modificirani organizam i postupak za proizvodnju biogoriva i/ili biokemikalija i biogoriva koja su proizvedena na taj način |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10155953B2 (hr) |
| EP (1) | EP3165609B1 (hr) |
| BR (2) | BR102014014407A2 (hr) |
| DK (1) | DK3165609T3 (hr) |
| ES (1) | ES2773639T3 (hr) |
| HR (1) | HRP20200240T1 (hr) |
| HU (1) | HUE048401T2 (hr) |
| PL (1) | PL3165609T3 (hr) |
| PT (1) | PT3165609T (hr) |
| RS (1) | RS59923B1 (hr) |
| SI (1) | SI3165609T1 (hr) |
| WO (1) | WO2015188244A1 (hr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11154302B2 (en) | 2014-03-31 | 2021-10-26 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
| US11076860B2 (en) | 2014-03-31 | 2021-08-03 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
| WO2018018111A1 (pt) * | 2016-07-28 | 2018-02-01 | Universidade Estadual De Campinas - Unicamp | Levedura industrial geneticamente modificada lvy127 com a via oxi-redutiva de conversão de xilose, cassetes de expressão gênica, processo de obtenção de etanol 2g e uso da levedura lvy127 |
| KR20190115474A (ko) | 2017-02-23 | 2019-10-11 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | 동맥류 장치 및 전달 시스템 |
| US10716574B2 (en) | 2017-12-22 | 2020-07-21 | DePuy Synthes Products, Inc. | Aneurysm device and delivery method |
| US10905430B2 (en) | 2018-01-24 | 2021-02-02 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US11058430B2 (en) | 2018-05-25 | 2021-07-13 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US11596412B2 (en) | 2018-05-25 | 2023-03-07 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US10939915B2 (en) | 2018-05-31 | 2021-03-09 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
| US11051825B2 (en) | 2018-08-08 | 2021-07-06 | DePuy Synthes Products, Inc. | Delivery system for embolic braid |
| US11123077B2 (en) | 2018-09-25 | 2021-09-21 | DePuy Synthes Products, Inc. | Intrasaccular device positioning and deployment system |
| US11076861B2 (en) | 2018-10-12 | 2021-08-03 | DePuy Synthes Products, Inc. | Folded aneurysm treatment device and delivery method |
| US11406392B2 (en) | 2018-12-12 | 2022-08-09 | DePuy Synthes Products, Inc. | Aneurysm occluding device for use with coagulating agents |
| US11272939B2 (en) | 2018-12-18 | 2022-03-15 | DePuy Synthes Products, Inc. | Intrasaccular flow diverter for treating cerebral aneurysms |
| US11134953B2 (en) | 2019-02-06 | 2021-10-05 | DePuy Synthes Products, Inc. | Adhesive cover occluding device for aneurysm treatment |
| US11337706B2 (en) | 2019-03-27 | 2022-05-24 | DePuy Synthes Products, Inc. | Aneurysm treatment device |
| US11672542B2 (en) | 2019-05-21 | 2023-06-13 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable ball segment |
| US10653425B1 (en) | 2019-05-21 | 2020-05-19 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
| US11497504B2 (en) | 2019-05-21 | 2022-11-15 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable implanted braid |
| US11607226B2 (en) | 2019-05-21 | 2023-03-21 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device with corrugations |
| US11278292B2 (en) | 2019-05-21 | 2022-03-22 | DePuy Synthes Products, Inc. | Inverting braided aneurysm treatment system and method |
| US11602350B2 (en) | 2019-12-05 | 2023-03-14 | DePuy Synthes Products, Inc. | Intrasaccular inverting braid with highly flexible fill material |
| US11413046B2 (en) | 2019-05-21 | 2022-08-16 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
| US11457926B2 (en) | 2019-12-18 | 2022-10-04 | DePuy Synthes Products, Inc. | Implant having an intrasaccular section and intravascular section |
| CN116814643A (zh) * | 2022-03-21 | 2023-09-29 | 郑州大学 | 植物诱导分泌型表达盒及其调控元件 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3950799A (en) * | 1998-04-20 | 1999-11-08 | Forskarpatent I Syd Ab | Genetically engineered yeast and mutants thereof for the efficient fermentation of lignocellulose hydrolysates |
| CN101914462B (zh) * | 2004-07-16 | 2013-04-24 | Dsm知识产权资产有限公司 | 发酵木糖的真核细胞的代谢工程 |
| EP2250262B1 (en) * | 2008-03-07 | 2015-07-29 | DSM IP Assets B.V. | A pentose sugar fermenting cell |
| CN103124783A (zh) * | 2010-06-03 | 2013-05-29 | 马斯科马公司 | 表达用于使用淀粉和纤维素进行联合生物加工的糖分解酶的酵母 |
| CN102174549B (zh) | 2011-02-22 | 2012-10-10 | 山东大学 | 一种编码木糖异构酶的核酸分子及其编码的木糖异构酶 |
| DK2877576T3 (da) | 2012-07-24 | 2019-08-12 | Bp Corp North America Inc | Xyloseisomeraser og anvendelser deraf |
-
2014
- 2014-06-12 BR BR102014014407A patent/BR102014014407A2/pt not_active IP Right Cessation
-
2015
- 2015-06-12 HU HUE15806997A patent/HUE048401T2/hu unknown
- 2015-06-12 SI SI201531095T patent/SI3165609T1/sl unknown
- 2015-06-12 PL PL15806997T patent/PL3165609T3/pl unknown
- 2015-06-12 ES ES15806997T patent/ES2773639T3/es active Active
- 2015-06-12 DK DK15806997.1T patent/DK3165609T3/da active
- 2015-06-12 RS RS20200166A patent/RS59923B1/sr unknown
- 2015-06-12 PT PT158069971T patent/PT3165609T/pt unknown
- 2015-06-12 EP EP15806997.1A patent/EP3165609B1/en active Active
- 2015-06-12 WO PCT/BR2015/050075 patent/WO2015188244A1/pt active Application Filing
- 2015-06-12 US US15/315,081 patent/US10155953B2/en active Active
- 2015-06-12 BR BR112016028778-9A patent/BR112016028778B1/pt active IP Right Grant
-
2020
- 2020-02-12 HR HRP20200240TT patent/HRP20200240T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3165609A1 (en) | 2017-05-10 |
| DK3165609T3 (da) | 2020-02-24 |
| US10155953B2 (en) | 2018-12-18 |
| BR112016028778B1 (pt) | 2023-01-17 |
| PT3165609T (pt) | 2020-02-25 |
| RS59923B1 (sr) | 2020-03-31 |
| BR112016028778A2 (pt) | 2018-01-09 |
| BR102014014407A2 (pt) | 2016-04-19 |
| SI3165609T1 (sl) | 2020-04-30 |
| US20170114350A1 (en) | 2017-04-27 |
| HUE048401T2 (hu) | 2020-07-28 |
| WO2015188244A1 (pt) | 2015-12-17 |
| EP3165609B1 (en) | 2019-11-13 |
| ES2773639T3 (es) | 2020-07-13 |
| EP3165609A4 (en) | 2017-09-27 |
| PL3165609T3 (pl) | 2020-06-01 |
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