HRP20192191T1 - Uporaba aril i hetaril karboksamida kao endoparaziticida - Google Patents
Uporaba aril i hetaril karboksamida kao endoparaziticida Download PDFInfo
- Publication number
- HRP20192191T1 HRP20192191T1 HRP20192191TT HRP20192191T HRP20192191T1 HR P20192191 T1 HRP20192191 T1 HR P20192191T1 HR P20192191T T HRP20192191T T HR P20192191TT HR P20192191 T HRP20192191 T HR P20192191T HR P20192191 T1 HRP20192191 T1 HR P20192191T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- thienyl
- cycloalkyl
- substituted
- poly
- Prior art date
Links
- -1 hetaryl carboxamides Chemical class 0.000 title claims 63
- 125000003118 aryl group Chemical group 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000004178 (C1-C4) alkyl group Chemical class 0.000 claims 15
- 125000000008 (C1-C10) alkyl group Chemical class 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000004765 (C1-C4) haloalkyl group Chemical class 0.000 claims 11
- 125000006552 (C3-C8) cycloalkyl group Chemical class 0.000 claims 8
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004122 cyclic group Chemical group 0.000 claims 8
- 229910052731 fluorine Inorganic materials 0.000 claims 8
- 239000011737 fluorine Substances 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000006374 C2-C10 alkenyl group Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 6
- 125000004399 C1-C4 alkenyl group Chemical class 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000006650 (C2-C4) alkynyl group Chemical class 0.000 claims 5
- 125000002941 2-furyl group Chemical class O1C([*])=C([H])C([H])=C1[H] 0.000 claims 5
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 5
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 5
- 125000000175 2-thienyl group Chemical class S1C([*])=C([H])C([H])=C1[H] 0.000 claims 5
- 125000001541 3-thienyl group Chemical class S1C([H])=C([*])C([H])=C1[H] 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 5
- 244000079386 endoparasite Species 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 3
- 125000004740 (C1-C6) haloalkylsulfanyl group Chemical group 0.000 claims 3
- 125000003682 3-furyl group Chemical class O1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000005336 allyloxy group Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000004770 (C1-C4) haloalkylsulfanyl group Chemical group 0.000 claims 2
- 125000004105 2-pyridyl group Chemical class N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003349 3-pyridyl group Chemical class N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000002541 furyl group Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000001544 thienyl group Chemical class 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims 1
- 125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 125000006125 ethylsulfonyl group Chemical group 0.000 claims 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical class 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical class 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (5)
1. Spojevi s formulom (I)
u kojima
X predstavlja mono- ili poli-M1-supstituirani fenil, tienil ili furanil;
Q predstavlja mono- ili poli-M1-supstituirani piridil, tienil, furanil ili izotiazolil;
Y predstavlja vodik ili predstavlja po izboru mono- ili poli-M2-supstituirani (C1-C10) -alkil, (C2-C10) -alkenil, (C2-C10) -alkinil, (C1-C10)-haloalkil, (C2-C10) -haloalkenil, (C2-C10)-haloalkinil, (C1-C10) -alkoksi, (C2-C10)-alkeniloksi, (C3-C10) -alkiniloksi, (C3-C14) -cikloalkil- (C1-C10)-alkil ili predstavlja po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
W predstavlja kisik ili sumpor;
L1 predstavlja -C(R11, R12)-, kisik, sumpor ili -N(R1)-;
L2 predstavlja -C(R21, R22)-;
L3 predstavlja -C(R31, R32)- ili izravnu vezu;
M1 predstavlja vodik, halogen, cijano, nitro, OH, (C1-C10) -alkil, (C1-C10) -haloalkil, (C1-C10)-alkoksi, (C1-C10) -haloalkoksi, (C1-C10) -alkiltio, (C1-C10)-haloalkiltio, (C1-C10)-alkilsulfonil, (C1-C10)-haloalkilsulfonil, (C1-C10)-alkilsulfanil, (C1-C10)-haloalkilsulfanil, (3- do 14-člana ciklička skupina)-O-;
R1 predstavlja vodik ili po izboru mono- ili poli-M2-supstituirani (C1-C10)-alkil, (C2-C10)-alkenil, (C2-C10)-alkinil, (C1-C10)-haloalkil, (C2-C10)-haloalkenil, (C2-C10)-haloalkinil, (C3-C10)-cikloalkil- (C1-C10)-alkil ili predstavlja po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
R11, R12 svaki međusobno neovisno predstavljaju vodik, halogen ili po izboru mono-ili poli-M2-supstituirani (C1-C10)-alkil, (C2-C10)-alkenil, (C2-C10)-alkinil, (C1-C10)-haloalkil, (C2-C10)-haloalkenil, (C2-C10)-haloalkinil, (C1-C10)-alkoksi, (C2-C10)-alkeniloksi, (C3-C10)-alkiniloksi, (C3-C14)-cikloalkil-(C1-C10)-alkil ili predstavljaju po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
R11, R12 zajedno predstavljaju svaki puta po izboru mono- ili poli-M2-supstituiranu spiro-vezanu 3- do 14-članu karbo- ili 3- do 10-članu heterocikličku skupinu;
R21, R22 svaki međusobno neovisno predstavljaju vodik, halogen ili po izboru mono- ili poli-M2-supstituirani (C1-C10)-alkil, (C2-C10)-alkenil, (C2-C10)-alkinil, (C1-C10)-haloalkil, (C2-C10)-haloalkenil, (C2-C10)-haloalkinil, (C1-C10)-alkoksi, (C1-C10)-haloalkoksi, (C2-C10)-alkeniloksi, (C3-C10)-alkiniloksi, (C3-C14)-cikloalkil-(C1-C10)-alkil ili predstavljaju po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
R21, R22 zajedno predstavljaju svaki puta po izboru mono- ili poli-M2-supstituiranu spiro- vezanu 3- do 14-članu karbo- ili 3- do 10-članu heterocikličku skupinu;
R31, R32 svaki međusobno neovisno predstavljaju vodik ili po izboru mono- ili poli-M2-supstituirani (C1-C10)-alkil, (C2-C10)-alkenil, (C2-C10)-alkinil, (C1-C10)-haloalkil, (C2-C10)-haloalkenil, (C2-C10)-haloalkinil, (C3-C14)-cikloalkil-(C1-C10)-alkil ili predstavljaju po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
R31, R32 zajedno predstavljaju svaki puta po izboru mono- ili poli-M2-supstituiranu spiro-vezanu 3- do 14-članu karbo- ili 3- do 10-članu heterocikličku skupinu;
M2 svaki međusobno neovisno predstavljaju halogen, formil, cijano, nitro, (C1-C10)-alkil, (C1-C10)-haloalkil, (C2-C10)-alkenil, (C2-C10)-haloalkenil, (C2-C10)-alkinil, (C2-C10)-haloalkinil, (C1-C10)-alkoksi, (C1-C10)-haloalkoksi, (C2-C10)-alkeniloksi, (C2-C10)-haloalkeniloksi, (C3-C10)-alkiniloksi, (C3-C10)-haloalkiniloksi, (C1-C10)-alkiltio, (C1-C10)-haloalkiltio, (C2-C10)-alkeniltio, (C2-C10)-haloalkeniltio, (C3-C10)-alkiniltio, (C3-C10)-haloalkiniltio, (C1-C10)-alkilsulfonil, (C1-C10)-haloalkilsulfonil, (C2-C10)-alkenilsulfonil, (C2-C10)-haloalkenilsulfonil, (C3-C10)-alkinilsulfonil, (C3-C10)-haloalkinilsulfonil, (C1-C10)-alkilsulfanil, (C1-C10)-haloalkilsulfanil, (C2-C10)-alkenilsulfanil, (C2-C10)-haloalkenilsulfanil, (C3-C10)-alkinilsulfanil, (C3-C10)-haloalkinilsulfanil, (C1-C10)-alkilkarbonil, (C1-C10)-haloalkilkarbonil, (C2-C10)-alkenilkarbonil, (C2-C10)-haloalkenilkarbonil, (C2-C10)-alkinilkarbonil, (C2-C10)-haloalkinilkarbonil, (C1-C10)-alkoksikarbonil, (C1-C10)-haloalkoksikarbonil, (C2-C10)-alkeniloksikarbonil, (C2-C10)-haloalkeniloksikarbonil, (C3-C10)-alkiniloksikarbonil, (C3-C10)-haloalkiniloksikarbonil, (C1-C10)-alkilkarboniloksi, (C1-C10)-haloalkilkarboniloksi, (C2-C10)-alkenilkarboniloksi, (C2-C10)-haloalkenilkarboniloksi, (C2-C10)-alkinilkarboniloksi, (C2-C10)-haloalkinilkarboniloksi, 3- do 14-članu cikličku skupinu;
i njihove soli, N-oksidi i tautomerni oblici;
za uporabu kao lijekovi za kontrolu endoparazita kod životinja ili ljudi.
2. Spojevi prema patentnom zahtjevu 1
gdje
X predstavlja mono- do poli-M1-supstituirani fenil, 2-tienil, 3-tienil, 2-furanil ili 3-furanil;
Q predstavlja mono- ili poli-M1-supstituirani 2-tienil, 3-tienil, 2-furanil, 5-izotiazolil, 3-piridil ili 2-piridil;
Y predstavlja vodik ili predstavlja po izboru mono- ili poli-M2-supstituirani (C1-C10) -alkil, (C2-C10)-alkenil, (C2-C10)-alkinil, (C1-C10)-haloalkil, (C2-C10)-haloalkenil, (C2-C10)-haloalkinil, (C1-C10)-alkoksi, (C2-C10)-alkeniloksi, (C3-C10)-alkiniloksi, (C3-C14)-cikloalkil-(C1-C10)-alkil ili predstavlja po izboru mono- ili poli-M2-supstituiranu 3- do 14-članu cikličku skupinu;
L1 predstavlja -C(R11, R12)-, kisik ili -N(R1)-;
M1 predstavlja vodik, halogen, cijano, nitro, OH, (C1-C6)-alkil, (C1-C6)-haloalkil, (C1-C6)-alkoksi, (C1-C6)-haloalkoksi, (C1-C6)-alkiltio, (C1-C6)-haloalkiltio, (C1-C6)-alkilsulfonil, (C1-C6)-haloalkilsulfonil, (C1-C6)-alkilsulfanil, (C1-C6)-haloalkilsulfanil, (C3-C14)-cikloalkil-O-, (C3-C14)-cikloalkenil-O-, (C6-C14)-aril-O-, halogenirani (C3-C14)-cikloalkil-O-, halogenirani (C3-C14)-cikloalkenil-O-, halogenirani (C6-C14)-aril-O-;
R1 predstavlja vodik ili po izboru mono- ili poli-M2-supstituirani (C1-C4)-alkil, (C2-C4)-alkenil, (C2-C4)-alkinil, (C1-C4)-haloalkil, (C2-C4)-haloalkenil, (C2-C4)-haloalkinil, (C3-C4)-cikloalkil-(C1-C10)-alkil ili predstavlja po izboru mono- ili poli-M2-supstituirani (C3-C8)-cikloalkil ili halogenirani (C3-C8)-cikloalkil;
R11, R12 svaki međusobno neovisno predstavljaju vodik, fluor ili po izboru mono- ili poli-M2-supstituirani (C1-C6)-alkil, (C1-C6)-haloalkil, (C1-C6)-alkoksi, (C3-C6)-cikloalkil-(C1-C6)-alkil, (C3-C8)-cikloalkil ili halogenirani (C3-C8)-cikloalkil;
R11, R12 predstavljaju C(R11, R12) kao spiro-C (CH2-CH2);
R21, R22 svaki međusobno neovisno predstavljaju vodik, fluor ili po izboru mono- ili poli-M2-supstituirani (C1-C4)-alkil, (C2-C4)-alkenil, (C2-C4)-alkinil, (C1-C4)-haloalkil, (C2-C4)-haloalkenil, (C2-C4)-haloalkinil, (C1-C6)-alkoksi, (C1-C4)-haloalkoksi, (C2-C4)-alkeniloksi, (C3-C4)-alkiniloksi, (C3-C4)-cikloalkil-(C1-C4)-alkil, (C3-C8)-cikloalkil ili halogenirani (C3-C8)-cikloalkil;
R21, R22 predstavljaju C(R21, R22) kao spiro-C(CH2-CH2);
R31, R32 svaki međusobno neovisno predstavljaju vodik ili po izboru mono- ili poli-M2-supstituirani (C1-C4)-alkil, (C2-C4)-alkenil, (C2-C4)-alkinil, (C1-C4)-haloalkil, (C2-C4)-haloalkenil, (C2-C4)-haloalkinil, (C1-C6)-alkoksi, (C1-C4)-haloalkoksi, (C2-C4)-alkeniloksi, (C3-C4)-alkiniloksi, (C3-C4)-cikloalkil-(C1-C4)-alkil ili predstavljaju po izboru mono- ili poli-M2-supstituirani (C3-C8)-cikloalkil ili halogenirani (C3-C8)-cikloalkil;
R31, R32 predstavljaju C(R31, R32) kao spiro-C(CH2-CH2);
M2 svaki međusobno neovisno predstavljaju halogen, formil, cijano, nitro, (C1-C4) -alkil, (C1-C4)-haloalkil, (C2-C4)-alkenil, (C2-C4)-haloalkenil, (C2-C4)-alkinil, (C2-C4)-haloalkinil, (C1-C4)-alkoksi, (C1-C4)-haloalkoksi, (C2-C4)-alkeniloksi, (C2-C4)-haloalkeniloksi, (C3-C4)-alkiniloksi, (C3-C4)-haloalkiniloksi, (C1-C4)-alkiltio, (C1-C4)-haloalkiltio, (C2-C4)-alkeniltio, (C2-C4)-haloalkeniltio, (C3-C4)-alkiniltio, (C3-C4)-haloalkiniltio, (C1-C4)-alkilsulfonil, (C1-C4)-haloalkilsulfonil, (C2-C4)-alkenilsulfonil, (C2-C4)-haloalkenilsulfonil, (C3-C4)-alkinilsulfonil, (C3-C4)-haloalkinilsulfonil, (C1-C4)-alkilsulfanil, (C1-C4)-haloalkilsulfanil, (C2-C4)-alkenilsulfanil, (C2-C4)-haloalkenilsulfanil, (C3-C4)-alkinilsulfanil, (C3-C4)-haloalkinilsulfanil, (C1-C4)-alkilkarbonil, (C1-C4)-haloalkilkarbonil, (C2-C4)-alkenilkarbonil, (C2-C4)-haloalkenilkarbonil, (C2-C4)-alkinilkarbonil, (C2-C4)-haloalkinilkarbonil, (C1-C4)-alkoksikarbonil, (C1-C4)-haloalkoksikarbonil, (C2-C4)-alkeniloksikarbonil, (C2-C4)-haloalkeniloksikarbonil, (C3-C4)-alkiniloksikarbonil, (C3-C4)-haloalkiniloksikarbonil, (C1-C4)-alkilkarboniloksi, (C1-C4)-haloalkilkarboniloksi, (C2-C4)-alkenilkarboniloksi, (C2-C4)-haloalkenilkarboniloksi, (C2-C4)-alkinilkarboniloksi, (C2-C4)-haloalkinilkarboniloksi ili (C3-C6)-cikloalkil;
i njihove soli, N-oksidi i tautomerni oblici;
za uporabu kao lijekovi za kontrolu endoparazita kod životinja ili ljudi.
3. Spojevi prema patentnom zahtjevu 1 ili 2
gdje
X predstavlja mono- do tri-M1-supstituirani fenil, 2-tienil, 3-tienil, 2-furanil ili 3-furanil;
Q predstavlja mono- ili di-M1-supstituirani 2-tienil, 3-tienil, 2-furanil, 5-izotiazolil, 3-piridil ili 2-piridil;
Y predstavlja vodik ili predstavlja po izboru mono- ili poli-M2-supstituirani (C1-C4)-alkil, (C2-C4)-alkenil, (C3-C4)-alkinil, (C1-C4)-haloalkil, (C2-C4) -haloalkenil, (C3-C4)-haloalkinil, (C1-C4)-alkoksi, (C2-C4)-alkeniloksi, (C3-C4)-alkiniloksi, (C3-C6)-cikloalkil-(C1-C4)-alkil ili predstavlja po izboru mono- ili poli-M2-supstituiranu C3- do C6-članu karbocikličku skupinu;
W predstavlja kisik;
M1 predstavlja vodik, halogen, cijano, nitro, OH, (C1-C4)-alkil, (C1-C4)-haloalkil, (C1-C4)-alkoksi, (C1-C4)-haloalkoksi, (C1-C4)-alkiltio, (C1-C4)-haloalkiltio, (C1-C4)-alkilsulfonil, (C1-C4)-haloalkilsulfonil, (C1-C4)-alkilsulfanil, (C1-C6)-haloalkilsulfanil, (C3-C14)-cikloalkil-O-, (C3-C14)-cikloalkenil-O-, (C6-C14)-aril-O-, halogenirani (C3-C14)-cikloalkil-O-, halogenirani (C3-C14)-cikloalkenil-O-, halogenirani (C6-C14)-aril)-O-;
R1 predstavlja vodik ili metil, etil, n-propil, izopropil, alil, propargil, ciklopropilmetil ili ciklopropil;
R11, R12 svaki međusobno neovisno predstavljaju vodik, fluor ili (C1-C6)-alkil, (C1-C6)-haloalkil, (C1-C6)-alkoksi, (C3-C6)-cikloalkil-(C1-C6)-alkil, (C3-C6)-cikloalkil;
R11, R12 predstavljaju C(R11, R12) kao spiro-C (CH2-CH2);
R21, R22 svaki međusobno neovisno predstavljaju vodik, fluor ili po izboru mono- ili poli-M2-supstituirani (C1-C4)-alkil, (C2-C4)-alkenil, (C2-C4)-alkinil, (C1-C4)-haloalkil, (C1-C6)-alkoksi, (C2-C4)-alkeniloksi, (C3-C4)-alkiniloksi, (C3-C4)-cikloalkil- (C1-C4)-alkil, (C3-C6)-cikloalkil;
R21, R22 predstavljaju C(R21, R22) kao spiro-C (CH2-CH2) ;
R31, R32 svaki međusobno neovisno predstavljaju vodik, metil, etil, n-propil, izopropil, tert-butil, alil, propargil, metoksi, etoksi, aliloksi, propargiloksi, ciklopropilmetil, ciklopropil;
R31, R32 predstavljaju C(R31, R32) kao spiro-C (CH2-CH2) ;
M2 svaki međusobno neovisno predstavljaju klor, fluor, formil, cijano, nitro, (C1-C4)-alkil, (C1-C4)-haloalkil, (C1-C4)-alkoksi, (C1-C4)-haloalkoksi, (C1-C4)-alkiltio, (C1-C4)-haloalkiltio, (C1-C4)-alkilsulfonil, (C1-C4)-haloalkilsulfonil, (C1-C4)-alkilsulfanil, (C1-C4)-haloalkilsulfanil, (C1-C4)-alkilkarbonil, (C1-C4)-haloalkilkarbonil ili (C3-C6)-cikloalkil;
i njihove soli, N-oksidi i tautomerni oblici;
za uporabu kao lijekovi za kontrolu endoparazita kod životinja ili ljudi.
4. Spojevi prema bilo kojem od patentnih zahtjeva 1 do 3
gdje
Q predstavlja 2-tienil, 3-fluoro-2-tienil, 3-kloro-2-tienil, 3,4-dikloro-2-tienil, 3,4,5-trikloro-2-tienil, 3-bromo-2-tienil, 3-jodo-2-tienil, 3-cijano-2-tienil, 3-metil-2-tienil, 3-(trifluorometil)-2-tienil, 3-metoksi-2-tienil, 3-etoksi-2-tienil, 3-tienil, 2-fluoro-3-tienil, 2-kloro-3-tienil, 2-bromo-3-tienil, 2-jodo-3-tienil, 2-cijano-3-tienil, 2-metil-3-tienil, 2-(trifluorometil)-3-tienil, 2-metoksi-3-tienil, 2-etoksi-3-tienil, 2-furanil, 3-fluoro-2-furanil, 3-kloro-2-furanil, 3-bromo-2-furanil, 3-jodo-2-furanil, 3-cijano-2-furanil, 3-metil-2-furanil, 3-(trifluorometil)-2-furanil, 3-metoksi-2-furanil, 3-etoksi-2-furanil, 3-furanil, 2-kloro-3-furanil, 2-bromo-3-furanil, 2-jodo-3-furanil, 2-cijano-3-furanil, 2-metil-3-furanil, 2-(trifluorometil)-3-furanil, 2-metoksi-3-furanil, 2-etoksi-3-furanil, 4-kloro-5-izotiazolil, 3,4-dikloro-5-izotiazolil, 2-kloro-3-piridil, 3-kloro-2-piridil ili 2-(trifluorometil)-3-piridil;
Y predstavlja vodik, metil, etil, n-propil, izopropil, n-butil, sec-butil, izobutil, tert-butil, cijanometil, 2,2-difluoroetil, 2,2,2-trifluoroetil, alil, butenil, propargil, butinil, 3,3-dikloroprop-2-enil, metoksi, etoksi, ciklopropilmetil, ciklopropil, ciklobutil, ciklopentil ili cikloheksil;
M1 predstavlja vodik, halogen, cijano, nitro, OH, (C1-C4)-alkil, (C1-C4)-haloalkil, (C1-C4)-alkoksi, (C1-C4)-haloalkoksi, (C1-C4)-alkiltio, (C1-C4)-haloalkiltio, (C1-C4)-alkilsulfonil, (C1-C4)-haloalkilsulfonil, (C1-C4)-alkilsulfanil, (C1-C6)-haloalkilsulfanil, (C6-C14)-aril-O-, halogenirani (C6-C14)-aril)-O-;
R1 predstavlja vodik ili (C1-C4)-alkil;
R11, R12 svaki međusobno neovisno predstavljaju vodik, fluor, metil, etil, n-propil, izopropil, alil, propargil, metoksi, etoksi, aliloksi, propargiloksi, ciklopropilmetil, ciklopropil;
R21, R22 svaki međusobno neovisno predstavljaju vodik, fluor, metil, etil, n-propil, izopropil, alil, propargil, metoksi, etoksi, aliloksi, propargiloksi, ciklopropilmetil, ciklopropil;
R31, R32 svaki međusobno neovisno predstavljaju vodik ili (C1-C4)-alkil;
M2 svaki međusobno neovisno predstavljaju fluor, brom, klor, jod, cijano, nitro, metil, etil, izopropil, tert-butil, trifluorometil, difluorometil, metoksi, etoksi, izopropoksi, trifluorometoksi, difluorometoksi, metiltio, trifluorometiltio, difluorometiltio, 2,2,2-trifluoroetiltio, metilsulfonil, etilsulfonil, trifluorometilsulfonil, 2,2,2-trifluoroetilsulfonil, metilsulfanil, etilsulfanil, trifluorometilsulfanil, 2,2,2-trifluoroetilsulfanil, ciklopropil, ciklobutil ili ciklopentil.
i njihove soli, N-oksidi i tautomerni oblici;
za uporabu kao lijekovi za kontrolu endoparazita kod životinja ili ljudi.
5. Spojevi prema bilo kojem od patentnih zahtjeva 1 do 4 za uporabu za kontrolu endoparazita kod životinja ili ljudi, naznačeni time što se spojevi prema bilo kojem od patentnih zahtjeva 1 do 4 i njihove soli, N-oksidi i tautomerni oblici primjenjuju profilaktički ili terapeutski na životinje ili ljude.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11190735 | 2011-11-25 | ||
| EP12788573.9A EP2782565B1 (de) | 2011-11-25 | 2012-11-23 | Verwendung von aryl- und hetarylcarboxamiden als endoparasitizide |
| PCT/EP2012/073431 WO2013076230A1 (de) | 2011-11-25 | 2012-11-23 | Verwendung von aryl- und hetarylcarboxamiden als endoparasitizide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192191T1 true HRP20192191T1 (hr) | 2020-02-21 |
Family
ID=47216313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192191TT HRP20192191T1 (hr) | 2011-11-25 | 2019-12-04 | Uporaba aril i hetaril karboksamida kao endoparaziticida |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9422276B2 (hr) |
| EP (1) | EP2782565B1 (hr) |
| JP (1) | JP6126115B2 (hr) |
| CN (1) | CN104203223A (hr) |
| AR (1) | AR088984A1 (hr) |
| AU (3) | AU2012342433A1 (hr) |
| BR (1) | BR112014012589A2 (hr) |
| DK (1) | DK2782565T3 (hr) |
| ES (1) | ES2762249T3 (hr) |
| HR (1) | HRP20192191T1 (hr) |
| HU (1) | HUE047738T2 (hr) |
| LT (1) | LT2782565T (hr) |
| MX (1) | MX349802B (hr) |
| PL (1) | PL2782565T3 (hr) |
| PT (1) | PT2782565T (hr) |
| RU (1) | RU2638830C2 (hr) |
| SI (1) | SI2782565T1 (hr) |
| WO (1) | WO2013076230A1 (hr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2891492T (pt) * | 2012-08-30 | 2022-12-13 | Univ Tokyo | Agente de controlo de endoparasitas |
| TWI598325B (zh) * | 2012-10-12 | 2017-09-11 | Ｈ 朗德貝克公司 | 苯甲醯胺類 |
| TW201507722A (zh) | 2013-04-30 | 2015-03-01 | Bayer Cropscience Ag | 做為殺線蟲劑及殺體內寄生蟲劑的ｎ－（２－鹵素－２－苯乙基）－羧醯胺類 |
| WO2015004091A1 (en) | 2013-07-12 | 2015-01-15 | Syngenta Participations Ag | Nicotinamide derivatives and their use against nematodes |
| WO2015007626A1 (en) * | 2013-07-18 | 2015-01-22 | Syngenta Participations Ag | Pyridine-2-carboxamides as nematocides |
| UY35772A (es) | 2013-10-14 | 2015-05-29 | Bayer Cropscience Ag | Nuevos compuestos plaguicidas |
| JP6470254B2 (ja) * | 2014-03-05 | 2019-02-13 | 国立大学法人 東京大学 | 内部寄生虫防除剤 |
| UY36196A (es) | 2014-07-25 | 2016-02-29 | Bayer Animal Health Gmbh | Compuestos para usar en el tratamiento antihelmíntico |
| GB201415569D0 (en) * | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
| UY36373A (es) | 2014-10-28 | 2016-04-29 | Bayer Animal Health Gmbh | Compuestos para usarse en el tratamiento antihelmíntico |
| US9661854B2 (en) * | 2015-09-04 | 2017-05-30 | Dow Agrosciences Llc | Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto |
| MX2018008139A (es) * | 2015-12-30 | 2018-09-03 | Du Pont | Amidas heterociclicas nematicidas. |
| GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
| WO2019148244A1 (en) | 2018-02-01 | 2019-08-08 | The University Of Sydney | Anti-cancer compounds |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4504484A (en) | 1982-11-04 | 1985-03-12 | Chevron Research Company | Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use |
| GB8403726D0 (en) * | 1984-02-13 | 1984-03-14 | Shell Int Research | Carboxamide derivatives |
| JPS6150969A (ja) * | 1984-08-20 | 1986-03-13 | Nippon Kayaku Co Ltd | ピリジン誘導体及びそれを有効成分とする農園芸用細菌病防除剤 |
| DD247598A5 (de) * | 1985-04-04 | 1987-07-15 | F. Hoffmann-La Roche U. Co. Ag,Ch | Fungizide mittel |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| JPH09249648A (ja) * | 1996-03-18 | 1997-09-22 | Dainippon Ink & Chem Inc | ２，６−ジクロロイソニコチン酸フェノキシアルキルアミド誘導体及び農薬 |
| DE19750012A1 (de) | 1997-11-12 | 1999-05-20 | Bayer Ag | Isothiazolcarbonsäureamide |
| EP1254135B1 (en) | 1999-12-02 | 2004-09-15 | Novartis AG | Aminoheterocyclylamides as pesticides and antiparasitic agents |
| CN1226277C (zh) | 2000-02-16 | 2005-11-09 | 石原产业株式会社 | 苯甲酰甲胺衍生物及其制法和含这些衍生物的有害生物防治剂 |
| JP2001316366A (ja) * | 2000-03-01 | 2001-11-13 | Nippon Bayer Agrochem Co Ltd | チオカルボキシアミド類及びその農業用殺菌剤として利用 |
| US7700656B2 (en) * | 2000-12-20 | 2010-04-20 | Novartis Ag | Organic compounds |
| AU2002310099A1 (en) * | 2001-05-22 | 2002-12-03 | President And Fellows Of Harvard College | Identification of anti-protozoal agents |
| TW200305556A (en) * | 2002-03-21 | 2003-11-01 | Novartis Ag | Organic compounds |
| OA19202A (en) | 2002-08-12 | 2006-10-13 | Trinity Bay Equipment Holdings, LLC | Protector assembly for flexible pipe coils and method of using same. |
| EP1449841A1 (en) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
| DE10307845A1 (de) | 2003-02-25 | 2004-09-02 | Bayer Cropscience Gmbh | Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| EP1500651A1 (en) | 2003-07-25 | 2005-01-26 | Bayer CropScience S.A. | N-[2-(2-Pyridinyl)ethyl]benzamide compounds and their use as fungicides |
| AR046757A1 (es) * | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
| EP1548007A1 (en) | 2003-12-19 | 2005-06-29 | Bayer CropScience S.A. | 2-Pyridinylethylcarboxamide derivatives and their use as fungicides |
| TWI368482B (en) | 2003-12-19 | 2012-07-21 | Bayer Sas | New 2-pyridinylethylbenzamide derivatives |
| EP1574511A1 (en) | 2004-03-03 | 2005-09-14 | Bayer CropScience S.A. | 2-Pyridinylethylcarboxamide derivatives and their use as fungicides |
| EP1710237A1 (en) | 2005-04-08 | 2006-10-11 | Bayer CropScience S.A. | New heterocyclylethylbenzamide derivatives |
| ES2502840T3 (es) * | 2005-04-08 | 2014-10-06 | Bayer Cropscience Ag | Derivados de heterocicliletilheterociclilcarboxamida como fungicidas |
| JP2008540433A (ja) | 2005-05-06 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性エポキシドヒドロラーゼインヒビター及びその使用方法 |
| EP1960350B1 (en) | 2005-11-22 | 2015-08-19 | Bayer Intellectual Property GmbH | New n-(1-methyl-2phenylethyl)benzamide derivatives |
| EP1792901A1 (en) | 2005-11-22 | 2007-06-06 | Bayer CropScience S.A. | N-(1-alkyl-2-phenylethyl)-carboxamide derivatives and use thereof as fungicides |
| EP1787981A1 (en) | 2005-11-22 | 2007-05-23 | Bayer CropScience S.A. | New N-phenethylcarboxamide derivatives |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| TWI435863B (zh) | 2006-03-20 | 2014-05-01 | Nihon Nohyaku Co Ltd | Ｎ-２-（雜）芳基乙基甲醯胺衍生物及含該衍生物之蟲害防治劑 |
| CL2008000512A1 (es) | 2007-02-22 | 2008-08-29 | Bayer Cropscience Sa | Compuestos derivados de n-(3-fenilpropil)carboxamida; procedimiento de preparacion de dichos compuestos; composicion fungicida; y metodo para combatir de forma preventiva o curativa los hongos fitopatogenos de cultivos. |
| JP5254957B2 (ja) | 2007-04-12 | 2013-08-07 | 日本農薬株式会社 | 殺線虫剤組成物及びその使用方法 |
| CL2008001647A1 (es) | 2007-06-08 | 2008-10-10 | Syngenta Participations Ag | Compuestos derivados de feniletil-amida de acido-1h-pirazol-4-carboxilico; compuestos derivados de (feniletil)amina; metodo para controlar o prevenir la infestacion de plantas por parte de microorganismos fitopatogenos; y composicion para el control |
| JP2011507910A (ja) * | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
| JP2011529867A (ja) * | 2008-08-01 | 2011-12-15 | バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト | 殺菌性ｎ−（２−フェノキシエチル）カルボキサミド誘導体並びにそれらのアザ類似体、チア類似体及びシラ類似体 |
| WO2010063700A2 (en) | 2008-12-05 | 2010-06-10 | Syngenta Participations Ag | Novel microbiocides |
| US20110028552A1 (en) * | 2009-06-24 | 2011-02-03 | Richard Franklin | Mexiletine amino acid and peptide prodrugs and uses thereof |
| UY33282A (es) * | 2010-03-25 | 2011-09-30 | Novartis Ag | Composiciones endoparasiticidas |
| WO2011128989A1 (ja) | 2010-04-14 | 2011-10-20 | アグロカネショウ株式会社 | ピラジン-2-カルボキサミド誘導体及びこれを有効成分とする殺菌剤 |
| CN108524480A (zh) * | 2011-03-02 | 2018-09-14 | 国立大学法人东京大学 | 体内寄生虫防除剂 |
| KR20140091025A (ko) * | 2011-11-04 | 2014-07-18 | 신젠타 파티서페이션즈 아게 | 살충제 화합물 |
-
2012
- 2012-11-23 AU AU2012342433A patent/AU2012342433A1/en not_active Abandoned
- 2012-11-23 DK DK12788573.9T patent/DK2782565T3/da active
- 2012-11-23 LT LTEP12788573.9T patent/LT2782565T/lt unknown
- 2012-11-23 RU RU2014125466A patent/RU2638830C2/ru not_active IP Right Cessation
- 2012-11-23 HU HUE12788573A patent/HUE047738T2/hu unknown
- 2012-11-23 ES ES12788573T patent/ES2762249T3/es active Active
- 2012-11-23 PT PT127885739T patent/PT2782565T/pt unknown
- 2012-11-23 US US14/360,332 patent/US9422276B2/en active Active
- 2012-11-23 BR BR112014012589A patent/BR112014012589A2/pt not_active Application Discontinuation
- 2012-11-23 SI SI201231697T patent/SI2782565T1/sl unknown
- 2012-11-23 AR ARP120104427A patent/AR088984A1/es active Pending
- 2012-11-23 EP EP12788573.9A patent/EP2782565B1/de not_active Not-in-force
- 2012-11-23 CN CN201280067982.5A patent/CN104203223A/zh active Pending
- 2012-11-23 JP JP2014542842A patent/JP6126115B2/ja active Active
- 2012-11-23 WO PCT/EP2012/073431 patent/WO2013076230A1/de active Application Filing
- 2012-11-23 MX MX2014006136A patent/MX349802B/es active IP Right Grant
- 2012-11-23 PL PL12788573T patent/PL2782565T3/pl unknown
-
2017
- 2017-10-06 AU AU2017239594A patent/AU2017239594A1/en not_active Abandoned
-
2019
- 2019-04-30 AU AU2019203000A patent/AU2019203000A1/en not_active Abandoned
- 2019-12-04 HR HRP20192191TT patent/HRP20192191T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2782565T3 (da) | 2020-01-02 |
| JP2015504437A (ja) | 2015-02-12 |
| AU2012342433A1 (en) | 2014-06-12 |
| RU2014125466A (ru) | 2015-12-27 |
| EP2782565B1 (de) | 2019-11-06 |
| PT2782565T (pt) | 2020-01-07 |
| MX2014006136A (es) | 2014-07-28 |
| NZ624536A (en) | 2016-09-30 |
| AR088984A1 (es) | 2014-07-23 |
| PL2782565T3 (pl) | 2020-08-24 |
| US9422276B2 (en) | 2016-08-23 |
| HUE047738T2 (hu) | 2020-05-28 |
| AU2017239594A1 (en) | 2017-10-26 |
| LT2782565T (lt) | 2019-12-27 |
| WO2013076230A1 (de) | 2013-05-30 |
| BR112014012589A2 (pt) | 2017-06-20 |
| AU2019203000A1 (en) | 2019-05-23 |
| ES2762249T3 (es) | 2020-05-22 |
| EP2782565A1 (de) | 2014-10-01 |
| MX349802B (es) | 2017-08-14 |
| US20140323736A1 (en) | 2014-10-30 |
| SI2782565T1 (sl) | 2019-12-31 |
| RU2638830C2 (ru) | 2017-12-18 |
| JP6126115B2 (ja) | 2017-05-10 |
| CN104203223A (zh) | 2014-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20192191T1 (hr) | Uporaba aril i hetaril karboksamida kao endoparaziticida | |
| HRP20201543T1 (hr) | Antagonisti cb1 receptora | |
| WO2014197876A3 (en) | Sharing three-dimensional gameplay | |
| JP2012125286A5 (hr) | ||
| ME02175B (me) | L-prolin i ko-kristali limunske kiseline od (2s, 3r, 4r, 5s, 6r)-2-(3- ((5- (4- fluorofenil) tiofen-2-il) metil)-4-metilfenil)-6- (hidroksimetil)tetrahidr0- 2h-piran- 3,4,s-triola | |
| IL222417A (en) | -So-Bicyclo [1.2.3] Oct-8-IL) - [5- (h1- Pyrazole-4-IL) -Tiophene-3-IL] Two-tiered methanes in position 3 as inhibitors 11 (beta) -1 HSD | |
| MX2014004849A (es) | Compuesto con actividad nematicida. | |
| JP2016528378A5 (hr) | ||
| EP3307722A4 (en) | Solid forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid | |
| WO2013050022A3 (de) | Beschichtungsmassen für anorganische giessformen und kerne enthaltend salze und deren verwendung | |
| SG11201507352YA (en) | Methods for purifying 5-(halomethyl)furfural | |
| HK1204788A1 (en) | Method of producing 4-[5-(pyridin-4-yl)-1h-1,2,4-triazole-3- yl]pyridin-2-carbonitrile, and intermediary thereof 4-[5-(-4-)-1h-124--3-]-2- | |
| BR112014001309A2 (pt) | pulverização do ferimento | |
| SG10201804289YA (en) | Method for controlling computer, control program and computer | |
| MY193787A (en) | Solid forms of 5-(halomethyl) furfural and methods for preparing thereof | |
| WO2016202425A8 (de) | Eingabevorrichtung zur kontrolle eines avatars in einer rechnergenerierten umgebung sowie verfahren zu deren steuerung | |
| EP2991972A4 (en) | 5- (HYDROXYMETHYL) FURAN-2-CARBALDEHYDE (HMF) -SULFONATE AND METHOD FOR SYNTHESIS THEREOF | |
| SG11201509680TA (en) | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy) but-2-ynyl] 6alpha, 9alpha-difluoro-17alpha-(furan-2-yl) carbonyloxy-11beta -hydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta -carbothioate. | |
| JP2014171862A5 (hr) | ||
| WO2012015750A3 (en) | Phenylalkyl n-hydroxyureas for treating leukotriene related pathologies | |
| JP2015112473A5 (hr) | ||
| JP2020000897A5 (hr) | ||
| JP2014184274A5 (hr) | ||
| JP2014176615A5 (hr) | ||
| JP2014198217A5 (hr) |